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Most-download articles are from the articles published in 2022 during the last three month.

Newsletters
What’s new in dermatopathology 2023: WHO 5th edition updates
Jonathan Ho, Chico J Collie
J Pathol Transl Med. 2023;57(6):337-340.   Published online October 17, 2023
DOI: https://doi.org/10.4132/jptm.2023.09.22
  • 2,877 View
  • 647 Download
AbstractAbstract PDF
The 5th edition WHO Classification of Skin Tumors (2022) has introduced changes to nomenclature and diagnostics. Important differences are discussed below. Changes in each category of skin tumor have been detailed, with particular emphasis on meaningful advances in our understanding of the molecular pathogenesis of the skin’s diverse tumor landscape.
What’s new in genitourinary pathology 2023: WHO 5th edition updates for urinary tract, prostate, testis, and penis
Bonnie Choy, Maria Tretiakova, Debra L. Zynger
J Pathol Transl Med. 2024;58(1):45-48.   Published online December 27, 2023
DOI: https://doi.org/10.4132/jptm.2023.12.11
  • 1,536 View
  • 286 Download
AbstractAbstract PDF
The 5th edition WHO Classification of Urinary and Male Genital Tumours (2022) introduced many significant changes relevant to urologic daily practice, mainly to renal tumors which was covered in the What’s New newsletter in September 2022. In this newsletter, we summarize the notable changes to bladder, prostate, testis, and penis based on the 5th edition of the WHO.
Reviews
Diagnosis of interstitial lung diseases: from Averill A. Liebow to artificial intelligence
Eunhee S. Yi, Paul Wawryko, Jay H. Ryu
J Pathol Transl Med. 2024;58(1):1-11.   Published online January 10, 2024
DOI: https://doi.org/10.4132/jptm.2023.11.17
  • 982 View
  • 218 Download
AbstractAbstract PDF
Histopathologic criteria of usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis (IPF) were defined over the years and endorsed by leading organizations decades after Dr. Averill A. Liebow first coined the term UIP in the 1960s as a distinct pathologic pattern of fibrotic interstitial lung disease. Novel technology and recent research on interstitial lung diseases with genetic component shed light on molecular pathogenesis of UIP/IPF. Two antifibrotic agents introduced in the mid-2010s opened a new era of therapeutic approaches to UIP/IPF, albeit contentious issues regarding their efficacy, side effects, and costs. Recently, the concept of progressive pulmonary fibrosis was introduced to acknowledge additional types of progressive fibrosing interstitial lung diseases with the clinical and pathologic phenotypes comparable to those of UIP/IPF. Likewise, some authors have proposed a paradigm shift by considering UIP as a stand-alone diagnostic entity to encompass other fibrosing interstitial lung diseases that manifest a relentless progression as in IPF. These trends signal a pendulum moving toward the tendency of lumping diagnoses, which poses a risk of obscuring potentially important information crucial to both clinical and research purposes. Recent advances in whole slide imaging for digital pathology and artificial intelligence technology could offer an unprecedented opportunity to enhance histopathologic evaluation of interstitial lung diseases. However, current clinical practice trends of moving away from surgical lung biopsies in interstitial lung disease patients may become a limiting factor in this endeavor as it would be difficult to build a large histopathologic database with correlative clinical data required for artificial intelligence models.
A stepwise approach to fine needle aspiration cytology of lymph nodes
Yosep Chong, Gyeongsin Park, Hee Jeong Cha, Hyun-Jung Kim, Chang Suk Kang, Jamshid Abdul-Ghafar, Seung-Sook Lee
J Pathol Transl Med. 2023;57(4):196-207.   Published online July 11, 2023
DOI: https://doi.org/10.4132/jptm.2023.06.12
  • 5,996 View
  • 540 Download
  • 1 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary Material
The cytological diagnosis of lymph node lesions is extremely challenging because of the diverse diseases that cause lymph node enlargement, including both benign and malignant or metastatic lymphoid lesions. Furthermore, the cytological findings of different lesions often resemble one another. A stepwise diagnostic approach is essential for a comprehensive diagnosis that combines: clinical findings, including age, sex, site, multiplicity, and ultrasonography findings; low-power reactive, metastatic, and lymphoma patterns; high-power population patterns, including two populations of continuous range, small monotonous pattern and large monotonous pattern; and disease-specific diagnostic clues including granulomas and lymphoglandular granules. It is also important to remember the histological features of each diagnostic category that are common in lymph node cytology and to compare them with cytological findings. It is also essential to identify a few categories of diagnostic pitfalls that often resemble lymphomas and easily lead to misdiagnosis, particularly in malignant small round cell tumors, poorly differentiated squamous cell carcinomas, and nasopharyngeal undifferentiated carcinoma. Herein, we review a stepwise approach for fine needle aspiration cytology of lymphoid diseases and suggest a diagnostic algorithm that uses this approach and the Sydney classification system.

Citations

Citations to this article as recorded by  
  • Immunocytochemical markers, molecular testing and digital cytopathology for aspiration cytology of metastatic breast carcinoma
    Joshua J. X. Li, Gary M. Tse
    Cytopathology.2024; 35(2): 218.     CrossRef
  • Response to comment on “A stepwise approach to fine needle aspiration cytology of lymph nodes”
    Yosep Chong, Gyeongsin Park, Hee Jeong Cha, Hyun-Jung Kim, Chang Suk Kang, Jamshid Abdul-Ghafar, Seung-Sook Lee
    Journal of Pathology and Translational Medicine.2024; 58(1): 43.     CrossRef
  • Comment on “A stepwise approach to fine needle aspiration cytology of lymph nodes”
    Elisabetta Maffei, Valeria Ciliberti, Pio Zeppa, Alessandro Caputo
    Journal of Pathology and Translational Medicine.2024; 58(1): 40.     CrossRef
Original Articles
Immunohistochemical expression of anaplastic lymphoma kinase in neuroblastoma and its relations with some clinical and histopathological features
Thu Dang Anh Phan, Thao Quyen Nguyen, Nhi Thuy To, Thien Ly Thanh, Dat Quoc Ngo
J Pathol Transl Med. 2024;58(1):29-34.   Published online January 10, 2024
DOI: https://doi.org/10.4132/jptm.2023.12.07
  • 1,099 View
  • 168 Download
AbstractAbstract PDF
Background
Anaplastic lymphoma kinase (ALK) mutations have been identified as a prominent cause of some familial and sporadic neuroblastoma (NB). ALK expression in NB and its relationship with clinical and histopathological features remains controversial. This study investigated ALK expression and its potential relations with these features in NB.
Methods
Ninety cases of NB at the Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam from 01/01/2018 to 12/31/2021, were immunohistochemically stained with ALK (D5F3) antibody. The ALK expression and its relations with some clinical and histopathological features were investigated.
Results
The rate of ALK expression in NB was 91.1%. High ALK expression (over 50% of tumor cells were positive with moderate-strong intensity) accounted for 65.6%, and low ALK expression accounted for 34.4%. All the MYCN-amplified NB patients had ALK immunohistochemistry positivity, most cases had high ALK protein expression. The undifferentiated subtype of NB had a lower ALK-positive rate than the poorly differentiated and differentiated subtype. The percentages of ALK positivity were significantly higher in more differentiated histological types of NB (p = .024). There was no relation between ALK expression and: age group, sex, primary tumor location, tumor stage, MYCN status, clinical risk, Mitotic-Karyorrhectic Index, prognostic group, necrosis, and calcification.
Conclusions
ALK was highly expressed in NB. ALK expression was not related to several clinical and histopathological features. More studies are needed to elucidate the association between ALK expression and ALK gene status and to investigate disease progression, especially the oncogenesis of ALK-positive NB.
Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors
Ayana Suzuki, Satoshi Nojima, Shinichiro Tahara, Daisuke Motooka, Masaharu Kohara, Daisuke Okuzaki, Mitsuyoshi Hirokawa, Eiichi Morii
J Pathol Transl Med. 2024;58(1):22-28.   Published online January 10, 2024
DOI: https://doi.org/10.4132/jptm.2023.11.21
  • 752 View
  • 160 Download
AbstractAbstract PDF
Background
Follicular tumors include follicular thyroid adenomas and carcinomas; however, it is difficult to distinguish between the two when the cytology or biopsy material is obtained from a portion of the tumor. The presence or absence of invasion in the resected material is used to differentiate between adenomas and carcinomas, which often results in the unnecessary removal of the adenomas. If nodules that may be follicular thyroid carcinomas are identified preoperatively, active surveillance of other nodules as adenomas is possible, which reduces the risk of surgical complications and the expenses incurred during medical treatment. Therefore, we aimed to identify biomarkers in the invasive subpopulation of follicular tumor cells.
Methods
We performed a spatial transcriptome analysis of a case of follicular thyroid carcinoma and examined the dynamics of CD74 expression in 36 cases.
Results
We identified a subpopulation in a region close to the invasive area, and this subpopulation expressed high levels of CD74. Immunohistochemically, CD74 was highly expressed in the invasive and peripheral areas of the tumor.
Conclusions
Although high CD74 expression has been reported in papillary and anaplastic thyroid carcinomas, it has not been analyzed in follicular thyroid carcinomas. Furthermore, the heterogeneity of CD74 expression in thyroid tumors has not yet been reported. The CD74-positive subpopulation identified in this study may be useful in predicting invasion of follicular thyroid carcinomas.
Tumor-infiltrating T lymphocytes evaluated using digital image analysis predict the prognosis of patients with diffuse large B-cell lymphoma
Yunjoo Cho, Jiyeon Lee, Bogyeong Han, Sang Eun Yoon, Seok Jin Kim, Won Seog Kim, Junhun Cho
J Pathol Transl Med. 2024;58(1):12-21.   Published online January 10, 2024
DOI: https://doi.org/10.4132/jptm.2023.11.02
  • 982 View
  • 158 Download
AbstractAbstract PDF
Background
The implication of the presence of tumor-infiltrating T lymphocytes (TIL-T) in diffuse large B-cell lymphoma (DLBCL) is yet to be elucidated. We aimed to investigate the effect of TIL-T levels on the prognosis of patients with DLBCL.
Methods
Ninety-six patients with DLBCL were enrolled in the study. The TIL-T ratio was measured using QuPath, a digital pathology software package. The TIL-T ratio was investigated in three foci (highest, intermediate, and lowest) for each case, resulting in TIL-T–Max, TIL-T–Intermediate, and TIL-T–Min. The relationship between the TIL-T ratios and prognosis was investigated.
Results
When 19% was used as the cutoff value for TIL-T–Max, 72 (75.0%) and 24 (25.0%) patients had high and low TIL-T–Max, respectively. A high TIL-T–Max was significantly associated with lower serum lactate dehydrogenase levels (p < .001), with patient group who achieved complete remission after RCHOP therapy (p < .001), and a low-risk revised International Prognostic Index score (p < .001). Univariate analysis showed that patients with a low TIL-T–Max had a significantly worse prognosis in overall survival compared to those with a high TIL-T–Max (p < .001); this difference remained significant in a multivariate analysis with Cox proportional hazards (hazard ratio, 7.55; 95% confidence interval, 2.54 to 22.42; p < .001).
Conclusions
Patients with DLBCL with a high TIL-T–Max showed significantly better prognosis than those with a low TIL-T–Max, and the TIL-T–Max was an independent indicator of overall survival. These results suggest that evaluating TIL-T ratios using a digital pathology system is useful in predicting the prognosis of patients with DLBCL.
Newsletter
What’s new in breast pathology 2022: WHO 5th edition and biomarker updates
Kristen Muller, Julie M. Jorns, Gary Tozbikian
J Pathol Transl Med. 2022;56(3):170-171.   Published online May 15, 2022
DOI: https://doi.org/10.4132/jptm.2022.04.25
  • 12,412 View
  • 1,053 Download
  • 8 Web of Science
  • 11 Crossref
AbstractAbstract PDF
The 5th edition WHO Classification of Breast Tumours (2019) has introduced changes to our practices. Highlights are presented below, with a focus on modifications to morphological subtype categorization. In addition, we summarize important updates to ER and PR testing made in the 2020 ASCO/CAP guidelines, and briefly discuss PD-L1 and Ki-67 testing in breast cancer.

Citations

Citations to this article as recorded by  
  • Correlation of Histopathology and Radiological Findings Among the Diverse Breast Lesions in a Tertiary Care Centre
    Ranjani Mohan, Sathish Selvakumar A, Ragupathy S, Meenakshisundaram K, Shanmugapriya S, Rajeswari Kathiah, Rajeswari T, Priavadhana Rajan Prasaad, Dinesh Kumar S, Sarika K
    Cureus.2024;[Epub]     CrossRef
  • Diagnostic Challenge in Veterinary Pathology: Metastatic Mammary Tumor in a Female Tiger (Panthera Tigris)
    Charisha Fraser, Mun Keong Kok, Intan Shameha Abdul Razak, Yulianna Puspitasari, Annas Salleh
    Veterinary Pathology.2024;[Epub]     CrossRef
  • Expression of cell surface zinc transporter LIV1 in triple negative breast cancer is an indicator of poor prognosis and therapy failure
    Roshni Saravanan, Vaishnavi Balasubramanian, Sandhya Sundaram, Bhawna Dev, Pavithra Vittalraj, Ravi Shankar Pitani, Gouthaman Shanmugasundaram, Suresh Kumar Rayala, Ganesh Venkatraman
    Journal of Cellular Physiology.2024;[Epub]     CrossRef
  • Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review
    Nausheen Aga, Ruchira Shreevats, Sonia Gupta, Harman Sandhu, Muna E.M. Hassan, Harnisha V. Prajapati
    Avicenna Journal of Medicine.2024;[Epub]     CrossRef
  • Immune checkpoint inhibitor resistance in hepatocellular carcinoma
    Zhijie Wang, Yichuan Wang, Peng Gao, Jin Ding
    Cancer Letters.2023; 555: 216038.     CrossRef
  • Demographic and Clinical Features of Patients with Metastatic Breast Cancer: A Retrospective Multicenter Registry Study of the Turkish Oncology Group
    Izzet Dogan, Sercan Aksoy, Burcu Cakar, Gul Basaran, Ozlem Ercelep, Nil Molinas Mandel, Taner Korkmaz, Erhan Gokmen, Cem Sener, Adnan Aydiner, Pinar Saip, Yesim Eralp
    Cancers.2023; 15(6): 1667.     CrossRef
  • The role of tumor microenvironment in drug resistance: emerging technologies to unravel breast cancer heterogeneity
    Vincenzo Salemme, Giorgia Centonze, Lidia Avalle, Dora Natalini, Alessio Piccolantonio, Pietro Arina, Alessandro Morellato, Ugo Ala, Daniela Taverna, Emilia Turco, Paola Defilippi
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Unraveling the Role of Adiponectin Receptors in Obesity-Related Breast Cancer
    Giuseppina Daniela Naimo, Alessandro Paolì, Francesca Giordano, Martina Forestiero, Maria Luisa Panno, Sebastiano Andò, Loredana Mauro
    International Journal of Molecular Sciences.2023; 24(10): 8907.     CrossRef
  • Novel Molecular Targets for Immune Surveillance of Hepatocellular Carcinoma
    Pietro Guerra, Andrea Martini, Patrizia Pontisso, Paolo Angeli
    Cancers.2023; 15(14): 3629.     CrossRef
  • Breast metastasis as the first presentation of an anorectal melanoma diagnosed on fine needle aspiration cytology: a case report
    Adil Aziz Khan, Shaivy Malik, Sana Ahuja, Mukul Singh
    Surgical and Experimental Pathology.2023;[Epub]     CrossRef
  • Meme Kanserinde Ki67 İndeks Ölçümlerinin Manuel ve Dijital Yöntemler Açısından Kıyaslanması
    Zuhal SİLAV
    İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi.2023; (20): 397.     CrossRef
Case Study
Primary leiomyosarcoma of the bone: a case report
Ala Abu-Dayeh, Samir Alhyassat
J Pathol Transl Med. 2024;58(1):35-39.   Published online January 10, 2024
DOI: https://doi.org/10.4132/jptm.2023.11.14
  • 633 View
  • 141 Download
AbstractAbstract PDF
Primary leiomyosarcoma of the bone is rare. Histologically, it resembles leiomyosarcoma of soft tissue. Given the rarity of this entity, its diagnosis should be made only after clinical studies and workup have excluded metastasis from other sites. Herein, we describe an additional case of primary bone leiomyosarcoma. We report a 32-year-old female patient, who presented with right knee pain and was found to have a right distal femur mass by imaging studies. Biopsy showed a neoplasm composed of fascicles of spindle cells, arranged in different patterns, with significant pleomorphism. The tumor cells were positive for smooth muscle actin, focally positive for desmin and H-caldesmon. No other masses in the body were detected by imaging studies. The diagnosis of leiomyosarcoma of the bone was rendered. Given the broad diagnostic differential of primary bone leiomyosarcoma, it is important to be aware of this rare bone tumor phenotype and of its histomorphologic and immunohistochemical features for an accurate diagnosis.
Review
A standardized pathology report for gastric cancer: 2nd edition
Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Hee Kyung Chang, Soomin Ahn, Mee Soo Chang, Song-Hee Han, Yoonjin Kwak, An Na Seo, Sung Hak Lee, Mee-Yon Cho
J Pathol Transl Med. 2023;57(1):1-27.   Published online January 15, 2023
DOI: https://doi.org/10.4132/jptm.2022.12.23
  • 6,181 View
  • 766 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract PDFSupplementary Material
The first edition of ‘A Standardized Pathology Report for Gastric Cancer’ was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. Since then, significant advances have been made in the pathologic diagnosis, molecular genetics, and management of gastric cancer (GC). To reflect those changes, a committee for publishing a second edition of the report was formed within the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. This second edition consists of two parts: standard data elements and conditional data elements. The standard data elements contain the basic pathologic findings and items necessary to predict the prognosis of GC patients, and they are adequate for routine surgical pathology service. Other diagnostic and prognostic factors relevant to adjuvant therapy, including molecular biomarkers, are classified as conditional data elements to allow each pathologist to selectively choose items appropriate to the environment in their institution. We trust that the standardized pathology report will be helpful for GC diagnosis and facilitate large-scale multidisciplinary collaborative studies.

Citations

Citations to this article as recorded by  
  • Genomic and Transcriptomic Characterization of Gastric Cancer with Bone Metastasis
    Sujin Oh, Soo Kyung Nam, Keun-Wook Lee, Hye Seung Lee, Yujun Park, Yoonjin Kwak, Kyu Sang Lee, Ji-Won Kim, Jin Won Kim, Minsu Kang, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim
    Cancer Research and Treatment.2024; 56(1): 219.     CrossRef
  • Pathological Interpretation of Gastric Tumors in Endoscopic Submucosal Dissection
    Jung Yeon Kim
    Journal of Digestive Cancer Research.2023; 11(1): 15.     CrossRef
  • Histopathology of Gastric Cancer
    Baek-hui Kim, Sung Hak Lee
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(2): 143.     CrossRef
  • Endoscopic submucosal dissection hands-on training with artificial mucosal layer EndoGEL
    Tae-Se Kim, Jun Haeng Lee
    Journal of Innovative Medical Technology.2023; 1(1): 5.     CrossRef
Original Article
Clinicopathological implications of immunohistochemical expression of TBX21, CXCR3, GATA3, CCR4, and TCF1 in nodal follicular helper T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified
Bogyeong Han, Sojung Lim, Jeemin Yim, Young Keun Song, Jiwon Koh, Sehui Kim, Cheol Lee, Young A Kim, Yoon Kyung Jeon
J Pathol Transl Med. 2024;58(2):59-71.   Published online January 22, 2024
DOI: https://doi.org/10.4132/jptm.2024.01.04
  • 708 View
  • 103 Download
AbstractAbstract PDFSupplementary Material
Background
The classification of nodal peripheral T-cell lymphoma (PTCL) has evolved according to histology, cell-of-origin, and genetic alterations. However, the comprehensive expression pattern of follicular helper T-cell (Tfh) markers, T-cell factor-1 (TCF1), and Th1- and Th2-like molecules in nodal PTCL is unclear.
Methods
Eighty-two cases of nodal PTCL were classified into 53 angioimmunoblastic T-cell lymphomas (AITLs)/nodal T-follicular helper cell lymphoma (nTFHL)-AI, 18 PTCLs-Tfh/nTFHL–not otherwise specified (NOS), and 11 PTCLs-NOS according to the revised 4th/5th World Health Organization classifications. Immunohistochemistry for TCF1, TBX21, CXCR3, GATA3, and CCR4 was performed.
Results
TCF1 was highly expressed in up to 68% of patients with nTFHL but also in 44% of patients with PTCL-NOS (p > .05). CXCR3 expression was higher in AITLs than in non-AITLs (p = .035), whereas GATA3 expression was higher in non-AITL than in AITL (p = .007) and in PTCL-Tfh compared to AITL (p = .010). Of the cases, 70% of AITL, 44% of PTCLTfh/ nTFHL-NOS, and 36% of PTCL-NOS were subclassified as the TBX21 subtype; and 15% of AITL, 38% of PTCL-Tfh/nTFHL-NOS, and 36% of PTCL-NOS were subclassified as the GATA3 subtype. The others were an unclassified subtype. CCR4 expression was associated with poor progression-free survival (PFS) in patients with PTCL-Tfh (p < .001) and nTFHL (p = .023). The GATA3 subtype showed poor overall survival in PTCL-NOS compared to TBX21 (p = .046) and tended to be associated with poor PFS in patients with non-AITL (p = .054).
Conclusions
The TBX21 subtype was more prevalent than the GATA3 subtype in AITL. The GATA3 subtype was associated with poor prognosis in patients with non-AITL and PTCL-NOS.
Case Studies
A rare goblet cell adenocarcinoma arising from Barrett’s esophagus: the first reported case in the esophagus
Chi Eun Oh, Sung Eun Kim, Sun-Ju Oh
J Pathol Transl Med. 2024;58(2):81-86.   Published online January 8, 2024
DOI: https://doi.org/10.4132/jptm.2023.12.26
  • 506 View
  • 103 Download
AbstractAbstract PDF
Goblet cell adenocarcinoma (GCA) is a rare and distinctive amphicrine tumor comprised of goblet-like mucinous cells and neuroendocrine cells. It is believed to originate from pluripotent stem cells located at the base of crypts. GCA predominantly arises from the appendix, with a few reported cases in extra-appendiceal locations such as the colorectum, small intestine, and stomach. In this case report, we present a unique instance of a 64-year-old male who initially received a diagnosis of neuroendocrine carcinoma in the distal esophagus based on biopsy but, following resection, was subsequently re-diagnosed with GCA arising from Barrett’s esophagus.
Fibrin-associated large B-cell lymphoma arising in an endovascular graft: first case report in Korea
Min Gyoung Pak, Mee Sook Roh
J Pathol Transl Med. 2024;58(2):87-90.   Published online January 24, 2024
DOI: https://doi.org/10.4132/jptm.2023.12.28
  • 624 View
  • 76 Download
AbstractAbstract PDF
Fibrin-associated large B-cell lymphoma (FA-LBCL) is an extremely rare subtype of LBCL that consists of microscopic aggregates of atypical large B cells in the background of fibrin. Here, we report the first case of FA-LBCL in Korea. A 57-year-old male presented with a large amount of thrombus in the thoracic aorta during follow-up for graft replacement of the thoracoabdominal aorta 8 years prior. The removed thrombus, measuring 4.3 × 3.1 cm, histologically exhibited eosinophilic fibrinous material with several small clusters of atypical lymphoid cells at the periphery. The atypical cells were positive for CD20 by immunohistochemistry and for Epstein-Barr virus by in situ hybridization. The Ki-67 proliferation rate was 85%. The patient was still alive with no recurrence at the 7-year follow-up after thrombectomy. Although the diagnosis can be very difficult and challenging due to its paucicellular features, pathologists should be aware of FALBCL, which has likely been underestimated in routine evaluations of thrombi.
Original Article
Senescent tumor cells in colorectal cancer are characterized by elevated enzymatic activity of complexes 1 and 2 in oxidative phosphorylation
Jun Sang Shin, Tae-Gyu Kim, Young Hwa Kim, So Yeong Eom, So Hyun Park, Dong Hyun Lee, Tae Jun Park, Soon Sang Park, Jang-Hee Kim
J Pathol Transl Med. 2023;57(6):305-314.   Published online November 7, 2023
DOI: https://doi.org/10.4132/jptm.2023.10.09
  • 1,610 View
  • 235 Download
AbstractAbstract PDFSupplementary Material
Background
Cellular senescence is defined as an irreversible cell cycle arrest caused by various internal and external insults. While the metabolic dysfunction of senescent cells in normal tissue is relatively well-established, there is a lack of information regarding the metabolic features of senescent tumor cells.
Methods
Publicly available single-cell RNA-sequencing data from the GSE166555 and GSE178341 datasets were utilized to investigate the metabolic features of senescent tumor cells. To validate the single-cell RNA-sequencing data, we performed senescence-associated β-galactosidase (SA-β-Gal) staining to identify senescent tumor cells in fresh frozen colorectal cancer tissue. We also evaluated nicotinamide adenine dinucleotide dehydrogenase–tetrazolium reductase (NADH-TR) and succinate dehydrogenase (SDH) activity using enzyme histochemical methods and compared the staining with SA-β-Gal staining. MTT assay was performed to reveal the complex 1 activity of the respiratory chain in in-vitro senescence model.
Results
Single-cell RNA-sequencing data revealed an upregulation in the activity of complexes 1 and 2 in oxidative phosphorylation, despite overall mitochondrial dysfunction in senescent tumor cells. Both SA-β-Gal and enzyme histochemical staining using fresh frozen colorectal cancer tissues indicated a high correlation between SA-β-Gal positivity and NADH-TR/SDH staining positivity. MTT assay showed that senescent colorectal cancer cells exhibit higher absorbance in 600 nm wavelength.
Conclusions
Senescent tumor cells exhibit distinct metabolic features, characterized by upregulation of complexes 1 and 2 in the oxidative phosphorylation pathway. NADH-TR and SDH staining represent efficient methods for detecting senescent tumor cells in colorectal cancer.
Review
Aneurysmal bone cyst: a review
Elham Nasri, John David Reith
J Pathol Transl Med. 2023;57(2):81-87.   Published online March 14, 2023
DOI: https://doi.org/10.4132/jptm.2023.02.23
  • 3,381 View
  • 298 Download
  • 4 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the vertebrae. Secondary, ABC-like changes can complicate a variety of other benign and malignant primary bone neoplasms, including giant cell tumor, fibrous dysplasia, and osteosarcoma. About two-third of primary ABCs have a rearrangement of the USP6 gene, which is not present in the ABC-like changes that occur secondary to other primary bone tumors (i.e., secondary ABC). Primary ABC of bone carries a variable but generally high rate of local recurrence. This paper provides an overview of the pathophysiology, clinical presentation, radiographic and pathologic findings, treatment, and prognosis of ABC.

Citations

Citations to this article as recorded by  
  • Management of aggressive recurrent thoracic spine aneurysmal bone cyst in a 7-year-old male: A case report and review of the literature
    Pedram Jahangiri, Faramarz Roohollahi, Zohreh Habibi, Mohammad Hosein Mirbolouk, Mohsen Rostami
    Surgical Neurology International.2024; 15: 30.     CrossRef
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    Jeonghyun Oh, Song Iy Han, Sung-Chul Lim
    Medicine.2024; 103(6): e37137.     CrossRef
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    Xinyao Wang, Wenbin Guan, Haibo Zhang, Lei Bao, Xiaoqiang Wang
    Oral and Maxillofacial Surgery.2024;[Epub]     CrossRef
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    T. Furuta, T. Sakuda, K. Yoshioka, K. Arihiro, N. Adachi
    International Journal of Surgery Case Reports.2023; 108: 108379.     CrossRef
  • Clear cell chondrosarcoma: a review of clinicopathologic characteristics, differential diagnoses, and patient management
    Borislav A. Alexiev, Erica R. Vormittag-Nocito, Terrance D. Peabody, Jonathan Samet, William B. Laskin
    Human Pathology.2023; 139: 126.     CrossRef
  • Malignant transformation of an aneurysmal bone cyst of the femoral neck: A case report
    Xiaoyang Song, Yongjie Qiao, Haoqiang Zhang, Lirong Sha, Jinpeng Lou, Xinyuan Yu, Hao Liu, Langfeng Zhu, Shenghu Zhou
    Experimental and Therapeutic Medicine.2023;[Epub]     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine