Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Most viewed

Page Path
HOME > Articles and issues > Most viewed
136 Most viewed
Filter
Filter
Article category
More +
Keywords
More +
Publication year
Authors
More +
Funded articles
More +

Most-read articles are from the articles published in 2023 during the last three month.

Review
Article image
Aneurysmal bone cyst: a review
Elham Nasri, John David Reith
J Pathol Transl Med. 2023;57(2):81-87.   Published online March 14, 2023
DOI: https://doi.org/10.4132/jptm.2023.02.23
  • 28,049 View
  • 757 Download
  • 27 Web of Science
  • 31 Crossref
AbstractAbstract PDF
Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the vertebrae. Secondary, ABC-like changes can complicate a variety of other benign and malignant primary bone neoplasms, including giant cell tumor, fibrous dysplasia, and osteosarcoma. About two-third of primary ABCs have a rearrangement of the USP6 gene, which is not present in the ABC-like changes that occur secondary to other primary bone tumors (i.e., secondary ABC). Primary ABC of bone carries a variable but generally high rate of local recurrence. This paper provides an overview of the pathophysiology, clinical presentation, radiographic and pathologic findings, treatment, and prognosis of ABC.

Citations

Citations to this article as recorded by  
  • Long‐Term Outcomes of Temporal Bone Aneurysmal Bone Cysts: Ambispective Study With Systematic Review and Pooled Analysis
    Nidhin Das K, Anant Mehrotra, Amit Keshri, Mohit Sinha, Nazrin Hameed, Kalyan Chidambaram, Mohd Aqib, Awadesh Kumar Jaiswal, Ravisankar Manogaran
    Otolaryngology–Head and Neck Surgery.2025; 172(5): 1493.     CrossRef
  • Assessment and management of periacetabular aneurysmal bone cysts—a series of four cases
    Reagan S.H Beyer, Quinn Steiner, David W Hennessy, Humberto G Rosas, David C Goodspeed, Andrea M Spiker
    Journal of Hip Preservation Surgery.2025; 12(1): 11.     CrossRef
  • Angiomatoid fibrous histiocytoma with EWSR1-CREB1 gene fusion occurs in lungs and ribs with systemic multiple metastases: a case report and review of the literature
    Dongmei Feng, Ying Li, Zhengjin Li, Yun Pan, Yixuan Gao, Jinyan Cha, Chunmei Zhang
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Complete remodelling post-intralesional resection of an aggressive proximal humerus aneurysmal bone cyst mimicking telangiectatic osteosarcoma
    Harpreet Singh, Sze Jet Aw, Arjandas Mahadev, Mohammad Ashik Bin Zainuddin, Kenneth Pak Leung Wong
    BMJ Case Reports.2025; 18(2): e263437.     CrossRef
  • First insights into the safety and effectiveness of additional courses with cladribine tablets under real-world conditions
    Christoph Kleinschnitz, Jelena Skuljec, Markus C. Kowarik, Michael Ernst, Lara Woitschach, Lukas Cepek, Daniela Rau, Benedicta Kühnler, Sylke Schlemilch-Paschen, Matthias Schwab, Refik Pul
    Multiple Sclerosis and Related Disorders.2025; 97: 106398.     CrossRef
  • Case Report: Giant cell lesions in the Maxillofacial region: diagnostic points and treatment strategies
    Xiaohan Gao, Shuangyi Wang, Xiaohong Zhan, Yanshan Liu, Liqiang Chen, Jian Sun, Haoyue Xu
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Endoscopic Curettage of Aneurysmal Bone Cyst of the Distal Fibula
    Tun Hing Lui, Ka Kin Cheung, Wun Kee Szeto
    Arthroscopy Techniques.2025; 14(7): 103561.     CrossRef
  • Reviewing superficial bone lesions: What the radiologist needs to know
    Dâmaris Versiani Caldeira Gonçalves, Isabela Azevedo Nicodemos da Cruz, Marcelo Astolfi Caetano Nico, Alípio Gomes Ormond Filho, Júlio Brandão Guimarães
    Clinical Imaging.2025; 123: 110493.     CrossRef
  • Juvenile ossifying fibroma and aneurysmal bone cyst in the mandible: A case report and mini review of literature
    Fatma Wageeh Attya, Walaa Hussein Abu El-Ela, Basma Abdelrahman Ahmed, Iman Mohamed Helmy
    Pediatric Dental Journal.2025; 35(3): 100354.     CrossRef
  • A clinical case of an aneurysmal bone cyst of the humerus
    N.S. Lysenko, V.V. Bayev, І.О. Voronzhev, S.M. Palchyk, А.М. Hrytsenko
    Український радіологічний та онкологічний журнал.2025; 33(2): 270.     CrossRef
  • Aneurysmal bone cyst of the rib. Robotic resection of a rare lesion
    Luis Arana-Bolaños, Xcaret Luna-Vargas, Amelia Fernández-Avendaño, Mónica Martínez-Ferman, Pablo Gomes-da Silva de Rosenzweig, Francina Bolaños-Morales
    Journal of Surgical Case Reports.2025;[Epub]     CrossRef
  • Musculoskeletal tumors and tumor-like lesions with “dark” signal intensity on T2-weighted MR images: A pictorial review
    Jingkun Zhang, Fengyuan Luo, Juan Chen, Huijuan Yang, Qi Zhang
    Medicine.2025; 104(41): e45179.     CrossRef
  • Escleroterapia con alcohol al 90% previo a exéresis de quiste óseo aneurismático maxilar: Reporte de caso
    Glenda Semanate Cajas
    Arandu UTIC.2025; 12(3): 4306.     CrossRef
  • Case Report: Adult proximal humeral aneurysmal bone cyst: radical resection and reconstruction with osteoconductive allograft & reverse arthroplasty—Ecuador's first reported case and functional outcomes
    Gabriel Gamecho Arteaga, Henry Hernández, Chrystian X. Mestanza, Jaime Zurita, Marlon Arias-Intriago, Juan S. Izquierdo-Condoy
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • Aggressive Aneurysmal Bone Cyst of the Mandible: A Rare Case of Rapid Expansion and Surgical Management
    Fatemeh Mashhadiabbas, Sanaz Gholami Toghchi, Sara Alehossein, Hoorisa Norouzi, Mohammadreza Kashefi Baher
    Clinical Case Reports.2025;[Epub]     CrossRef
  • Management of aggressive recurrent thoracic spine aneurysmal bone cyst in a 7-year-old male: A case report and review of the literature
    Pedram Jahangiri, Faramarz Roohollahi, Zohreh Habibi, Mohammad Hosein Mirbolouk, Mohsen Rostami
    Surgical Neurology International.2024; 15: 30.     CrossRef
  • Intraosseous hemangioma with aneurysmal bone cyst-like changes of the hyoid bone: Case report and literature review
    Jeonghyun Oh, Song Iy Han, Sung-Chul Lim
    Medicine.2024; 103(6): e37137.     CrossRef
  • Fibrous dysplasia with aneurysmal bone cyst-like change occurring in pediatric orbit: case report and literature review
    Xinyao Wang, Wenbin Guan, Haibo Zhang, Lei Bao, Xiaoqiang Wang
    Oral and Maxillofacial Surgery.2024; 28(2): 999.     CrossRef
  • Pathological Fractures in Aneurysmal Bone Cysts: A Systematic Review
    Doriana Di Costa, Elena Gabrielli, Mariagrazia Cerrone, Emidio Di Gialleonardo, Giulio Maccauro, Raffaele Vitiello
    Journal of Clinical Medicine.2024; 13(9): 2485.     CrossRef
  • Quiste óseo aneurismático torácico, descompresión mediante costotransversectomía, corpectomía y caja telescópica expandible. Reporte de un caso y revisión de literatura
    Karoll Ortíz-Guillén, José M García-De la Rosa, Everardo García, Adriana Vargas-Oviedo
    Cirugía de Columna.2024; 2(3): 188.     CrossRef
  • The Role of Denosumab Treatment in Recurrent Giant Cell Bone Tumor of the Orbit
    Arjav Gupta, Bruce Colwell, David B. Clarke, Emad A. Massoud, Sidney Croul, Ahsen Hussain
    Ophthalmic Plastic & Reconstructive Surgery.2024; 40(5): e161.     CrossRef
  • Denosumab Re-Challenge and Long-Term Efficacy for Aneurysmal Bone Cyst of the Spine: Enhanced Treatment Algorithm
    Gisberto Evangelisti, Franziska C. S. Altorfer, Luigi Falzetti, Emanuela Palmerini, Cristiana Griffoni, Riccardo Ghermandi, Stefano Boriani, Annalisa Monetta, Marilena Cesari, Toni Ibrahim, Alessandro Gasbarrini
    Journal of Clinical Medicine.2024; 13(15): 4522.     CrossRef
  • Rare Aneurysmal Bone Cyst Presentation in the Orbit: A Systematic Review of the Literature with an Illustrative Case Report
    Sean O'Leary, Fakhar Hayat, Saketh Amasa, Muhammad Ammar Haider, Saad Akram Asbeutah, Usama AlDallal, Umaru Barrie, Mohamed Ismail
    World Neurosurgery.2024; 191: 1.     CrossRef
  • Primary osseous leiomyosarcoma of humerus misinterpreted as aneurysmal bone cyst: A case report and literature review
    Yong Jin Cho, Young Kwon Koh, Sung-Chul Lim
    Medicine.2024; 103(38): e39762.     CrossRef
  • Recurrent Aneurysmal Bone Cyst Treated with Percutaneous Doxycycline Sclerotherapy
    Cory Gall, Daniel C. Allison
    JBJS Case Connector.2024;[Epub]     CrossRef
  • Development and Printing of a Customized 3D Model of a Solitary Humeral Cyst as a Stage in Surgical Treatment of Bone Defects Using Orgignal Bone Replased Material
    Bakhtiyar Makhatov, Berik Tuleubayev, Amina Koshanova
    Journal of Clinical Medicine of Kazakhstan.2024; 21(6): 91.     CrossRef
  • Diagnosis and management of bone cysts
    Deepak C. D., Anitha Boregowdanapalya
    International Journal of Research in Medical Sciences.2024; 13(1): 509.     CrossRef
  • A rare case of cavitated Schmorl’s node in the cervical spine: imaging features of bone scan and magnetic resonance
    Yung-Cheng Chang, Yu-Jing Kao, Ling Chun Sun, Wen-Hsuan Hsiao, Shin-Tsu Chang
    MOJ Orthopedics & Rheumatology.2024; 16(5): 278.     CrossRef
  • Metastatic patellar bone tumor due to gastric cancer resembling a primary or secondary aneurysmal bone cyst: A case report
    T. Furuta, T. Sakuda, K. Yoshioka, K. Arihiro, N. Adachi
    International Journal of Surgery Case Reports.2023; 108: 108379.     CrossRef
  • Clear cell chondrosarcoma: a review of clinicopathologic characteristics, differential diagnoses, and patient management
    Borislav A. Alexiev, Erica R. Vormittag-Nocito, Terrance D. Peabody, Jonathan Samet, William B. Laskin
    Human Pathology.2023; 139: 126.     CrossRef
  • Malignant transformation of an aneurysmal bone cyst of the femoral neck: A case report
    Xiaoyang Song, Yongjie Qiao, Haoqiang Zhang, Lirong Sha, Jinpeng Lou, Xinyuan Yu, Hao Liu, Langfeng Zhu, Shenghu Zhou
    Experimental and Therapeutic Medicine.2023;[Epub]     CrossRef
Review Article
Article image
Multiple sclerosis: a practical review for pathologists
Rachel A. Multz, Pouya Jamshidi, Jared T. Ahrendsen
J Pathol Transl Med. 2025;59(4):203-213.   Published online June 27, 2025
DOI: https://doi.org/10.4132/jptm.2025.05.20
  • 11,680 View
  • 397 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system. It is a chronic disorder resulting in neurologic dysfunction that is disseminated both in time (multiple discrete episodes) and space (involving multiple sites). Histologically, MS is characterized by localized loss of myelin with relative preservation of axons. This review will discuss the epidemiology, clinical, laboratory, radiologic, and pathologic features of multiple sclerosis, as well as briefly touch on the differential diagnosis, treatment, and prognosis of the disease, especially as they relate to the pathologic interpretation of tissue specimens.

Citations

Citations to this article as recorded by  
  • White Matter in Crisis: Oligodendrocytes and the Pathophysiology of Multiple Sclerosis
    Mario García-Domínguez
    Cells.2025; 14(18): 1408.     CrossRef
  • Tumefactive demyelinating lesions: a case report and literature review
    Raneem Jaki, Zyad Al-Frejat, Ziad Bitar
    BMC Neurology.2025;[Epub]     CrossRef
Newsletter
Article image
What’s new in neuropathology 2024: CNS WHO 5th edition updates
Heather Smith, Jared T. Ahrendsen
J Pathol Transl Med. 2024;58(6):346-349.   Published online September 30, 2024
DOI: https://doi.org/10.4132/jptm.2024.09.11
  • 18,307 View
  • 1,060 Download
  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDF
The fifth edition of the World Health Organization (WHO) Classification of Central Nervous System (CNS) Tumors was released in 2021, just five years following the updated fourth edition. Advanced molecular testing such as next-generation sequencing, RNA fusion analysis, and DNA methylation profiling has led to more precise grading and classification of pre-existing tumor types as well as the recognition of new ones. Herein, we outline the major updates of the 2021 WHO Classification of CNS tumors, with emphasis on the expanded molecular characterization of CNS tumors.

Citations

Citations to this article as recorded by  
  • Bioinformatics insights into ACSL1 and ACSL5: prognostic and immune roles in low-grade glioma
    Cheng Zhang, Zhonghua Lv, Hongsheng Liang, Fulan Hu, Haoran Bi
    BMC Cancer.2025;[Epub]     CrossRef
  • Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis
    Aghdas Ramezani, Maryam Rahnama, Fatemeh Mahmoudian, Fatemeh Shirazi, Mahmoud Ganji, Shohreh Bakhshi, Bahman Khalesi, Zahra Sadat Hashemi, Saeed Khalili
    Journal of Neuroimmune Pharmacology.2025;[Epub]     CrossRef
  • Diagnostic Utility of Intratumoral Susceptibility Signals in Adult Diffuse Gliomas: Tumor Grade Prediction and Correlation with Molecular Markers Within the WHO CNS5 (2021) Classification
    José Ignacio Tudela Martínez, Victoria Vázquez Sáez, Guillermo Carbonell, Héctor Rodrigo Lara, Florentina Guzmán-Aroca, Juan de Dios Berna Mestre
    Journal of Clinical Medicine.2025; 14(11): 4004.     CrossRef
  • Glioblastoma in Puerto Rico: A 21-year population-based study
    Carlos E Calderon-Valero, Esteban Rivera, Odaly Balasquide, Alejandro E Cedeño-Moran, Aixa De Jesus, Miguel Mayol Del Valle
    Neuro-Oncology Advances.2025;[Epub]     CrossRef
  • Brain Tumors, AI and Psychiatry: Predicting Tumor-Associated Psychiatric Syndromes with Machine Learning and Biomarkers
    Matei Șerban, Corneliu Toader, Răzvan-Adrian Covache-Busuioc
    International Journal of Molecular Sciences.2025; 26(17): 8114.     CrossRef
  • Engineered bacteria/bacterial components strategy for glioma
    Yan Zhu, Meilin Shen, Qi Chen, Huanghao Yang
    Chemical Engineering Journal.2025; 525: 170539.     CrossRef
Reviews
Article image
A review of liver fibrosis and cirrhosis regression
Michael J. Lee
J Pathol Transl Med. 2023;57(4):189-195.   Published online June 20, 2023
DOI: https://doi.org/10.4132/jptm.2023.05.24
  • 25,754 View
  • 840 Download
  • 22 Web of Science
  • 23 Crossref
AbstractAbstract PDF
Cirrhosis has traditionally been considered an irreversible process of end-stage liver disease. With new treatments for chronic liver disease, there is regression of fibrosis and cirrhosis, improvement in clinical parameters (i.e. liver function and hemodynamic markers, hepatic venous pressure gradient), and survival rates, demonstrating that fibrosis and fibrolysis are a dynamic process moving in two directions. Microscopically, hepatocytes push into thinning fibrous septa with eventual perforation leaving behind delicate periportal spikes in the portal tracts and loss of portal veins. Obliterated portal veins during progressive fibrosis and cirrhosis due to parenchymal extinction, vascular remodeling and thrombosis often leave behind a bile duct and hepatic artery within the portal tract. Traditional staging classification systems focused on a linear, progressive process; however, the Beijing classification system incorporates both the bidirectional nature for the progression and regression of fibrosis. However, even with regression, vascular lesions/remodeling, parenchymal extinction and a cumulative mutational burden place patients at an increased risk for developing hepatocellular carcinoma and should continue to undergo active clinical surveillance. It is more appropriate to consider cirrhosis as another stage in the evolution of chronic liver disease as a bidirectional process rather than an end-stage, irreversible state.

Citations

Citations to this article as recorded by  
  • Molecular and cellular secrets revealed: How umbilical cord-derived mesenchymal stem cells can target hepatocellular carcinoma
    Mohammad Sadegh Izadi, Reza Arefnezhad, Amirmasoud Asadi, Aryan Rezaee, Leila Kalantari, Farzad Nasrpour Tahouneh, Mohammad Mehdi Shadravan, Seyyed Taher Seyyed Mahmoudi, Zahra GhaniBeygi, Fatemeh Rostamnezhad, Armin Razman, Fardad Ejtehadi, Fatemeh Rezae
    Tissue and Cell.2026; 98: 103200.     CrossRef
  • Low-Grade Chronic Inflammation: a Shared Mechanism for Chronic Diseases
    Mariana Cifuentes, Hugo E. Verdejo, Pablo F. Castro, Alejandro H. Corvalan, Catterina Ferreccio, Andrew F. G. Quest, Marcelo J. Kogan, Sergio Lavandero
    Physiology.2025; 40(1): 4.     CrossRef
  • Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma
    Melchor Alpízar Salazar, Samantha Estefanía Olguín Reyes, Andrea Medina Estévez, Julieta Alejandra Saturno Lobos, Jesús Manuel De Aldecoa Castillo, Juan Carlos Carrera Aguas, Samary Alaniz Monreal, José Antonio Navarro Rodríguez, Dulce María Fernanda Alpí
    Medicina.2025; 61(1): 88.     CrossRef
  • Unveiling the Link between Albumin-Bilirubin Grade and Liver Fibrosis in Patients with a History of Gallstone and Gallbladder Surgery: A Focus on Metabolic Dysfunction-Associated Steatohepatitis
    Mohammadjavad Sotoudeheian
    The Korean Journal of Pancreas and Biliary Tract.2025; 30(1): 10.     CrossRef
  • Impact of Weight Loss on Metabolic Dysfunction Associated Steatohepatitis and Hepatic Fibrosis
    Marina W. Takawy, Manal F. Abdelmalek
    Current Diabetes Reports.2025;[Epub]     CrossRef
  • Nanoparticle-based therapeutic strategies for chronic liver diseases: Advances and insights
    Sathiyamoorthy Padmanaban, Ji-Won Baek, Sai Sahithya Chamarthy, Saipriya Chandrasekaran, Antony V Samrot, Vijayakumar Gosu, In-Kyu Park, Kamalakannan Radhakrishnan, Don-Kyu Kim
    Liver Research.2025; 9(2): 104.     CrossRef
  • Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes
    Ashok Kumar Sah, Mohd Afzal, Rabab H. Elshaikh, Anass M. Abbas, Manar G. Shalabi, Pranav Kumar Prabhakar, Asaad M. A. Babker, Fariza Tursunbaevna Khalimova, Velilyaeva Aliya Sabrievna, Ranjay Kumar Choudhary
    Life.2025; 15(5): 779.     CrossRef
  • Poly(I:C)-Stimulated Exosomes Mitigate Cholesterol-Induced Hepatic Fibrosis by Modulating the TGF-β/Smad3 Signal Transduction Pathway
    Shahla Asadizadeh, Parichehreh Yaghmaei, Nasim Hayati Roodbari, Azam Khedri
    Hepatitis Monthly.2025;[Epub]     CrossRef
  • The postbiotic ReFerm® versus standard nutritional support in advanced alcohol-related liver disease (GALA-POSTBIO): a randomized controlled phase 2 trial
    Johanne K. Hansen, Mads Israelsen, Suguru Nishijima, Sara E. Stinson, Peter Andersen, Stine Johansen, Camilla D. Hansen, Maximilian Joseph Brol, Sabine Klein, Robert Schierwagen, Frank Erhard Uschner, Karolina Sulek, Ida F. Villesen, Katrine P. Lindvig, K
    Nature Communications.2025;[Epub]     CrossRef
  • ADVANCING CURCUMIN APPLICATIONS IN HEPATOCELLULAR CARCINOMA: INSIGHTS INTO PHARMACOKINETICS, PHARMACODYNAMICS AND NANODELIVERY SYSTEMS
    RESHMA T. MATE, ANURADHA N. CHIVATE, NAMDEO R. JADHAV, NIRANJAN D. CHIVATE
    International Journal of Applied Pharmaceutics.2025; : 19.     CrossRef
  • Genetic Determinants of Apoptosis Regulate Liver Cirrhosis Risk: The FAS/FASL Polymorphism Connection in Iraqi Population
    Wisam Hindawi Hoidy, Ahmed Ghdhban Al-Ziaydi
    Indian Journal of Clinical Biochemistry.2025;[Epub]     CrossRef
  • Histological and Molecular Evaluation of Liver Biopsies: A Practical and Updated Review
    Joon Hyuk Choi
    International Journal of Molecular Sciences.2025; 26(16): 7729.     CrossRef
  • Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation
    Sachin Sharma, Vijaya Prathigudupu, Carson Cable, Lia R. Serrano, Srilaxmi Nerella, Alina Chen, Ghmkin Hassan, Johnathon Lakins, Carlos Lizama Valenzuela, Tatsuya Tsukui, Roopa Ramamoorthi, Jae-Jun Kim, Holger Willenbring, Aras N. Mattis, Regan F. Volk, B
    Science Translational Medicine.2025;[Epub]     CrossRef
  • Association of ANGPT2 and NOS3 Gene Variants With Esophageal Variceal Progression in HCV‐Induced Cirrhosis
    Omnia S. Nabih, Mohamed Abdel‐Samiee, Marwa A. Tahoon, Elaf Abozeid, Heba Demerdash, Fatma Omar Khalil, Randa M. Seddik, Marwa L. Helal, Gamalat A. El Gedawy, HalaA E. Khalil, Badawy W AboBakr. Yossef, Ahmed B. Zaid, Mai I. Elashmawy
    Journal of Medical Virology.2025;[Epub]     CrossRef
  • Emerging advanced approaches for diagnosis and inhibition of liver fibrogenesis
    Tamer A. Addissouky, Majeed M. A. Ali, Ibrahim El Tantawy El Sayed, Yuliang Wang
    The Egyptian Journal of Internal Medicine.2024;[Epub]     CrossRef
  • Inhibition of hepatic stellate cell activation by nutraceuticals: an emphasis on mechanisms of action
    Vasudevan Sekar, Venkateish VP, Vani Vijay, Annapoorna BR, Nivya Vijayan, Madan Kumar Perumal
    Journal of Food Science and Technology.2024; 61(11): 2046.     CrossRef
  • The Role of Macrophage Inhibitory Factor in TAA-Induced Liver Fibrosis in Mice: Modulatory Effects of Betaine
    Tatjana Radosavljevic, Dusan Vukicevic, Jasmina Djuretić, Kristina Gopcevic, Milica Labudovic Borovic, Sanja Stankovic, Janko Samardzic, Milica Radosavljevic, Danijela Vucevic, Vladimir Jakovljevic
    Biomedicines.2024; 12(6): 1337.     CrossRef
  • Fibrosis and Hepatocarcinogenesis: Role of Gene-Environment Interactions in Liver Disease Progression
    Anindita Banerjee, Patrizia Farci
    International Journal of Molecular Sciences.2024; 25(16): 8641.     CrossRef
  • Multiomic predictors for regression of cirrhosis: Clinical implications and future directions
    Binghua Li, Decai Yu
    iLIVER.2024; 3(4): 100116.     CrossRef
  • Commonly encountered symptoms and their management in patients with cirrhosis
    Cyriac Abby Philips
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • Antioxidant Potential of Xanthohumol in Disease Prevention: Evidence from Human and Animal Studies
    Jakub Piekara, Dorota Piasecka-Kwiatkowska
    Antioxidants.2024; 13(12): 1559.     CrossRef
  • AdhMMP8 Vector Administration in Muscle: An Alternate Strategy to Regress Hepatic Fibrosis
    Jesús García-Bañuelos, Edén Oceguera-Contreras, Ana Sandoval-Rodríguez, Blanca Estela Bastidas-Ramírez, Silvia Lucano-Landeros, Daniela Gordillo-Bastidas, Belinda C. Gómez-Meda, Arturo Santos, Eira Cerda-Reyes, Juan Armendariz-Borunda
    Cells.2023; 12(17): 2127.     CrossRef
  • Nutritional deficiency in patients with liver cirrhosis
    Maria S. Zhigalova, Vladimir V. Kiselev, Alla A. Ryk, Petr A. Yartsev
    Clinical nutrition and metabolism.2023; 4(4): 265.     CrossRef
Article image
A standardized pathology report for gastric cancer: 2nd edition
Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Hee Kyung Chang, Soomin Ahn, Mee Soo Chang, Song-Hee Han, Yoonjin Kwak, An Na Seo, Sung Hak Lee, Mee-Yon Cho
J Pathol Transl Med. 2023;57(1):1-27.   Published online January 15, 2023
DOI: https://doi.org/10.4132/jptm.2022.12.23
  • 30,209 View
  • 1,490 Download
  • 21 Web of Science
  • 17 Crossref
AbstractAbstract PDFSupplementary Material
The first edition of ‘A Standardized Pathology Report for Gastric Cancer’ was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. Since then, significant advances have been made in the pathologic diagnosis, molecular genetics, and management of gastric cancer (GC). To reflect those changes, a committee for publishing a second edition of the report was formed within the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. This second edition consists of two parts: standard data elements and conditional data elements. The standard data elements contain the basic pathologic findings and items necessary to predict the prognosis of GC patients, and they are adequate for routine surgical pathology service. Other diagnostic and prognostic factors relevant to adjuvant therapy, including molecular biomarkers, are classified as conditional data elements to allow each pathologist to selectively choose items appropriate to the environment in their institution. We trust that the standardized pathology report will be helpful for GC diagnosis and facilitate large-scale multidisciplinary collaborative studies.

Citations

Citations to this article as recorded by  
  • Spatial and Temporal Tumor Heterogeneity in Gastric Cancer: Discordance of Predictive Biomarkers
    Hye Seung Lee
    Journal of Gastric Cancer.2025; 25(1): 192.     CrossRef
  • PD-L1 as a Biomarker in Gastric Cancer Immunotherapy
    Yunjoo Cho, Soomin Ahn, Kyoung-Mee Kim
    Journal of Gastric Cancer.2025; 25(1): 177.     CrossRef
  • Korean Gastric Cancer Association-Led Nationwide Survey on Surgically Treated Gastric Cancers in 2023
    Dong Jin Kim, Jeong Ho Song, Ji-Hyeon Park, Sojung Kim, Sin Hye Park, Cheol Min Shin, Yoonjin Kwak, Kyunghye Bang, Chung-sik Gong, Sung Eun Oh, Yoo Min Kim, Young Suk Park, Jeesun Kim, Ji Eun Jung, Mi Ran Jung, Bang Wool Eom, Ki Bum Park, Jae Hun Chung, S
    Journal of Gastric Cancer.2025; 25(1): 115.     CrossRef
  • A Comprehensive and Comparative Review of Global Gastric Cancer Treatment Guidelines: 2024 Update
    Sang Soo Eom, Keun Won Ryu, Hye Sook Han, Seong-Ho Kong
    Journal of Gastric Cancer.2025; 25(1): 153.     CrossRef
  • Korea, Japan, Europe, and the United States: Why are guidelines for gastric cancer different?
    Emily E. Stroobant, Seong-Ho Kong, Maria Bencivenga, Takahiro Kinoshita, Tae-Han Kim, Takeshi Sano, Giovanni de Manzoni, Han-Kwang Yang, Yuko Kitagawa, Vivian E. Strong
    Gastric Cancer.2025; 28(4): 559.     CrossRef
  • Can the Japanese guidelines for endoscopic submucosal dissection be safely applied to Korean gastric cancer patients? A multicenter retrospective study based on the Korean Gastric Cancer Association nationwide survey
    Hayemin Lee, Mi Ryeong Park, Junhyun Lee
    Annals of Surgical Treatment and Research.2025; 109(2): 81.     CrossRef
  • Double optimal transport for differential gene regulatory network inference with unpaired samples
    Mengyu Li, Bencong Zhu, Cheng Meng, Xiaodan Fan, Laura Cantini
    Bioinformatics.2025;[Epub]     CrossRef
  • A Randomized Controlled Trial to Evaluate the Effect of Fibrin Glue on Bleeding after Gastric Endoscopic Submucosal Dissection
    Tae-Se Kim, Tae-Jun Kim, Yang Won Min, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee, Jae J. Kim
    Gut and Liver.2025; 19(5): 677.     CrossRef
  • Genomic and Transcriptomic Characterization of Gastric Cancer with Bone Metastasis
    Sujin Oh, Soo Kyung Nam, Keun-Wook Lee, Hye Seung Lee, Yujun Park, Yoonjin Kwak, Kyu Sang Lee, Ji-Won Kim, Jin Won Kim, Minsu Kang, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim
    Cancer Research and Treatment.2024; 56(1): 219.     CrossRef
  • Microscopic tumor mapping of post-neoadjuvant therapy pancreatic cancer specimens to predict post-surgical recurrence: A prospective cohort study
    Yeshong Park, Yeon Bi Han, Jinju Kim, MeeYoung Kang, Boram Lee, Eun Sung Ahn, Saemi Han, Haeryoung Kim, Hee-Young Na, Ho-Seong Han, Yoo-Seok Yoon
    Pancreatology.2024; 24(4): 562.     CrossRef
  • Effect of Neoadjuvant Chemotherapy on Tumor-Infiltrating Lymphocytes in Resectable Gastric Cancer: Analysis from a Western Academic Center
    Elliott J. Yee, Danielle Gilbert, Jeffrey Kaplan, Sachin Wani, Sunnie S. Kim, Martin D. McCarter, Camille L. Stewart
    Cancers.2024; 16(7): 1428.     CrossRef
  • Interpretation of PD-L1 expression in gastric cancer: summary of a consensus meeting of Korean gastrointestinal pathologists
    Soomin Ahn, Yoonjin Kwak, Gui Young Kwon, Kyoung-Mee Kim, Moonsik Kim, Hyunki Kim, Young Soo Park, Hyeon Jeong Oh, Kyoungyul Lee, Sung Hak Lee, Hye Seung Lee
    Journal of Pathology and Translational Medicine.2024; 58(3): 103.     CrossRef
  • Expression of claudin 18.2 in poorly cohesive carcinoma and its association with clinicopathologic parameters in East Asian patients
    Moonsik Kim, Byung Woog Kang, Jihyun Park, Jin Ho Baek, Jong Gwang Kim
    Pathology - Research and Practice.2024; 263: 155628.     CrossRef
  • Clinicopathological analysis of claudin 18.2 focusing on intratumoral heterogeneity and survival in patients with metastatic or unresectable gastric cancer
    T.-Y. Kim, Y. Kwak, S.K. Nam, D. Han, D.-Y. Oh, S.-A. Im, H.S. Lee
    ESMO Open.2024; 9(12): 104000.     CrossRef
  • Pathological Interpretation of Gastric Tumors in Endoscopic Submucosal Dissection
    Jung Yeon Kim
    Journal of Digestive Cancer Research.2023; 11(1): 15.     CrossRef
  • Histopathology of Gastric Cancer
    Baek-hui Kim, Sung Hak Lee
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(2): 143.     CrossRef
  • Endoscopic submucosal dissection hands-on training with artificial mucosal layer EndoGEL
    Tae-Se Kim, Jun Haeng Lee
    Journal of Innovative Medical Technology.2023; 1(1): 5.     CrossRef
Newsletter
Article image
What’s new in thyroid pathology 2024: updates from the new WHO classification and Bethesda system
Andrey Bychkov, Chan Kwon Jung
J Pathol Transl Med. 2024;58(2):98-101.   Published online March 13, 2024
DOI: https://doi.org/10.4132/jptm.2024.03.06
  • 22,394 View
  • 1,909 Download
  • 7 Crossref
AbstractAbstract PDF
In line with the release of the 5th edition WHO Classification of Tumors of Endocrine Organs (2022) and the 3rd edition of the Bethesda System for Reporting Thyroid Cytopathology (2023), the field of thyroid pathology and cytopathology has witnessed key transformations. This digest brings to the fore the refined terminologies, newly introduced categories, and contentious methodological considerations pivotal to the updated classification.

Citations

Citations to this article as recorded by  
  • Diagnosis and management of thyroid nodule
    Suganya Sekar, Deepak Thomas Abraham
    Current Opinion in Endocrinology, Diabetes & Obesity.2025; 32(5): 167.     CrossRef
  • Impact of thyroid Bethesda category IV (follicular neoplasm) terminology unification on atypia of undetermined significance reporting patterns in thyroid fine-needle aspiration
    Shirin Abbasi, Lorena Marcano-Bonilla, Syed Z. Ali
    Journal of the American Society of Cytopathology.2025;[Epub]     CrossRef
  • Cytologic and Clinicopathologic Features of Papillary Thyroid Carcinoma with Prominent Hobnail Features on FNAC
    Deepali Saxena, Ravi Hari Phulware, Prashant Durgapal, Arvind Kumar, Amit Kumar Tyagi
    Indian Journal of Otolaryngology and Head & Neck Surgery.2024; 76(5): 4885.     CrossRef
  • FHL1: A novel diagnostic marker for papillary thyroid carcinoma
    Yeting Zeng, Dehua Zeng, Xingfeng Qi, Hanxi Wang, Xuzhou Wang, Xiaodong Dai, Lijuan Qu
    Pathology International.2024; 74(9): 520.     CrossRef
  • Nouveautés en pathologie thyroïdienne : classification OMS 2022, système Bethesda 2023, biologie moléculaire et testing moléculaire
    Mohamed Amine Bani, Sophie Moog, Voichita Suciu, Livia Lamartina, Abir Al Ghuzlan
    Bulletin du Cancer.2024; 111(10): 10S5.     CrossRef
  • Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes
    Agnes Stephanie Harahap, Chan Kwon Jung
    Journal of Pathology and Translational Medicine.2024; 58(6): 265.     CrossRef
  • Surgical and Pathological Challenges in Thyroidectomy after Thermal Ablation of Thyroid Nodules
    Ting-Chun Kuo, Kuen-Yuan Chen, Hsiang-Wei Hu, Jie-Yang Jhuang, Ming-Tsan Lin, Chin-Hao Chang, Ming-Hsun Wu
    Thyroid®.2024; 34(12): 1503.     CrossRef
Reviews
Article image
A stepwise approach to fine needle aspiration cytology of lymph nodes
Yosep Chong, Gyeongsin Park, Hee Jeong Cha, Hyun-Jung Kim, Chang Suk Kang, Jamshid Abdul-Ghafar, Seung-Sook Lee
J Pathol Transl Med. 2023;57(4):196-207.   Published online July 11, 2023
DOI: https://doi.org/10.4132/jptm.2023.06.12
  • 42,414 View
  • 2,230 Download
  • 11 Web of Science
  • 12 Crossref
AbstractAbstract PDFSupplementary Material
The cytological diagnosis of lymph node lesions is extremely challenging because of the diverse diseases that cause lymph node enlargement, including both benign and malignant or metastatic lymphoid lesions. Furthermore, the cytological findings of different lesions often resemble one another. A stepwise diagnostic approach is essential for a comprehensive diagnosis that combines: clinical findings, including age, sex, site, multiplicity, and ultrasonography findings; low-power reactive, metastatic, and lymphoma patterns; high-power population patterns, including two populations of continuous range, small monotonous pattern and large monotonous pattern; and disease-specific diagnostic clues including granulomas and lymphoglandular granules. It is also important to remember the histological features of each diagnostic category that are common in lymph node cytology and to compare them with cytological findings. It is also essential to identify a few categories of diagnostic pitfalls that often resemble lymphomas and easily lead to misdiagnosis, particularly in malignant small round cell tumors, poorly differentiated squamous cell carcinomas, and nasopharyngeal undifferentiated carcinoma. Herein, we review a stepwise approach for fine needle aspiration cytology of lymphoid diseases and suggest a diagnostic algorithm that uses this approach and the Sydney classification system.

Citations

Citations to this article as recorded by  
  • Development and Validation of Explainable Artificial Intelligence System for Automatic Diagnosis of Cervical Lymphadenopathy From Ultrasound Images
    Ming Xu, Yubiao Yue, Zhenzhang Li, Yinhong Li, Guoying Li, Haihua Liang, Di Liu, Xiaohong Xu, Mohamadreza (Mohammad) Khosravi
    International Journal of Intelligent Systems.2025;[Epub]     CrossRef
  • Application of the Sydney system for classification and reporting lymph node cytopathology: a retrospective analysis at a tertiary centre
    Ashok Teja Kummari, Pramod Kumar Pamu, Krishna Kiran Ganna, Param Jyothi, Sadashivudu
    International Journal of Research in Medical Sciences.2025;[Epub]     CrossRef
  • Diagnostic approach to FNA biopsy of cystic lesions of the head and neck
    Stefen Andrianus, Olivia Leung, Zubair Baloch
    Cancer Cytopathology.2025;[Epub]     CrossRef
  • Applicability of Fine-Needle Aspiration Biopsy of Lymph Nodes Using WHO Reporting System: Comparison between Pediatric and Adult Brazilian Populations
    Leonardo Fávaro Ficoto, Deolino João Camilo Júnior, Gustavo Resende Nora, Vitor Bonetti Valente, Daniel Galera Bernabé, José Cândido Caldeira Xavier-Júnior
    Acta Cytologica.2025; : 1.     CrossRef
  • Intraoperative cytological assessment of sentinel lymph nodes in gynecologic cancer: diagnostic accuracy and limitations
    O. V. Pankova, S. V. Vtorushin, M. V. Klimova, D. S. Pismenny, M. O. Ochirov, L. A. Kolomiets, V. M. Perelmuter
    Siberian journal of oncology.2025; 24(5): 72.     CrossRef
  • Immunocytochemical markers, molecular testing and digital cytopathology for aspiration cytology of metastatic breast carcinoma
    Joshua J. X. Li, Gary M. Tse
    Cytopathology.2024; 35(2): 218.     CrossRef
  • Response to comment on “A stepwise approach to fine needle aspiration cytology of lymph nodes”
    Yosep Chong, Gyeongsin Park, Hee Jeong Cha, Hyun-Jung Kim, Chang Suk Kang, Jamshid Abdul-Ghafar, Seung-Sook Lee
    Journal of Pathology and Translational Medicine.2024; 58(1): 43.     CrossRef
  • Comment on “A stepwise approach to fine needle aspiration cytology of lymph nodes”
    Elisabetta Maffei, Valeria Ciliberti, Pio Zeppa, Alessandro Caputo
    Journal of Pathology and Translational Medicine.2024; 58(1): 40.     CrossRef
  • The Incidence of Thyroid Cancer in Bethesda III Thyroid Nodules: A Retrospective Analysis at a Single Endocrine Surgery Center
    Iyad Hassan, Lina Hassan, Nahed Balalaa, Mohamad Askar, Hussa Alshehhi, Mohamad Almarzooqi
    Diagnostics.2024; 14(10): 1026.     CrossRef
  • Efficiency of Fine-Needle Aspiration (FNA) in Relation to Tru-Cut Biopsy of Lateral Neck Swellings
    Mohammed S Al Olaimat, Fahad S Al Qooz, Zaid R Alzoubi, Elham M Alsharaiah, Ali S Al Murdif, Mohammad O Alanazi
    Cureus.2024;[Epub]     CrossRef
  • Pitfalls in the Cytological Diagnosis of Nodal Hodgkin Lymphoma
    Uma Handa, Rasheeda Mohamedali, Rajpal Singh Punia, Simrandeep Singh, Ranjeev Bhagat, Phiza Aggarwal, Manveen Kaur
    Diagnostic Cytopathology.2024; 52(12): 715.     CrossRef
  • Rapid 3D imaging at cellular resolution for digital cytopathology with a multi-camera array scanner (MCAS)
    Kanghyun Kim, Amey Chaware, Clare B. Cook, Shiqi Xu, Monica Abdelmalak, Colin Cooke, Kevin C. Zhou, Mark Harfouche, Paul Reamey, Veton Saliu, Jed Doman, Clay Dugo, Gregor Horstmeyer, Richard Davis, Ian Taylor-Cho, Wen-Chi Foo, Lucas Kreiss, Xiaoyin Sara J
    npj Imaging.2024;[Epub]     CrossRef
Article image
Perspectives on single-nucleus RNA sequencing in different cell types and tissues
Nayoung Kim, Huiram Kang, Areum Jo, Seung-Ah Yoo, Hae-Ock Lee
J Pathol Transl Med. 2023;57(1):52-59.   Published online January 10, 2023
DOI: https://doi.org/10.4132/jptm.2022.12.19
  • 20,530 View
  • 454 Download
  • 34 Web of Science
  • 33 Crossref
AbstractAbstract PDF
Single-cell RNA sequencing has become a powerful and essential tool for delineating cellular diversity in normal tissues and alterations in disease states. For certain cell types and conditions, there are difficulties in isolating intact cells for transcriptome profiling due to their fragility, large size, tight interconnections, and other factors. Single-nucleus RNA sequencing (snRNA-seq) is an alternative or complementary approach for cells that are difficult to isolate. In this review, we will provide an overview of the experimental and analysis steps of snRNA-seq to understand the methods and characteristics of general and tissue-specific snRNA-seq data. Knowing the advantages and limitations of snRNA-seq will increase its use and improve the biological interpretation of the data generated using this technique.

Citations

Citations to this article as recorded by  
  • Müller cell glutamine metabolism links photoreceptor and endothelial injury in diabetic retinopathy
    Katia Corano Scheri, Yi-Wen Hsieh, Thomas Tedeschi, James B Hurley, Amani A Fawzi
    Life Science Alliance.2026; 9(2): e202503434.     CrossRef
  • Single-cell and spatial omics: exploring hypothalamic heterogeneity
    Muhammad Junaid, Eun Jeong Lee, Su Bin Lim
    Neural Regeneration Research.2025; 20(6): 1525.     CrossRef
  • Exploring the utility of snRNA-seq in profiling human bladder tissue: A comprehensive comparison with scRNA-seq
    Briana Santo, Emily E. Fink, Alexandra E. Krylova, Yi-Chia Lin, Mohamed Eltemamy, Alvin Wee, Oliver Wessely, Byron H. Lee, Angela H. Ting
    iScience.2025; 28(1): 111628.     CrossRef
  • Applications and emerging challenges of single-cell RNA sequencing technology in tumor drug discovery
    Lu Zhang, Yueying Yang, Jianjun Tan
    Drug Discovery Today.2025; 30(2): 104290.     CrossRef
  • Techniques and analytic workflow for spatial transcriptomics and its application to allergy and inflammation
    Haihan Zhang, Matthew T. Patrick, Jingyu Zhao, Xintong Zhai, Jialin Liu, Zheng Li, Yiqian Gu, Joshua Welch, Xiang Zhou, Robert L. Modlin, Lam C. Tsoi, Johann E. Gudjonsson
    Journal of Allergy and Clinical Immunology.2025; 155(3): 678.     CrossRef
  • Single-cell RNA sequencing in autoimmune diseases: New insights and challenges
    Jialing Huang, Yuelin Hu, Shuqing Wang, Yuefang Liu, Xin Sun, Xin Wang, Hongsong Yu
    Pharmacology & Therapeutics.2025; 267: 108807.     CrossRef
  • SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice
    Ziying Jiang, Bin Liu, Tangsheng Lu, Xiaoxing Liu, Renjun Lv, Kai Yuan, Mengna Zhu, Xinning Wang, Shangbin Li, Song Xu, Xinyu Wang, Yifei Wang, Zhenfang Gao, Peiqing Zhao, Zongyong Zhang, Junwei Hao, Lin Lu, Qingqing Yin
    Nature Communications.2025;[Epub]     CrossRef
  • Unraveling cell–cell communication with NicheNet by inferring active ligands from transcriptomics data
    Chananchida Sang-aram, Robin Browaeys, Ruth Seurinck, Yvan Saeys
    Nature Protocols.2025; 20(6): 1439.     CrossRef
  • Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder
    Anna S. Warden, Nihal A. Salem, Eric Brenner, Greg T. Sutherland, Julia Stevens, Manav Kapoor, Alison M. Goate, R. Dayne Mayfield
    Biological Psychiatry.2025;[Epub]     CrossRef
  • A versatile and efficient method to isolate nuclei from low-input cryopreserved tissues for single-nuclei transcriptomics
    Cristopher Segovia, Vincent Desrosiers, Fatemeh Khadangi, Karine Robitaille, Victoria Saavedra Armero, Myreille D’Astous, Gabriel Khelifi, Alain Bergeron, Samer Hussein, Maxime Richer, Yohan Bossé, Yves Fradet, Vincent Fradet, Steve Bilodeau
    Scientific Reports.2025;[Epub]     CrossRef
  • Application of single-cell sequencing technology and its clinical implications in Parkinson’s disease and Alzheimer’s disease: a narrative review
    Zhonghao Chen, Jack Shi, Longfei Li
    Advanced Technology in Neuroscience.2025; 2(1): 9.     CrossRef
  • SGK1 upregulation in GFAP+ neurons in the frontal association cortex protects against neuronal apoptosis after spinal cord injury
    Anbiao Wu, Guang Yang, Genyu Liu, Jiyan Zhang
    Cell Death & Disease.2025;[Epub]     CrossRef
  • Expert recommendations to standardize transcriptomic analysis in inflammatory bowel disease clinical trials
    Bryan Linggi, Salas Azucena, Boyd Steere, Bram Verstockt, Dahham Alsoud, David Casero, Dermot McGovern, Eileen Chan, Michelle I Smith, Federica Ungaro, Florian Rieder, Konrad Aden, Lisa M Shackelton, Luca Massimino, Markus Neurath, Matthieu Allez, Raja At
    Journal of Crohn's and Colitis.2025;[Epub]     CrossRef
  • Transcriptional characterization of sepsis in a LPS porcine model
    Ryan Neill
    Molecular Genetics and Genomics.2025;[Epub]     CrossRef
  • Single nuclear‐spatial transcriptomic sequencing reveals distinct puncture‐induced cell subpopulations in the intervertebral disc of a rat model
    Guoyan Liang, Jing Tan, Chong Chen, Yuying Liu, Yongyu Ye, Xiaolin Pan, Qiujian Zheng, Yunbing Chang, Feng‐Juan Lyu
    Clinical and Translational Medicine.2025;[Epub]     CrossRef
  • Harp: data harmonization for computational tissue deconvolution across diverse transcriptomics platforms
    Zahra Nozari, Paul Hüttl, Jakob Simeth, Marian Schön, James A Hutchinson, Rainer Spang, Macha Nikolski
    Bioinformatics.2025;[Epub]     CrossRef
  • Transformation of an Olfactory Placode-Derived Cell into One with Stem Cell Characteristics by Disrupting Epigenetic Barriers
    Ghazia Abbas, Rutesh Vyas, Joyce C. Noble, Brian Lin, Robert P. Lane
    Cellular Reprogramming.2025; 27(4): 164.     CrossRef
  • Altered Neuroinflammatory Transcriptomic Profile in the Hippocampal Dentate Gyrus Three Weeks After Lateral Fluid Percussion Injury in Rats
    Anthony J. DeSana, Yara Alfawares, Roshni Khatri, Tracy M. Hopkins, Faith V. Best, Jennifer L. McGuire, Laura B. Ngwenya
    International Journal of Molecular Sciences.2025; 26(18): 9140.     CrossRef
  • Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing
    Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
    Advanced Science.2025;[Epub]     CrossRef
  • A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito
    Olivia V. Goldman, Alexandra E. DeFoe, Yanyan Qi, Yaoyu Jiao, Shih-Che Weng, Brittney Wick, Leah Houri-Zeevi, Priyanka Lakhiani, Takeshi Morita, Jacopo Razzauti, Adriana Rosas-Villegas, Yael N. Tsitohay, Madison M. Walker, Ben R. Hopkins, Joshua X.D. Ang,
    Cell.2025;[Epub]     CrossRef
  • Mapping the cellular landscape of Atlantic salmon head kidney by single cell and single nucleus transcriptomics
    Adriana M.S. Andresen, Richard S. Taylor, Unni Grimholt, Rose Ruiz Daniels, Jianxuan Sun, Ross Dobie, Neil C. Henderson, Samuel A.M. Martin, Daniel J. Macqueen, Johanna H. Fosse
    Fish & Shellfish Immunology.2024; 146: 109357.     CrossRef
  • Single-cell and spatially resolved transcriptomics for liver biology
    Ping Lin, Xi Yan, Siyu Jing, Yanhong Wu, Yiran Shan, Wenbo Guo, Jin Gu, Yu Li, Haibing Zhang, Hong Li
    Hepatology.2024; 80(3): 698.     CrossRef
  • Single-cell transcriptomics in thyroid eye disease
    Sofia Ahsanuddin, Albert Y. Wu
    Taiwan Journal of Ophthalmology.2024; 14(4): 554.     CrossRef
  • Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses
    Jonathan M. Packer, Chelsea E. Bray, Nicolas B. Beckman, Lynde M. Wangler, Amara C. Davis, Ethan J. Goodman, Nathaniel E. Klingele, Jonathan P. Godbout
    Glia.2024; 72(2): 300.     CrossRef
  • Adipose tissue macrophage heterogeneity in the single-cell genomics era
    Haneul Kang, Jongsoon Lee
    Molecules and Cells.2024; 47(2): 100031.     CrossRef
  • A Comprehensive Review on Circulating cfRNA in Plasma: Implications for Disease Diagnosis and Beyond
    Pengqiang Zhong, Lu Bai, Mengzhi Hong, Juan Ouyang, Ruizhi Wang, Xiaoli Zhang, Peisong Chen
    Diagnostics.2024; 14(10): 1045.     CrossRef
  • Single-Cell Sequencing Technology in Ruminant Livestock: Challenges and Opportunities
    Avery Lyons, Jocelynn Brown, Kimberly M. Davenport
    Current Issues in Molecular Biology.2024; 46(6): 5291.     CrossRef
  • Single-Cell Transcriptomics Sheds Light on Tumor Evolution: Perspectives from City of Hope’s Clinical Trial Teams
    Patrick A. Cosgrove, Andrea H. Bild, Thanh H. Dellinger, Behnam Badie, Jana Portnow, Aritro Nath
    Journal of Clinical Medicine.2024; 13(24): 7507.     CrossRef
  • Integrated analysis of single-cell and bulk RNA-seq establishes a novel signature for prediction in gastric cancer
    Fei Wen, Xin Guan, Hai-Xia Qu, Xiang-Jun Jiang
    World Journal of Gastrointestinal Oncology.2023; 15(7): 1215.     CrossRef
  • Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology
    Elana R. Elkin, Kyle A. Campbell, Samantha Lapehn, Sean M. Harris, Vasantha Padmanabhan, Kelly M. Bakulski, Alison G. Paquette
    Molecular and Cellular Endocrinology.2023; 578: 112066.     CrossRef
  • Analyzing alternative splicing in Alzheimer’s disease postmortem brain: a cell-level perspective
    Mohammad-Erfan Farhadieh, Kamran Ghaedi
    Frontiers in Molecular Neuroscience.2023;[Epub]     CrossRef
  • Single-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism
    Shangchen Yang, Tianming Lan, Rongping Wei, Ling Zhang, Lin Lin, Hanyu Du, Yunting Huang, Guiquan Zhang, Shan Huang, Minhui Shi, Chengdong Wang, Qing Wang, Rengui Li, Lei Han, Dan Tang, Haimeng Li, Hemin Zhang, Jie Cui, Haorong Lu, Jinrong Huang, Yonglun
    BMC Biology.2023;[Epub]     CrossRef
  • Progress in research on tumor microenvironment-based spatial omics technologies
    FANGMEI XIE, NAITE XI, ZEPING HAN, WENFENG LUO, JIAN SHEN, JINGGENG LUO, XINGKUI TANG, TING PANG, YUBING LV, JIABING LIANG, LIYIN LIAO, HAOYU ZHANG, YONG JIANG, YUGUANG LI, JINHUA HE
    Oncology Research.2023; 31(6): 877.     CrossRef
Article image
Interpretation of PD-L1 expression in gastric cancer: summary of a consensus meeting of Korean gastrointestinal pathologists
Soomin Ahn, Yoonjin Kwak, Gui Young Kwon, Kyoung-Mee Kim, Moonsik Kim, Hyunki Kim, Young Soo Park, Hyeon Jeong Oh, Kyoungyul Lee, Sung Hak Lee, Hye Seung Lee
J Pathol Transl Med. 2024;58(3):103-116.   Published online April 25, 2024
DOI: https://doi.org/10.4132/jptm.2024.03.15
  • 16,672 View
  • 666 Download
  • 7 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary Material
Nivolumab plus chemotherapy in the first-line setting has demonstrated clinical efficacy in patients with human epidermal growth factor receptor 2–negative advanced or metastatic gastric cancer, and is currently indicated as a standard treatment. Programmed death-ligand 1 (PD-L1) expression is an important biomarker for predicting response to anti–programmed death 1/PD-L1 agents in several solid tumors, including gastric cancer. In the CheckMate-649 trial, significant clinical improvements were observed in patients with PD-L1 combined positive score (CPS) ≥ 5, determined using the 28-8 pharmDx assay. Accordingly, an accurate interpretation of PD-L1 CPS, especially at a cutoff of 5, is important. The CPS method evaluates both immune and tumor cells and provides a comprehensive assessment of PD-L1 expression in the tumor microenvironment of gastric cancer. However, CPS evaluation has several limitations, one of which is poor interobserver concordance among pathologists. Despite these limitations, clinical indications relying on PD-L1 CPS are increasing. In response, Korean gastrointestinal pathologists held a consensus meeting for the interpretation of PD-L1 CPS in gastric cancer. Eleven pathologists reviewed 20 PD-L1 slides with a CPS cutoff close to 5, stained with the 28-8 pharmDx assay, and determined the consensus scores. The issues observed in discrepant cases were discussed. In this review, we present cases of gastric cancer with consensus PD-L1 CPS. In addition, we briefly touch upon current practices and clinical issues associated with assays used for the assessment of PD-L1 expression in gastric cancer.

Citations

Citations to this article as recorded by  
  • Adjuvant immunotherapy in patients with resected gastric and oesophagogastric junction cancer following preoperative chemotherapy with high risk for recurrence (ypN+ and/or R1): European Organisation of Research and Treatment of Cancer (EORTC) 1707 VESTIG
    F. Lordick, M.E. Mauer, G. Stocker, C.A. Cella, I. Ben-Aharon, G. Piessen, L. Wyrwicz, G. Al-Haidari, T. Fleitas-Kanonnikoff, V. Boige, R. Lordick Obermannová, U.M. Martens, C. Gomez-Martin, P. Thuss-Patience, V. Arrazubi, A. Avallone, K.K. Shiu, P. Artru
    Annals of Oncology.2025; 36(2): 197.     CrossRef
  • PD-L1 as a Biomarker in Gastric Cancer Immunotherapy
    Yunjoo Cho, Soomin Ahn, Kyoung-Mee Kim
    Journal of Gastric Cancer.2025; 25(1): 177.     CrossRef
  • PD-L1 importance in malignancies comprehensive insights into the role of PD-L1 in malignancies: from molecular mechanisms to therapeutic opportunities
    Mojdeh Soltani, Mohammad Abbaszadeh, Hamed Fouladseresht, Mark J. M. Sullman, Nahid Eskandari
    Clinical and Experimental Medicine.2025;[Epub]     CrossRef
  • CLDN18.2 expression in gastroesophageal adenocarcinoma: prevalence, heterogeneity, and prognostic implications in Spanish patients
    Carolina Martinez-Ciarpaglini, María Ortega, Sandra Pérez-Buira, Aitana Bolea, Beatriz Casado Guerra, Carmen Herencia Bellido, Paula Tornero Piñero, Dolores Naranjo-Hans, Brenda Palomar, Hernán Quiceno, Amanda Sardón Fernández, Ariadna Torner Calvo, Feder
    Virchows Archiv.2025;[Epub]     CrossRef
  • Distinct clinicopathological and survival profiles of CLDN18.2 and PD-L1 expression in advanced gastric cancer and gastroesophageal junction adenocarcinoma
    D.R. Castillo, M. Guo, P. Shah, M. Hazeltin, D. Tai, F. Al-Manaseer, S. Mlamba, D. Perez, S. Yeremian, S. Guzman, R. Mannan, C. Crook, C. Lau, N. Tawar, G. Brar, M. Raoof, Y. Woo, S.P. Wu, D. Li
    ESMO Gastrointestinal Oncology.2025; 10: 100261.     CrossRef
  • Best Practice PD-L1 Staining and Interpretation in Gastric Cancer Using PD-L1 IHC PharmDx 22C3 and PD-L1 IHC PharmDx 28-8 Assays, with Reference to Common Issues and Solutions
    Soomin Ahn, Inwoo Hwang, Yuyeon Kim, Somin Lee, Yunjoo Cho, So Young Kang, Deok Geun Kim, Jeeyun Lee, Kyoung-Mee Kim
    Biomedicines.2025; 13(11): 2824.     CrossRef
  • PD-L1 thresholds predict efficacy of immune checkpoint inhibition in first-line treatment of advanced gastroesophageal adenocarcinoma. A systematic review and meta-analysis of seven phase III randomized trials
    V. Formica, C. Morelli, L. Fornaro, S. Riondino, M. Rofei, E. Fontana, E.C. Smyth, M. Roselli, H.-T. Arkenau
    ESMO Open.2024; 9(11): 103967.     CrossRef
Newsletter
Article image
What’s new in hematopathology 2025: myeloid neoplasms in the WHO 5th edition and ICC
Barina Aqil
J Pathol Transl Med. 2025;59(6):472-475.   Published online October 22, 2025
DOI: https://doi.org/10.4132/jptm.2025.09.24
  • 3,232 View
  • 129 Download
AbstractAbstract PDF
The previous edition of the World Health Organization (WHO) classification of hematolymphoid neoplasms was published in 2008 and later revised in 2017. A new 5th edition of the WHO classification of hematolymphoid neoplasms was released in 2022. Additionally, the Clinical Advisory Committee developed the International Consensus Classification (ICC) of hematolymphoid tumors, which differs from the WHO classification in several key defining features as outlined below.
Reviews
Article image
Breast fine-needle aspiration cytology in the era of core-needle biopsy: what is its role?
Ahrong Kim, Hyun Jung Lee, Jee Yeon Kim
J Pathol Transl Med. 2025;59(1):26-38.   Published online January 15, 2025
DOI: https://doi.org/10.4132/jptm.2024.11.01
Correction in: J Pathol Transl Med 2025;59(2):147
  • 9,978 View
  • 405 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Fine-needle aspiration cytology (FNAC) has long been recognized as a minimally invasive, cost-effective, and reliable diagnostic tool for breast lesions. However, with the advent of core-needle biopsy (CNB), the role of FNAC has diminished in some clinical settings. This review aims to re-evaluate the diagnostic value of FNAC in the current era, focusing on its complementary use alongside CNB, the adoption of new approaches such as the International Academy of Cytology Yokohama System, and the implementation of rapid on-site evaluation to reduce inadequate sample rates. Advances in liquid-based cytology, receptor expression testing, molecular diagnostics, and artificial intelligence are discussed, highlighting their potential to enhance the diagnostic accuracy of FNAC. Despite challenges, FNAC remains a valuable diagnostic method, particularly in low-resource settings and specific clinical scenarios, and its role continues to evolve with technology.

Citations

Citations to this article as recorded by  
  • Bulk-lysis protocols as a sensitive method for investigation of circulating CK19 cells in the peripheral blood of patients with breast cancer by flow cytometry
    Daniella Serafin Couto Vieira, Laura Otto Walter, Maria Eduarda Cunha da Silva, Lisandra de Oliveira Silva, Heloísa Zorzi Costa, Chandra Chiappin Cardoso, Fernando Carlos de Lander Schmitt, Maria Cláudia Santos-Silva
    Analytical Methods.2025; 17(23): 4771.     CrossRef
Article image
Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes
Agnes Stephanie Harahap, Chan Kwon Jung
J Pathol Transl Med. 2024;58(6):265-282.   Published online November 7, 2024
DOI: https://doi.org/10.4132/jptm.2024.10.11
  • 11,282 View
  • 554 Download
  • 7 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, characterized by a range of subtypes that differ in their cytologic features, clinical behavior, and prognosis. Accurate cytologic evaluation of PTC using fine-needle aspiration is essential but can be challenging due to the morphologic diversity among subtypes. This review focuses on the distinct cytologic characteristics of various PTC subtypes, including the classic type, follicular variant, tall cell, columnar cell, hobnail, diffuse sclerosing, Warthin-like, solid/trabecular, and oncocytic PTCs. Each subtype demonstrates unique nuclear features, architectural patterns, and background elements essential for diagnosis and differentiation from other thyroid lesions. Recognizing these distinct cytologic patterns is essential for identifying aggressive subtypes like tall cell, hobnail, and columnar cell PTCs, which have a higher risk of recurrence, metastasis, and poorer clinical outcomes. Additionally, rare subtypes such as diffuse sclerosing and Warthin-like PTCs present unique cytologic profiles that must be carefully interpreted to avoid diagnostic errors. The review also highlights the cytologic indicators of lymph node metastasis and high-grade features, such as differentiated high-grade thyroid carcinoma. The integration of molecular testing can further refine subtype diagnosis by identifying specific genetic mutations. A thorough understanding of these subtype-specific cytologic features and molecular profiles is vital for accurate diagnosis, risk stratification, and personalized management of PTC patients. Future improvements in diagnostic techniques and standardization are needed to enhance cytologic evaluation and clinical decision-making in thyroid cancer.

Citations

Citations to this article as recorded by  
  • Nuclear pseudoinclusion is associated with BRAFV600E mutation: Analysis of nuclear features in papillary thyroid carcinoma
    Agnes Stephanie Harahap, Dina Khoirunnisa, Salinah, Maria Francisca Ham
    Annals of Diagnostic Pathology.2025; 75: 152434.     CrossRef
  • 2025 Korean Thyroid Association Clinical Management Guideline on Active Surveillance for Low-Risk Papillary Thyroid Carcinoma
    Eun Kyung Lee, Min Joo Kim, Seung Heon Kang, Bon Seok Koo, Kyungsik Kim, Mijin Kim, Bo Hyun Kim, Ji-hoon Kim, Shin Je Moon, Kyorim Back, Young Shin Song, Jong-hyuk Ahn, Hwa Young Ahn, Ho-Ryun Won, Won Sang Yoo, Min Kyoung Lee, Jeongmin Lee, Ji Ye Lee, Kyo
    International Journal of Thyroidology.2025; 18(1): 30.     CrossRef
  • Structure-based molecular screening and dynamic simulation of phytocompounds targeting VEGFR-2: a novel therapeutic approach for papillary thyroid carcinoma
    Shuai Wang, Lingqian Zhang, Wenjun Zhang, Xiong Zeng, Jie Mei, Weidong Xiao, Lijie Yang
    Frontiers in Pharmacology.2025;[Epub]     CrossRef
  • 2025 Korean Thyroid Association Clinical Management Guideline on Active Surveillance for Low-Risk Papillary Thyroid Carcinoma
    Eun Kyung Lee, Min Joo Kim, Seung Heon Kang, Bon Seok Koo, Kyungsik Kim, Mijin Kim, Bo Hyun Kim, Ji-hoon Kim, Shinje Moon, Kyorim Back, Young Shin Song, Jong-hyuk Ahn, Hwa Young Ahn, Ho-Ryun Won, Won Sang Yoo, Min Kyoung Lee, Jeongmin Lee, Ji Ye Lee, Kyon
    Endocrinology and Metabolism.2025; 40(3): 307.     CrossRef
  • Oncocytic Thyroid Tumours With Pathogenic FLCN Mutations Mimic Oncocytic Papillary Thyroid Carcinoma on Fine‐Needle Aspiration
    Adeel M. Ashraf, Faisal Hassan, Adrian A. Dawkins, Julie C. Dueber, Derek B. Allison, Thèrése J. Bocklage
    Cytopathology.2025;[Epub]     CrossRef
  • A Case of Warthin-Like Variant of Papillary Thyroid Cancer
    Amy Chow, Israa Laklouk
    Cureus.2025;[Epub]     CrossRef
  • Propensity score-matched analysis of the ‘2+2’ parathyroid strategy in total thyroidectomy with central neck dissection
    Hao Gong, Simei Yao, Tianyuchen Jiang, Yi Yang, Yuhan Jiang, Zhujuan Wu, Anping Su
    Frontiers in Endocrinology.2025;[Epub]     CrossRef
Article image
Inflammatory bowel disease–associated intestinal fibrosis
Ji Min Park, Jeongseok Kim, Yoo Jin Lee, Sung Uk Bae, Hye Won Lee
J Pathol Transl Med. 2023;57(1):60-66.   Published online January 10, 2023
DOI: https://doi.org/10.4132/jptm.2022.11.02
  • 16,979 View
  • 458 Download
  • 32 Web of Science
  • 32 Crossref
AbstractAbstract PDF
Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix following chronic inflammation, and this replacement of organ tissue with fibrotic tissue causes a loss of function. Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, and intestinal fibrosis is common in IBD patients, resulting in several complications that require surgery, such as a stricture or penetration. This review describes the pathogenesis and various factors involved in intestinal fibrosis in IBD, including cytokines, growth factors, epithelial-mesenchymal and endothelial-mesenchymal transitions, and gut microbiota. Furthermore, histopathologic findings and scoring systems used for stenosis in IBD are discussed, and differences in the fibrosis patterns of ulcerative colitis and Crohn’s disease are compared. Biomarkers and therapeutic agents targeting intestinal fibrosis are briefly mentioned at the end.

Citations

Citations to this article as recorded by  
  • Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease
    Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig
    Advanced Healthcare Materials.2025;[Epub]     CrossRef
  • Prominence of Microbiota to Predict Fibrous Stenosis in Crohn’s Disease
    Xue Yang, Yan Pan, Cai-Ping Gao, Hang Li, Ying-Hui Zhang, Chun-Li Huang, Lu Cao, Shi-Yu Xiao, Zhou Zhou
    Journal of Inflammation Research.2025; Volume 18: 1413.     CrossRef
  • Fibrosierende Erkrankungen im Gastrointestinaltrakt
    Elke Roeb
    Die Innere Medizin.2025; 66(7): 695.     CrossRef
  • Roles of fibroblasts in the pathogenesis of inflammatory bowel diseases and IBD-associated fibrosis
    Takayoshi Ito, Hisako Kayama
    International Immunology.2025; 37(7): 379.     CrossRef
  • Disease Clearance in Ulcerative Colitis: A Narrative Review
    Silvio Danese, Laurent Peyrin‐Biroulet, Vipul Jairath, Ferdinando D'Amico, Shashi Adsul, Christian Agboton, Fernando Magro
    United European Gastroenterology Journal.2025; 13(6): 902.     CrossRef
  • Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease
    Caiguang Liu, Rongchang Li, Jing Nie, Jinshen He, Zihao Lin, Xiaomin Wu, Jinyu Tan, Zishan Liu, Longyuan Zhou, Xiaozhi Li, Zhirong Zeng, Minhu Chen, Shixian Hu, Yijun Zhu, Ren Mao
    United European Gastroenterology Journal.2025; 13(7): 1092.     CrossRef
  • Per- and polyfluoroalkyl substances (PFAS): immunotoxicity at the primary sites of exposure
    Emma Arnesdotter, Charlotte B. A. Stoffels, Wiebke Alker, Arno C. Gutleb, Tommaso Serchi
    Critical Reviews in Toxicology.2025; 55(4): 484.     CrossRef
  • Disease-Specific Novel Role of Growth Differentiation Factor 15 in Organ Fibrosis
    Harshal Sawant, Alip Borthakur
    International Journal of Molecular Sciences.2025; 26(12): 5713.     CrossRef
  • Galectin-3—Insights from Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
    Thomas Grewal, Hauke Christian Tews, Christa Buechler
    International Journal of Molecular Sciences.2025; 26(13): 6101.     CrossRef
  • Revealing Fibrosis Genes as Biomarkers of Ulcerative Colitis: A Bioinformatics Study Based on ScRNA and Bulk RNA Datasets
    Yandong Wang, Li Liu, Weihao Wang
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2025; 25(9): 710.     CrossRef
  • Fibrosis in Immune-Mediated and Autoimmune Disorders
    Magdalena Żurawek, Iwona Ziółkowska-Suchanek, Katarzyna Iżykowska
    Journal of Clinical Medicine.2025; 14(18): 6636.     CrossRef
  • Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway
    Yi You, Yaping Shen, Yan Yang, Xiaoyang Wei, Yuheng Zhou, Foxing Tan, Longcheng Deng, Haolin Du, Sen Wang, Cheng Wang, Yan Huang, Vinay Kumar,
    PLOS One.2025; 20(10): e0335225.     CrossRef
  • (R)-Bambuterol attenuates DSS-induced chronic colitis by suppressing inflammation, repairing intestinal barrier, and modulating gut microbiota and serum metabolomic profile
    Liangjun Deng, Le Tian, Dan Su, Jiukun Xie, Yuer Qian, Yipeng Li, Shidong Zhang, Shanping Wang, Zhihua Liu
    European Journal of Pharmacology.2025; 1008: 178346.     CrossRef
  • Beyond inflammation: what drives the self-perpetuating cycle of fibrosis in IBD?
    Yutong Wei, Zhou Zhou, Shiyu Xiao
    Annals of Medicine.2025;[Epub]     CrossRef
  • Neurokinin-1 Receptor Regulation of Fibroblast Phenotype and Function
    Scott P. Levick
    Receptors.2025; 4(4): 23.     CrossRef
  • Tumor Development in Ulcerative Colitis: Perspectives From Biomechanical Characteristics
    Hirotaka Tao
    Development, Growth & Differentiation.2025;[Epub]     CrossRef
  • Resistance to apoptosis in complicated Crohn's disease: Relevance in ileal fibrosis
    M. Seco-Cervera, D. Ortiz-Masiá, D.C. Macias-Ceja, S. Coll, L. Gisbert-Ferrándiz, J. Cosín-Roger, C. Bauset, M. Ortega, B. Heras-Morán, F. Navarro-Vicente, M. Millán, J.V. Esplugues, S. Calatayud, M.D. Barrachina
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(2): 166966.     CrossRef
  • Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel Disease
    Ilaria Laudadio, Claudia Carissimi, Noemi Scafa, Alex Bastianelli, Valerio Fulci, Alessandra Renzini, Giusy Russo, Salvatore Oliva, Roberta Vitali, Francesca Palone, Salvatore Cucchiara, Laura Stronati
    Inflammation Research.2024; 73(8): 1359.     CrossRef
  • Food additives impair gut microbiota from healthy individuals and IBD patients in a colonic in vitro fermentation model
    Irma Gonza, Elizabeth Goya-Jorge, Caroline Douny, Samiha Boutaleb, Bernard Taminiau, Georges Daube, Marie–Louise Scippo, Edouard Louis, Véronique Delcenserie
    Food Research International.2024; 182: 114157.     CrossRef
  • Epigenetic Regulation of EMP/EMT-Dependent Fibrosis
    Margherita Sisto, Sabrina Lisi
    International Journal of Molecular Sciences.2024; 25(5): 2775.     CrossRef
  • Mechanisms and therapeutic research progress in intestinal fibrosis
    Yanjiang Liu, Tao Zhang, Kejian Pan, He Wei
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • Disease clearance in ulcerative colitis: A new therapeutic target for the future
    Syed Adeel Hassan, Neeraj Kapur, Fahad Sheikh, Anam Fahad, Somia Jamal
    World Journal of Gastroenterology.2024; 30(13): 1801.     CrossRef
  • Urinary Hydroxyproline as an Inflammation-Independent Biomarker of Inflammatory Bowel Disease
    Muriel Huss, Tanja Elger, Johanna Loibl, Arne Kandulski, Benedicta Binder, Petra Stoeckert, Patricia Mester, Martina Müller, Christa Buechler, Hauke Christian Tews
    Gastroenterology Insights.2024; 15(2): 486.     CrossRef
  • Inflammatory Bowel Disease: Immune Function, Tissue Fibrosis and Current Therapies
    Jesús Cosín-Roger
    International Journal of Molecular Sciences.2024; 25(12): 6416.     CrossRef
  • The Diagnosis of Intestinal Fibrosis in Crohn’s Disease—Present and Future
    Sara Jarmakiewicz-Czaja, Jolanta Gruszecka, Rafał Filip
    International Journal of Molecular Sciences.2024; 25(13): 6935.     CrossRef
  • Role of gut microbiota in Crohn’s disease pathogenesis: Insights from fecal microbiota transplantation in mouse model
    Qiang Wu, Lian-Wen Yuan, Li-Chao Yang, Ya-Wei Zhang, Heng-Chang Yao, Liang-Xin Peng, Bao-Jia Yao, Zhi-Xian Jiang
    World Journal of Gastroenterology.2024; 30(31): 3689.     CrossRef
  • Ultrasound of the bowel with a focus on IBD: the new best practice
    Christina Merrill, Stephanie R. Wilson
    Abdominal Radiology.2024; 50(2): 555.     CrossRef
  • Unveiling the anti-inflammatory potential of 11β,13-dihydrolactucin for application in inflammatory bowel disease management
    Melanie S. Matos, María Ángeles Ávila-Gálvez, Antonio González-Sarrías, Nuno-Valério Silva, Carolina Lage Crespo, António Jacinto, Ana Teresa Serra, Ana A. Matias, Cláudia Nunes dos Santos
    Food & Function.2024; 15(18): 9254.     CrossRef
  • Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn’s disease
    Anis Hasnaoui, Racem Trigui, Mario Giuffrida
    World Journal of Gastroenterology.2024; 30(46): 4969.     CrossRef
  • Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention
    Ruyuf Alfurayhi, Lei Huang, Kirsten Brandt
    Foods.2023; 12(6): 1192.     CrossRef
  • Time to eRAASe chronic inflammation: current advances and future perspectives on renin-angiotensin-aldosterone-system and chronic intestinal inflammation in dogs and humans
    Romy M. Heilmann, Georg Csukovich, Iwan A. Burgener, Franziska Dengler
    Frontiers in Veterinary Science.2023;[Epub]     CrossRef
  • Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition
    Dulce C. Macias-Ceja, M. Teresa Mendoza-Ballesteros, María Ortega-Albiach, M. Dolores Barrachina, Dolores Ortiz-Masià
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
Original Article
Article image
Diagnostic yield of fine needle aspiration with simultaneous core needle biopsy for thyroid nodules
Mohammad Ali Hasannia, Ramin Pourghorban, Hoda Asefi, Amir Aria, Elham Nazar, Hojat Ebrahiminik, Alireza Mohamadian
J Pathol Transl Med. 2025;59(3):180-187.   Published online April 16, 2025
DOI: https://doi.org/10.4132/jptm.2025.03.04
  • 7,149 View
  • 210 Download
AbstractAbstract PDF
Background
Fine needle aspiration (FNA) is a widely utilized technique for assessing thyroid nodules; however, its inherent non-diagnostic rate poses diagnostic challenges. The present study aimed to evaluate and compare the diagnostic efficacy of FNA, core needle biopsy (CNB), and their combined application in the assessment of thyroid nodules.
Methods
A total of 56 nodules from 50 patients was analyzed using both FNA and simultaneous CNB. The ultrasound characteristics were categorized according to the American College of Radiology Thyroid Imaging Reporting and Data Systems classification system. The study compared the sensitivity, specificity, and accuracy of FNA, CNB, and the combination of the two techniques.
Results
The concordance between FNA and CNB was notably high, with a kappa coefficient of 0.837. The sensitivity for detecting thyroid malignancy was found to be 25.0% for FNA, 66.7% for CNB, and 83.3% for the combined FNA/CNB approach, with corresponding specificities of 84.6%, 97.4%, and 97.4%. The accuracy of the FNA/CNB combination was the highest at 94.1%.
Conclusions
The findings of this study indicate that both CNB and the FNA/CNB combination offer greater diagnostic accuracy for thyroid malignancy compared to FNA alone, with no significant complications reported. Integrating CNB with FNA findings may enhance management strategies and treatment outcomes for patients with thyroid nodules.
Newsletter
Article image
What’s new in hematopathology 2023: updates on mature T-cell neoplasms in the 5th edition of the WHO classification
Mario L. Marques-Piubelli, Roberto N. Miranda
J Pathol Transl Med. 2023;57(4):246-249.   Published online June 27, 2023
DOI: https://doi.org/10.4132/jptm.2023.06.15
  • 8,955 View
  • 476 Download
AbstractAbstract PDF
The overview of the upcoming Blue Book of the 5th edition of the World Health Organization Classification of Hematolymphoid Tumors was published in Leukemia in June 2022. The updates on mature T-/NK-cell lymphomas and leukemias are organized in nine groups based on cell of origin, morphology, clinical scenario, and localization, and are highlighted in this newsletter.
Original Article
Article image
Single umbilical artery and associated birth defects in perinatal autopsies: prenatal diagnosis and management
Manushree Saxena, Bhagyashri Hungund
J Pathol Transl Med. 2024;58(5):214-218.   Published online July 9, 2024
DOI: https://doi.org/10.4132/jptm.2024.07.03
  • 10,865 View
  • 412 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Background
The umbilical cord forms the connection between the fetus and the placenta at the feto-maternal interface and normally comprises two umbilical arteries and one umbilical vein. In some cases, only a single umbilical artery (SUA) is present. This study was conducted to evaluate associations between SUA and other congenital malformations discovered in perinatal autopsies and to ascertain the existence of preferential associations between SUA and certain anomalies.
Methods
We evaluated records of all fetuses sent for autopsy to the Department of Pathology during the 10-year period from 2013 through 2022 (n = 1,277). The data were obtained from the hospital’s pathology laboratory records. The congenital anomalies were grouped by organ or system for analysis and included cardiovascular, urinary tract, nervous system, gastrointestinal tract, musculoskeletal, and lung anomalies.
Results
A SUA was present in 8.61% of the autopsies. The gestational age of the affected fetuses ranged between 13 to 40 weeks. An SUA presented as an isolated single anomaly in 44 cases (3.4%). Of the 110 SUA cases, 60% had other congenital anomalies. There was a significant association between birth defects and SUAs (p < .001). Strong associations between SUA and urinary tract, lung, and musculoskeletal anomalies were observed.
Conclusions
A SUA is usually seen in association with other congenital malformations rather than as an isolated defect. Therefore, examination for associated anomalies when an SUA is detected either antenatally or postnatally is imperative. The findings of this study should be helpful in counseling expectant mothers and their families in cases of SUA.

Citations

Citations to this article as recorded by  
  • Single Umbilical Artery with Symmetrical IUGR and Multiple Fetal Anomalies - An Interesting Case Report
    Amulya Choudary Kotapati, Bhargavi Khandru, Vijayasree M.
    Journal of Evolution of Medical and Dental Sciences.2025; : 10.     CrossRef
  • Epidemiological and Histopathological Characteristics of Fetuses with Congenital Disorders: A Study in Greece
    Despoina Nteli, Maria Nteli, Konstantinos Konstantinidis, Maria Ouzounidou, Paschalis Theotokis, Maria-Eleni Manthou, Iasonas Dermitzakis, Xeni Miliara, Chrysoula Gouta, Stamatia Angelidou, Dimosthenis Miliaras, Soultana Meditskou
    Biology.2025; 14(6): 626.     CrossRef
Review
Article image
Cervical intraepithelial neoplasia and cervical cytology in pregnancy
Ji-Young Kim, Jeong Yun Shim
J Pathol Transl Med. 2024;58(6):283-290.   Published online November 7, 2024
DOI: https://doi.org/10.4132/jptm.2024.10.17
  • 8,698 View
  • 413 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Cervical cancer screening during pregnancy presents unique challenges for cytologic interpretation. This review focuses on pregnancy-associated cytomorphological changes and their impact on diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer. Pregnancy-induced alterations include navicular cells, hyperplastic endocervical cells, immature metaplastic cells, and occasional decidual cells or trophoblasts. These changes can mimic abnormalities such as koilocytosis, adenocarcinoma in situ, and high-grade squamous intraepithelial lesions, potentially leading to misdiagnosis. Careful attention to nuclear features and awareness of pregnancy-related changes are crucial for correct interpretation. The natural history of CIN during pregnancy shows higher regression rates, particularly for CIN 2, with minimal risk of progression. Management of abnormal cytology follows modified risk-based guidelines to avoid invasive procedures, with treatment typically deferred until postpartum. The findings reported in this review emphasize the importance of considering pregnancy status in cytological interpretation, highlight potential problems, and provide guidance on differentiating benign pregnancy-related changes from true abnormalities. Understanding these nuances is essential for accurate diagnosis and proper management of cervical abnormalities in pregnant women.

Citations

Citations to this article as recorded by  
  • The significance of biological samples from pregnant women in cervical intraepithelial neoplasia
    Xue Mi, Maharjan Rashmi, Zangyu Pan, Di Wu, Jinwei Miao
    Frontiers in Medicine.2025;[Epub]     CrossRef
  • Oncologic and pregnancy outcomes of cervical high-grade intraepithelial lesions and delivery mode
    Olga P. Matylevich, Ilya A. Tarasau, Sviatlana Y. Shelkovich, Aliaksandr F. Martsinkevich
    Academia Oncology.2025;[Epub]     CrossRef
Original Article
Article image
International Academy of Cytology standardized reporting of breast fine-needle aspiration cytology with cyto-histopathological correlation of breast carcinoma
Shweta Pai
J Pathol Transl Med. 2024;58(5):241-248.   Published online September 13, 2024
DOI: https://doi.org/10.4132/jptm.2024.07.14
  • 6,590 View
  • 378 Download
AbstractAbstract PDF
Background
The International Academy of Cytology (IAC) has developed a standardized approach for reporting the findings of breast fine-needle aspiration cytology (FNAC). Accordingly, there are five chief categories of breast lesions, C1 (insufficient material), C2 (benign), C3 (atypical), C4 (suspicious), and C5 (malignant). The prognostication and management of breast carcinoma can be performed readily on the basis of this classification system. The aim of this study was to classify various breast lesions into one of the above-named categories and to further grade the C5 lesions specifically using the Robinson system. The latter grades were then correlated with modified Scarff-Bloom-Richardson (SBR) grades.
Methods
This retrospective study was undertaken in the pathology department of a hospital located in the urban part of the city of Bangalore. All FNAC procedures performed on breast lumps spanning the year 2020 were included in the study.
Results
A total of 205 breast lesions was classified according to the IAC guidelines into C1 (6 cases, 2.9%), C2 (151 cases, 73.7%), C3 (13 cases, 6.3%), C4 (5 cases, 2.5%), and C5 (30 cases, 14.6%) groups. The C5 cases were further graded using Robinson’s system. The latter showed a significant correlation with the SBR system (concordance=83.3%, Spearman correlation=0.746, Kendall’s tau-b=0.736, kappa=0.661, standard error=0.095, p≤.001).
Conclusions
A standardized approach for FNAC reporting of breast lesions, as advocated for by the IAC, improves the quality and clarity of the reports and assures diagnostic reproducibility on a global scale. Further, the cytological grading of C5 lesions provides reliable cyto-prognostic scores that can help assess a tumor’s aggressiveness and predict its histological grade.
Newsletters
Article image
What’s new in dermatopathology 2023: WHO 5th edition updates
Jonathan Ho, Chico J Collie
J Pathol Transl Med. 2023;57(6):337-340.   Published online October 17, 2023
DOI: https://doi.org/10.4132/jptm.2023.09.22
  • 12,868 View
  • 1,385 Download
  • 17 Crossref
AbstractAbstract PDF
The 5th edition WHO Classification of Skin Tumors (2022) has introduced changes to nomenclature and diagnostics. Important differences are discussed below. Changes in each category of skin tumor have been detailed, with particular emphasis on meaningful advances in our understanding of the molecular pathogenesis of the skin’s diverse tumor landscape.

Citations

Citations to this article as recorded by  
  • Primary cutaneous cribriform tumor: A case report and literature review
    Doukou Jiang, Yongzhen Tian, Jiabin Tian, Hui Liu, Yang Guan
    Journal of Cutaneous Pathology.2025; 52(1): 9.     CrossRef
  • Pediatric Cutaneous T‐Cell Neoplasms: Clinical and Pathological Features, Updated Classifications, and Critical Differential Diagnoses
    Jinjun Cheng, Birte Wistinghausen, A. Yasmine Kirkorian
    Pediatric Dermatology.2025; 42(1): 11.     CrossRef
  • Histologic and Immunohistochemical Patterns in Lymphomatoid Papulosis: A Systematic Review of Published Cases
    Torben Fricke, Werner Kempf, Michael P. Schön, Christina Mitteldorf
    Dermatopathology.2025; 12(1): 6.     CrossRef
  • Unveiling cutaneous adenosquamous carcinoma: A systematic review and case analysis of a rare cutaneous malignancy
    Adam Christie, Jessica Falon, Jennifer Kim, Julie Howle
    EJC Skin Cancer.2025; 3: 100733.     CrossRef
  • Merkel Cell Carcinoma: An Updated Review Focused on Bone and Bone Marrow Metastases
    Biagio Scotti, Elisabetta Broseghini, Costantino Ricci, Barbara Corti, Costanza Viola, Cosimo Misciali, Carlotta Baraldi, Sabina Vaccari, Martina Lambertini, Federico Venturi, Elisabetta Magnaterra, Aurora Alessandrini, Tiziano Ferrari, Massimo Lepri, Gab
    Cancers.2025; 17(13): 2253.     CrossRef
  • Melanoma
    Mette Mogensen, Terese von Knorring, Lisbet Rosenkrantz Hölmich, Torben Steiniche, Johanne Lade-Keller, Katrine Karmisholt, Silje Haukali Omland
    Ugeskrift for Læger.2025; : 1.     CrossRef
  • Prognosis and Follow‐Up Recommendations for Subcutaneous and Dermal Leiomyosarcoma: Local Recurrence, Metastasis, and Overall Survival in a Danish Nationwide Cohort of 661 Patients
    Kiya Abebe, Mathias Ørholt, Erik E. F. Bak, Andreas Larsen, Anne Lene Wagenblast, Grethe Schmidt, David Hebbelstrup Jensen, Michael M. Petersen, Anand C. Loya, Søren Daugaard, Mikkel Herly, Jason L. Hornick, Thomas Mentzel, Peter Vester‐Glowinski
    Journal of Surgical Oncology.2025; 132(6): 1076.     CrossRef
  • Diagnostic and prognostic value of immunohistochemical markers HMB-45, Melan-A/MART-1, and S100 in different histological subtypes of melanoma
    Kirill A. Silakov, Ekaterina Yu. Demenkova, Vladimir I. Shchekin, Maksim A. Bobrov, Grigory A. Demyashkin
    Morphology.2025; 163(4): 353.     CrossRef
  • Rethinking Melanocytic Tumors: A Critical Appraisal of the WHO Classification and the Myth of Nevus-to-Melanoma Progression
    Giuseppe Argenziano, Giulia Briatico, Eugenia Veronica Di Brizzi, Camila Scharf, Gabriella Brancaccio, Elvira Moscarella, Maria Maddalena Nicoletti, Pasquale Verolino, Aimilios Lallas, Harald Kittler
    Dermatology Practical & Conceptual.2025; 15(4): 6994.     CrossRef
  • Translating Features to Findings: Deep Learning for Melanoma Subtype Prediction
    Dorra Guermazi, Sarina Khemchandani, Samer Wahood, Cuong Nguyen, Elie Saliba
    Dermatopathology.2025; 12(4): 42.     CrossRef
  • Multiple Onychopapillomas and BAP1 Tumor Predisposition Syndrome
    Alexandra Lebensohn, Azam Ghafoor, Luke Bloomquist, Michael C. Royer, Leslie Castelo-Soccio, Kelli Karacki, Olanda Hathaway, Tenin Maglo, Cathy Wagner, Maria G. Agra, Andrew M. Blakely, David S. Schrump, Raffit Hassan, Edward W. Cowen
    JAMA Dermatology.2024; 160(8): 838.     CrossRef
  • Molecular and Histopathological Characterization of Metastatic Cutaneous Squamous Cell Carcinomas: A Case–Control Study
    Alessia Paganelli, Marco Zaffonato, Benedetta Donati, Federica Torricelli, Veronica Manicardi, Michela Lai, Marco Spadafora, Simonetta Piana, Alessia Ciarrocchi, Caterina Longo
    Cancers.2024; 16(12): 2233.     CrossRef
  • The Gray Zone of Melanocytic Tumors - A Clinical Point of View
    Camila Scharf, Giulia Briatico, Gabriella Brancaccio, Elvira Moscarella, Andrea Ronchi, Giuseppe Argenziano
    Dermatology Practical & Conceptual.2024; 14(2): e2024153.     CrossRef
  • Biologic Gray Zone of Melanocytic Tumors, Fiction or Reality?
    Harald Kittler
    Dermatology Practical & Conceptual.2024; 14(2): e2024148.     CrossRef
  • Minimally Invasive Plasma Device Management of Multiple Benign Skin Cancers Associated with Rare Genodermatoses—Case Series and Review of the Therapeutic Methods
    Anna Płatkowska, Monika Słowińska, Joanna Zalewska, Zbigniew Swacha, Anna Szumera-Ciećkiewicz, Michał Wągrodzki, Janusz Patera, Katarzyna Łapieńska-Rey, Małgorzata Lorent, Iwona Ługowska, Piotr Rutkowski, Witold Owczarek
    Journal of Clinical Medicine.2024; 13(15): 4377.     CrossRef
  • Clinical Variables Influencing Outcomes in Patients with Atypical Intradermal Smooth Muscle Neoplasms (Formerly Cutaneous Leiomyosarcomas): Single-Institution Study of 95 Surgical Patients
    Alicia Gingrich, Sintawat Wangsiricharoen, Madeline B. Torres, Vinod Ravi, Ravin Ratan, Emily Z. Keung, Christopher P. Scally, Alexander J. Lazar, Wei-Lien Wang, Christina L. Roland, Kelly K. Hunt, Wendong Yu, Keila E. Torres
    Annals of Surgical Oncology.2024; 31(12): 7950.     CrossRef
  • A Narrative Review of Molecular, Immunohistochemical and In-Situ Techniques in Dermatopathology
    J. A. Gabriel, N. Weerasinghe, P. Balachandran, R. Salih, G. E. Orchard
    British Journal of Biomedical Science.2024;[Epub]     CrossRef
Article image
What’s new in genitourinary pathology 2023: WHO 5th edition updates for urinary tract, prostate, testis, and penis
Bonnie Choy, Maria Tretiakova, Debra L. Zynger
J Pathol Transl Med. 2024;58(1):45-48.   Published online December 27, 2023
DOI: https://doi.org/10.4132/jptm.2023.12.11
  • 10,067 View
  • 858 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
The 5th edition WHO Classification of Urinary and Male Genital Tumours (2022) introduced many significant changes relevant to urologic daily practice, mainly to renal tumors which was covered in the What’s New newsletter in September 2022. In this newsletter, we summarize the notable changes to bladder, prostate, testis, and penis based on the 5th edition of the WHO.

Citations

Citations to this article as recorded by  
  • Predicting variant histology in bladder cancer: the role of multiparametric MRI and vesical imaging-reporting and data system (VI-RADS)
    Serdar Aslan, Merve Nur Tasdemir, Ertugrul Cakir, Ural Oguz, Birgul Tok
    Abdominal Radiology.2025; 50(10): 4700.     CrossRef
  • Pictorial review of multiparametric MRI in bladder urothelial carcinoma with variant histology: pearls and pitfalls
    Yuki Arita, Sungmin Woo, Lisa Ruby, Thomas C. Kwee, Keisuke Shigeta, Ryo Ueda, Sunny Nalavenkata, Hiromi Edo, Kosuke Miyai, Jeeban Das, Pamela I. Causa Andrieu, Hebert Alberto Vargas
    Abdominal Radiology.2024; 49(8): 2797.     CrossRef
  • Oncological outcomes and prognostic implications of T1 histo-anatomic substaging in the management of high-Grade non-muscle invasive bladder cancer: results from a large single centre series
    Marco Finati, Antonio Fanelli, Francesco Cinelli, Nicola Schiavone, Ugo Giovanni Falagario, Anna Ricapito, Nicola d’Altilia, Richard Naspro, Angelo Porreca, Felice Crocetto, Biagio Barone, Ciro Imbimbo, Carlo Bettocchi, Francesca Sanguedolce, Luigi Cormio
    World Journal of Urology.2024;[Epub]     CrossRef
Review
Article image
Infections and immunity: associations with obesity and related metabolic disorders
Amitabha Ray, Melissa J. L. Bonorden, Rajashree Pandit, Katai J. Nkhata, Anupam Bishayee
J Pathol Transl Med. 2023;57(1):28-42.   Published online January 15, 2023
DOI: https://doi.org/10.4132/jptm.2022.11.14
  • 13,196 View
  • 286 Download
  • 15 Web of Science
  • 20 Crossref
AbstractAbstract PDF
About one-fourth of the global population is either overweight or obese, both of which increase the risk of insulin resistance, cardiovascular diseases, and infections. In obesity, both immune cells and adipocytes produce an excess of pro-inflammatory cytokines that may play a significant role in disease progression. In the recent coronavirus disease 2019 (COVID-19) pandemic, important pathological characteristics such as involvement of the renin-angiotensin-aldosterone system, endothelial injury, and pro-inflammatory cytokine release have been shown to be connected with obesity and associated sequelae such as insulin resistance/type 2 diabetes and hypertension. This pathological connection may explain the severity of COVID-19 in patients with metabolic disorders. Many studies have also reported an association between type 2 diabetes and persistent viral infections. Similarly, diabetes favors the growth of various microorganisms including protozoal pathogens as well as opportunistic bacteria and fungi. Furthermore, diabetes is a risk factor for a number of prion-like diseases. There is also an interesting relationship between helminths and type 2 diabetes; helminthiasis may reduce the pro-inflammatory state, but is also associated with type 2 diabetes or even neoplastic processes. Several studies have also documented altered circulating levels of neutrophils, lymphocytes, and monocytes in obesity, which likely modifies vaccine effectiveness. Timely monitoring of inflammatory markers (e.g., C-reactive protein) and energy homeostasis markers (e.g., leptin) could be helpful in preventing many obesity-related diseases.

Citations

Citations to this article as recorded by  
  • The Human Energy Balance: Uncovering the Hidden Variables of Obesity
    Nikolaos Theodorakis, Maria Nikolaou
    Diseases.2025; 13(2): 55.     CrossRef
  • Candida infections in COVID-19 patients: A review of prevalence, risk factors, and mortality
    Eduardo Franco Tulio, Fabíola Lucini, Allan Carminatti de Lima, Natalia Daiane Garoni Martins do Carmo, Marcelo dos Santos Barbosa, Gleyce Hellen de Almeida de Souza, Luana Rossato
    Indian Journal of Medical Microbiology.2025; 55: 100831.     CrossRef
  • Cell therapies for immune-mediated disorders
    Natalia Wiewiórska-Krata, Bartosz Foroncewicz, Krzysztof Mucha, Radosław Zagożdżon
    Frontiers in Medicine.2025;[Epub]     CrossRef
  • Adipose Tissue in Chagas Disease: A Neglected Component of Pathogenesis
    Vitória França dos Santos Pessoa, Mariana Hecht, Nadjar Nitz, Luciana Hagström
    Pathogens.2025; 14(4): 339.     CrossRef
  • The Impact of Obesity on Readmission and Healthcare Costs in Patients with Skin and Subcutaneous Tissue Infections
    David Suh, Seung-Mi Lee
    Risk Management and Healthcare Policy.2025; Volume 18: 1579.     CrossRef
  • SARS-CoV-2 mRNA vaccines confer protection in diet-induced obese mice despite altered immune cell profiles in the lung
    Katherine S. Lee, Dylan T. Boehm, Olivia A. Miller-Stump, Nathaniel A. Rader, Melissa Cooper, Holly A. Cyphert, Emel Sen-Kilic, Mariette Barbier, F. Heath Damron
    Scientific Reports.2025;[Epub]     CrossRef
  • Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling
    Laura Schwartz, Kristin Salamon, Aaron Simoni, Israel Cotzomi-Ortega, Yuriko Sanchez-Zamora, Sarah Linn-Peirano, Preeti John, Juan de Dios Ruiz-Rosado, Ashley R. Jackson, Xin Wang, John David Spencer
    iScience.2025; 28(11): 113862.     CrossRef
  • Theory of the Leaky Intestine: Gender Differences in Intestinal Parasitic Infections, Cytoskeletal Wall Dysfunctions, and Hypertension
    Philip Njemanze, Anthonia Chioma Amadi, Joy E. Onuchukwu, Chinwendu C. Darlington, Nneoma E. Ukeje, Clinton O. Mezu, Clara C. Ofoegbu, Chidera Okuh, Chidimma O. Ukaegbu, Linda O. Uzoma, Marvis Amuchie, Faustina N. Ojilere, Lilian C. Mbara, Esther C. Nneke
    Qeios.2024;[Epub]     CrossRef
  • The potential of DNA methylation markers in the study of obesity
    A. F. Nikolaeva, K. O. Petrova, O. V. Vasyukova, R. M. Guseinova, I. R. Minniakhmetov, R. I. Khusainova, N. G. Mokrysheva, V. O. Sigin
    Obesity and metabolism.2024; 20(4): 301.     CrossRef
  • Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration
    Nasir Uddin Mahbub, Md Minarul Islam, Seong-Tshool Hong, Hea-Jong Chung
    Frontiers in Cellular and Infection Microbiology.2024;[Epub]     CrossRef
  • Sarcoma Size and Limb Dimensions Predict Complications, Recurrence, and Death in Patients with Soft Tissue Sarcoma in the Thigh: A Multidimensional Analysis
    Rami Elmorsi, Luis Camacho, David D. Krijgh, Gordon S. Tilney, Heather Lyu, Raymond S. Traweek, Russell G. Witt, Margaret S. Roubaud, Christina L. Roland, Alexander F. Mericli
    Annals of Surgical Oncology.2024; 31(8): 5421.     CrossRef
  • Theory of the Leaky Intestine: Sex Differences in Intestinal Parasitic Infections, Cytoskeletal Wall Dysfunctions, and Hypertension
    Philip Njemanze, Anthonia Chioma Amadi, Joy E. Onuchukwu, Chinwendu C. Darlington, Nneoma E. Ukeje, Clinton O. Mezu, Clara C. Ofoegbu, Chidera Okuh, Chidimma O. Ukaegbu, Linda O. Uzoma, Marvis Amuchie, Faustina N. Ojilere, Lilian C. Mbara, Esther C. Nneke
    Qeios.2024;[Epub]     CrossRef
  • Cellular immune response to a single dose of live attenuated hepatitis a virus vaccine in obese children and adolescents
    Tanatchabhorn Soponkanabhorn, Narissara Suratannon, Supranee Buranapraditkun, Chomchanat Tubjareon, Sittichoke Prachuapthunyachart, Sutha Eiamkulbutr, Voranush Chongsrisawat
    Heliyon.2024; 10(16): e36610.     CrossRef
  • Increased Fruit and Vegetable Consumption Prevents Dysregulated Immune and Inflammatory Responses in High-Fat Diet-Induced Obese Mice
    Weimin Guo, Dayong Wu, Lijun Li, Erin D Lewis, Simin Nikbin Meydani
    The Journal of Nutrition.2024; 154(10): 3144.     CrossRef
  • Sex differences in the inflammation-depression link: A systematic review and meta-analysis
    Dana A. Jarkas, Ally H. Villeneuve, Ayeila Z.B. Daneshmend, Paul J. Villeneuve, Robyn J. McQuaid
    Brain, Behavior, and Immunity.2024; 121: 257.     CrossRef
  • The Strong Effect of Propolis in Suppressing NF-κB, CysC, and ACE2 on a High-fat Diet
    Muhammad Reza Primaguna, Haerani Rasyid, Makbul Aman, Syakib Bakri, Hasyim Kasim, Harun Iskandar, Ressy Dwiyanti, Ade Rifka Junita, Ridwan Ridwan, Rizki Amelia Noviyanthi, Nur Indah Purnamasar, Mochammad Hatta
    Biomedical and Pharmacology Journal.2024; 17(3): 1539.     CrossRef
  • How market integration impacts human disease ecology
    Lev Kolinski, Tyler M Barrett, Randall A Kramer, Charles L Nunn
    Evolution, Medicine, and Public Health.2024; 12(1): 229.     CrossRef
  • Molecular Pathways Linking High-Fat Diet and PM2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis
    Sagrario Lobato, Víctor Manuel Salomón-Soto, Claudia Magaly Espinosa-Méndez, María Nancy Herrera-Moreno, Beatriz García-Solano, Ernestina Pérez-González, Facundo Comba-Marcó-del-Pont, Mireya Montesano-Villamil, Marco Antonio Mora-Ramírez, Claudia Mancilla
    Biomolecules.2024; 14(12): 1607.     CrossRef
  • Anti-Obesity Effects of Marine Macroalgae Extract Caulerpa lentillifera in a Caenorhabditis elegans Model
    Kawita Chumphoochai, Preeyanuch Manohong, Nakorn Niamnont, Montakan Tamtin, Prasert Sobhon, Krai Meemon
    Marine Drugs.2023; 21(11): 577.     CrossRef
  • Obesity and consequent changes in the body
    Bojana Kisić, Dragana Puhalo-Sladoje, Dijana Mirić, Dragiša Rašić, Tatjana Novaković
    Praxis medica.2022; 51(3): 35.     CrossRef
Original Articles
Article image
Thoracic aortic calcification as a predictor of coronary artery disease: a systematic review and meta-analysis
Hussein Nafakhi, Alaa Salah Jumaah, Akeel Abed Yasseen
J Pathol Transl Med. 2025;59(3):161-170.   Published online April 30, 2025
DOI: https://doi.org/10.4132/jptm.2025.03.05
  • 5,303 View
  • 159 Download
  • 1 Crossref
AbstractAbstract PDFSupplementary Material
Background
The relationship between coronary atherosclerosis (progression, outcome) and calcification in the thoracic aorta (TAC), particularly across its various segments, is complex and often shows conflicting associations in the literature. To address this debated and complex relationship, we aimed to evaluate how TAC and its segments correlate with the presence and severity of coronary artery disease (CAD).
Methods
We reviewed all articles published between January 1990 and September 2024 that examined the link between TAC and CAD and were indexed in PubMed, Scopus, or EMBASE. Using a random-effects model, we calculated pooled proportions, odds ratios, and corresponding 95% confidence intervals (CIs) to evaluate the association between TAC and CAD, with consideration of severity.
Results
The study included 17 studies with 8,187 participants, 2,775 of whom had CAD (1,059 with severe CAD), and 5,412 of whom did not. The pooled odds ratio of TAC in patients with CAD compared to that in those without was 3.874 (95% CI, 2.789 to 5.381). For severe CAD versus mild CAD, the odds ratio was 8.005 (95% CI, 2.611 to 24.542). Calcification of the aortic root (pooled proportion, 51%; 95% CI, 0.282 to 0.733) or descending aorta (pooled proportion, 53.4%; 95% CI, 0.341 to 0.718) had the strongest association with CAD compared to calcification of the arch or ascending aorta.
Conclusions
TAC is significantly associated with both the presence and severity of CAD. Calcification in the descending aorta and aortic root is more strongly linked to CAD than calcification in the arch or ascending aorta.

Citations

Citations to this article as recorded by  
  • International Liver Transplantation Society/Liver Intensive Care Group of Europe guidelines for cardiovascular assessment before liver transplantation
    Emmanuel Weiss, Gonzalo Crespo, Alexandra Anderson, Gianni Biancofiore, Ryan Chadha, Jacek B. Cywinski, Andrea De Gasperi, James Findlay, Marc Giménez-Milà, Constantine Karvellas, Michael Kaufman, Ashish Malik, Marina Moguilevitch, Sher-Lu Pai, Koen Reynt
    American Journal of Transplantation.2025;[Epub]     CrossRef
Article image
AMACR is a highly sensitive and specific immunohistochemical marker for diagnosing prostate cancer on biopsy: a systematic review and meta-analysis
Johannes Cansius Prihadi, Stevan Kristian Lionardi, Nicolas Daniel Widjanarko, Steven Alvianto, Fransiskus Xaverius Rinaldi, Archie Fontana Iskandar
J Pathol Transl Med. 2025;59(4):235-248.   Published online July 3, 2025
DOI: https://doi.org/10.4132/jptm.2025.04.16
  • 4,911 View
  • 189 Download
AbstractAbstract PDFSupplementary Material
Background
Alpha-methylacyl-CoA racemase (AMACR) is the preferred biomarker for distinguishing malignant from benign glands in prostate biopsies, showing high sensitivity and specificity for prostate cancer. A meta-analysis of immunohistochemistry (IHC) for AMACR is essential to further assess its diagnostic accuracy across diverse sample sources. Methods: A systematic search of databases including MEDLINE, ScienceDirect, ProQuest, Google Scholar, and the Cochrane Library was performed, focusing on studies of AMACR to diagnose prostate cancer, particularly in biopsy samples analyzed through IHC over the last 20 years. Quality of studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 tool, followed by a meta-analysis of regions and subgroups to calculate summary estimates of diagnostic test accuracy. Results: In the final analysis, 37 studies, with a pooled size of 5,898 samples, were included from the examination of 94 full-text papers. Among them, 27 studies with similar sample sources and testing methodologies underwent meta-analysis, yielding a combined sensitivity estimate of 0.90 (95% confidence interval [CI], 0.86 to 0.93) and specificity of 0.91 (95% CI, 0.83 to 0.95), both with significant heterogeneity (p < .01). The region beneath the hierarchical summary receiver operating characteristic curve was 0.95 (95% CI, 0.93 to 0.97), positive likelihood ratio was 9.6 (95% CI, 5.3 to 17.4), negative likelihood ratio was 0.11 (95% CI, 0.08 to 0.15), and diagnostic odds ratio was 88 (95% CI, 42 to 181). Conclusions: Our meta-analysis findings substantiate AMACR as a highly accurate tool for diagnosing prostate cancer, specifically in biopsy samples, via immunohistochemical staining. Further studies involving diverse samples are needed to enhance our understanding of the AMACR diagnostic accuracy in a range of clinical settings.
Reviews
Article image
Single-cell and spatial sequencing application in pathology
Yoon-Seob Kim, Jinyong Choi, Sug Hyung Lee
J Pathol Transl Med. 2023;57(1):43-51.   Published online January 10, 2023
DOI: https://doi.org/10.4132/jptm.2022.12.12
  • 9,471 View
  • 387 Download
  • 10 Web of Science
  • 8 Crossref
AbstractAbstract PDF
Traditionally, diagnostic pathology uses histology representing structural alterations in a disease’s cells and tissues. In many cases, however, it is supplemented by other morphology-based methods such as immunohistochemistry and fluorescent in situ hybridization. Single-cell RNA sequencing (scRNA-seq) is one of the strategies that may help tackle the heterogeneous cells in a disease, but it does not usually provide histologic information. Spatial sequencing is designed to assign cell types, subtypes, or states according to the mRNA expression on a histological section by RNA sequencing. It can provide mRNA expressions not only of diseased cells, such as cancer cells but also of stromal cells, such as immune cells, fibroblasts, and vascular cells. In this review, we studied current methods of spatial transcriptome sequencing based on their technical backgrounds, tissue preparation, and analytic procedures. With the pathology examples, useful recommendations for pathologists who are just getting started to use spatial sequencing analysis in research are provided here. In addition, leveraging spatial sequencing by integration with scRNA-seq is reviewed. With the advantages of simultaneous histologic and single-cell information, spatial sequencing may give a molecular basis for pathological diagnosis, improve our understanding of diseases, and have potential clinical applications in prognostics and diagnostic pathology.

Citations

Citations to this article as recorded by  
  • Trends and Challenges of the Modern Pathology Laboratory for Biopharmaceutical Research Excellence
    Sílvia Sisó, Anoop Murthy Kavirayani, Suzana Couto, Birgit Stierstorfer, Sunish Mohanan, Caroline Morel, Mathiew Marella, Dinesh S. Bangari, Elizabeth Clark, Annette Schwartz, Vinicius Carreira
    Toxicologic Pathology.2025; 53(1): 5.     CrossRef
  • Incorporating Novel Technologies in Precision Oncology for Colorectal Cancer: Advancing Personalized Medicine
    Pankaj Ahluwalia, Kalyani Ballur, Tiffanie Leeman, Ashutosh Vashisht, Harmanpreet Singh, Nivin Omar, Ashis K. Mondal, Kumar Vaibhav, Babak Baban, Ravindra Kolhe
    Cancers.2024; 16(3): 480.     CrossRef
  • Potential therapeutic targets for hypotension in duchenne muscular dystrophy
    Harshi Saxena, Neal L. Weintraub, Yaoliang Tang
    Medical Hypotheses.2024; 185: 111318.     CrossRef
  • The crosstalk role of CDKN2A between tumor progression and cuproptosis resistance in colorectal cancer
    Xifu Cheng, Famin Yang, Yuanheng Li, Yuke Cao, Meng Zhang, Jiameng JI, Yuxiao Bai, Qing Li, Qiongfang Yu, Dian Gao
    Aging.2024; 16(12): 10512.     CrossRef
  • Enquête exclusive sur le psoriasis
    Imrane Ben Moussa, Bienfait Abasi-Ali, Fatima-Zahra Afarhkhane, Inès Mountadir, Claire Deligne
    médecine/sciences.2024; 40(6-7): 584.     CrossRef
  • Mechanisms of radiation‐induced tissue damage and response
    Lin Zhou, Jiaojiao Zhu, Yuhao Liu, Ping‐Kun Zhou, Yongqing Gu
    MedComm.2024;[Epub]     CrossRef
  • A comparative analysis of single-cell transcriptomic technologies in plants and animals
    Vamsidhar Reddy Netla, Harshraj Shinde, Gulshan Kumar, Ambika Dudhate, Jong Chan Hong, Ulhas Sopanrao Kadam
    Current Plant Biology.2023; 35-36: 100289.     CrossRef
  • Fibroblasts – the cellular choreographers of wound healing
    Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
    Frontiers in Immunology.2023;[Epub]     CrossRef
Article image
Professional biobanking education in Korea based on ISO 20387
Jong Ok Kim, Chungyeul Kim, Sangyong Song, Eunah Shin, Ji-Sun Song, Mee Sook Roh, Dong-chul Kim, Han-Kyeom Kim, Joon Mee Kim, Yeong Jin Choi
J Pathol Transl Med. 2025;59(1):11-25.   Published online January 15, 2025
DOI: https://doi.org/10.4132/jptm.2024.11.04
  • 4,716 View
  • 179 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDF
To ensure high-quality bioresources and standardize biobanks, there is an urgent need to develop and disseminate educational training programs in accordance with ISO 20387, which was developed in 2018. The standardization of biobank education programs is also required to train biobank experts. The subdivision of categories and levels of education is necessary for jobs such as operations manager (bank president), quality manager, practitioner, and administrator. Essential training includes programs tailored for beginner, intermediate, and advanced practitioners, along with customized training for operations managers. We reviewed and studied ways to develop an appropriate range of education and training opportunities for standard biobanking education and the training of experts based on KS J ISO 20387. We propose more systematic and professional biobanking training programs in accordance with ISO 20387, in addition to the certification programs of the National Biobank and the Korean Laboratory Accreditation System. We suggest various training programs appropriate to a student’s affiliation or work, such as university biobanking specialized education, short-term job training at unit biobanks, biobank research institute symposiums by the Korean Society of Pathologists, and education programs for biobankers and researchers. Through these various education programs, we expect that Korean biobanks will satisfy global standards, meet the needs of users and researchers, and contribute to the advancement of science.

Citations

Citations to this article as recorded by  
  • Development of a big data platform for collecting and utilizing clinical information from the Korea Biobank Network
    Yun Seon Im, Seol Whan Oh, Ki Hoon Kim, Wona Choi, In Young Choi
    BMC Medical Informatics and Decision Making.2025;[Epub]     CrossRef
  • Frozen section histopathology and preanalytical factors affecting nucleic acid integrity in biobanked fresh-frozen human cancer tissues
    Soungeun Kim, Jaewon Kang, Boyeon Kim, Yoonjin Kwak, Hye Seung Lee
    Journal of Pathology and Translational Medicine.2025; 59(6): 398.     CrossRef
Article image
Diagnosis of interstitial lung diseases: from Averill A. Liebow to artificial intelligence
Eunhee S. Yi, Paul Wawryko, Jay H. Ryu
J Pathol Transl Med. 2024;58(1):1-11.   Published online January 10, 2024
DOI: https://doi.org/10.4132/jptm.2023.11.17
  • 6,718 View
  • 415 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Histopathologic criteria of usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis (IPF) were defined over the years and endorsed by leading organizations decades after Dr. Averill A. Liebow first coined the term UIP in the 1960s as a distinct pathologic pattern of fibrotic interstitial lung disease. Novel technology and recent research on interstitial lung diseases with genetic component shed light on molecular pathogenesis of UIP/IPF. Two antifibrotic agents introduced in the mid-2010s opened a new era of therapeutic approaches to UIP/IPF, albeit contentious issues regarding their efficacy, side effects, and costs. Recently, the concept of progressive pulmonary fibrosis was introduced to acknowledge additional types of progressive fibrosing interstitial lung diseases with the clinical and pathologic phenotypes comparable to those of UIP/IPF. Likewise, some authors have proposed a paradigm shift by considering UIP as a stand-alone diagnostic entity to encompass other fibrosing interstitial lung diseases that manifest a relentless progression as in IPF. These trends signal a pendulum moving toward the tendency of lumping diagnoses, which poses a risk of obscuring potentially important information crucial to both clinical and research purposes. Recent advances in whole slide imaging for digital pathology and artificial intelligence technology could offer an unprecedented opportunity to enhance histopathologic evaluation of interstitial lung diseases. However, current clinical practice trends of moving away from surgical lung biopsies in interstitial lung disease patients may become a limiting factor in this endeavor as it would be difficult to build a large histopathologic database with correlative clinical data required for artificial intelligence models.

Citations

Citations to this article as recorded by  
  • Identification of early genes in the pathophysiology of fibrotic interstitial lung disease in a new model of pulmonary fibrosis
    Nathan Hennion, Corentin Bedart, Léonie Vandomber, Frédéric Gottrand, Sarah Humez, Cécile Chenivesse, Jean-Luc Desseyn, Valérie Gouyer
    Cellular and Molecular Life Sciences.2025;[Epub]     CrossRef
  • Radiological Insights into UIP Pattern: A Comparison Between IPF and Non-IPF Patients
    Stefano Palmucci, Miriam Adorna, Angelica Rapisarda, Alessandro Libra, Sefora Fischetti, Gianluca Sambataro, Letizia Antonella Mauro, Emanuele David, Pietro Valerio Foti, Claudia Mattina, Corrado Spatola, Carlo Vancheri, Antonio Basile
    Journal of Clinical Medicine.2025; 14(12): 4162.     CrossRef
Newsletter
Article image
What’s new in medical renal pathology 2025: Updates on podocytopathy and immunofluorescence staining in medical kidney
Astrid Weins, Ibrahim Batal, Paola Romagnani, Geetika Singh, Rahul Raj, Nicole Andeen, Jonathan Zuckerman, Martina Uzzo, Mariam Priya Alexander, Anjali Satoskar
J Pathol Transl Med. 2025;59(4):269-272.   Published online July 10, 2025
DOI: https://doi.org/10.4132/jptm.2025.06.19
  • 4,507 View
  • 301 Download
AbstractAbstract PDF
Diffuse podocytopathy, including minimal change disease and primary focal segmental glomerulosclerosis, is a common cause of nephrotic syndrome in adults and children. It is increasingly recognized to be autoimmune-mediated associated with anti-nephrin and other emerging anti-slit diaphragm antibodies, and can recur in the kidney allograft. Immunofluorescence is routinely used in evaluation of kidney biopsies, and updates include those on fibrillar diseases, monoclonal staining, lupus-like staining, and use of antibody KM55 in IgA-dominant glomerulonephritis.
Reviews
Article image
Trouble-makers in cytologic interpretation of the uterine cervix
Eunah Shin, Jaeeun Yu, Soon Won Hong
J Pathol Transl Med. 2023;57(3):139-146.   Published online May 15, 2023
DOI: https://doi.org/10.4132/jptm.2023.04.25
  • 10,174 View
  • 458 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
The development and standardization of cytologic screening of the uterine cervix has dramatically decreased the prevalence of squamous cell carcinoma of the uterine cervix. Advances in the understanding of biology of human papillomavirus have contributed to upgrading the histologic diagnosis of the uterine cervix; however, cytologic screening that should triage those that need further management still poses several difficulties in interpretation. Cytologic features of high grade intraepithelial squamous lesion (HSIL) mimics including atrophy, immature metaplasia, and transitional metaplasia, and glandular lesion masquerades including tubal metaplasia and HSIL with glandular involvement are described with accentuation mainly on the differential points. When the cytologic features lie in a gray zone between the differentials, the most important key to the more accurate interpretation is sticking to the very basics of cytology; screening the background and cellular architecture, and then scrutinizing the nuclear and cytoplasmic details.

Citations

Citations to this article as recorded by  
  • Risk of cervical stenosis after cervical excision in postmenopausal patients
    Eva Hauge, Line Winther Gustafson, Mette Tranberg, Pinar Bor
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2025; 308: 208.     CrossRef
  • Pitfalls in Gynecological Cytology: Review of the Common and Less Frequent Entities in Pap Test
    Danijela Vrdoljak-Mozetič, Snježana Štemberger-Papić, Damjana Verša Ostojić, Roberta Rubeša, Marko Klarić, Senija Eminović
    Acta Cytologica.2024; 68(3): 281.     CrossRef
  • Cytological features of human papillomavirus‐infected immature squamous metaplastic cells from cervical intraepithelial neoplasia grade 2
    Mitsuaki Okodo, Kaori Okayama, Koji Teruya, Ruku Shinohara, Shuichi Mizuno, Rei Settsu, Yasuyoshi Ishii, Masahiko Fujii, Hirokazu Kimura, Mizue Oda
    Journal of Medical Virology.2023;[Epub]     CrossRef
Article image
Exploring histological predictive biomarkers for immune checkpoint inhibitor therapy response in non–small cell lung cancer
Uiju Cho, Soyoung Im, Hyung Soon Park
J Pathol Transl Med. 2024;58(2):49-58.   Published online February 26, 2024
DOI: https://doi.org/10.4132/jptm.2024.01.31
  • 8,358 View
  • 339 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Treatment challenges persist in advanced lung cancer despite the development of therapies beyond the traditional platinum-based chemotherapy. The early 2000s marked a shift to tyrosine kinase inhibitors targeting epidermal growth factor receptor, ushering in personalized genetic-based treatment. A further significant advance was the development of immune checkpoint inhibitors (ICIs), especially for non–small cell lung cancer. These target programmed death-ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen 4, which enhanced the immune response against tumor cells. However, not all patients respond, and immune-related toxicities arise. This review emphasizes identifying biomarkers for ICI response prediction. While PD-L1 is a widely used, validated biomarker, its predictive accuracy is imperfect. Investigating tumor-infiltrating lymphocytes, tertiary lymphoid structure, and emerging biomarkers such as high endothelial venule, Human leukocyte antigen class I, T-cell immunoreceptors with Ig and ITIM domains, and lymphocyte activation gene-3 counts is promising. Understanding and exploring additional predictive biomarkers for ICI response are crucial for enhancing patient stratification and overall care in lung cancer treatment.

Citations

Citations to this article as recorded by  
  • Machine learning methods for histopathological image analysis: Updates in 2024
    Daisuke Komura, Mieko Ochi, Shumpei Ishikawa
    Computational and Structural Biotechnology Journal.2025; 27: 383.     CrossRef
  • Beyond single biomarkers: multi-omics strategies to predict immunotherapy outcomes in blood cancers
    Mohammad Pirouzbakht, Soroosh Hamzeh, Hamed Soleimani Samarkhazan
    Clinical and Experimental Medicine.2025;[Epub]     CrossRef
Newsletter
Article image
What’s new in adrenal gland pathology: WHO 5th edition for adrenal cortex
Carol N. Rizkalla, Maria Tretiakova
J Pathol Transl Med. 2024;58(4):201-204.   Published online June 25, 2024
DOI: https://doi.org/10.4132/jptm.2024.06.07
  • 5,686 View
  • 525 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
The 5th edition of WHO Classification of Endocrine and Neuroendocrine Tumors (2022) introduced many significant changes relevant to endocrine daily practice. In this newsletter, we summarize the notable changes to the adrenal cortex based on the 5th edition of the WHO classification [1].

Citations

Citations to this article as recorded by  
  • Ectopic adrenal gland in the liver leading to a misdiagnosis of hepatocellular carcinoma: A case report
    Min-Qiu Qin, Yi-Peng Zhao, Ju-Ping Xie
    World Journal of Hepatology.2025;[Epub]     CrossRef
Review
Article image
Next step of molecular pathology: next-generation sequencing in cytology
Ricella Souza da Silva, Fernando Schmitt
J Pathol Transl Med. 2024;58(6):291-298.   Published online November 7, 2024
DOI: https://doi.org/10.4132/jptm.2024.10.22
  • 5,256 View
  • 356 Download
  • 1 Web of Science
  • 3 Crossref
AbstractAbstract PDF
The evolving landscape of precision oncology underscores the pivotal shift from morphological diagnosis to treatment decisions driven by molecular profiling. Recent guidelines from the European Society for Medical Oncology recomend the use of next-generation sequencing (NGS) across a broader range of cancers, reflecting its superior efficiency and clinical value. NGS not only updates oncology testing by offering quicker, sample-friendly, and sensitive analysis but also reduces the need for multiple individual tests. Cytology samples, often obtained through less invasive methods, can yield high-quality genetic material suitable for molecular analysis. This article focuses on optimizing the use of cytology samples in NGS, and outlines their potential benefits in identifying actionable molecular alterations for targeted therapies across various solid tumors. It also addresses the need for validation studies and the strategies to incorporate or combine different types of samples into routine clinical practice. Integrating cytological and liquid biopsies into routine clinical practice, alongside conventional tissue biopsies, offers a comprehensive approach to tumor genotyping, early disease detection, and monitoring of therapeutic responses across various solid tumor types. For comprehensive biomarker characterization, all patient specimens, although limited, is always valuable.

Citations

Citations to this article as recorded by  
  • The World Health Organization Reporting System for Lymph Node, Spleen, and Thymus Cytopathology: Part 1 – Lymph Node
    Immacolata Cozzolino, Mats Ehinger, Maria Calaminici, Andrea Ronchi, Mousa A. Al-Abbadi, Helena Barroca, Beata Bode-Lesniewska, David F. Chhieng, Ruth L. Katz, Oscar Lin, L. Jeffrey Medeiros, Martha Bishop Pitman, Arvind Rajwanshi, Fernando C. Schmitt, Ph
    Acta Cytologica.2025; : 1.     CrossRef
  • The impact of cytological preparation techniques on RNA quality: A comparative study on smear samples
    Cisel Aydin Mericoz, Gulsum Caylak, Elif Sevin Sanioglu, Zeynep Seçil Satilmis, Ayse Humeyra Dur Karasayar, Ibrahim Kulac
    Cancer Cytopathology.2025;[Epub]     CrossRef
  • Reimagining cytopathology in the molecular era: Integration or fragmentation?
    Sumanta Das, R. Naveen Kumar, Biswajit Dey, Pranjal Kalita
    Cytojournal.2025; 22: 94.     CrossRef
Case Study
Article image
Colorectal cancer with a germline BRCA1 variant inherited paternally: a case report
Kyoung Min Kim, Min Ro Lee, Ae Ri Ahn, Myoung Ja Chung
J Pathol Transl Med. 2024;58(6):341-345.   Published online September 5, 2024
DOI: https://doi.org/10.4132/jptm.2024.08.14
  • 5,614 View
  • 303 Download
AbstractAbstract PDF
BRCA genes have well-known associations with breast and ovarian cancers. However, variations in the BRCA gene, especially germline variations, have also been reported in colorectal cancer (CRC). We present the case of a rectal cancer with a germline BRCA1 variation inherited from the paternal side. A 39-year-old male was admitted with rectal cancer. The patient underwent surgical resection and the pathologic diagnosis was adenocarcinoma. Next-generation sequencing was performed and a BRCA1 variant was detected. Reviewing the public database and considering the young age of the patient, the variant was suggested to be germline. The patient’s father had had prostate cancer and next-generation sequencing testing revealed an identical BRCA1 variant. In the BRCA cancer group, there is relatively little attention paid to male cancers. The accumulation of male CRC cases linked to BRCA variations may help clarify the potential pathological relationship between the two.
Original Article
Article image
Histopathologic classification and immunohistochemical features of papillary renal neoplasm with potential therapeutic targets
Jeong Hwan Park, Su-Jin Shin, Hyun-Jung Kim, Sohee Oh, Yong Mee Cho
J Pathol Transl Med. 2024;58(6):321-330.   Published online September 12, 2024
DOI: https://doi.org/10.4132/jptm.2024.07.31
  • 5,353 View
  • 408 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Background
Papillary renal cell carcinoma (pRCC) is the second most common histological subtype of renal cell carcinoma and is considered a morphologically and molecularly heterogeneous tumor. Accurate classification and assessment of the immunohistochemical features of possible therapeutic targets are needed for precise patient care. We aimed to evaluate immunohistochemical features and possible therapeutic targets of papillary renal neoplasms
Methods
We collected 140 papillary renal neoplasms from three different hospitals and conducted immunohistochemical studies on tissue microarray slides. We performed succinate dehydrogenase B, fumarate hydratase, and transcription factor E3 immunohistochemical studies for differential diagnosis and re-classified five cases (3.6%) of papillary renal neoplasms. In addition, we conducted c-MET, p16, c-Myc, Ki-67, p53, and stimulator of interferon genes (STING) immunohistochemical studies to evaluate their pathogenesis and value for therapeutic targets.
Results
We found that c-MET expression was more common in pRCC (classic) (p = .021) among papillary renal neoplasms and Ki-67 proliferation index was higher in pRCC (not otherwise specified, NOS) compared to that of pRCC (classic) and papillary neoplasm with reverse polarity (marginal significance, p = .080). Small subsets of cases with p16 block positivity (4.5%) (pRCC [NOS] only) and c-Myc expression (7.1%) (pRCC [classic] only) were found. Also, there were some cases showing STING expression and those cases were associated with increased Ki-67 proliferation index (marginal significance, p = .063).
Conclusions
Our findings suggested that there are subsets of pRCC with c-MET, p16, c-MYC, and STING expression and those cases could be potential candidates for targeted therapy.

Citations

Citations to this article as recorded by  
  • Tissue-Based Biomarkers Important for Prognostication and Management of Genitourinary Tumors, Including Surrogate Markers of Genomic Alterations
    Leonie Beauchamp, Shreeya Indulkar, Eric Erak, Mohammad Salimian, Andres Matoso
    Surgical Pathology Clinics.2025; 18(1): 175.     CrossRef
  • Papillary renal neoplasm with reverse polarity: a case report and literature review
    Diego Gonzalez, Kris Kokoneshi, Sam Kwon, Ryan Thomas Mathews, Ryan Michael Antar, Maher Ali, Abiye Kassa, Michael Whalen
    Frontiers in Oncology.2025;[Epub]     CrossRef
Review
Article image
The Asian Thyroid Working Group, from 2017 to 2023
Kennichi Kakudo, Chan Kwon Jung, Zhiyan Liu, Mitsuyoshi Hirokawa, Andrey Bychkov, Huy Gia Vuong, Somboon Keelawat, Radhika Srinivasan, Jen-Fan Hang, Chiung-Ru Lai
J Pathol Transl Med. 2023;57(6):289-304.   Published online November 14, 2023
DOI: https://doi.org/10.4132/jptm.2023.10.04
  • 7,954 View
  • 302 Download
  • 12 Web of Science
  • 11 Crossref
AbstractAbstract PDFSupplementary Material
The Asian Thyroid Working Group was founded in 2017 at the 12th Asia Oceania Thyroid Association (AOTA) Congress in Busan, Korea. This group activity aims to characterize Asian thyroid nodule practice and establish strict diagnostic criteria for thyroid carcinomas, a reporting system for thyroid fine needle aspiration cytology without the aid of gene panel tests, and new clinical guidelines appropriate to conservative Asian thyroid nodule practice based on scientific evidence obtained from Asian patient cohorts. Asian thyroid nodule practice is usually designed for patient-centered clinical practice, which is based on the Hippocratic Oath, “First do not harm patients,” and an oriental filial piety “Do not harm one’s own body because it is a precious gift from parents,” which is remote from defensive medical practice in the West where physicians, including pathologists, suffer from severe malpractice climate. Furthermore, Asian practice emphasizes the importance of resource management in navigating the overdiagnosis of low-risk thyroid carcinomas. This article summarizes the Asian Thyroid Working Group activities in the past 7 years, from 2017 to 2023, highlighting the diversity of thyroid nodule practice between Asia and the West and the background reasons why Asian clinicians and pathologists modified Western systems significantly.

Citations

Citations to this article as recorded by  
  • Risk of Infertility in Reproductive-Age Patients With Thyroid Cancer Receiving or Not Receiving 131I Treatment
    Chun-Yi Lin, Cheng-Li Lin, Chia-Hung Kao
    Clinical Nuclear Medicine.2025; 50(3): 201.     CrossRef
  • Association Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Thyroid Cancer
    Sang Yi Moon, Minkook Son, Jung-Hwan Cho, Hye In Kim, Ji Min Han, Ji Cheol Bae, Sunghwan Suh
    Thyroid®.2025; 35(1): 79.     CrossRef
  • Letter: “High Rates of Unnecessary Surgery for Indeterminate Thyroid Nodules in the Absence of Molecular Test and the Cost-Effectiveness of Utilizing Molecular Test in an Asian Population: A Decision Analysis” by Fung et al
    Kennichi Kakudo, Andrey Bychkov, Jen-Fan Hang, Mitsuyoshi Hirokawa, Somboon Keelawat, Zhiyan Liu, Radhika Srinivasan, Chan Kwon Jung
    Thyroid®.2025; 35(5): 595.     CrossRef
  • Thyroid Nodules with Nuclear Atypia of Undetermined Significance (AUS-Nuclear) Hold a Two-Times-Higher Risk of Malignancy than AUS-Other Nodules Regardless of EU-TIRADS Class of the Nodule or Borderline Tumor Interpretation
    Dorota Słowińska-Klencka, Bożena Popowicz, Joanna Duda-Szymańska, Mariusz Klencki
    Cancers.2025; 17(8): 1365.     CrossRef
  • Response to Kakudo et al.: “High Rates of Unnecessary Surgery for Indeterminate Thyroid Nodules in the Absence of Molecular Test and the Cost-Effectiveness of Utilizing Molecular Test in an Asian Population: A Decision Analysis”
    Man Him Matrix Fung, Ching Tang, Gin Wai Kwok, Tin Ho Chan, Yan Luk, David Tak Wai Lui, Carlos King Ho Wong, Brian Hung Hin Lang
    Thyroid®.2025; 35(5): 597.     CrossRef
  • Molecular Testing Could Drive Smarter Decision-Marking for Indeterminate Thyroid Nodule if the Price was Right
    Sarah C. Brennan, Matti L. Gild, Venessa Tsang
    Clinical Thyroidology®.2025; 37(5): 165.     CrossRef
  • Performance of Two‐Tiered Subclassification of Atypia of Undetermined Significance in Thyroid Fine‐Needle Aspiration Without Routine Molecular Testing
    Pocholo D. Santos, Chiung‐Ru Lai, Jen‐Fan Hang
    Diagnostic Cytopathology.2025;[Epub]     CrossRef
  • Welcoming the new, revisiting the old: a brief glance at cytopathology reporting systems for lung, pancreas, and thyroid
    Rita Luis, Balamurugan Thirunavukkarasu, Deepali Jain, Sule Canberk
    Journal of Pathology and Translational Medicine.2024; 58(4): 165.     CrossRef
  • Are we ready to bridge classification systems? A comprehensive review of different reporting systems in thyroid cytology
    Esther Diana Rossi, Liron Pantanowitz
    Cytopathology.2024; 35(6): 674.     CrossRef
  • Aggressive Types of Malignant Thyroid Neoplasms
    Maria Boudina, Eleana Zisimopoulou, Persefoni Xirou, Alexandra Chrisoulidou
    Journal of Clinical Medicine.2024; 13(20): 6119.     CrossRef
  • Fine needle aspiration cytology diagnoses of follicular thyroid carcinoma: results from a multicenter study in Asia
    Hee Young Na, Miyoko Higuchi, Shinya Satoh, Kaori Kameyama, Chan Kwon Jung, Su-Jin Shin, Shipra Agarwal, Jen-Fan Hang, Yun Zhu, Zhiyan Liu, Andrey Bychkov, Kennichi Kakudo, So Yeon Park
    Journal of Pathology and Translational Medicine.2024; 58(6): 331.     CrossRef
Review Article
Article image
Central nervous system tumors with BCOR internal tandem duplications: a systematic review of clinical, radiological, and pathological features in 69 cases
Ji Young Lee, Sung Sun Kim, Hee Jo Baek, Tae-Young Jung, Kyung-Sub Moon, Jae-Hyuk Lee, Kyung-Hwa Lee
J Pathol Transl Med. 2025;59(5):273-280.   Published online September 1, 2025
DOI: https://doi.org/10.4132/jptm.2025.07.23
  • 2,601 View
  • 152 Download
AbstractAbstract PDFSupplementary Material
Central nervous system tumors with BCL6 corepressor (BCOR) internal tandem duplications (ITDs) constitute a rare, recently characterized pediatric neoplasm with distinct molecular and histopathological features. To date, 69 cases have been documented in the literature, including our institutional case. These neoplasms predominantly occur in young children, with the cerebellum representing the most frequent anatomical location. Radiologically, these tumors present as large, well-circumscribed masses frequently demonstrating necrosis, hemorrhage, and heterogeneous enhancement. Histologically, they are characterized by a monomorphic cellular population featuring ependymoma-like perivascular pseudorosettes, myxoid stroma, and elevated mitotic activity. Immunohistochemically, these tumors exhibit sparse glial fibrillary acidic protein expression while consistently demonstrating positive staining for vimentin and CD56. The defining molecular hallmark is a heterozygous ITD within exon 15 of the BCOR gene, with insertions ranging from 9 to 42 amino acids in length. BCOR immunohistochemistry reveals nuclear positivity in 97.9% of examined cases, although this finding is not pathognomonic for BCOR ITDs. This comprehensive review synthesizes data from all published cases of this novel tumor entity, providing a detailed analysis of clinical presentation, neuroimaging findings, histopathological features with differential diagnostic considerations, therapeutic approaches, and prognostic outcomes.
Original Articles
Article image
Low Ki-67 labeling index is a clinically useful predictive factor for recurrence-free survival in patients with papillary thyroid carcinoma
Takashi Masui, Katsunari Yane, Ichiro Ota, Kennichi Kakudo, Tomoko Wakasa, Satoru Koike, Hirotaka Kinugawa, Ryuji Yasumatsu, Tadashi Kitahara
J Pathol Transl Med. 2025;59(2):115-124.   Published online February 18, 2025
DOI: https://doi.org/10.4132/jptm.2024.11.08
  • 4,252 View
  • 238 Download
  • 2 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Background
We report a new risk stratification of invasive stage papillary thyroid carcinomas (PTCs) by combining invasive status, using extrathyroid invasion (Ex) status, and tumor growth speed using the Ki-67 labeling index (LI). Methods: We examined tumor recurrence in 167 patients with PTC who were surgically treated at the Kindai University Nara Hospital between 2010 and 2022. The patients were classified according to the degree of invasion [negative (Ex0) or positive (Ex1, Ex2, and Ex3)] and tumor growth speed expressed with Ki-67 LI, as low (<5%) or high (>5%). This study confirmed previous findings that the disease-free survival (DFS) rate in PTCs significantly differed between patients with a high and low Ki-67 index. Results: When combining Ex status (negative or positive) and Ki-67 proliferation status (low or high), the DFS rate of invasion in the negative, low Ki-67 LI group was only 1.1%, while that of invasion in the positive, high Ki-67 LI was 44.1%. This study reports for the first time that recurrence risks can be stratified accurately when combining carcinoma’s essential two features of extrathyroid invasion status and tumor growth speed. Conclusions: We believe the evidence for low tumor recurrence risk may contribute to use of more conservative treatment options for invasive-stage PTCs and help alleviate patient anxiety about tumor recurrence and death.

Citations

Citations to this article as recorded by  
  • Research Progress on the Correlation between Three Biomarkers, Ki-67, CAIX and VEGF and Clear Cell Renal Cell Carcinoma
    锦容 马
    Advances in Clinical Medicine.2025; 15(09): 326.     CrossRef
  • Immunophenotypic Panel for Comprehensive Characterization of Aggressive Thyroid Carcinomas
    Mihail Ceausu, Mihai Alin Publik, Dana Terzea, Carmen Adina Cristea, Dumitru Ioachim, Dana Manda, Sorina Schipor
    Cells.2025; 14(19): 1554.     CrossRef
  • High Ki-67 labeling index correlates with aggressive clinicopathological features in papillary thyroid carcinoma: a retrospective study
    Defi Nurlia Erdian, Maria Francisca Ham, Dina Khoirunnisa, Agnes Stephanie Harahap
    Thyroid Research.2025;[Epub]     CrossRef
Article image
Characterization of undifferentiated carcinoma of the salivary gland: clinicopathological and immunohistochemical analyses in comparison with lymphoepithelial carcinoma
Sangjoon Choi, Gyuheon Choi, Hee Jin Lee, Joon Seon Song, Yoon Se Lee, Seung-Ho Choi, Kyung-Ja Cho
J Pathol Transl Med. 2025;59(6):361-370.   Published online September 8, 2025
DOI: https://doi.org/10.4132/jptm.2025.07.07
  • 1,872 View
  • 147 Download
AbstractAbstract PDF
Background
This study aimed to reclassify a subset of poorly differentiated salivary gland carcinoma that do not conform to any entities of the current World Health Organization (WHO) classification into the category of undifferentiated carcinoma (UDC) because they lack specific histologic differentiation or immunophenotype. Methods: Cases of salivary gland carcinomas from Asan Medical Center (2002–2020) that did not fit any existing WHO classification criteria and were diagnosed as poorly differentiated carcinoma, high-grade carcinoma, or UDC, were retrospectively reviewed. Immunohistochemical (IHC) staining for p40, neuroendocrine markers, androgen receptor (AR), and gross cystic disease fluid protein 15 (GCDFP-15) and Epstein-Barr virus (EBV) in situ hybridization (ISH) were performed. Clinical data were collected from the electronic medical records. Results: Six salivary gland carcinomas did not align with any specific entities and lacked distinct differentiation. Two of six cases displayed lymphoepithelial carcinoma (LEC)-like morphology but were negative or showed negligible immunoreactivity for p40 and EBV ISH, distinguishing them from LEC of the salivary gland. Two cases showed strong AR positivity, suggesting a potential overlap with salivary duct carcinoma (SDC) but lacked classic SDC morphologies and GCDFP-15 expression. No cases expressed neuroendocrine markers. Conclusions: This study proposes reclassifying these poorly differentiated or high-grade salivary gland carcinomas as UDC based on their indeterminate differentiation and IHC profiles. This may lead to a clearer diagnostic category and enhance our understanding of these high-grade tumors.
Article image
Categorizing high-grade serous ovarian carcinoma into clinically relevant subgroups using deep learning–based histomic clusters
Byungsoo Ahn, Eunhyang Park
J Pathol Transl Med. 2025;59(2):91-104.   Published online February 18, 2025
DOI: https://doi.org/10.4132/jptm.2024.10.23
  • 4,264 View
  • 231 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFSupplementary Material
Background
High-grade serous ovarian carcinoma (HGSC) exhibits significant heterogeneity, posing challenges for effective clinical categorization. Understanding the histomorphological diversity within HGSC could lead to improved prognostic stratification and personalized treatment approaches. Methods: We applied the Histomic Atlases of Variation Of Cancers model to whole slide images from The Cancer Genome Atlas dataset for ovarian cancer. Histologically distinct tumor clones were grouped into common histomic clusters. Principal component analysis and K-means clustering classified HGSC samples into three groups: highly differentiated (HD), intermediately differentiated (ID), and lowly differentiated (LD). Results: HD tumors showed diverse patterns, lower densities, and stronger eosin staining. ID tumors had intermediate densities and balanced staining, while LD tumors were dense, patternless, and strongly hematoxylin-stained. RNA sequencing revealed distinct patterns in mitochondrial oxidative phosphorylation and energy metabolism, with upregulation in the HD, downregulation in the LD, and the ID positioned in between. Survival analysis showed significantly lower overall survival for the LD compared to the HD and ID, underscoring the critical role of mitochondrial dynamics and energy metabolism in HGSC progression. Conclusions: Deep learning-based histologic analysis effectively stratifies HGSC into clinically relevant prognostic groups, highlighting the role of mitochondrial dynamics and energy metabolism in disease progression. This method offers a novel approach to HGSC categorization.

Citations

Citations to this article as recorded by  
  • Learning Disabilities in the 21st Century: Integrating Neuroscience, Education, and Technology for Better Outcomes
    Syed Mohammed Basheeruddin Asdaq, Ahmad H. Alhowail, Syed Imam Rabbani, Naira Nayeem, Syed Mohammed Emaduddin Asdaq, Faiqa Nausheen
    SAGE Open.2025;[Epub]     CrossRef
Article image
Expression of specific microRNAs in tissue and plasma in colorectal cancer
Allan Fellizar, Vivencio Refuerzo, John Donnie Ramos, Pia Marie Albano
J Pathol Transl Med. 2023;57(3):147-157.   Published online May 3, 2022
DOI: https://doi.org/10.4132/jptm.2022.02.19
  • 10,676 View
  • 599 Download
  • 18 Web of Science
  • 15 Crossref
AbstractAbstract PDF
Background
MicroRNAs (miRNA/miR) play significant roles in the regulation of cell differentiation, cell cycle progression, and apoptosis. They become dysregulated during carcinogenesis and are eventually released into the circulation, enabling their detection in body fluids. Thus, this study compared the miRNA expression in tissue and plasma samples of colorectal cancer (CRC) patients and clinically healthy controls and determined miRNA expression as a potential CRC biomarker.
Methods
Using quantitative reverse transcription polymerase chain reaction (RT-qPCR), miR-21-5p, miR-29a-3p, miR-92a-3p, miR-135b-5p, miR-196b-5p, and miR-197-3p, expression was analyzed and compared between the malignant (n = 41) and the adjacent neoplasm free mucosal tissues (n = 41) of CRC patients. The findings were validated in plasma samples (n = 36) collected from the same CRC patients prior to surgery or any form of treatment and compared to plasma from their age and sex-matched controls (n = 36).
Results
MiR-21-5p, miR-29a-3p, miR-92a-3p, and miR- 196b-5p were upregulated and miR-135b-5p was downregulated in CRC malignant tissues compared to their expression in adjacent neoplasm-free tissue. This was further observed in the plasma of the same CRC cases compared to controls. MiR-92a-3p showed itself the most sensitive (0.93; p < .001) and most specific (0.95; p < .001) in detecting CRC in tissue. In plasma, miR-196b-5p was the most sensitive (0.97; p < .001) and specific (0.94; p < .001) in detecting CRC. Plasma miR-92a-3p and miR-196b-5p were the most sensitive (0.95; p < .001) and specific (0.94; p < .001) in the early detection of CRC.
Conclusions
Results show that specific miRNAs dysregulated in malignant tissues are released and can be detected in the circulation, supporting their potential as non-invasive biomarkers of CRC.

Citations

Citations to this article as recorded by  
  • Liquid biopsy for the management of gastrointestinal cancers
    Zeinab Salehnia, Delsuz Rezaee, Sajad Ehtiati, Mohammad Bakhtiari, Mohammad Amin Khalilzad, Sajad Najafi
    Clinica Chimica Acta.2026; 578: 120474.     CrossRef
  • Except for Robust Outliers, Rapamycin Increases Lesion Burden in a Murine Model of Cerebral Cavernous Malformations
    Roberto J. Alcazar-Felix, Robert Shenkar, Christian R. Benavides, Akash Bindal, Abhinav Srinath, Ying Li, Serena Kinkade, Tatiana Terranova, Evon DeBose-Scarlett, Rhonda Lightle, Dorothy DeBiasse, Hanadi Almazroue, Diana Vera Cruz, Sharbel Romanos, Aditya
    Translational Stroke Research.2025; 16(3): 859.     CrossRef
  • miR-135b: A key role in cancer biology and therapeutic targets
    Yingchun Shao, Shuangshuang Zhang, Yuxin Pan, Zhan Peng, Yinying Dong
    Non-coding RNA Research.2025; 12: 67.     CrossRef
  • The role of tumor-associated fibroblast-derived exosomes in chemotherapy resistance of colorectal cancer and its application prospect
    Meichen Liu, Teng-zheng Li, Congcong Xu
    Biochimica et Biophysica Acta (BBA) - General Subjects.2025; 1869(6): 130796.     CrossRef
  • A Systematic Review of MicroRNAs in Hemorrhagic Neurovascular Disease: Cerebral Cavernous Malformations as a Paradigm
    Roberto J. Alcazar-Felix, Aditya Jhaveri, Javed Iqbal, Abhinav Srinath, Carolyn Bennett, Akash Bindal, Diana Vera Cruz, Sharbel Romanos, Stephanie Hage, Agnieszka Stadnik, Justine Lee, Rhonda Lightle, Robert Shenkar, Janne Koskimäki, Sean P. Polster, Romu
    International Journal of Molecular Sciences.2025; 26(8): 3794.     CrossRef
  • microRNA-196b-5p expression in cancer tissues is closely associated with clinical and pathological characteristics and prognosis of patients with non-small cell lung cancer
    Wei Liu, Xiaomin Lu, Changgang Yang, Fengjun Ji, Xiaodan Wu
    Journal of Cardiothoracic Surgery.2025;[Epub]     CrossRef
  • Association of mir196a2 and mir146a polymorphisms and colorectal cancer risk: A meta-analysis
    Zahraa isam jameel, Hanan Ali Kareem, Zahraa Mohammed Yahya, Ahmed Ali Hussein, zahraa abdel Kareem
    Human Gene.2025; 45: 201448.     CrossRef
  • Micro RNA in Colorectal Cancer—Potential Diagnostic and Prognostic Markers—An Updated Review
    Weronika Pająk, Jakub Kleinrok, Joanna Pec, Karolina Michno, Jan Wojtas, Miłosz Badach, Barbara Teresińska, Jacek Baj
    International Journal of Molecular Sciences.2025; 26(17): 8615.     CrossRef
  • Identification of miRNAs Present in Cell- and Plasma-Derived Extracellular Vesicles—Possible Biomarkers of Colorectal Cancer
    Marzena Lenart, Izabela Siemińska, Rafał Szatanek, Anna Mordel, Antoni Szczepanik, Mateusz Rubinkiewicz, Maciej Siedlar, Monika Baj-Krzyworzeka
    Cancers.2024; 16(13): 2464.     CrossRef
  • The emerging role of blood-based biomarkers in early detection of colorectal cancer: A systematic review
    Faris Shweikeh, Yuhao Zeng, Abdur Rahman Jabir, Erica Whittenberger, Saurav P. Kadatane, Yuting Huang, Mohamad Mouchli, Dani Ran Castillo
    Cancer Treatment and Research Communications.2024; 42: 100872.     CrossRef
  • The Role of Extracellular Vesicles in Colorectal Cancer
    Yujian Xia, Chaoran Yu, Ernest Johann Helwig, Yousheng Li
    Technology in Cancer Research & Treatment.2023;[Epub]     CrossRef
  • HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer
    Yiling Li, Kexin Li, Xiaoying Lou, Yue Wu, Samuel Seery, Danfei Xu, Yuqing Pei, Benheng Qian, Yuxin Wu, Shuang Liang, Kui Wu, Wei Cui
    Cancers.2023; 15(4): 1367.     CrossRef
  • Role of salivary miRNAs in the diagnosis of gastrointestinal disorders: a mini-review of available evidence
    Maria Oana Săsăran, Claudia Bănescu
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • Exploring the Role of Circulating Cell-Free RNA in the Development of Colorectal Cancer
    Chau-Ming Kan, Xiao Meng Pei, Martin Ho Yin Yeung, Nana Jin, Simon Siu Man Ng, Hin Fung Tsang, William Chi Shing Cho, Aldrin Kay-Yuen Yim, Allen Chi-Shing Yu, Sze Chuen Cesar Wong
    International Journal of Molecular Sciences.2023; 24(13): 11026.     CrossRef
  • Lynch Syndrome Biopathology and Treatment: The Potential Role of microRNAs in Clinical Practice
    Serena Ascrizzi, Grazia Maria Arillotta, Katia Grillone, Giulio Caridà, Stefania Signorelli, Asad Ali, Caterina Romeo, Pierfrancesco Tassone, Pierosandro Tagliaferri
    Cancers.2023; 15(15): 3930.     CrossRef
Case Studies
Article image
Primary renal BCOR::CCNB3 sarcoma in a female patient: case report
Somang Lee, Binnari Kim
J Pathol Transl Med. 2025;59(1):84-90.   Published online January 15, 2025
DOI: https://doi.org/10.4132/jptm.2024.09.30
  • 4,079 View
  • 166 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
BCOR-rearranged sarcoma was classified by the World Health Organization in 2020 as a new subgroup of undifferentiated small round-cell sarcoma. It is known to occur very rarely in the kidney. This report presents the first case of a primary renal BCOR::CCNB3 sarcoma in a 22-year-old woman. An 8-cm cystic mass was identified in the left kidney by abdominal pelvic computed tomography. Histopathologic examination revealed the mass to be composed of small round to oval or spindle cells with fibrous septa and a delicate vascular network. A BCOR::CCNB3 fusion was detected by next-generation sequencing–based molecular testing. BCOR::CCNB3 sarcoma presents diagnostic difficulties, highlighting the importance of recognizing its histological features. Immunohistochemical markers are helpful for diagnosis, but genetic molecular testing is necessary for accurate diagnosis. These tumors have a very poor and aggressive prognosis, and an optimal therapeutic regimen has not yet been defined. Therefore, further studies are needed.

Citations

Citations to this article as recorded by  
  • Update on the management of BCOR::CCNB3 sarcoma
    Jungo Imanishi, Kenji Sato, Yoshinao Kikuchi, Asako Yamamoto, Shiori Watabe, Taisuke Matsuyama, Chiaki Sato, Hiroshi Kobayashi, Hirotaka Kawano
    Japanese Journal of Clinical Oncology.2025; 55(10): 1097.     CrossRef
Article image
Thyroid pathology, a clue to PTEN hamartoma tumor syndrome
Yurimi Lee, Young Lyun Oh
J Pathol Transl Med. 2023;57(3):178-183.   Published online March 30, 2023
DOI: https://doi.org/10.4132/jptm.2023.03.04
  • 6,635 View
  • 203 Download
  • 9 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) is a hereditary disorder caused by germline inactivating mutations in the PTEN tumor suppressor gene. As a type of PHTS, Cowden syndrome is associated with abnormalities of the thyroid, breast, uterus, and gastrointestinal tract. A 52-year-old-woman visited the outpatient clinic of our endocrinology clinic with multiple thyroid nodules and Hashimoto's thyroiditis. Computed tomography imaging revealed a multinodular mass measuring up to 3.5 cm in the left thyroid lobe, causing laryngotracheal airway displacement. The total thyroidectomy specimen revealed multiple follicular adenomas and adenomatous nodules with lymphocytic thyroiditis and lipomatous metaplasia in the background. The patient was suspected of PTHS based on her thyroid pathology, family history, and numerous hamartomatous lesions of the breast, uterus, and skin. Her diagnosis was confirmed through molecular testing. This case demonstrates that pathologists must be well acquainted with thyroid pathology in PHTS.

Citations

Citations to this article as recorded by  
  • A clinical case of papillary thyroid cancer associated with a PTEN gene defect
    R. A. Atanesyan, L. Ja. Klimov, T. M. Vdovina, G. A. Saneeva, E. I. Andreeva, I. A. Stremenkova, R. I. Arakelyan, I. K. Gasparyan
    Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics).2025; 69(6): 85.     CrossRef
  • Pediatric cancer predisposition syndromes involving non-central nervous system solid pediatric tumors: a review on their manifestations with a focus on histopathology
    B. Schurink, M. Reyes-Múgica, R. R. de Krijger
    Virchows Archiv.2025; 486(1): 3.     CrossRef
  • Dedifferentiated Leiomyosarcoma of the Uterine Corpus with Heterologous Component: Clinicopathological Analysis of Five Consecutive Cases from a Single Institution and Comprehensive Literature Review
    Suyeon Kim, Hyunsik Bae, Hyun-Soo Kim
    Diagnostics.2024; 14(2): 160.     CrossRef
  • Case report: Rare oral manifestations in Cowden syndrome with PTEN mutation
    Wei Yuan, Yanbin Liu, Haibin Sun, Ming Su, Lizheng Qin, Xin Huang
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Can thyroid histomorphology identify patients with PTEN hamartoma tumour syndrome?
    Melad N Dababneh, Laura Rabinowitz, Gilman Plitt, Charis Eng, Christopher C Griffith
    Histopathology.2024; 85(6): 929.     CrossRef
  • A novel mutation in PTEN in anaplastic thyroid carcinoma: A case report
    Yanli Zhao
    Biomedical Reports.2024;[Epub]     CrossRef
Original Article
Article image
Clinicopathological implications of immunohistochemical expression of TBX21, CXCR3, GATA3, CCR4, and TCF1 in nodal follicular helper T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified
Bogyeong Han, Sojung Lim, Jeemin Yim, Young Keun Song, Jiwon Koh, Sehui Kim, Cheol Lee, Young A Kim, Yoon Kyung Jeon
J Pathol Transl Med. 2024;58(2):59-71.   Published online January 22, 2024
DOI: https://doi.org/10.4132/jptm.2024.01.04
  • 6,747 View
  • 367 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary Material
Background
The classification of nodal peripheral T-cell lymphoma (PTCL) has evolved according to histology, cell-of-origin, and genetic alterations. However, the comprehensive expression pattern of follicular helper T-cell (Tfh) markers, T-cell factor-1 (TCF1), and Th1- and Th2-like molecules in nodal PTCL is unclear.
Methods
Eighty-two cases of nodal PTCL were classified into 53 angioimmunoblastic T-cell lymphomas (AITLs)/nodal T-follicular helper cell lymphoma (nTFHL)-AI, 18 PTCLs-Tfh/nTFHL–not otherwise specified (NOS), and 11 PTCLs-NOS according to the revised 4th/5th World Health Organization classifications. Immunohistochemistry for TCF1, TBX21, CXCR3, GATA3, and CCR4 was performed.
Results
TCF1 was highly expressed in up to 68% of patients with nTFHL but also in 44% of patients with PTCL-NOS (p > .05). CXCR3 expression was higher in AITLs than in non-AITLs (p = .035), whereas GATA3 expression was higher in non-AITL than in AITL (p = .007) and in PTCL-Tfh compared to AITL (p = .010). Of the cases, 70% of AITL, 44% of PTCLTfh/ nTFHL-NOS, and 36% of PTCL-NOS were subclassified as the TBX21 subtype; and 15% of AITL, 38% of PTCL-Tfh/nTFHL-NOS, and 36% of PTCL-NOS were subclassified as the GATA3 subtype. The others were an unclassified subtype. CCR4 expression was associated with poor progression-free survival (PFS) in patients with PTCL-Tfh (p < .001) and nTFHL (p = .023). The GATA3 subtype showed poor overall survival in PTCL-NOS compared to TBX21 (p = .046) and tended to be associated with poor PFS in patients with non-AITL (p = .054).
Conclusions
The TBX21 subtype was more prevalent than the GATA3 subtype in AITL. The GATA3 subtype was associated with poor prognosis in patients with non-AITL and PTCL-NOS.

Citations

Citations to this article as recorded by  
  • CXCR Family and Hematologic Malignancies in the Bone Marrow Microenvironment
    Yanquan Liu, Huanwen Tang
    Biomolecules.2025; 15(5): 716.     CrossRef
  • Diagnostic and therapeutic pathways for lymphoma patients: expert consensus through Nominal Group Technique and Delphi methodology
    Attilio Guarini, Valentina Bozzoli, Sabino Ciavarella, Michele Cimminiello, Francesca Donatelli, Angelo Fama, Vincenza Fernanda Fesce, Vincenzo Fraticelli, Francesco Gaudio, Giuseppina Greco, Augusto Martellini, Francesca Merchionne, Rosanna Maria Miccoli
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Prognostic Significance of TBX21 and GATA3 Subtype Classification in Indolent Adult T‐Cell Leukemia‐Lymphoma With Cutaneous Lesions
    Kazuhiro Kawai, Youhei Uchida, Takuro Kanekura
    The Journal of Dermatology.2025; 52(11): 1674.     CrossRef
Review
Article image
Post-transplant liver biopsies: a concise and practical approach for beginners
Mohamad Besher Ourfali, David Hirsch, Marianna Scranton, Tony El Jabbour
J Pathol Transl Med. 2025;59(1):1-10.   Published online January 15, 2025
DOI: https://doi.org/10.4132/jptm.2024.11.15
  • 3,752 View
  • 355 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Exposure to post-transplant liver biopsies varies among pathology residencies and largely depends on the institution's training program, particularly if the hospital has a liver transplant program. The interpretation of biopsies from transplanted livers presents its own set of challenges, even for those with a solid understanding of non-transplant medical liver biopsies. In this review, we aim to provide a succinct, step-by-step approach to help you interpret liver transplant biopsies. This article may be beneficial for residents interested in liver pathology, gastrointestinal and liver pathology fellows in the early stages of training, clinical gastroenterology and hepatology fellows, hepatologists and general pathologists who are curious about this niche.

Citations

Citations to this article as recorded by  
  • Histological and Molecular Evaluation of Liver Biopsies: A Practical and Updated Review
    Joon Hyuk Choi
    International Journal of Molecular Sciences.2025; 26(16): 7729.     CrossRef
Original Articles
Article image
Comparison of tissue-based and plasma-based testing for EGFR mutation in non–small cell lung cancer patients
Yoon Kyung Kang, Dong Hoon Shin, Joon Young Park, Chung Su Hwang, Hyun Jung Lee, Jung Hee Lee, Jee Yeon Kim, JooYoung Na
J Pathol Transl Med. 2025;59(1):60-67.   Published online January 15, 2025
DOI: https://doi.org/10.4132/jptm.2024.10.01
  • 4,031 View
  • 192 Download
AbstractAbstract PDF
Background
Epidermal growth factor receptor (EGFR) gene mutation testing is crucial for the administration of tyrosine kinase inhibitors to treat non–small cell lung cancer. In addition to traditional tissue-based tests, liquid biopsies using plasma are increasingly utilized, particularly for detecting T790M mutations. This study compared tissue- and plasma-based EGFR testing methods.
Methods
A total of 248 patients were tested for EGFR mutations using tissue and plasma samples from 2018 to 2023 at Pusan National University Yangsan Hospital. Tissue tests were performed using PANAmutyper, and plasma tests were performed using the Cobas EGFR Mutation Test v2.
Results
All 248 patients underwent tissue-based EGFR testing, and 245 (98.8%) showed positive results. Of the 408 plasma tests, 237 (58.1%) were positive. For the T790M mutation, tissue biopsies were performed 87 times in 69 patients, and 30 positive cases (38.6%) were detected. Plasma testing for the T790M mutation was conducted 333 times in 207 patients, yielding 62 positive results (18.6%). Of these, 57 (27.5%) were confirmed to have the mutation via plasma testing. Combined tissue and plasma tests for the T790M mutation were positive in nine patients (13.4%), while 17 (25.4%) were positive in tissue only and 12 (17.9%) in plasma only. This mutation was not detected in 28 patients (43.3%).
Conclusions
Although the tissue- and plasma-based tests showed a sensitivity of 37.3% and 32.8%, respectively, combined testing increased the detection rate to 56.7%. Thus, neither test demonstrated superiority, rather, they were complementary.
Article image
The spectrum of microvascular patterns in adult diffuse glioma and their correlation with tumor grade
Soni , Vaishali Walke, Deepti Joshi, Tanya Sharma, Adesh Shrivastava, Amit Agrawal
J Pathol Transl Med. 2024;58(3):127-133.   Published online May 14, 2024
DOI: https://doi.org/10.4132/jptm.2024.03.11
  • 6,028 View
  • 336 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Background
Primary brain tumors constitute the leading cause of cancer-related mortality. Among them, adult diffuse gliomas are the most common type, affecting the cerebral hemispheres and displaying a diffuse infiltrative pattern of growth in the surrounding neuropil that accounts for about 80% of all primary intracranial tumors. The hallmark feature of gliomas is blood vessel proliferation, which plays an important role in tumor growth, tumor biological behavior, and disease outcome. High-grade gliomas exhibit increased vascularity, the worst prognosis, and lower survival rates. Several angiogenic receptors and factors are upregulated in glioblastomas and stimulate angiogenesis signaling pathways by means of activating oncogenes and/or down-regulating tumor-suppressor genes. Existing literature has emphasized that different microvascular patterns (MVPs) are displayed in different subtypes of adult diffuse gliomas.
Methods
We examined the distribution and biological characteristics of different MVPs in 50 patients with adult diffuse gliomas. Haematoxylin and eosin staining results, along with periodic acid–Schiff and CD34 dual-stained sections, were examined to assess the vascular patterns and correlate with different grades of diffuse glioma.
Results
The present observational study on adult diffuse glioma evaluated tumor grade and MVPs. Microvascular sprouting was the most common pattern, while a bizarre pattern (type 2) was associated with the presence of a high-grade glioma. Vascular mimicry was observed in 6% of cases, all of which were grade 4 gliomas.
Conclusions
This study supplements the role of neo-angiogenesis and aberrant vasculature patterns in the grading and progression of adult diffuse gliomas, which can be future targets for planning treatment strategies.

Citations

Citations to this article as recorded by  
  • Unlocking therapeutic potential: Exploring nuclear receptors in brain cancer treatment
    Sujitha Jayaprakash, Hiu Yan Lam, Ravichandran Vishwa, Bandari BharathwajChetty, Kenneth C-H Yap, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Alan Prem Kumar, Ajaikumar B. Kunnumakkara
    Chinese Medical Journal.2025; 138(21): 2722.     CrossRef
  • Uptake patterns of Adult-type Non-Enhanced diffuse gliomas on [11C] methionine positron emission tomography
    Shoji Yasuda, Naoya Imai, Hirohito Yano, Yuka Ikegame, Soko Ikuta, Takashi Maruyama, Noriyuki Nakayama, Morio Kumagai, Yoshihiro Muragaki, Jun Shinoda, Tsuyoshi Izumo
    Neuroradiology.2025; 67(10): 2611.     CrossRef
  • Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration
    Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel
    Advanced Science.2025;[Epub]     CrossRef
  • High ORC6 expression is a prognostic indicator of poor survival in glioma patients
    Mengjie Wang, Song Feng, Chen Zhang, Feng Jin
    Scientific Reports.2025;[Epub]     CrossRef
Article image
Attitudes toward artificial intelligence in pathology: a survey-based study of pathologists in northern India
Manupriya Sharma, Kavita Kumari, Navpreet Navpreet, Sushma Bharti, Rajneesh Kumari
J Pathol Transl Med. 2025;59(6):382-389.   Published online October 2, 2025
DOI: https://doi.org/10.4132/jptm.2025.07.10
  • 1,107 View
  • 98 Download
AbstractAbstract PDFSupplementary Material
Background
Artificial intelligence (AI) is transforming pathology by enhancing diagnostic accuracy, efficiency, and workflow standardization. Despite its growing presence, AI adoption remains limited, particularly in resource-constrained settings like India. This study assessed the knowledge, awareness, and perceptions of AI among pathologists in Northern India. Methods: A cross-sectional survey was conducted among 138 practicing pathologists in Northern India between April and June 2024. A structured online questionnaire was used to collect data on demographics, AI awareness, self-reported knowledge, sources of AI education, technological proficiency, and interest in AI-related training programs. Data analysis included descriptive statistics and chi-square tests, with p < .05 considered statistically significant. Results: AI awareness was high (88.4%), with significant sex differences (93.5% in females vs. 78.3% in males, p = .008). However, formal AI training was limited (6.5%), and only 16.7% had used AI as a diagnostic tool. Academic pathologists were more likely to engage with AI literature than their non-academic counterparts (p = .003). Interest in AI workshops was strong (92.8%). Access to whole slide imaging (WSI) correlated with higher AI knowledge (p = .008), as did self-reported technological proficiency (p = .001). Conclusions: Despite high AI awareness among pathologists, significant gaps remain in training, infrastructure, and practical application. Expanding access to digital pathology tools like WSI and improving digital literacy could facilitate AI adoption. Structured educational programs and greater investment in digital infrastructure are crucial for integrating AI into pathology practice.
Article image
Frozen section histopathology and preanalytical factors affecting nucleic acid integrity in biobanked fresh-frozen human cancer tissues
Soungeun Kim, Jaewon Kang, Boyeon Kim, Yoonjin Kwak, Hye Seung Lee
J Pathol Transl Med. 2025;59(6):398-407.   Published online September 12, 2025
DOI: https://doi.org/10.4132/jptm.2025.07.22
  • 1,517 View
  • 127 Download
AbstractAbstract PDFSupplementary Material
Background
In this study, we evaluated the effects of storage duration and ischemic time on nucleic acid quality of fresh-frozen tissue (FFT) from colon adenocarcinoma (COAD), hepatocellular carcinoma (HCC), and renal cell carcinoma (RCC) collected at the Cancer Tissue Bank of Seoul National University Hospital. Methods: A total of 102 FFT samples were analyzed to compare DNA integrity number (DIN) and RNA integrity number (RIN) according to storage duration and ischemic time. Additionally, the effects of histopathologic features—such as tumor cell proportion, inflammatory cell infiltration, and stromal fibrosis—on nucleic acid quality were evaluated. Results: DIN and RIN remained stable overall even though the storage duration increased, with no statistically significant differences observed. In particular, there was almost no decrease in RNA quality in HCC and RCC samples, but in COAD samples, RIN tended to decrease slightly as the storage duration increased. No significant difference was confirmed between ischemic time and nucleic acid quality, but in COAD tissue, RNA quality variability tended to increase as the ischemic time increased. Furthermore, RIN increased as the tumor cell proportion increased, whereas inflammatory cell infiltration and extracellular mucin pool were identified as independent negative predictors of RIN. Conclusions: This study confirmed that nucleic acid integrity can be maintained even during long-term storage of FFT and demonstrated that histologic features are closely related to RNA quality. This study would contribute to the establishment of quality assessment and management standards for biobank FFT samples.
Article image
Fine needle aspiration cytology diagnoses of follicular thyroid carcinoma: results from a multicenter study in Asia
Hee Young Na, Miyoko Higuchi, Shinya Satoh, Kaori Kameyama, Chan Kwon Jung, Su-Jin Shin, Shipra Agarwal, Jen-Fan Hang, Yun Zhu, Zhiyan Liu, Andrey Bychkov, Kennichi Kakudo, So Yeon Park
J Pathol Transl Med. 2024;58(6):331-340.   Published online November 7, 2024
DOI: https://doi.org/10.4132/jptm.2024.10.12
  • 4,954 View
  • 259 Download
AbstractAbstract PDFSupplementary Material
Background
This study was designed to compare diagnostic categories of thyroid fine needle aspiration cytology (FNAC) and incidence of thyroid tumors in the multi-institutional Asian series with a special focus on diagnostic category IV (suspicious for a follicular neoplasm) and follicular thyroid carcinomas (FTCs). Methods: Distribution of FNAC categories, incidence of thyroid tumors in resection specimens and cytologic diagnoses of surgically confirmed follicular adenomas (FAs) and FTCs were collected from 10 institutes from five Asian countries and were compared among countries and between FAs and FTCs. Results: The frequency of category IV diagnoses (3.0%) in preoperative FNAC were significantly lower compared to those in Western countries (10.1%). When comparing diagnostic categories among Asian countries, category IV was more frequent in Japan (4.6%) and India (7.9%) than in Taiwan (1.4%), Korea (1.4%), and China (3.6%). Similarly, incidence of FAs and FTCs in surgical resection specimens was significantly higher in Japan (10.9%) and India (10.1%) than in Taiwan (5.5%), Korea (3.0%), and China (2.5%). FTCs were more commonly diagnosed as category IV in Japan (77.5%) than in Korea (33.3%) and China (35.0%). Nuclear pleomorphism, nuclear crowding, microfollicular pattern, and dyshesive cell pattern were more common in FTCs compared with FAs. Conclusions: Our study highlighted the difference in FNAC diagnostic categories of FTCs among Asian countries, which is likely related to different reporting systems and thyroid cancer incidence. Cytologic features such as nuclear pleomorphism, nuclear crowding, microfollicular pattern, and dyshesive cell pattern were found to be useful in diagnosing FTCs more effectively.
Review
Article image
Clinical practice recommendations for the use of next-generation sequencing in patients with solid cancer: a joint report from KSMO and KSP
Miso Kim, Hyo Sup Shim, Sheehyun Kim, In Hee Lee, Jihun Kim, Shinkyo Yoon, Hyung-Don Kim, Inkeun Park, Jae Ho Jeong, Changhoon Yoo, Jaekyung Cheon, In-Ho Kim, Jieun Lee, Sook Hee Hong, Sehhoon Park, Hyun Ae Jung, Jin Won Kim, Han Jo Kim, Yongjun Cha, Sun Min Lim, Han Sang Kim, Choong-Kun Lee, Jee Hung Kim, Sang Hoon Chun, Jina Yun, So Yeon Park, Hye Seung Lee, Yong Mee Cho, Soo Jeong Nam, Kiyong Na, Sun Och Yoon, Ahwon Lee, Kee-Taek Jang, Hongseok Yun, Sungyoung Lee, Jee Hyun Kim, Wan-Seop Kim
J Pathol Transl Med. 2024;58(4):147-164.   Published online January 10, 2024
DOI: https://doi.org/10.4132/jptm.2023.11.01
  • 7,452 View
  • 488 Download
  • 1 Crossref
AbstractAbstract PDF
In recent years, next-generation sequencing (NGS)–based genetic testing has become crucial in cancer care. While its primary objective is to identify actionable genetic alterations to guide treatment decisions, its scope has broadened to encompass aiding in pathological diagnosis and exploring resistance mechanisms. With the ongoing expansion in NGS application and reliance, a compelling necessity arises for expert consensus on its application in solid cancers. To address this demand, the forthcoming recommendations not only provide pragmatic guidance for the clinical use of NGS but also systematically classify actionable genes based on specific cancer types. Additionally, these recommendations will incorporate expert perspectives on crucial biomarkers, ensuring informed decisions regarding circulating tumor DNA panel testing.

Citations

Citations to this article as recorded by  
  • Apport de la génomique dans la prise en charge des cancers
    Étienne Rouleau, Lucie Karayan-Tapon, Marie-Dominique Galibert, Alexandre Harlé, Isabelle Soubeyran
    Revue Francophone des Laboratoires.2025; 2025(568): 67.     CrossRef
Original Article
Article image
Characteristics of RET gene mutations in Vietnamese medullary thyroid carcinoma patients: a single-center analysis
Van Hung Pham, Quoc Thang Pham, Minh Nguyen, Hoa Nhat Ngo, Thao Thi Thu Luu, Nha Dao Thi Minh, Trâm Đặng, Anh Tu Thai, Hoang Anh Vu, Dat Quoc Ngo
J Pathol Transl Med. 2025;59(2):125-132.   Published online March 14, 2025
DOI: https://doi.org/10.4132/jptm.2025.01.18
  • 4,320 View
  • 175 Download
AbstractAbstract PDFSupplementary Material
Background
The RET gene point mutation is the main molecular alteration involved in medullary thyroid carcinoma (MTC) tumorigenesis. Previous studies in Vietnam mainly consisted of case reports, with limited data on larger sample sizes. In this study, we investigated RET gene mutations in exons 10, 11, and 16 and analyzed clinicopathological features of a series of Vietnamese MTC patients. Methods: We collected 33 tissue samples from patients with MTC and analyzed RET mutations using the Sanger sequencing method. The relationship between hotspot RET mutations (exons 10, 11, 16) and clinicopathological features were investigated. Results: Among the 33 analyzed cases, 17 tumors (52%) harbored RET mutations in exon 10, 11, or 16. A total of 10 distinct genetic alterations were identified, including eight missense mutations and two short indels. Of these, seven were classified as pathogenic mutations based on previous publications, with p.M918T being the most frequent (4 cases), followed by p.C634R (3 cases) and p.C618R (3 cases). Mutations were significantly associated with specific histological patterns, such as the nested/insular pattern (p=.026), giant cells (p=.007), nuclear pleomorphism (p=.018), stippled chromatin (p=.044), and amyloid deposits (p=.024). No mutations were found in germline analyses, suggesting these were somatic alterations. Conclusions: Our results provided the first comprehensive analysis of RET mutations in Vietnamese MTC patients. The most frequent mutation was p.M918T, followed by p.C634R and p.C618R. Mutations in these three exons were linked to specific histopathological features. Information on mutational profiles of patients with MTC will further aid in the development of targeted therapeutics to ensure effective disease management.
J Pathol Transl Med : Journal of Pathology and Translational Medicine
© The Korean Society of Pathologists and the Korean Society for Cytopathology.
TOP