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Original Articles
- Contribution of cytologic examination to diagnosis of poorly differentiated thyroid carcinoma
- Na Rae Kim, Jae Yeon Seok, Yoo Seung Chung, Joon Hyop Lee, Dong Hae Chung
- J Pathol Transl Med. 2020;54(2):171-178. Published online February 5, 2020
- DOI: https://doi.org/10.4132/jptm.2019.12.03
- 8,771 View
- 208 Download
- 4 Web of Science
- 6 Crossref
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Abstract
PDF - Background
The cytologic diagnosis of poorly differentiated thyroid carcinoma (PDTC) is difficult because it lacks salient cytologic findings and shares cytologic features with more commonly encountered neoplasms. Due to diverse cytologic findings and paucicellularity of PDTC, standardization of cytologic diagnostic criteria is limited. The purpose of this study is to investigate and recognize diverse thyroid findings of fine needle aspiration (FNA) cytology and frozen smear cytology in diagnosis of this rare but aggressive carcinoma.
Methods
The present study included six cases of FNA cytology and frozen smears of histologically diagnosed PDTCs.
Results
PDTC showed cytologic overlap with well-differentiated thyroid carcinomas (WDTCs). Five of six cases showed dedifferentiation arising from well differentiated thyroid carcinomas. Only one de novo PDTC showed highly cellular smears composed of discohesive small cells, high nuclear/cytoplasmic (N/C) ratio, prominent micronucleoli, and irregular nuclei. Retrospectively reviewed, these findings are highly suspicious for PDTC. Cytologic findings of nuclear atypia, pleomorphism, and irregularity were frequently found, whereas scattered small cells were seen only in the de novo case.
Conclusions
Heterogeneous cytologic findings of PDTCs are shared with those of WDTCs and contribute to difficult preoperative cytologic diagnoses. Most PDTCs show dedifferentiation from WDTCs. Albeit rare, de novo PDTC should be considered with cytology showing discohesive small cells with high N/C ratio. This will enable precise diagnosis and prompt treatment of this aggressive malignancy -
Citations
Citations to this article as recorded by
- Practical and challenging issue in thyroid cytopathology
Qianqian Zhang, Belen Padial Urtueta, Elisabetta Merenda, Gabriele Rotondaro, Noemi Morelli, Alessia Piermattei, Patrizia Straccia, Federica Cianfrini, Angela Feraco, Alessia Granitto, Antonino Mule, Esther Diana Rossi
Human Pathology.2025; : 106019. CrossRef - Non-papillary thyroid carcinoma diagnoses in The Bethesda System for Reporting Thyroid Cytopathology categories V and VI: An institutional experience
Myunghee Kang, Na Rae Kim, Jae Yeon Seok
Annals of Diagnostic Pathology.2024; 71: 152263. CrossRef - Cytologic features of differentiated high‐grade thyroid carcinoma: A multi‐institutional study of 40 cases
Vanda F. Torous, Tikamporn Jitpasutham, Zubair Baloch, Richard L. Cantley, Darcy A. Kerr, Xiaoying Liu, Zahra Maleki, Ross Merkin, Vania Nosé, Liron Pantanowitz, Isabella Tondi Resta, Esther D. Rossi, William C. Faquin
Cancer Cytopathology.2024; 132(8): 525. CrossRef - An Unexpected Finding of Poorly Differentiated Thyroid Carcinoma in a Toxic Thyroid Nodule
Kimberly Yuang, Huda Al-Bahadili, Alan Chang
JCEM Case Reports.2023;[Epub] CrossRef - Revisiting the cytomorphological features of poorly differentiated thyroid carcinoma: a comparative analysis with indeterminate thyroid fine-needle aspiration samples
Yazeed Alwelaie, Ali Howaidi, Mohammed Tashkandi, Ahmad Almotairi, Hisham Saied, Moammar Muzzaffar, Doaa Alghamdi
Journal of the American Society of Cytopathology.2023; 12(5): 331. CrossRef - Characterization of the genomic alterations in poorly differentiated thyroid cancer
Yeeun Lee, SeongRyeol Moon, Jae Yeon Seok, Joon-Hyop Lee, Seungyoon Nam, Yoo Seung Chung
Scientific Reports.2023;[Epub] CrossRef
- Practical and challenging issue in thyroid cytopathology
- Comparison of papanicolaou smear and human papillomavirus (HPV) test as cervical screening tools: can we rely on HPV test alone as a screening method? An 11-year retrospective experience at a single institution
- Myunghee Kang, Seung Yeon Ha, Hyun Yee Cho, Dong Hae Chung, Na Rae Kim, Jungsuk An, Sangho Lee, Jae Yeon Seok, Juhyeon Jeong
- J Pathol Transl Med. 2020;54(1):112-118. Published online January 15, 2020
- DOI: https://doi.org/10.4132/jptm.2019.11.29
- 14,095 View
- 266 Download
- 20 Web of Science
- 23 Crossref
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Abstract
PDF
- Background
The decrease in incidence of cervical dysplasia and carcinoma has not been as dramatic as expected with the development of improved research tools and test methods. The human papillomavirus (HPV) test alone has been suggested for screening in some countries. The National Cancer Screening Project in Korea has applied Papanicolaou smears (Pap smears) as the screening method for cervical dysplasia and carcinoma. We evaluated the value of Pap smear and HPV testing as diagnostic screening tools in a single institution.
Methods
Patients co-tested with HPV test and Pap smear simultaneously or within one month of each other were included in this study. Patients with only punch biopsy results were excluded because of sampling errors. A total of 999 cases were included, and the collected reports encompassed results of smear cytology, HPV subtypes, and histologic examinations.
Results
Sensitivity and specificity of detecting high-grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma (SCC) were higher for Pap smears than for HPV tests (sensitivity, 97.14%; specificity, 85.58% for Pap smears; sensitivity, 88.32%; specificity, 54.92% for HPV tests). HPV tests and Pap smears did not differ greatly in detection of low-grade squamous intraepithelial lesion (85.35% for HPV test, 80.31% for Pap smears). When atypical glandular cells were noted on Pap smears, the likelihood for histologic diagnosis of adenocarcinoma following Pap smear was higher than that of high-risk HPV test results (18.8 and 1.53, respectively).
Conclusions
Pap smears were more useful than HPV tests in the diagnosis of HSIL, SCC, and glandular lesions. -
Citations
Citations to this article as recorded by- Development of a Nano-Real-Time Polymerase Chain Reaction (RT-PCR) Kit for Detection and Genotyping of High-Risk Human Papillomavirus (HPV) Strains Using Dedicated TaqMan Probes
Mohammad Panji, Mohammad Hossein Modarresi, Zahra Azizi, Moloud Absalan, Elahe Motevaseli
Cureus.2026;[Epub] CrossRef - Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears
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Health Promotion International.2025;[Epub] CrossRef - Bibliometric analysis: a study of the microenvironment in cervical cancer (2000-2024)
Yun-Tao Zhang, Yan-Ni Wei, Chen-Chen Liu, Mai-Qing Yang
Frontiers in Oncology.2025;[Epub] CrossRef - Liquid biopsy biomarkers in cervical cancer: A systematic review and meta-analysis
Isaac Kinyua Njangiru, Bizhar Ahmed Tayeb, Hazhmat Ali, Rafl M. Kamil
The Journal of Liquid Biopsy.2025; 10: 100328. CrossRef - Diagnostic Utility of Human Papilloma Virus Testing in Comparison with Pap Cytology and Histopathology in Unvaccinated Women with Cervical High-Grade Dysplasia and Carcinoma in Botswana
Patricia Setsile Rantshabeng, Nametso Dire, Andrew Khulekani Ndlovu, Ishmael Kasvosve
Venereology.2025; 4(4): 15. CrossRef - Challenges in the diagmosis of cervical pathologies
D. Y. Chernov, O. A. Tikhonovskaya, S. V. Logvinov, I. A. Petrov, Y. S. Yuriev, A. A. Zhdankina, A. V. Gerasimov, I. V. Zingalyuk, G. A. Mikheenko
Bulletin of Siberian Medicine.2024; 22(4): 201. CrossRef - “Barriers and Advantages of Self-Sampling Tests, for HPV Diagnosis: A Qualitative Field Experience Before Implementation in a Rural Community in Ecuador”
Bernardo Vega-Crespo, Vivian Alejandra Neira, Ruth Maldonado - Rengel, Diana López, Dayanara Delgado-López, Gabriela Guerra Astudillo, Veronique Verhoeven
International Journal of Women's Health.2024; Volume 16: 947. CrossRef - Cervical Human Papillomavirus Testing
Carol N. Rizkalla, Eric C. Huang
Surgical Pathology Clinics.2024; 17(3): 431. CrossRef - Segmentation of Overlapping Cells in Cervical Cytology Images: A Survey
E Chen, Hua-Nong Ting, Joon Huang Chuah, Jun Zhao
IEEE Access.2024; 12: 114170. CrossRef - Knowledge and awareness regarding pap test and HPV typing for cervical cancer screening in Edo North, Nigeria
Amina Momodu, Johnsolomon Eghosa Ohenhen, Godfrey Innocent Iyare, Musa Abidemi Muhibi, Godwin Avwioro
Discover Public Health.2024;[Epub] CrossRef - Colposcopy Value in Young Child-bearing Women: Is New Recommendations Necessary?
Fahimeh Sabet, Avishan Aminizad, Fariba Behnamfar, Tajossadat Allameh, Seyedeh Ghazal Shahrokh, Rostami Koushan, Amirmohammad Taravati, Leila Mousavi Seresht
Advanced Biomedical Research.2024;[Epub] CrossRef - Selection of endogenous control and identification of significant microRNA deregulations in cervical cancer
T. Stverakova, I. Baranova, P. Mikyskova, B. Gajdosova, H. Vosmikova, J. Laco, V. Palicka, H. Parova
Frontiers in Oncology.2023;[Epub] CrossRef - Cytology Versus Molecular Diagnosis of HPV for Cervical Cancer Screening. Comparison of the Diagnostic Properties of Four Tests in a Rural Community of Cuenca Ecuador
Bernardo Vega Crespo, Vivian Alejandra Neira, Rocío Murillo, Cristina Ochoa Avilés
ESPOCH Congresses: The Ecuadorian Journal of S.T.E.A.M..2023; 3(1): 139. CrossRef - Attitudes towards prevention of cervical cancer and early diagnosis among female academicians
Nurhan Doğan, Gamze Fışkın
Journal of Obstetrics and Gynaecology Research.2022; 48(6): 1433. CrossRef - Role of Self-Sampling for Cervical Cancer Screening: Diagnostic Test Properties of Three Tests for the Diagnosis of HPV in Rural Communities of Cuenca, Ecuador
Bernardo Vega Crespo, Vivian Alejandra Neira, José Ortíz Segarra, Ruth Maldonado Rengel, Diana López, María Paz Orellana, Andrea Gómez, María José Vicuña, Jorge Mejía, Ina Benoy, Tesifón Parrón Carreño, Veronique Verhoeven
International Journal of Environmental Research and Public Health.2022; 19(8): 4619. CrossRef - Utility of Scoring System for Screening and Early Warning of Cervical Cancer Based on Big Data Analysis
Dan Hou, Binjie Yang, Yangdan Li, Ming Sun
Frontiers in Public Health.2022;[Epub] CrossRef - Evaluation of Urine and Vaginal Self-Sampling versus Clinician-Based Sampling for Cervical Cancer Screening: A Field Comparison of the Acceptability of Three Sampling Tests in a Rural Community of Cuenca, Ecuador
Bernardo Vega Crespo, Vivian Alejandra Neira, José Ortíz S, Ruth Maldonado-Rengel, Diana López, Andrea Gómez, María José Vicuña, Jorge Mejía, Ina Benoy, Tesifón Parrón Carreño, Veronique Verhoeven
Healthcare.2022; 10(9): 1614. CrossRef - Diagnostic distribution and pitfalls of glandular abnormalities in cervical cytology: a 25-year single-center study
Jung-A Sung, Ilias P. Nikas, Haeryoung Kim, Han Suk Ryu, Cheol Lee
Journal of Pathology and Translational Medicine.2022; 56(6): 354. CrossRef - Primary screening of cervical cancer by Pap smear in women of reproductive age group
Ruchi Mishra, Dakshina Bisht, Manisha Gupta
Journal of Family Medicine and Primary Care.2022; 11(9): 5327. CrossRef - Comparison of Learning Transfer Using Simulation Problem-Based Learning and Demonstration: An Application of Papanicolaou Smear Nursing Education
Jeongim Lee, Hae Kyoung Son
International Journal of Environmental Research and Public Health.2021; 18(4): 1765. CrossRef - Investigating host-virus interaction mechanism and phylogenetic analysis of viral proteins involved in the pathogenesis
Ahmad Abu Turab Naqvi, Farah Anjum, Alaa Shafie, Sufian Badar, Abdelbaset Mohamed Elasbali, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan, Timir Tripathi
PLOS ONE.2021; 16(12): e0261497. CrossRef - Utility of Human Papillomavirus Testing for Cervical Cancer Screening in Korea
Mee-seon Kim, Eun Hee Lee, Moon-il Park, Jae Seok Lee, Kisu Kim, Mee Sook Roh, Hyoun Wook Lee
International Journal of Environmental Research and Public Health.2020; 17(5): 1726. CrossRef
- Development of a Nano-Real-Time Polymerase Chain Reaction (RT-PCR) Kit for Detection and Genotyping of High-Risk Human Papillomavirus (HPV) Strains Using Dedicated TaqMan Probes
Case Studies
- Primary carcinoid tumor in the external auditory canal
- Dong Hae Chung, Gyu Cheol Han, Na Rae Kim
- J Pathol Transl Med. 2020;54(2):184-187. Published online November 13, 2019
- DOI: https://doi.org/10.4132/jptm.2019.11.07
- 9,013 View
- 167 Download
- 4 Web of Science
- 3 Crossref
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Abstract
PDF
- A 39-year-old man visited the department of otolaryngology due to an ongoing hearing disturbance that had lasted for 1 year. Temporal bone computed tomography revealed soft tissue density nearly obliterating the left external auditory canal (EAC). The mass was composed of sheets of round tumor cells containing moderate amounts of fine granular cytoplasm and salt and pepper chromatin. Neither mitosis nor necrosis was found. The Ki-67 proliferation index was less than 2%. Cells were positive for CD56 and synaptophysin but negative for chromogranin, cytokeratin (CK) 20, and CK7. Based on these findings, the tumor was diagnosed as a carcinoid tumor, well differentiated neuroendocrine carcinoma, grade 1 (G1) according to current World Health Organization (WHO) classification of head and neck tumors; and a neuroendocrine tumor, G1 according to neuroendocrine neoplasm (NEN)-2018 WHO standard classification. He remained free of local recurrence and metastasis after 20 months of follow up. To date, only six cases of primary NENs in the EAC have been reported. Metastatic tumor should be included in the differential diagnoses. Because of its rarity, the prognosis and treatment have not yet been clarified.
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Citations
Citations to this article as recorded by- First Report on a Rare Poorly Differentiated Neuroendocrine Tumour of the External Auditory Canal Involving Pinna
Akash Varshney, Amit Kumar Tyagi, Prashant Durgapal, Kajal Mahto, Akhilesh Chandra Yadav, Ankita Semwal
Indian Journal of Otolaryngology and Head & Neck Surgery.2025; 77(4): 1922. CrossRef - Incidental finding of a neuroendocrine neoplasm in a suspected ear canal exostosis
Alexander Wieck Fjaeldstad, Gerda Elisabeth Villadsen, Gitte Dam, Stephen Jacques Hamilton-Dutoit, Thomas Winther Frederiksen
Otolaryngology Case Reports.2022; 22: 100394. CrossRef - 68Ga-DOTATATE Uptake in Well-Differentiated Neuroendocrine Tumor of the External Auditory Canal
Özge Erol Fenercioğlu, Ediz Beyhan, Rahime Şahin, Mehmet Can Baloğlu, Tevfik Fikret Çermik
Clinical Nuclear Medicine.2022; 47(8): e552. CrossRef
- First Report on a Rare Poorly Differentiated Neuroendocrine Tumour of the External Auditory Canal Involving Pinna
- Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
- Myunghee Kang, Na Rae Kim, Dong Hae Chung, Gie-Taek Yie
- J Pathol Transl Med. 2019;53(3):192-197. Published online April 11, 2019
- DOI: https://doi.org/10.4132/jptm.2019.03.20
- 7,788 View
- 160 Download
- 7 Web of Science
- 8 Crossref
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Abstract
PDF
- A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.
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Citations
Citations to this article as recorded by- A Rare Case of Cervical Solitary Fibrous Tumor in a Pediatric Patient: Case Report and Literature Review
Eleonora Becattini, Lorenzo Sgarbanti, Giuseppina Bevacqua, Valentina Grespi, Carlo Conti
NeuroSci.2025; 6(2): 49. CrossRef - Meningeal Solitary Fibrous Tumor: A Cytological Report With Emphasis on the Usefulness of Immunocytochemical Analysis for STAT6
Hiroyuki Okanishi, Mitsuaki Ishida, Naoto Kohno, Isako Kataoka, Mari Tomiuka, Mayumi Uragami, Shizuka Ono, Chihiro Deguchi, Reika Takeda, Yoshitaka Kurisu, Yoshinobu Hirose
Diagnostic Cytopathology.2025;[Epub] CrossRef - Cytologic features of mesenchymal, melanocytic and haematolymphoid tumours of the central nervous system and metastases
Carmen Bárcena, José A. Jiménez‐Heffernan
Cytopathology.2024; 35(5): 590. CrossRef - A Hemangiopericytoma in the External Auditory Canal: A Rare Clinical Presentation and Management
Vaibhavi Patil, Prasad Deshmukh, Sagar S Gaurkar , Ayushi Ghosh Moulic, Jasleen Kaur
Cureus.2024;[Epub] CrossRef - Scoring system for intraoperative diagnosis of intracranial schwannoma by squash cytology
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Cytopathology.2022; 33(2): 196. CrossRef - Occurrence of a solitary fibrous tumor adjacent to the resection bed of a high-grade meningioma: A case report
Coby Cunningham, Rocco Dabecco, Justin Davanzo
Interdisciplinary Neurosurgery.2021; 25: 101277. CrossRef - A case of solitary fibrous tumor arising in the meninge
Saori NAKANISHI, Naoto KURODA, Toshiko TAKAI, Mari KOJIMA, Misato OONOGI
The Journal of the Japanese Society of Clinical Cytology.2021; 60(4): 224. CrossRef - Intraoperative frozen cytology of intraosseous cystic meningioma in the sphenoid bone
Na Rae Kim, Gie-Taek Yie
Journal of Pathology and Translational Medicine.2020; 54(6): 508. CrossRef
- A Rare Case of Cervical Solitary Fibrous Tumor in a Pediatric Patient: Case Report and Literature Review
- Primary Necrobiotic Xanthogranulomatous Sialadenitis with Submandibular Gland Localization without Skin Involvement
- Myunghee Kang, Na Rae Kim, Dong Hae Chung, Jae Yeon Seok, Dong Young Kim
- J Pathol Transl Med. 2019;53(4):261-265. Published online January 16, 2019
- DOI: https://doi.org/10.4132/jptm.2019.01.08
- 8,933 View
- 169 Download
- 2 Web of Science
- 6 Crossref
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Abstract
PDF
- Necrobiotic xanthogranulomatous reaction is a multiorgan, non-Langerhans cell histiocytosis with an unknown etiology. Occurrence in the salivary gland is extremely rare. We recently identified a case of necrobiotic xanthogranulomatous sialadenitis in a 73-year-old Korean woman who presented with a painless palpable lesion in the chin. There was no accompanying cutaneous lesion. Partial resection and subsequent wide excision with neck dissection were performed. Pathological examination showed a severe inflammatory lesion that included foamy macrophages centrally admixed with neutrophils, eosinophils, lymphocytes, plasma cells, and scattered giant cells, as well as necrobiosis. During the 12-month postoperative period, no grossly remarkable change in size was noted. Necrobiotic xanthogranulomatous inflammation may be preceded by or combined with hematologic malignancy. Although rare, clinicians and radiologists should be aware that an adhesive necrobiotic xanthogranuloma in the salivary gland may present with a mass-like lesion. Further evaluation for hematologic disease and close follow-up are needed when a pathologic diagnosis is made.
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Citations
Citations to this article as recorded by- Salivary gland macrophages in health and disease: heterogeneity, niche crosstalk, and therapeutic avenues
Xinglei Li, Yan Feng, Huixin Xue, Xinxin Ni
Frontiers in Immunology.2025;[Epub] CrossRef - Five Cases of Xanthogranulomatous Sialadenitis
Satoshi Kiyama, Hiroyuki Iuchi, Kotoko Ito, Kengo Nishimoto, Tsutomu Matsuzaki, Masaru Yamashita
Practica Oto-Rhino-Laryngologica.2022; 115(4): 315. CrossRef - Xanthogranulomatous change in a pleomorphic adenoma: An extremely rare variant/degenerative change. Is it fine needle aspiration induced?
Mukta Pujani, Dipti Sidam, Kanika Singh, Aparna Khandelwal, Khushbu Katarya
Diagnostic Cytopathology.2021;[Epub] CrossRef - A Case of Xanthogranulomatous Sialadenitis with Facial Palsy Mimicking Malignancy
Sang Hyun Kim, Sun Woo Kim, Sang Hyuk Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2021; 64(6): 422. CrossRef - Xanthogranulomatous Sialadenitis, an Uncommon Reactive Change is Often Associated with Warthin’s Tumor
Lihong Bu, Hui Zhu, Emilian Racila, Sobia Khaja, David Hamlar, Faqian Li
Head and Neck Pathology.2020; 14(2): 525. CrossRef - A Case of Xanthogranulomatous Sialadenitis of the Sublingual Gland:A Review of Literature
Naoya KITAMURA, Seiji OHNO, Tetsuya YAMAMOTO
Journal of Japanese Society of Oral Medicine.2019; 25(1): 20. CrossRef
- Salivary gland macrophages in health and disease: heterogeneity, niche crosstalk, and therapeutic avenues
Original Article
- Intraoperative Frozen Cytology of Central Nervous System Neoplasms: An Ancillary Tool for Frozen Diagnosis
- Myunghee Kang, Dong Hae Chung, Na Rae Kim, Hyun Yee Cho, Seung Yeon Ha, Sangho Lee, Jungsuk An, Jae Yeon Seok, Gie-Taek Yie, Chan Jong Yoo, Sang Gu Lee, Eun Young Kim, Woo Kyung Kim, Seong Son, Sun Jin Sym, Dong Bok Shin, Hee Young Hwang, Eung Yeop Kim, Kyu Chan Lee
- J Pathol Transl Med. 2019;53(2):104-111. Published online January 14, 2019
- DOI: https://doi.org/10.4132/jptm.2018.11.10
- 14,632 View
- 684 Download
- 9 Web of Science
- 8 Crossref
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Abstract
PDF
- Background
Pathologic diagnosis of central nervous system (CNS) neoplasms is made by comparing light microscopic, immunohistochemical, and molecular cytogenetic findings with clinicoradiologic observations. Intraoperative frozen cytology smears can improve the diagnostic accuracy for CNS neoplasms. Here, we evaluate the diagnostic value of cytology in frozen diagnoses of CNS neoplasms.
Methods
Cases were selected from patients undergoing both frozen cytology and frozen sections. Diagnostic accuracy was evaluated.
Results
Four hundred and fifty-four cases were included in this retrospective single-center review study covering a span of 10 years. Five discrepant cases (1.1%) were found after excluding 53 deferred cases (31 cases of tentative diagnosis, 22 cases of inadequate frozen sampling). A total of 346 cases of complete concordance and 50 cases of partial concordance were classified as not discordant cases in the present study. Diagnostic accuracy of intraoperative frozen diagnosis was 87.2%, and the accuracy was 98.8% after excluding deferred cases. Discrepancies between frozen and permanent diagnoses (n = 5, 1.1%) were found in cases of nonrepresentative sampling (n = 2) and misinterpretation (n = 3). High concordance was observed more frequently in meningeal tumors (97/98, 99%), metastatic brain tumors (51/52, 98.1%), pituitary adenomas (86/89, 96.6%), schwannomas (45/47, 95.8%), high-grade astrocytic tumors (47/58, 81%), low grade astrocytic tumors (10/13, 76.9%), non-neoplastic lesions (23/36, 63.9%), in decreasing frequency.
Conclusions
Using intraoperative cytology and frozen sections of CNS tumors is a highly accurate diagnostic ancillary method, providing subtyping of CNS neoplasms, especially in frequently encountered entities. -
Citations
Citations to this article as recorded by- Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors
Takahiro Hayashi, Kensuke Tateishi, Shinichiro Matsuyama, Hiromichi Iwashita, Yohei Miyake, Akito Oshima, Hirokuni Honma, Jo Sasame, Katsuhiro Takabayashi, Kyoka Sugino, Emi Hirata, Naoko Udaka, Yuko Matsushita, Ikuma Kato, Hiroaki Hayashi, Taishi Nakamur
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Surgical Neurology International.2023; 14: 325. CrossRef - A Comparative Study of Squash Smear Cytology Diagnosis and Radiological Diagnosis with Histopathology in Central Nervous System Lesions
B N Kumarguru, G Santhipriya, S Kranthi Kumar, R Ramesh Kumar, A S Ramaswamy, P Janakiraman
Journal of Cytology.2022; 39(1): 1. CrossRef - Intraoperative squash cytology provides a qualitative intraoperative diagnosis for cases in which frozen section yields a diagnosis of equivocal brain tumour
Hirotaka Fujita, Takuma Tajiri, Tomohisa Machida, Nozomi Nomura, Suguru Toguchi, Hitoshi Itoh, Shinichiro Hiraiwa, Tomoko Sugiyama, Masaaki Imai, Shinri Oda, Masami Shimoda, Naoya Nakamura
Cytopathology.2020; 31(2): 106. CrossRef - Intraoperative frozen cytology of intraosseous cystic meningioma in the sphenoid bone
Na Rae Kim, Gie-Taek Yie
Journal of Pathology and Translational Medicine.2020; 54(6): 508. CrossRef - Use of 5-Aminolevulinic Acid for Confirmation of Lesional Biopsy Sample in Presumed High-Grade Glioma
Victoria L. Watson, Jeffrey W. Cozzens
World Neurosurgery.2019; 132: 21. CrossRef
- Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors
Case Study
- Squamous Cell Carcinoma of the Extrahepatic Common Hepatic Duct
- Myunghee Kang, Na Rae Kim, Dong Hae Chung, Hyun Yee Cho, Yeon Ho Park
- J Pathol Transl Med. 2019;53(2):112-118. Published online October 1, 2018
- DOI: https://doi.org/10.4132/jptm.2018.09.03
- 8,963 View
- 177 Download
- 9 Web of Science
- 11 Crossref
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Abstract
PDF
- We report a rare case of hilar squamous cell carcinoma. A 62-year-old Korean woman complaining of nausea was referred to our hospital. Her biliary computed tomography revealed a 28 mm-sized protruding solid mass in the proximal common bile duct. The patient underwent left hemihepatectomy with S1 segmentectomy and segmental excision of the common bile duct. Microscopically, the tumor was a moderately differentiated squamous cell carcinoma of the extrahepatic bile duct, without any component of adenocarcinoma or metaplastic portion in the biliary epithelium. Immunohistochemically, the tumor was positive for cytokeratin (CK) 5/6, CK19, p40, and p63. Squamous cell carcinoma of the extrahepatic bile duct is rare. To date, only 24 cases of biliary squamous cell carcinomas have been reported. Here, we provide a clinicopathologic review of previously reported extrahepatic bile duct squamous cell carcinomas.
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Citations
Citations to this article as recorded by- Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution
Chunliang Liu, Xiang Wang, Erdong Liu, Yali Zong, Wenlong Yu, Youhai Jiang, Jianan Chen, Mingye Gu, Zhengyuan Meng, Jingfeng Li, Yang Liu, Yongjie Zhang, Jing Tang, Hongyang Wang, Jing Fu
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Jared Beyersdorf, M. Lisa Zhang
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Jane Chiang
Journal of Diagnostic Medical Sonography.2024; 40(6): 609. CrossRef - A Rare Case of Squamous Cell Carcinoma of the Bile Duct
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ACG Case Reports Journal.2023; 10(8): e01119. CrossRef - Metastatic Anal Squamous Cell Carcinoma Presenting as an Indeterminate Biliary Stricture Diagnosed By Cholangioscopy
Ritu Nahar, Ian Holmes, Jeffrey Baliff, Austin Chiang, Thomas Kowalski
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Milind Javle, Sunyoung Lee, Nilofer S Azad, Mitesh J Borad, Robin Kate Kelley, Smitha Sivaraman, Anna Teschemaker, Ishveen Chopra, Nora Janjan, Shreekant Parasuraman, Tanios S Bekaii-Saab
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Dhouha BACHA, Mohamed HAJRI, Wael FERJAOUI, Ghofrane TALBI, Lasaad GHARBI, Mohamed Taher KHALFALLAH, Sana ben SLAMA, Ahlem LAHMAR
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo).2021;[Epub] CrossRef - S1510 A Rare Case of Squamous Cell Carcinoma of the Bile Duct
Stefanie Gallagher, Kyley Leroy, Julianna Tantum, Babak Etemad
American Journal of Gastroenterology.2021; 116(1): S688. CrossRef - Heparin
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Gastroenterología y Hepatología (English Edition).2019; 42(7): 436. CrossRef
- Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution
Brief Case Report
- Post-transplant Amputation Traumatic Neuroma of the Hilum and Extrahepatic Duct in a Liver Donor
- Na Rae Kim, Hyun Yee Cho, Dong Hae Chung, Keon Kuk Kim, Jae Hee Cho, Seung Joon Choi
- J Pathol Transl Med. 2018;52(3):191-194. Published online August 4, 2017
- DOI: https://doi.org/10.4132/jptm.2017.01.20
- 7,242 View
- 113 Download
- 1 Web of Science
- 2 Crossref
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Citations
Citations to this article as recorded by- Biliary tree traumatic neuroma following laparoscopic cholecystectomy: A case report and literature review
Hemn Kaka Ali, Dana Gharib, Marwan Hassan, Ari Abdullah, Deari Ismaeil, Omar Ghalib Hawramy, Dlshad Ahmed, Dilan Hiwa, Berun Abdalla, Fahmi Kakamad
Medicine International.2023;[Epub] CrossRef - Hilar Biliary Amputation Neuroma Following Liver Transplant: A Case Report and Review of the Literature for this Diagnostic and Therapeutic Challenge
Sarang Thaker, Najib Nassani, Bartlomiej Lukasz Radzik, Christine Chan, Wadih Chacra, Sean Koppe, Grace Guzman, Adam E. Mikolajczyk
Transplantation Direct.2022; 8(12): e1405. CrossRef
- Biliary tree traumatic neuroma following laparoscopic cholecystectomy: A case report and literature review
Original Article
- Morphologic Analysis of Cytomegalovirus Infected Cells in Bronchial Washing Cytology: Comparison of Liquid-Based Preparation and Conventional Smear
- Jae Yeon Seok, Jungsuk An, Seung Yeon Ha, Dong Hae Chung, Sangho Lee, Hyunchul Kim
- J Pathol Transl Med. 2016;50(2):147-154. Published online February 15, 2016
- DOI: https://doi.org/10.4132/jptm.2015.12.25
- 12,040 View
- 94 Download
- 4 Web of Science
- 3 Crossref
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Abstract
PDF
- Background
The cytopathic effects of cytomegalovirus (CMV) infection have been well described since the virus was first reported; however, the morphology of CMV infection has not been clearly studied. We examined the difference in detailed cytologic findings in bronchial washing cytology between liquid-based and conventionally prepared smears. Methods: Bronchial washing cytology was processed using either the conventional preparation (CP) or liquid-based preparation (LBP). Sixty-nine cells with typical cytopathic effects of CMV infection were detected on CP slides and 18 cells on LBP slides. Using the image analyzer, area, circumference, major axis, and minor axis of the cytoplasm, nucleus, and intranuclear inclusion were measured in singly scattered CMV-infected cells, and histiocytes were used as a control. Results: The mean cytoplasmic area of CMV-infected cells was 1.47 times larger than that of histiocytes in CP and 2.92 times larger in LBP (p<.05). The mean nuclear area of CMV-infected cells was 2.61 times larger than that of histiocytes in CP and 4.25 times larger in LBP (p<.05). The nucleus to cytoplasm ratio and intranuclear inclusion to cytoplasm ratio of the mean area, circumference, major axis, and minor axis in CP were larger than those in LBP (p<.05). Conclusions: The sizes of cytoplasm, nucleus, and intranuclear inclusion were larger in LBP than in CP, indicating that CMV-infected cells are easily detectable in LBP. However, the nucleus-to-cytoplasm ratio was larger in CP, suggesting that differentiation from malignancy or regenerative atypia requires caution in CP. -
Citations
Citations to this article as recorded by- Pathogens That Rewrite the Rules: Ascoviruses, Elegant Manipulators of Cell Death Pathways and Architects of the Extracellular Viral Paradigm
Sarah R. Rudd, Leticia S. Miranda, Sharon J. Asariah, Chloe S. Rodgers, Jenive T. Estrada, Michael A. Alonzo, Dennis K. Bideshi
Pathogens.2025; 14(11): 1094. CrossRef - Tissue Pathogens and Cancers: A Review of Commonly Seen Manifestations in Histo- and Cytopathology
Tzy Harn Chua, Lavisha S Punjabi, Li Yan Khor
Pathogens.2021; 10(11): 1410. CrossRef - Diagnosis of Infectious Diseases in the Lower Respiratory Tract: A Cytopathologist's Perspective
Rebecca J. Baldassarri, Deepika Kumar, Stephen Baldassarri, Guoping Cai
Archives of Pathology & Laboratory Medicine.2019; 143(6): 683. CrossRef
- Pathogens That Rewrite the Rules: Ascoviruses, Elegant Manipulators of Cell Death Pathways and Architects of the Extracellular Viral Paradigm
Case Study
- Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread
- Na Rae Kim, Hyun Yee Cho, Jeong-Heum Baek, Juhyeon Jeong, Seung Yeon Ha, Jae Yeon Seok, Sung Won Park, Sun Jin Sym, Kyu Chan Lee, Dong Hae Chung
- J Pathol Transl Med. 2016;50(3):231-237. Published online October 8, 2015
- DOI: https://doi.org/10.4132/jptm.2015.08.08
- 13,587 View
- 141 Download
- 5 Web of Science
- 5 Crossref
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Abstract
PDF
- A 61-year-old woman was referred to surgery for incidentally found colonic polyps during a health examination. Physical examination revealed widespread eczematous skin lesion without pruritus in the perianal and vulvar area. Abdominopelvic computed tomography showed an approximately 4-cm-sized, soft tissue lesion in the right perianal area. Inguinal lymph node dissection and Mils’ operation extended to perianal and perivulvar skin was performed. Histologically, the anal canal lesion was composed of mucin-containing signet ring cells, which were similar to those found in Pagetoid skin lesions. It was diagnosed as an anal canal signet ring cell carcinoma (SRCC) with perianal and vulvar Pagetoid spread and bilateral inguinal lymph node metastasis. Anal canal SRCC is rare, and the current case is the third reported case in the English literature. Seven additional cases were retrieved from the world literature. Here, we describe this rare case of anal canal SRCC with perianal Pagetoid spread and provide a literature review.
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Citations
Citations to this article as recorded by- Primary Carcinomas of the Episiotomy Scar Site: A Systematic Literature Review
Andrea Palicelli, Federica Torricelli, Gabriele Tonni, Alessandra Bisagni, Eleonora Zanetti, Magda Zanelli, Venus Damaris Medina-Illueca, Beatrice Melli, Maurizio Zizzo, Andrea Morini, Maria Paola Bonasoni, Giacomo Santandrea, Giuseppe Broggi, Rosario Cal
Current Oncology.2025; 32(2): 65. CrossRef - Metastatic Carcinomas at the Episiotomy Site: A Systematic Literature Review
Andrea Palicelli, Gabriele Tonni, Federica Torricelli, Beatrice Melli, Vincenza Ylenia Cusenza, Sandra Martinelli, Eleonora Zanetti, Alessandra Bisagni, Magda Zanelli, Maria Paola Bonasoni, Teresa Rossi, Lucia Mangone, Venus Damaris Medina-Illueca, Mauriz
Cancers.2025; 17(17): 2801. CrossRef - A Case of Prostatic Signet-Ring Cell-like Carcinoma with Pagetoid Spread and Intraductal Carcinoma and Long-Term Survival: PD-L1 and Mismatch Repair System Proteins (MMR) Immunohistochemical Evaluation with Systematic Literature Review
Nektarios Koufopoulos, Argyro-Ioanna Ieronimaki, Andriani Zacharatou, Alina Roxana Gouloumis, Danai Leventakou, Ioannis Boutas, Dionysios T. Dimas, Adamantia Kontogeorgi, Kyparissia Sitara, Lubna Khaldi, Magda Zanelli, Andrea Palicelli
Journal of Personalized Medicine.2023; 13(6): 1016. CrossRef - Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report
Masamichi Yamaura, Takeshi Yamada, Rei Watanabe, Hitomi Kawai, Suguru Hirose, Hiroki Tajima, Masashi Sato, Yuichi Uchida, Daisuke Suganuma, Yoshiyuki Yamamoto, Toshikazu Moriwaki, Ichinosuke Hyodo
BMC Cancer.2018;[Epub] CrossRef - Solitary left axillary lymph node metastasis after curative resection of carcinoma at the colostomy site: a case report
Ken Imaizumi, Shigenori Homma, Tadashi Yoshida, Tatsushi Shimokuni, Hideyasu Sakihama, Norihiko Takahashi, Hideki Kawamura, Emi Takakuwa, Akinobu Taketomi
Surgical Case Reports.2016;[Epub] CrossRef
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Original Article
- Comparison of Cytologic Characteristics between Adenoid Cystic Carcinoma and Adenoid Basal Carcinoma in the Uterine Cervix
- Juhyeon Jeong, Seung Yeon Ha, Hyun Yee Cho, Dong Hae Chung, Jungsuk An
- J Pathol Transl Med. 2015;49(5):396-402. Published online August 17, 2015
- DOI: https://doi.org/10.4132/jptm.2015.07.08
- 11,023 View
- 96 Download
- 1 Web of Science
- 2 Crossref
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Abstract
PDF
- Background
Adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are rare in the uterine cervix. ACC is more aggressive than ABC, thus accurate differential diagnosis is important. In this study, we identified cytologic features useful in distinguishing these two tumors for diagnosis. Methods: Three cases of ACC and five cases of ABC were selected for this study. Cervicovaginal smear slides were reviewed retrospectively, and the area, circumference, major axis, and minor axis of nuclei were measured using an image analyzer. Results: ACC displayed three-dimensional clusters with a small acini pattern. ABC displayed peripheral palisading without an acini pattern. The nuclei of ACC were more irregular and angulated than those of ABC, and the former showed a coarsely granular chromatin pattern. The nucleic area, circumference, major axis, and minor axis were 18.556±8.665 µm2, 23.320±11.412 µm, 5.664±1.537 µm, and 4.127±1.107 µm in ACC and 11.017±4.440 µm2, 15.920±5.664 µm, 4.612±1.025 µm, and 3.088±0.762 µm in the cases of ABC. All measured values showed statistically significant difference (p < .001). Conclusions: Although the nuclei of both of these tumor types were oval shaped, inferred from the ratio of minor axis to major axis (0.728 in ACC and 0.669 in ABC), the area of nuclei was approximately 1.7 times larger in ACC than in ABC. Distinguishing nucleic features, including area, morphology, and chromatin pattern, may be helpful in making a correct diagnosis. -
Citations
Citations to this article as recorded by- Adenoid basal carcinoma of the uterine cervix
Anas Mohamed, Tesfalem Korga, Ahlam Ali, Javier Laurini
International Journal of Gynecological Cancer.2025; : 101873. CrossRef - Adenoid Basal Carcinoma of the Uterine Cervix: A Case Report
Tatsuya Kanuma, Keiko Kigure, Tosio Nishimura, Yuji Ibuki, Shigeru Tsuchida, Harumi Kamiyama, Misa Iijima, Kazuto Nakamura
The KITAKANTO Medical Journal.2016; 66(1): 11. CrossRef
- Adenoid basal carcinoma of the uterine cervix
Brief Case Reports
- Alveolar Rhabdomyosarcoma of the Lip in an Adult with Clear Cell Features
- Jae Yeon Seok, Juhyeon Jeong, Young Woo Cheon, Hyun Yee Cho, Seung Yeon Ha, Dong Hae Chung
- J Pathol Transl Med. 2015;49(1):81-84. Published online January 15, 2015
- DOI: https://doi.org/10.4132/jptm.2014.06.03
- 13,600 View
- 107 Download
- Cystic Brunner’s Gland Hamartoma in the Gastric Body: A Case Report
- Dong Hae Chung, Na Rae Kim, Hyun Yee Cho, Yoon Jae Kim
- Korean J Pathol. 2014;48(5):371-374. Published online October 27, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.371
- 10,917 View
- 63 Download
- 1 Crossref
- Bilateral Stafne Bone Cavity in the Anterior Mandible with Heterotopic Salivary Gland Tissue: A Case Report
- Hyunchul Kim, Jae Yeon Seok, Sangho Lee, Jungsuk An, Na Rae Kim, Dong Hae Chung, Hyun Yee Cho, Seung Yeon Ha
- Korean J Pathol. 2014;48(3):248-249. Published online June 26, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.248
- 15,175 View
- 108 Download
- 14 Crossref
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PDF
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Citations
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Hak-Sun Kim
Journal of Dental Sciences.2025; 20(1): 502. CrossRef - Static bone cavity occurred in the buccal side of the mandible: A case report and review of literature
Hideki Hojo, Takanori Eguchi, Yumi Ito, Yoshiki Hamada
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2025; 37(4): 698. CrossRef - Bilateral incomplete mandibular canals: an embryological analysis of their possible etiology
Kanitin Rumpansuwon, Thewarid Berkban, Nutmethee Kruepunga, Wattana Weerachatyanukul, Somluk Asuvapongpatana, Arada Chaiyamoon, Benrita Jitaree, R. Shane Tubbs, Joe Iwanaga, Thanyaporn Senarai, Athikhun Suwannakhan
Surgical and Radiologic Anatomy.2025;[Epub] CrossRef - A Rare Case of Anterior Stafne Bone Cavity in the Mandibular Region
Hideki Suito, Yuuri Oku, Koichi Kani, Keiko Aota, Naoki Maeda
Cureus.2025;[Epub] CrossRef - Benign Mandibular Cavity/Stafne's Bone Cyst: A Case Report and Review
Fawzia M. Butt, Shamim M. Butt, Mark L. Chindia
Clinical Case Reports.2025;[Epub] CrossRef - Bilateral Stafne Bone Cavity in the Body of the Mandible: An Unusual Case Report and Literature Review
Mayank Pahadia, Rutvi Vyas
Cureus.2023;[Epub] CrossRef - Effect of Stafne bone defect on the adjacent tooth: A review of the literature
Mahdi Niknami, Azin Parsa, Zahra Khodadadi
Imaging Science in Dentistry.2022; 52(2): 165. CrossRef - Assessment of prevalence and volumetric estimation of possible Stafne bone concavities on cone beam computed tomography images
Alaettin Koç, Cennet Neslihan Eroğlu, Ersen Bilgili
Oral Radiology.2020; 36(3): 254. CrossRef - Stafne’s bone cyst revisited and renamed: the benign mandibular concavity
Johan K.M. Aps, Natasha Koelmeyer, Cina Yaqub
Dentomaxillofacial Radiology.2020; 49(4): 20190475. CrossRef - Cone‐beam computed tomography analysis of lingual mandibular bone depression in the premolar region: A case report
Saeed Asgary, Naghmeh Emadi
Clinical Case Reports.2020; 8(3): 523. CrossRef - Letters to the Editor
Ariyan S Araghi, Richard M Graham
Dental Update.2019; 46(8): 792. CrossRef - Radiographic features of lingual mandibular bone depression using dental cone beam computed tomography
Liu Liu, Byung Cheol Kang, Suk Ja Yoon, Jae Seo Lee, Sel Ae Hwang
Dentomaxillofacial Radiology.2018; 47(6): 20170383. CrossRef - Stafne's bone cavity – unusual presentation in the anterior mandible
Ioan Davies, Holly Boyes, James Wykes, Graham Smith
Dental Update.2018; 45(4): 340. CrossRef - Anterior stafne bone cyst mimicking periapical cyst: a case report
Ji-Young Song
Journal of Dental Rehabilitation and Applied Science.2016; 32(3): 209. CrossRef
- Diagnostic approach for the rare anterior variant of mandibular bone depression often misdiagnosed as tumorous lesions
- Crush Cytology of Microcystic Meningioma with Extensive Sclerosis
- Jae Yeon Seok, Na Rae Kim, Hyun Yee Cho, Dong Hae Chung, Gi-Taek Yee, Eung Yeop Kim
- Korean J Pathol. 2014;48(1):77-80. Published online February 25, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.77
- 11,377 View
- 57 Download
- 6 Crossref
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PDF
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Citations
Citations to this article as recorded by- Cytologic features of meningioma: An analysis of common and uncommon subtypes and diagnostic difficulties during intraoperative procedures
Ana M. Rodríguez‐García, Isabel Esteban‐Rodríguez, José A. Jiménez‐Heffernan, Carmen Bárcena, Samuel López‐Muñoz, Pilar López‐Ferrer
Cytopathology.2024; 35(5): 581. CrossRef - Exploring the role of epidermal growth factor receptor variant III in meningeal tumors
Rashmi Rana, Vaishnavi Rathi, Kirti Chauhan, Kriti Jain, Satnam Singh Chhabra, Rajesh Acharya, Samir Kumar Kalra, Anshul Gupta, Sunila Jain, Nirmal Kumar Ganguly, Dharmendra Kumar Yadav, Timir Tripathi
PLOS ONE.2021; 16(9): e0255133. CrossRef - Intraoperative frozen cytology of intraosseous cystic meningioma in the sphenoid bone
Na Rae Kim, Gie-Taek Yie
Journal of Pathology and Translational Medicine.2020; 54(6): 508. CrossRef - Can amide proton transfer–weighted imaging differentiate tumor grade and predict Ki-67 proliferation status of meningioma?
Hao Yu, Xinrui Wen, Pingping Wu, Yueqin Chen, Tianyu Zou, Xianlong Wang, Shanshan Jiang, Jinyuan Zhou, Zhibo Wen
European Radiology.2019; 29(10): 5298. CrossRef - Intraoperative Frozen Cytology of Central Nervous System Neoplasms: An Ancillary Tool for Frozen Diagnosis
Myunghee Kang, Dong Hae Chung, Na Rae Kim, Hyun Yee Cho, Seung Yeon Ha, Sangho Lee, Jungsuk An, Jae Yeon Seok, Gie-Taek Yie, Chan Jong Yoo, Sang Gu Lee, Eun Young Kim, Woo Kyung Kim, Seong Son, Sun Jin Sym, Dong Bok Shin, Hee Young Hwang, Eung Yeop Kim, K
Journal of Pathology and Translational Medicine.2019; 53(2): 104. CrossRef - Crush Cytology of Secretory Meningioma: A Case Report
Na Rae Kim, Gie-Taek Yee, Hyun Yee Cho
Brain Tumor Research and Treatment.2015; 3(2): 147. CrossRef
- Cytologic features of meningioma: An analysis of common and uncommon subtypes and diagnostic difficulties during intraoperative procedures
- Adenocarcinoma Arising in a Colonic Duplication Cyst: A Case Report and Review of the Literature
- Myunghee Kang, Jungsuk An, Dong Hae Chung, Hyun Yee Cho
- Korean J Pathol. 2014;48(1):62-65. Published online February 25, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.62
- 7,865 View
- 60 Download
- 12 Crossref
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PDF
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Citations
Citations to this article as recorded by- Low-grade mucinous neoplasm originating from intestinal duplication: a case report and review of the literature
Huihui Yin, Jie Yu, Yunzhao Chen
World Journal of Surgical Oncology.2025;[Epub] CrossRef - Adenocarcinoma originating from a colonic duplication cyst: A case report
Jeehye Lee, Jung Wook Suh
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef - Low-Grade Mucinous Neoplasm Arising in an Enteric Duplication Cyst of Pancreas: A Case Report and Literature Review
Mengjing Fan, Fang Yang
International Journal of Surgical Pathology.2024; 32(2): 422. CrossRef - Colonic duplication in an adult with chronic constipation: a case report and review of its surgical management
Muhammad Ash-Shafhawi Adznan, Hizami Amin Tai, Aras Emre Canda, Nevra Elmas, Mustafa Cem Terzi
Annals of Coloproctology.2024; 40(Suppl 1): S6. CrossRef - Tubular adenoma arising in tubular colonic duplication: a case report
Heonwoo Lee, Hyeong Rok An, Chan Wook Kim, Young Soo Park
Journal of Pathology and Translational Medicine.2024; 58(4): 198. CrossRef - Right-Sided Colonic Duplication Cyst with a Malignant Twist in a Young Adult — a Case Report
Laxmi Radhakrishnan, Joseph George, Latha K. Abraham
Journal of Gastrointestinal Cancer.2022; 53(3): 805. CrossRef - Endoscopic resection of a duodenal duplication cyst: A case report
Sayumi Kurita, Kazuo Kitagawa, Naoki Toya, Masahiko Kawamura, Muneo Kawamura, Ken Eto
DEN Open.2022;[Epub] CrossRef - Complete colonic duplication presenting as hip fistula in an adult with pelvic malformation: A case report
Xuan Cai, Jing-Tao Bi, Zhi-Xue Zheng, Ya-Qi Liu
World Journal of Clinical Cases.2022; 10(30): 11037. CrossRef - Sigmoid colon duplication seen as a rare cause of ileus in adult: case report
Barış BAYRAKTAR, Salih BOLUK, Sümeyra Emine BÖLÜK
Anatolian Current Medical Journal.2022; 4(3): 323. CrossRef - Successful management of tubular colonic duplication using a laparoscopic approach: A case report and review of the literature
Gan-Bin Li, Jia-Gang Han, Zhen-Jun Wang, Zhi-Wei Zhai, Yu Tao
World Journal of Clinical Cases.2020; 8(15): 3291. CrossRef - Sigmoid colon duplication with ectopic immature renal tissue in an adult: A case report
Hwan Namgung
World Journal of Clinical Cases.2020; 8(24): 6346. CrossRef - Retroperitoneal Mucinous Neoplasm Arising from Colonic Duplication Cyst
María M. Rojas-Rojas, Marcela Mejiah, Martha Mora, Jorge Otero, Fernando Arias-Amézquita, Eduardo Londoño-Schimmer, Paula A. Rodríguez-Urrego
Journal of Gastrointestinal Cancer.2019; 50(3): 583. CrossRef
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Original Article
- Uncommon and Rare Human Papillomavirus Genotypes Relating to Cervical Carcinomas
- Na Rae Kim, Myunghee Kang, Soon Pyo Lee, Hyunchul Kim, Jungsuk An, Dong Hae Chung, Seung Yeon Ha, Hyun Yee Cho
- Korean J Pathol. 2014;48(1):43-49. Published online February 25, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.43
- 10,329 View
- 56 Download
- 10 Crossref
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Abstract
PDF
Background Human papillomavirus (HPV) is an oncogenic virus in cervical cancer and most invasive carcinomas (ICs) are caused by HPV16 and 18. However, the roles and contributions of other uncommon and rare genotypes remain uncertain.
Methods HPV genotypes were retrospectively assessed using an HPV DNA chip that can specify up to 32 HPV genotypes. We arbitrarily regarded genotypes accounting for less than 6% of the total as uncommon and rare genotypes.
Results A total of 3,164 HPV-positive cases were enrolled. In groups 2A, 2B, 3, and unclassified HPV genotypes, 2.4% of cases with uncommon HPV genotypes (68, 26, 34, 53, 66, 69, 70, 73, 40, 42, 43, 44, 54, 55, 61, 62, 6, and 11) showed high grade squamous intraepithelial lesions and ICs. There were no HPV32- and 57-infected cases.
Conclusions We found that the uncommon and rare HPV genotypes may provide incremental etiologic contributions in cervical carcinogenesis, especially HPV68, 70, and 53. Further studies on these uncommon and rare HPV genotypes will be of importance in establishing the significance of genotypes in different regions, especially in planning a strategy for further vaccine development as well as follow-up on the effectiveness of the currently used vaccines.
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Citations
Citations to this article as recorded by- High-risk human papillomavirus diversity among indigenous women of western Botswana with normal cervical cytology and dysplasia
Patricia S. Rantshabeng, Billy M. Tsima, Andrew K. Ndlovu, Keneilwe Motlhatlhedi, Kirthana Sharma, Carol B. Masole, Natasha O. Moraka, Kesego Motsumi, Angela K. T. Maoto-Mokote, Alemayehu B. Eshetu, Leabaneng Tawe, Tendani Gaolathe, Sikhulile Moyo, Lynnet
BMC Infectious Diseases.2024;[Epub] CrossRef - Human Papillomavirus (HPV69/HPV73) Coinfection associated with Simultaneous Squamous Cell Carcinoma of the Anus and Presumed Lung Metastasis
Stephanie Shea, Marina Muñoz, Stephen C. Ward, Mary B. Beasley, Melissa R Gitman, Michael D Nowak, Jane Houldsworth, Emilia Mia Sordillo, Juan David Ramirez, Alberto E. Paniz Mondolfi
Viruses.2020; 12(3): 349. CrossRef - Human Papillomavirus Selected Properties and Related Cervical Cancer Prevention Issues
Saule Balmagambetova, Andrea Tinelli, Ospan A. Mynbaev, Arip Koyshybaev, Olzhas Urazayev, Nurgul Kereyeva, Elnara Ismagulova
Current Pharmaceutical Design.2020; 26(18): 2073. CrossRef - Periungual Bowen's disease with a narrow longitudinal melanonychia mimicking periungual warts
Taiyo HITAKA, Michiko HASEGAWA, Akira SHIMIZU, Yuko KURIYAMA, Atsushi TAMURA
Skin Cancer.2019; 33(3): 211. CrossRef - Detection of HPV RNA molecules in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent cervical intraepithelial lesion: a case report
Shiho Fukui, Kazunori Nagasaka, Naoko Iimura, Ranka Kanda, Takayuki Ichinose, Takeru Sugihara, Haruko Hiraike, Shunsuke Nakagawa, Yuko Sasajima, Takuya Ayabe
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María Guadalupe Flores-Miramontes, Luis Alberto Torres-Reyes, Liliana Alvarado-Ruíz, Salvador Angel Romero-Martínez, Verenice Ramírez-Rodríguez, Luz María Adriana Balderas-Peña, Verónica Vallejo-Ruíz, Patricia Piña-Sánchez, Elva Irene Cortés-Gutiérrez, Lu
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Adela Carrillo-García, Sergio Ponce-de-León-Rosales, David Cantú-de-León, Verónica Fragoso-Ontiveros, Imelda Martínez-Ramírez, Asunción Orozco-Colín, Alejandro Mohar, Marcela Lizano
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Jin Hee Kang, Hwa young Ahn, Miri Kim, Shin Taek Oh, Baik Kee Cho, Hyun Jeong Park
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- High-risk human papillomavirus diversity among indigenous women of western Botswana with normal cervical cytology and dysplasia
Brief Case Reports
- Primary Gastric Melanoma with Rhabdoid Features: A Case Report
- Na Rae Kim, Woon Kee Lee, Dong Hae Chung
- Korean J Pathol. 2013;47(6):606-609. Published online December 24, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.606
- 7,198 View
- 52 Download
- 6 Crossref
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Citations
Citations to this article as recorded by- Primary Cutaneous Rhabdomyosarcomatous Melanomas—A Report of Two Cases and Literature Review
Andreea Iliesiu, Victor Nimigean, Dana Antonia Tapoi, Mariana Costache
Diagnostics.2025; 15(11): 1357. CrossRef - Primary gastric melanoma in adult population: a systematic review of the literature
Dimitrios Schizas, Nefeli Tomara, Ioannis Katsaros, Stratigoula Sakellariou, Nikolaos Machairas, Anna Paspala, Diamantis I. Tsilimigras, Ioannis S. Papanikolaou, Dimitrios Mantas
ANZ Journal of Surgery.2021; 91(3): 269. CrossRef - A Rare Case of Primary Gastric Melanoma
Maciej Wiewiora, Katrzyna Steplewska, Jerzy Z. Piecuch, Jerzy Piecuch
Indian Journal of Surgery.2020; 82(3): 442. CrossRef - Primary malignant melanoma of the stomach: A rare neoplasm
Samreen Zaheer, Divya Khosla, Kannan Periasamy, Sakshi Rana, Renu Madan, Geethanjali Gude, RakeshK Vasishta, Rakesh Kapoor
Clinical Cancer Investigation Journal.2020; 9(5): 216. CrossRef - The Challenge of Primary Gastric Melanoma: a Systematic Review
Gregory S Mellotte, Diya Sabu, Mary O’Reilly, Ray McDermott, Anthony O’Connor, Barbara M Ryan
Melanoma Management.2020;[Epub] CrossRef - Primary Gastric Melanoma: Case Report of a Rare Malignancy
Alexander Augustyn, Emma Diaz de Leon, Adam C. Yopp
Rare Tumors.2015; 7(1): 46. CrossRef
- Primary Cutaneous Rhabdomyosarcomatous Melanomas—A Report of Two Cases and Literature Review
- Fine Needle Aspiration Cytology of Postoperative Spindle Cell Nodule in Neck after Thyroidectomy: A Case Report
- Myunghee Kang, Seung Yeon Ha, Hyun Yee Cho, Jungsuk An, Dong Hae Chung, Yoo Seung Chung
- Korean J Pathol. 2013;47(1):89-91. Published online February 25, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.89
- 8,880 View
- 44 Download
- 3 Crossref
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Citations
Citations to this article as recorded by- Post-surgical thyroid bed myofibroma simulating a recurrent papillary thyroid carcinoma: A case report and review of the literature
Jun Hyeon Park, Kyung Sik Yi, Chi-Hoon Choi, Yook Kim, Jisun Lee, Yeongtae Park, Ok-Jun Lee
Medicine.2024; 103(2): e36945. CrossRef - USP6‐associated neoplasm as a tentative subset of postoperative spindle cell nodule
Lili Sun, Zehua Zhao, Yanmei Zhu
Histopathology.2023; 82(4): 587. CrossRef - Diagnostic Performance of Core Needle Biopsy for Characterizing Thyroidectomy Bed Lesions
So Yeong Jeong, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Dong Eun Song, Ki-Wook Chung, Won Woong Kim, Jeong Hyun Lee
Korean Journal of Radiology.2022; 23(10): 1019. CrossRef
- Post-surgical thyroid bed myofibroma simulating a recurrent papillary thyroid carcinoma: A case report and review of the literature
Case Report
- Cervical Lymphadenopathy Mimicking Angioimmunoblastic T-Cell Lymphoma after Dapsone-Induced Hypersensitivity Syndrome
- Min Young Rim, Junshik Hong, Inku Yo, Hyeonsu Park, Dong Hae Chung, Jeong Yeal Ahn, Sanghui Park, Jinny Park, Yun Soo Kim, Jae Hoon Lee
- Korean J Pathol. 2012;46(6):606-610. Published online December 26, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.606
- 10,473 View
- 62 Download
- 7 Crossref
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Abstract
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A 36-year-old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice after 8 months of dapsone therapy. Her symptoms had developed progressively, and a physical examination revealed bilateral cervical lymphadenopathy and splenomegaly. Excisional biopsy of a cervical lymph node showed effacement of the normal architecture with atypical lymphoid hyperplasia and proliferation of high endothelial venules compatible with angioimmunoblastic T-cell lymphoma. However, it was assumed that the cervical lymphadenopathy was a clinical manifestation of a systemic hypersensitivity reaction because her clinical course was reminiscent of dapsone-induced hypersensitivity syndrome. A liver biopsy revealed drug-induced hepatitis with no evidence of lymphomatous involvement. Intravenous glucocorticoid was immediately initiated and her symptoms and clinical disease dramatically improved. The authors present an unusual case of cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma as an adverse reaction to dapsone.
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Citations
Citations to this article as recorded by- Non-leprosy related dapsone hypersensitivity syndrome: A case report and literature review
Hang-Qi Zhu, Si-Hua Jiang, Guo-Lin Song
Medicine.2025; 104(27): e43073. CrossRef - Morphologic Spectrum of Lymphadenopathy in Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome
Hui-Chun Chen, Ren Ching Wang, Huey-Pin Tsai, L. Jeffrey Medeiros, Kung-Chao Chang
Archives of Pathology & Laboratory Medicine.2022; 146(9): 1084. CrossRef - Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review
Shiva Sharifzadeh, Amir Hooshang Mohammadpour, Ashraf Tavanaee, Sepideh Elyasi
European Journal of Clinical Pharmacology.2021; 77(3): 275. CrossRef - Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma
Faaria Gowani, Bradley Gehrs, Teresa Scordino
Case Reports in Hematology.2018; 2018: 1. CrossRef - In vitrotesting for diagnosis of idiosyncratic adverse drug reactions: Implications for pathophysiology
Abdelbaset A. Elzagallaai, Michael J. Rieder
British Journal of Clinical Pharmacology.2015; 80(4): 889. CrossRef - Dapsone-induced drug reaction with eosinophilia and systemic symptoms syndrome, misdiagnosed as lymphoma
Bomi Shin, So Young Park, Sun-Young Yoon, Eun-Hye Shin, Young-Joo Yang, Hyung-Jin Cho, Il-Young Jang, Dong-Uk Kang, Tae-Bum Kim, You Sook Cho, Hee-Bom Moon, Hyouk-Soo Kwon
Allergy, Asthma & Respiratory Disease.2013; 1(4): 400. CrossRef - T-cell lymphoma presenting as drug rash with eosinophilia and systemic symptoms syndrome
Mi-Ae Kim, Hye-Soo Yoo, Sun Hyuk Hwang, Yoo Seob Shin, Dong-Ho Nahm, Hae-Sim Park
Allergy Asthma & Respiratory Disease.2013; 1(3): 280. CrossRef
- Non-leprosy related dapsone hypersensitivity syndrome: A case report and literature review
Original Article
- Morphometric Analysis for Pulmonary Small Cell Carcinoma Using Image Analysis.
- Sun Min Jeong, Seung Yeon Ha, Jungsuk An, Hyun Yee Cho, Dong Hae Chung, Na Rae Kim, Sanghui Park
- Korean J Pathol. 2011;45(1):87-91.
- DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.87
- 4,316 View
- 28 Download
- 1 Crossref
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Abstract
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- BACKGROUND
There are few studies of how to diagnose small cell lung cancer in cytological tests through morphometric analysis. We tried to measure and analyze characteristics of small cell carcinoma in lung by image analysis.
METHODS
We studied three types of cytologic specimens from 89 patients who were diagnosed with small cell lung cancer by immunohistochemistry. We measured area, perimeter, maximal length and maximal width of cells from small cell carcinoma using image analysis.
RESULTS
In lung aspirates, the nuclear mean area, perimeter, maximal length and maximal width of small cell lung cancer were 218.69 microm2, 55 microm, 18.48 microm and 14.65 microm. In bronchial washings, nuclear measurements were 194.66 microm2, 50.07 microm, 16.27 microm and 14.1 microm. In pleural fluid, values were 177.85 microm2, 48.09 microm, 15.7 microm and 13.37 microm.
CONCLUSIONS
Nuclear size of small cell lung carcinoma is variable and depends on the cytology method. Nuclei are spindle-shaped and larger in small cell carcinoma from lung aspirates than in bronchial washings or pleural fluid. The cytoplasms of the cells in bronchial washings and pleural fluid were swollen. Therefore, one should consider morphologic changes when trying to diagnose small cell lung cancer through cytological tests. -
Citations
Citations to this article as recorded by- Interobserver Variability in Diagnosing High-Grade Neuroendocrine Carcinoma of the Lung and Comparing It with the Morphometric Analysis
Seung Yeon Ha, Joungho Han, Wan-Seop Kim, Byung Seong Suh, Mee Sook Roh
Korean Journal of Pathology.2012; 46(1): 42. CrossRef
- Interobserver Variability in Diagnosing High-Grade Neuroendocrine Carcinoma of the Lung and Comparing It with the Morphometric Analysis
Case Report
- The Fine Needle Aspiration Cytology of a Metastatic Pulmonary Adrenocortical Carcinoma Mimicking Primary Large Cell Carcinoma of the Lung.
- Na Rae Kim, Dong Hae Chung, Jae Ik Lee, Seung Yeon Ha
- Korean J Pathol. 2010;44(5):558-563.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.558
- 3,264 View
- 17 Download
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Abstract
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- Adrenocortical carcinoma is a rare neoplasm and it has an invariably lethal prognosis. We report here on the fine needle aspiration cytologic findings of a solitary metastatic pulmonary adrenocortical carcinoma in a 24-year-old woman. The aspirate smears were very cellular and they were composed of a monomorphic population of large polyhedral cells with abundant granular or vacuolated cytoplasm, and the cells were predominantly singly scattered in a necrotic background. Multinucleated pleomorphic tumor cells were also found. Pleomorphic nuclei with thickened nuclear membranes were impinging on the cell membranes. Mitotic activity was occasionally seen. The cytologic findings of pleomorphic cells with microvacuolated cytoplasm and the presence of vague gland-like sheets, as well as the patient's history of undergoing adrenalectomy for primary adrenocortical carcinoma helped the pathologist reach the diagnosis of metastatic adrenocortical carcinoma. Here, we focus on the cytologic differential points of metastastic pulmonary adrenocortical carcinoma and primary pulmonary carcinoma, especially large cell carcinoma.
Original Article
- The Analysis and Clinical Usefulness of HPV DNA Chip Test in the Uterine Cervix.
- Joo hyeon Jeong, Hyun Yee Cho, Na Rae Kim, Dong Hae Chung, Sanghui Park, Seung Yeon Ha
- Korean J Pathol. 2010;44(1):77-82.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.1.77
- 4,435 View
- 27 Download
- 3 Crossref
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Abstract
PDF
- BACKGROUND
The genotypes of human papillomavirus (HPV) are important in carcinogenesis in uterine cervical cancer and may be different in geographic distribution.
METHODS
In 2,086 women, we analyzed the prevalence of HPV and HPV genotypes in uterine cervix by HPV-DNA chip test (n = 2,086), cytology (PAP smear, n = 1997) and biopsy (n = 546).
RESULTS
Of the 2,086 cases, 1,019 cases (48.8%) were HPV-positive and 1,067 cases (51.2%) were negative for HPV. Single infection occurred most commonly (72.1% of women). HPV genotypes in the high-risk and low-risk groups, respectively were HPV-16/-58/-18/-52/-53 and HPV-70/-6/-11. The detection rates of HPV-70 in subjects older than 50 years increased significantly (p < 0.05). Infection in high risk subjects was detected in high grade lesions compared with infection in low risk subjects (p < 0.05).
CONCLUSIONS
HPV-16/-58/-18/-52/-53/-70/-6/-11 genotypes were common in the patient group similar to findings in East Asia. HPV-70 infection is predominant in those older than 40 years. -
Citations
Citations to this article as recorded by- Current Status of and Perspectives on Cervical Cancer Screening in Korea
Sung-Chul Lim, Chong Woo Yoo
Journal of Pathology and Translational Medicine.2019; 53(4): 210. CrossRef - Cervical cytology of atypical squamous cells, cannot exclude high-grade squamous intra-epithelial lesion: significance of age, human papillomavirus DNA detection and previous abnormal cytology on follow-up outcomes
Chang Ohk Sung, Young Lyun Oh, Sang Yong Song
European Journal of Obstetrics & Gynecology and Reproductive Biology.2011; 159(1): 155. CrossRef - Cytomorphologic Features According to HPV DNA Type in Histologically Proven Cases of the Uterine Cervix
In Ho Choi, So-Young Jin, Dong Wha Lee, Dong Won Kim, Yoon Mi Jeen
The Korean Journal of Pathology.2011; 45(6): 612. CrossRef
- Current Status of and Perspectives on Cervical Cancer Screening in Korea
Case Reports
- Ovarian Endometrioid Adenocarcinoma with a Yolk Sac Tumor Component.
- Dong Hae Chung, Sanghui Park, Hee Eun Kyung, Na Rae Kim, Seung Yeon Ha, Soyi Lim, Hyun Yee Cho
- Korean J Pathol. 2009;43(6):570-574.
- DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.570
- 3,809 View
- 27 Download
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Abstract
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- Ovarian endometrioid adenocarcinoma (EAC) with a yolk sac tumor (YST) component is extremely rare. Only twelve cases have been reported in the English literature. We report here two additional cases of this rare tumor. The YST component showed classic microscopic features, and immunohistochemically stained positive for alpha-fetoprotein (AFP), but negative for cytokeratin 7 (CK7), epithelial membrane antigen (EMA), estrogen receptor (ER) and progesterone receptor (PR). The EAC appeared to blend into the YST in several areas and immunohistochemically stained positive for CK7, EMA, ER, and PR, but negative for AFP.
- Eosinophilic Fasciitis Associated with Overlying Intraepidermal Blister Formation: A Case Report.
- Na Rae Kim, Dong Hae Chung, Seung Yeon Ha
- Korean J Pathol. 2009;43(5):478-481.
- DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.5.478
- 3,706 View
- 19 Download
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Abstract
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- Eosinophilic fasciitis is a scleroderma-like disease and it may present with paraneoplastic syndrome or as an isolated form of the disease. We report here on a case of eosinophilic fasciitis in a 20-year-old woman who presented with an abrupt onset of subcutaneous limb swelling and peripheral eosinophilia. Pathologically, the specimen was characterized by acute inflammation and thickening of the collagen bundles in the reticular dermis and superficial muscle fascia in addition to the overlying intraepidermal blisters that contained many eosinophils. Eosinophils, some lymphocytes and plasma cells were infiltrated in the superficial muscle fascia and subcutaneous fat. The diagnosis of eosinophilic fasciitis was confirmed by biopsy. It is intriguing that eosinophilic fasciitis showed the microscopic findings of intraepidermal blister with predominant inflammation, and the patient showed a good response to steroid therapy.
- The Cytology of Metastatic Angiosarcoma in Pleural Fluid : A Case Report.
- Na Rae Kim, Dong Hae Chung, Hyun Yee Cho
- Korean J Pathol. 2009;43(3):285-259.
- DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.3.285
- 4,544 View
- 60 Download
- 4 Crossref
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Abstract
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- A 74-year-old woman presented with an abrupt onset of dyspnea that she had experienced for a week. She had been suffering from cutaneous nodules in the scalp for a year. Thoracentesis of the pleural fluid was performed. The Papanicolaou-stained smears, Thin prep and cell block preparations revealed clusters of oval-shaped cells concentrically layered about amorphous acellular cores, i.e., there was microacinar lumen formation as well as singly scattered atypical cells. The cells occasionally demonstrated intracytoplasmic vacuoles and hemosiderin deposits. Those cells stained for CD31 and they were negative for pancytokeratin. Punch biopsy from the scalp nodules revealed angiosarcoma. There are currently few reported cases of angiosarcoma in an exfoliative pleural effusion. Angiosarcoma has diverse, heterogeneous cytologic features. Making the cytologic diagnosis of metastatic angiosarcoma in pleural fluid is a challenge for pathologists. Knowledge of the clinical history is of great help for diagnosing this tumor when it appears in rare sites. Immunopanels with CD31, pancytokeratin and TTF-1 are helpful for making the differential diagnosis. The pathologists should look for clues suggesting the presence of vascular differentiation in the exfoliative cytologic materials when a diagnosis of angiosarcoma is suspected.
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Citations
Citations to this article as recorded by- Metastatic pleural angiosarcoma: A diagnostic pitfall might be overcome by morphologic clues and clinical correlation
Ok Ran Shin, Uiju Cho, Eundeok Chang, Kyung Jin Seo
Diagnostic Cytopathology.2015; 43(8): 669. CrossRef - Pleural fluid cytology in metastatic uterine angiosarcoma—A case report—
Shiho KURODA, Shioto SUZUKI, Akira KURITA, Mari MURAKI, Fumihiko TANIOKA
The Journal of the Japanese Society of Clinical Cytology.2014; 53(6): 498. CrossRef - Intranasal delivery of biologics to the central nervous system
Jeffrey J. Lochhead, Robert G. Thorne
Advanced Drug Delivery Reviews.2012; 64(7): 614. CrossRef - Fine Needle Aspiration Cytologic Findings of Angiosarcoma - Report of Two Cases -
Jin Xian Ji, Young Chae Chu, Lucia Kim, Suk Jin Choi, In Suh Park, Jee Young Han, Joon Mee Kim, Kyu Ho Kim, Ju Young Song
The Korean Journal of Pathology.2011; 45(2): 217. CrossRef
- Metastatic pleural angiosarcoma: A diagnostic pitfall might be overcome by morphologic clues and clinical correlation
Original Article
- The Usefulness of the HPV DNA Microchip Test for Women with ASC-US.
- Hee Eun Kyeong, Seung Yeon Ha, Dong Hae Chung, Na Rae Kim, Sanghui Park, Hyun Yee Cho
- Korean J Pathol. 2009;43(3):254-259.
- DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.3.254
- 4,077 View
- 28 Download
- 1 Crossref
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Abstract
PDF
- BACKGROUND
This study was performed to ascertain the usefulness of the human papillomavirus (HPV) DNA microchip test for the screening and management of women with atypical squamous cells of undetermined significance (ASC-US).
METHODS
The subject group consisted of 534 patients, and all of whom were diagnosed as ASC-US according to a Papanicolaou smear, and they all underwent concomitant HPV DNA microchip test.
RESULTS
The occurrence rates of overall squamous lesions and high risk lesion (cervical intraepithelial neoplasia grade 2 and grade 3, and invasive carcinoma) of the HPV-positive ASC-US patients were significantly higher than those of the HPV-negative ASC-US patients. High risk lesion was detected more frequently among the older patients and the patients with HPV 56, 33 or 70. On the follow-up HPV DNA microchip test, only 1 of 11 (9.1%) HPV type-switched women developed squamous lesion compared with 8 of 13 (61.6%) HPV type-persistent women who developed squamous lesion.
CONCLUSIONS
The HPV DNA microchip test is useful for the management of ASC-US patients. HPV-positive ASC-US patients should undergo a HPV DNA microchip test periodically. If the same genotype of HPV is persistent on the follow-up test, more increased surveillance is needed. -
Citations
Citations to this article as recorded by- Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study
Jaehyun Seong, Sangmi Ryou, JeongGyu Lee, Myeongsu Yoo, Sooyoung Hur, Byeong-Sun Choi
Virology Journal.2021;[Epub] CrossRef
- Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study
Case Report
- Pulmonary Adenocarcinoma with a Micropapillary Pattern Detected by Bronchial Washing: A Brief Case Report.
- Jae Hong Park, Seung Yeon Ha, Hyun Yee Cho, Dong Hae Chung, Na Rae Kim, Sanghui Park
- J Pathol Transl Med. 2008;19(2):206-208.
- DOI: https://doi.org/10.3338/kjc.2008.19.2.206
- 2,490 View
- 19 Download
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Abstract
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- Adenocarcinomas with micropapillary patterns are generally aggressive and show lymphotropism. Only a few reports on pulmonary adenocarcinoma with micropapillary patterns have described cytologic findings. A 70-year-old Korean woman was admitted to the hospital because of intermittent dry cough and chest pain. Cytology after bronchial washing showed neoplastic cells in small, angulated, cohesive clusters consisting of 3-20 cells without a fibrovascular core. The resected right middle lobe showed a tumor occupying almost the entire lobe. Histologically, about 90% of neoplastic cells proliferated with micropapillary morphology in the background of bronchioloalveolar carcinoma. Cytologic smears of a bronchial washing showing tumor cells in small, cohesive clusters without a fibrovascular core may indicate an adenocarcinoma with micropapillary pattern.
Original Articles
- The Usefulness of Cervicovaginal Cytology as a Primary Screening Test.
- Jae Hong Park, Seung Yeon Ha, Hyun Yee Cho, Dong Hae Chung, Na Rae Kim, Sanghui Park
- J Pathol Transl Med. 2008;19(2):107-110.
- DOI: https://doi.org/10.3338/kjc.2008.19.2.107
- 2,942 View
- 15 Download
- 1 Crossref
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Abstract
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- We evaluated the usefulness of cervicovaginal cytology as a primary screening test by analyzing the cytologic and histological diagnoses of 2,254 women. Cervicovaginal cytology had 93.0% sensitivity, 86.1% specificity, 88.2% positive predictive value, and 91.7% of negative predictive value. Cervicovaginal cytology as a primary screening test showed much higher specificity but slightly lower sensitivity than HPV DNA testing. However, the sensitivity of cervicovaginal cytology will be improved continuously due to the development of liquid-based cytology. We regard cervicovaginal cytology as a good primary screening test for cervical intraepithelial neoplasia or carcinoma.
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Citations
Citations to this article as recorded by- Working Conditions that Impact the Workload of Cytotechnologists: A Study Calculating the Actual Man Power Required
Soo Il Jee, Yong Ho Ahn, Hwa-Jeong Ha, Jeong Eun Kang, Jun Ho Won
The Korean Journal of Clinical Laboratory Science.2021; 53(2): 174. CrossRef
- Working Conditions that Impact the Workload of Cytotechnologists: A Study Calculating the Actual Man Power Required
- Quality Assurance of Intraoperative Consultation Review Analysis of 2,392 frozen sections.
- Dong Hae Chung, Jae Hee Suh, On Ja Kim
- Korean J Pathol. 1997;31(4):332-341.
- 2,687 View
- 48 Download
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Abstract
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- A retrospective quality assurance study of intraoperative consultation (frozen section) was carried out to assess the accuracy and to determine the reasons of discordance. Of 14,977 surgical pathology cases accessioned over a 6-month period in Asan Medical Center, frozen sections were done on 1,270 (8.5%) patients and 2,392 frozen sections (1.88 frozen sections/case) were performed. Discordance was noted in 106 cases (4.4%) and diagnosis was deferred in 26 cases (1.1%). All deferred cases were reviewed with the result of 53.8% justified and 46.2% unjustified. The discordant cases were divided into three categories as to their clinical significances: category A (no affect on patient care) 61.3%, B (minimal affect) 9.4%, and C (major affect) 29.2%. Of 31 category C cases, 7 cases were false positive and 24 cases were false negative. Misinterpretation (70.8%) was the leading cause of discordance, followed by sampling error (15.1%), failure to identify lesion (8.5%), and technical problem (5.7%). More than one-third (35.8%) of all discordances were of central nervous system cases. Total central nervous system cases were 403 (16.8%) with a significantly higher disordance rate (9.8%) and deferral rate (2.5%) in comparison to the other cases with 3.4% discordance rate and 0.8% deferral rate. There were 43 colorectal cancer cases of intraoperative consultation for adequacy of resectional margins. The surgical margins were between 0.4 cm and 28 cm (mean: 6.7 cm) away from the tumor and there was no tumor-positive case. The study indicates surgical pathology should 1) promote interpretative skills in cases involving minute fragments of neurosurgical cases, 2) defer the diagnosis and ask for more tissue on inadequate or inappropriate specimens and 3) give only gross opinions without unnecessary frozen section procedures in the event of simple, clear-cut cases.
Case Reports
- Oncocytic Glomus Tumor: A Case Report.
- Na Rae Kim, Jae Y Ro, Dong Hae Chung
- Korean J Pathol. 2004;38(4):268-269.
- 2,064 View
- 21 Download
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Abstract
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- Oncocytic glomus tumor is a newly recognized, rare variant of glomus tumor. In this study, we describe a case of oncocytic glomus tumor occurring in the nail bed of the finger. A 25-year-old woman presented with a tiny and painful mass on her hand, and she had had this lesion for six years. Upon microscopic examination, there were oval to polygonal tumor cells characterized by plump eosinophilic granular cytoplasm, which were arranged in sheets around the thin vessels. Immunohistochemically, the tumor cells were strongly reactive for smooth muscle actin, vimentin, and negative for S-100 protein, alpha-fetoprotein, HMB-45, desmin, CD34, and pancytokeratin. The diagnosis was a glomus tumor of the oncocytic variant.
- Cytologic Features of Signet Ring Cell Carcinoma of the Uterine Cervix: A Report of Two Cases.
- Hyun Yee Cho, Seung Yeon Ha, Jaegul Chung, Young Ha Oh, Dong Hae Chung, Na Rae Kim, Jong Min Lee, Eui Don Lee
- J Pathol Transl Med. 2003;14(2):66-70.
- 2,431 View
- 37 Download
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Abstract
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- Signet ring cell carcinoma is a rare type of mucinous adenocarcinoma of the uterine cervix. To the best of our knowledge, there is no report on cytologic findings of primary signet ring cell carcinoma of the uterine cervix in the literature. Recently, we experienced two cases of signet ring cell carcinoma of the uterine cervix. The finding of characteristic signet ring cells on cervicovaginal smear led to the diagnosis of signet ring cell carcinoma. However, primary signet ring cell carcinoma could not be cytologically distinguished from more common metastatic tumor. Therefore, diagnosis rests upon the recognition of signet ring cells and the absence of signet ring cell carcinoma elsewhere.
- Plexogenic Pulmonary Arteriopathy in Congenital Heart Disease: A Report of Two Cases.
- Seung Yeon Ha, Kook Yang Park, Hyun Yee Cho, Young Ha Oh, Jae Gul Chung, Dong Hae Chung, Chung Yeul Kim, Han Kyeom Kim
- Korean J Pathol. 2002;36(6):412-415.
- 2,240 View
- 24 Download
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Abstract
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- Hypertensive pulmonary vascular disease can develop in those cases of congenital cardiac shunt in which critical levels of pulmonary artery pressure and flow are reached and exceeded. We have experienced two cases of plexogenic arteriopathy in complex congenital heart disease and tried to evaluate of distribution of arterial lesions by total mapping of the explanted lung. Case 1 and 2 were 12-year-old boy and 36 year-old man. They were treated with combined heart-lung transplantation. Mapping of the both lungs was done, and graded according to Heath and Edward's grading scheme. The elastic pulmonary artery was tortuous, dilated and aortic configuration. Both lungs showed mostly grade 3. Plexiform lesion or veinlike branches of hypertrophied muscular arteries arosed in a lateral branch of a muscular artery that might be proximal to an area of occlusion. Comprising the right and left lung, the right was more severe than the left. By getting closer to the distal part, the grade tended to increase to 4 to 5. By analyzing the pulmonary lobe, severe pulmonary hypertension of grade 4 or 5 was comparatively disseminated throughout the right lung. On the other hand, in the left lung, the grade of the lower lobe was higher than that of the upper lobe, and within the upper lobe, there was a tendency for the grade of inferior segment to be higher than that of the corresponding apical segment.
- Fine Needle Aspiration Cytology of Langerhans Cell Histiocytosis in a Lymph Node: A Case Report.
- Seung Yeon Ha, Min Jung Kim, Gou Young Kim, Hyun Yee Cho, Dong Hae Chung, Na Rae Kim
- J Pathol Transl Med. 2007;18(1):87-91.
- 2,402 View
- 30 Download
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Abstract
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- Langerhans cell histiocytosis (LCH) is a pleomorphic disease entity characterized by local or disseminated atypical Langerhans cells (LCs) found most commonly in bone, lungs, mucocutaneous structures and endocrine organs. Among different sites, unifocal disease confined to a lymph node (LN) is rare. We report a case of LCH confined to a LN in a 38-year-old male who presented with a 2 cm-sized cervical mass. The fine needle aspiration (FNA) smears of cervical LN showed high cellularity having isolated LCs with contorted nuclei and nuclear grooves mixed in multinucleated giant cells, small lymphocytes and eosinophils. Charcot-Leyden crystals were also seen, as were a few dendritic-like cells and intranuclear inclusions. Confirmation of LCH was made by histopathologic studies, positive reactions for S-100 protein and CD1a immunohistochemical staining and by the demonstration of Birbeck granules on electron microscopy. The differentials to be considered include dermatopathic lymphadenitis, sinus histiocytosis with massive lymphadenopathy, Hodgkin's lymphoma and malignant histiocytosis. The characteristic cytomorphologic pattern of LCH in a LN FNA smear plays an important role in suggesting the diagnosis of LCH.
Original Articles
- Isolated Pulmonary Cryptococcosis: Report of Six Cases and Review of the Korean Cases.
- Na Rae Kim, Seung Yeon Ha, Dong Hae Chung, Joungho Han, Kyung Soo Lee, O Jung Kwon, Kwan Min Kim
- Korean J Pathol. 2003;37(3):193-198.
- 2,295 View
- 12 Download
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Abstract
PDF
- BACKGROUND
Isolated pulmonary cryptococcosis is uncommon, and it can be seen in both immunocompetent and immunocompromised individuals. In Korea, twenty cases have been described thus far.
METHODS
We report six additional cases of isolated pulmonary cryptococcosis, which were diagnosed by surgical biopsies or fine needle aspiration cytology. We also reviewed the clinicoradiologic and pathologic findings of all the previously published Korean cases of isolated pulmonary cryptococcosis.
RESULTS
Only two patients out of six cases exhibited mild cough and/or fever. Radiologically, three cases presented with multiple subpleural nodules, two with a solitary pulmonary nodule, and one with patchy pneumonic infiltration. On systemic steroid therapy, one case was in severe immunocompromised status at the time of the diagnoses; but three cases had histories of gastric or uterine cervix carcinomas, raising the initial clinical impression of hematogeneous pulmonary metastatic nodules, and one case was accompanied by synchronous pulmonary adenocarcinoma. After reviewing all twenty-six cases of isolated pulmonary cryptococcosis (twenty reported in Korea and our six additional cases), the most common radiologic finding was solitary pulmonary nodule (50%), followed by subpleurally located, multiple nodules (26.9%), pneumonic infiltrates (19.2%), and pleural effusion with thickened pleura (3.8%). Two cases were also accompanied by hilar lymphadenopathy (7.7%). Clinically, presenting symptoms varied: 18 of 26 cases (69.2%) were accompanied by cough and mild fever, but 8 of 26 cases (30.8%) were entirely asymptomatic.
CONCLUSIONS
Since isolated pulmonary cryptococcosis presents itself with nonspecific clinicoradiologic findings, early recognition and differentiation from malignant tumors and pulmonary tuberculosis -the most common causes of solitary pulmonary nodules in Korea- are important to avoiding unnecessary treatment.
- Fine Needle Aspiration Cytology of Intraoral Lesions .
- Ho Jung Lee, Gyungyub Gong, Dong Hae Chung, Jooryung Huh, On Ja Kim
- J Pathol Transl Med. 1998;9(2):155-160.
- 2,245 View
- 21 Download
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Abstract
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- Fine needle aspiration cytology(FNAC) has become a popular method for the diagnosis of a wide variety of both superficial and deep-seated lesions. However, there are few reports about the potential of FNAC for the diagnosis of intraoral lesions. We experienced 44 FNACs from intraoral lesions at Asan Medical Center: 22 from the palate, 6 from the tongue, 5 from the parapharyngeal space, 5 from the lip, 2 from the floor of mouth, 1 from the buccal mucosa, and 3 from other intraoral sites. Histological confirmation was obtained in 32 cases and we analyzed 27 cases excluding 5 cases of inadequate aspirates. Diagnosis was specifically made in 19 of 27 cases(70%) including 1 mucoepidermoid carcinoma, 1 undifferentiated carcinoma, 1 chordoma, 9 pleomorphic adenomas, 1 neurofibroma, and 6 benign lesions. There were three false negative cases(sensitivity, 62.5%) and no false positive cases(specificity, 100%): Two cases diagnosed as "cystic lesion" were confirmed to be mucoepidermoid carcinomas and a case diagnosed as pleomorphic adenoma was proved to be adenoid cystic carcinoma. The results of our study suggest that FNAC is a useful technique in the diagnosis of intraoral lesion.
Case Report
- Osteofibrous Dysplasia-Like Adamantinoma: A Case Report with its Immunohistochemical and Ultrastructural Studies.
- Na Rae Kim, Geunghwan Ahn, Geun Woo Kim, Hyun Yee Cho, Young Ha Oh, Dong Hae Chung
- Korean J Pathol. 2004;38(1):50-55.
- 2,859 View
- 33 Download
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Abstract
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- Osteofibrous dysplasia (OFD)-like adamantinoma is a rare skeletal tumor that is characterized by the predominant OFD-like pattern with scattered epithelial nests. Adamantinoma shares clinical features (the majority of lesions in the tibia and the prevalent age group), radiologic findings (radiolucency with sclerotic shadow), and pathologic similarities (particularly the presence of scattered cytokeratin-positive stromal cells) with OFD. We describe a case of OFD-like adamantinoma. Epithelial cell nests express the epithelial membrane antigen, pancytokeratin, CK14, and collagen type IV. Ultrastructurally, the oval to spindle cells in the epithelial foci had abundant tonofilaments, and well-formed desmosomes with dense plaques, of which well preserved desmosomes are demonstrated for the first time in OFD-like adamantinoma. These immunohistochemical and ultrastructural findings further support that the origin of epithelial cells of classic and OFD-like adamantinoma are epithelial cells transformed from fibroblastic cells in the proliferating osteofibrous tissue.
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