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JPTM > Volume 43(6); 2009 > Article
The Korean Journal of Pathology 2009;43(6): 570-574.
doi: https://doi.org/10.4132/KoreanJPathol.2009.43.6.570
Ovarian Endometrioid Adenocarcinoma with a Yolk Sac Tumor Component.
Dong Hae Chung, Sanghui Park, Hee Eun Kyung, Na Rae Kim, Seung Yeon Ha, Soyi Lim, Hyun Yee Cho
1Department of Pathology, Gachon University Gil Hospital, Incheon, Korea. hicho@gilhospital.com
2Department of Obstetrics and Gynecology, Gachon University Gil Hospital, Incheon, Korea.
ABSTRACT
Ovarian endometrioid adenocarcinoma (EAC) with a yolk sac tumor (YST) component is extremely rare. Only twelve cases have been reported in the English literature. We report here two additional cases of this rare tumor. The YST component showed classic microscopic features, and immunohistochemically stained positive for alpha-fetoprotein (AFP), but negative for cytokeratin 7 (CK7), epithelial membrane antigen (EMA), estrogen receptor (ER) and progesterone receptor (PR). The EAC appeared to blend into the YST in several areas and immunohistochemically stained positive for CK7, EMA, ER, and PR, but negative for AFP.
Key Words: Ovary; Yolk sac tumor; Endometrioid adenocarcinoma; Endodermal sinus tumor