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JPTM > Volume 44(1); 2010 > Article
The Korean Journal of Pathology 2010;44(1): 77-82.
doi: https://doi.org/10.4132/KoreanJPathol.2010.44.1.77
The Analysis and Clinical Usefulness of HPV DNA Chip Test in the Uterine Cervix.
Joo hyeon Jeong, Hyun Yee Cho, Na Rae Kim, Dong Hae Chung, Sanghui Park, Seung Yeon Ha
1Department of Pathology, Graduate School of Medicine, Gachon University, Incheon, Korea.
2Department of Pathology, Gachon University Gil Hospital, Incheon, Korea. syha@gilhospital.com
ABSTRACT
BACKGROUND: The genotypes of human papillomavirus (HPV) are important in carcinogenesis in uterine cervical cancer and may be different in geographic distribution. METHODS: In 2,086 women, we analyzed the prevalence of HPV and HPV genotypes in uterine cervix by HPV-DNA chip test (n = 2,086), cytology (PAP smear, n = 1997) and biopsy (n = 546). RESULTS: Of the 2,086 cases, 1,019 cases (48.8%) were HPV-positive and 1,067 cases (51.2%) were negative for HPV. Single infection occurred most commonly (72.1% of women). HPV genotypes in the high-risk and low-risk groups, respectively were HPV-16/-58/-18/-52/-53 and HPV-70/-6/-11. The detection rates of HPV-70 in subjects older than 50 years increased significantly (p < 0.05). Infection in high risk subjects was detected in high grade lesions compared with infection in low risk subjects (p < 0.05). CONCLUSIONS: HPV-16/-58/-18/-52/-53/-70/-6/-11 genotypes were common in the patient group similar to findings in East Asia. HPV-70 infection is predominant in those older than 40 years.
Key Words: Human papillomavirus; Oligonucleotide array sequence analysis; Cytology; Cervix uteri