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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2019.03.20    [Epub ahead of print]
Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
Myunghee Kang1, Na Rae Kim1, Dong Hae Chung1, Gie-Taek Yie2
1Department of Pathology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
2Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
Corresponding Author: Na Rae Kim ,Tel: +82 32 460 3073, Fax: +82 32 460 2394, Email: clara_nrk@gilhospital.com
Received: January 28, 2019;  Revised: February 27, 2019  Accepted: March 20, 2019.  Published online: April 11, 2019.
ABSTRACT
A 51-year-old woman presented with severe dizziness. The brain MRI revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for STAT6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.
Key Words: Solitary fibrous tumor, Hemangiopericytoma, Frozen, Cytology, Central nervous system