Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Search

Page Path
HOME > Search
22 "Kyung-Ja Cho"
Filter
Filter
Article category
Keywords
More +
Publication year
More +
Authors
More +
Funded articles
Original Articles
Article image
Characterization of undifferentiated carcinoma of the salivary gland: clinicopathological and immunohistochemical analyses in comparison with lymphoepithelial carcinoma
Sangjoon Choi, Gyuheon Choi, Hee Jin Lee, Joon Seon Song, Yoon Se Lee, Seung-Ho Choi, Kyung-Ja Cho
J Pathol Transl Med. 2025;59(6):361-370.   Published online September 8, 2025
DOI: https://doi.org/10.4132/jptm.2025.07.07
  • 2,780 View
  • 255 Download
AbstractAbstract PDF
Background
This study aimed to reclassify a subset of poorly differentiated salivary gland carcinoma that do not conform to any entities of the current World Health Organization (WHO) classification into the category of undifferentiated carcinoma (UDC) because they lack specific histologic differentiation or immunophenotype. Methods: Cases of salivary gland carcinomas from Asan Medical Center (2002–2020) that did not fit any existing WHO classification criteria and were diagnosed as poorly differentiated carcinoma, high-grade carcinoma, or UDC, were retrospectively reviewed. Immunohistochemical (IHC) staining for p40, neuroendocrine markers, androgen receptor (AR), and gross cystic disease fluid protein 15 (GCDFP-15) and Epstein-Barr virus (EBV) in situ hybridization (ISH) were performed. Clinical data were collected from the electronic medical records. Results: Six salivary gland carcinomas did not align with any specific entities and lacked distinct differentiation. Two of six cases displayed lymphoepithelial carcinoma (LEC)-like morphology but were negative or showed negligible immunoreactivity for p40 and EBV ISH, distinguishing them from LEC of the salivary gland. Two cases showed strong AR positivity, suggesting a potential overlap with salivary duct carcinoma (SDC) but lacked classic SDC morphologies and GCDFP-15 expression. No cases expressed neuroendocrine markers. Conclusions: This study proposes reclassifying these poorly differentiated or high-grade salivary gland carcinomas as UDC based on their indeterminate differentiation and IHC profiles. This may lead to a clearer diagnostic category and enhance our understanding of these high-grade tumors.
Article image
Primary Merkel cell carcinoma of the salivary gland: a clinicopathologic study of four cases with a review of literature
Gyuheon Choi, Joon Seon Song, Hee Jin Lee, Gi Hwan Kim, Young Ho Jung, Yoon Se Lee, Kyung-Ja Cho
J Pathol Transl Med. 2025;59(3):171-179.   Published online April 30, 2025
DOI: https://doi.org/10.4132/jptm.2025.03.25
  • 3,576 View
  • 154 Download
  • 1 Crossref
AbstractAbstract PDF
Background
Primary Merkel cell carcinoma of the salivary gland is currently not listed in the World Health Organization classification. However, cases of Merkel cell type neuroendocrine carcinomas of the salivary gland with perinuclear cytokeratin 20 positivity have been intermittently reported. We here investigated the clinicopathologic features of additional cases.
Methods
Data of four cases of Merkel cell type small cell neuroendocrine carcinoma of the salivary gland were retrieved. To confirm the tumors’ primary nature, clinical records and pathologic materials were reviewed. Optimal immunohistochemical staining was performed to support the diagnosis.
Results
All tumors were located in the parotid gland. Possibilities of metastasis were excluded in all cases through a meticulous clinicopathological review. Tumor histology was consistent with the diagnosis of small cell neuroendocrine carcinoma. Tumors’ immunohistochemical phenotypes were consistent with Merkel cell carcinoma, including Merkel cell polyomavirus large T antigen positivity in two of the four cases.
Conclusions
Merkel cell carcinomas can originate in salivary glands and are partly associated with Merkel cell polyomavirus infection as in cutaneous Merkel cell carcinomas.

Citations

Citations to this article as recorded by  
  • Parotid intranodal metastasis of Merkel cell carcinoma: a rare case report
    Tong Gao, Dengshun Wang, Hongwei Yu, Yu’e Wang, Haibin Lu
    BMC Oral Health.2025;[Epub]     CrossRef
Case Study
Article image
Rhabdomyosarcoma of the skull with EWSR1 fusion and ALK and cytokeratin expression: a case report
Hyeong Rok An, Kyung-Ja Cho, Sang Woo Song, Ji Eun Park, Joon Seon Song
J Pathol Transl Med. 2024;58(5):255-260.   Published online September 5, 2024
DOI: https://doi.org/10.4132/jptm.2024.08.15
  • 4,223 View
  • 218 Download
  • 1 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Rhabdomyosarcoma (RMS) comprises of heterogeneous group of neoplasms that occasionally express epithelial markers on immunohistochemistry (IHC). We herein report the case of a patient who developed RMS of the skull with EWSR1 fusion and anaplastic lymphoma kinase (ALK) and cytokeratin expression as cytomorphologic features. A 40-year-old man presented with a mass in his forehead. Surgical resection was performed, during which intraoperative frozen specimens were obtained. Squash cytology showed scattered or clustered spindle and epithelioid cells. IHC revealed that the resected tumor cells were positive for desmin, MyoD1, cytokeratin AE1/ AE3, and ALK. Although EWSR1 rearrangement was identified on fluorescence in situ hybridization, ALK, and TFCP2 rearrangement were not noted. Despite providing adjuvant chemoradiation therapy, the patient died of tumor progression 10 months after diagnosis. We emphasize that a subset of RMS can express cytokeratin and show characteristic histomorphology, implying the need for specific molecular examination.

Citations

Citations to this article as recorded by  
  • Rhabdomyosarcomas of Bone
    Ahmed Shah, Andrew L. Folpe
    Surgical Pathology Clinics.2025; 18(3): 503.     CrossRef
  • Review of imaging modalities and radiological findings of calvarial lesions
    Erkan Gökçe, Murat Beyhan
    World Journal of Radiology.2025;[Epub]     CrossRef
  • Molecular Morphology of Telangiectatic Osteosarcoma Associated With Сystic Content: A Case Report
    David Makaridze, Armaz Mariamidze, Tamuna Gvianishvili, Giulia Ottaviani , Liana Gogiashvili
    Cureus.2025;[Epub]     CrossRef
Original Articles
Article image
Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea
Miseon Lee, Uiree Jo, Joon Seon Song, Youn Soo Lee, Chang Gok Woo, Dong-Hoon Kim, Jung Yeon Kim, Sun Och Yoon, Kyung-Ja Cho
J Pathol Transl Med. 2023;57(3):166-177.   Published online May 10, 2023
DOI: https://doi.org/10.4132/jptm.2023.04.12
  • 6,160 View
  • 171 Download
  • 6 Web of Science
  • 5 Crossref
AbstractAbstract PDFSupplementary Material
Background
Research regarding cervical metastasis from an unknown primary tumor (CUP) according to human papillomavirus (HPV) and Epstein-Barr virus (EBV) status in Korea has been sporadic and small-scale. This study aims to analyze and understand the characteristics of CUP in Korea according to viral and p16 and p53 status through a multicenter study.
Methods
Ninety-five cases of CUP retrieved from six hospitals in Korea between January 2006 and December 2016 were subjected to high-risk HPV detection (DNA in situ hybridization [ISH] or real-time polymerase chain reaction), EBV detection (ISH), and immunohistochemistry for p16 and p53.
Results
CUP was HPV-related in 37 cases (38.9%), EBV-related in five cases (5.3%), and unrelated to HPV or EBV in 46 cases (48.4%). HPV-related CUP cases had the best overall survival (OS) (p = .004). According to the multivariate analysis, virus-unrelated disease (p = .023) and longer smoking duration (p < .005) were prognostic factors for poor OS. Cystic change (p = .016) and basaloid pattern (p < .001) were more frequent in HPV-related cases, and lymphoepithelial lesion was frequent in EBV-related cases (p = .010). There was no significant association between viral status and p53 positivity (p = .341), smoking status (p = .728), or smoking duration (p = .187). Korean data differ from Western data in the absence of an association among HPV, p53 positivity, and smoking history.
Conclusions
Virus-unrelated CUP in Korea had the highest frequency among all CUP cases. HPV-related CUP is similar to HPV-mediated oropharyngeal cancer and EBVrelated CUP is similar to nasopharyngeal cancer in terms of characteristics, respectively.

Citations

Citations to this article as recorded by  
  • Differenzierung von benignen und malignen Halszysten – eine diagnostische Herausforderung
    Christina Sauter, Matthias Sand, Karim Plath, Michaela Maria Plath
    Laryngo-Rhino-Otologie.2025; 104(05): 296.     CrossRef
  • Unlocking the Hidden: Advancing Imaging Techniques in Diagnosing Cancers of Unknown Primary in the Head and Neck Region
    Daniela Messineo, Filippo Valentini, Giovanni Francesco Niccolini, Federica Zoccali, Francesca Ripari, Enrico Marotta, Marcello Caratozzolo, Pasquale Frisina
    Applied Sciences.2025; 15(4): 2194.     CrossRef
  • Characterization of undifferentiated carcinoma of the salivary gland: clinicopathological and immunohistochemical analyses in comparison with lymphoepithelial carcinoma
    Sangjoon Choi, Gyuheon Choi, Hee Jin Lee, Joon Seon Song, Yoon Se Lee, Seung-Ho Choi, Kyung-Ja Cho
    Journal of Pathology and Translational Medicine.2025; 59(6): 361.     CrossRef
  • Management of squamous cell carcinoma of unknown primary in the head and neck: current evidence-based diagnostic and treatment strategies
    Marcel Kloppenburg, Matthias Santer, Lukas Schmutzler, Felix Johnson, Benedikt Hofauer, Teresa Steinbichler
    memo - Magazine of European Medical Oncology.2025;[Epub]     CrossRef
  • Expansion of tumor-infiltrating lymphocytes from head and neck squamous cell carcinoma to assess the potential of adoptive cell therapy
    Sangjoon Choi, Mofazzal Hossain, Hyun Lee, Jina Baek, Hye Seon Park, Chae-Lyul Lim, DoYeon Han, Taehyun Park, Jong Hyeok Kim, Gyungyub Gong, Mi-Na Kweon, Hee Jin Lee
    Cancer Immunology, Immunotherapy.2024;[Epub]     CrossRef
Article image
Frequent apocrine changes in pleomorphic adenoma with malignant transformation: a possible pre-malignant step in ductal carcinoma ex pleomorphic adenoma
Joon Seon Song, Yeseul Kim, Yoon-Se Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho
J Pathol Transl Med. 2023;57(3):158-165.   Published online May 10, 2023
DOI: https://doi.org/10.4132/jptm.2023.03.13
  • 6,837 View
  • 192 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Background
The most common type of carcinoma ex pleomorphic adenoma (CPA) is histologically equivalent to salivary duct carcinoma, which has an apocrine phenotype. Invasive CPA is often accompanied by non-invasive or in situ carcinoma, an observation that suggests the presence of precursor lesions. The aim of this study was to identify candidate precursor lesions of CPA within pleomorphic adenoma (PA).
Methods
Eleven resected cases of CPA with residual PA and 17 cases of PA with atypical changes were subjected to immunohistochemistry (IHC) for p53, human epidermal growth factor receptor 2 (HER2), androgen receptor (AR), pleomorphic adenoma gene 1, gross cystic disease fluid protein-15 (GCDFP-15), and anti-mitochondrial antibody.
Results
Invasive or in situ carcinoma cells in all CPAs were positive for AR, GCDFP-15, and HER2. Atypical foci in PAs corresponded to either apocrine or oncocytic changes on the basis of their reactivity to AR, GCDFP-15, and anti-mitochondrial antibody. Atypical cells in PAs surrounding CPAs had an apocrine phenotype without HER2 expression.
Conclusions
Our study identified frequent apocrine changes in residual PAs in CPA cases, suggesting a possible precursor role of apocrine changes. We recommend the use of HER2 IHC in atypical PAs, and that clinicians take HER2 positivity into serious consideration.

Citations

Citations to this article as recorded by  
  • Pleomorphic Adenoma with Epithelial Atypia, Apocrine Metaplasia, and/or In situ/Intracapsular Salivary Duct Carcinoma Are Indolent Lesions with Good Prognosis: A Proposal for Unified Nomenclature and Clinical Observation
    Grayson G. Cole, Matt Levin, David Ferber, Spencer C. Roark, Peter M. Sadow, Daniel Lubin, Julie Guilmette, Jason R. Pettus, Adam S. Fisch, Dipti P. Sajed, Fouad R. Zakka, Mark W. Lingen, Nicole A. Cipriani
    Head and Neck Pathology.2025;[Epub]     CrossRef
  • Progression of Nasopharyngeal Pleomorphic Adenoma to Carcinoma Ex Pleomorphic Adenoma With Metastases: A Case Report
    Krystsina Zhukovich, Alisher Tashbayev, Vladimir Osipov
    Cureus.2025;[Epub]     CrossRef
  • Characterization of a Molecularly Distinct Subset of Oncocytic Pleomorphic Adenomas/Myoepitheliomas Harboring Recurrent ZBTB47-AS1::PLAG1 Gene Fusion
    Ziyad Alsugair, Jimmy Perrot, Françoise Descotes, Jonathan Lopez, Anne Champagnac, Daniel Pissaloux, Claire Castain, Mihaela Onea, Philippe Céruse, Pierre Philouze, Charles Lépine, Marie-Delphine Lanic, Marick Laé, Valérie Costes-Martineau, Nazim Benzerdj
    American Journal of Surgical Pathology.2024; 48(5): 551.     CrossRef
Case Study
Article image
A sinonasal yolk sac tumor in an adult
Jaehoon Shin, Ji Heui Kim, Kyeong Cheon Jung, Kyung-Ja Cho
J Pathol Transl Med. 2022;56(3):152-156.   Published online January 26, 2022
DOI: https://doi.org/10.4132/jptm.2021.12.09
  • 7,512 View
  • 225 Download
  • 4 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Yolk sac tumors (YSTs), which are also called endodermal sinus tumors, are malignant tumors of germ cell origin. These tumors usually occur in the gonads, but 20% of cases have been reported at extragonadal sites. The head and neck is a rarely affected region that accounts for just 1% of all malignant tumors of germ cell origin. In addition, YSTs arise mostly in childhood. We present a rare pathologically pure case of primary adult YST in the sinonasal area. A 45-year-old male patient presented with a rapidly growing mass in the nasal cavity, which caused nasal obstruction and bloody post-nasal drip. The histopathologic features indicated pure YST, and immunohistochemical analysis revealed positive reactivity for Sal-like protein 4 and alpha-fetoprotein. Herein, we discuss the clinical, radiologic, and histologic features of this YST and review other cases of sinonasal YST in adults.

Citations

Citations to this article as recorded by  
  • SMARCB1-deficient Sinonasal Carcinoma
    Neha Mittal, Saurabh Nagar, Asawari Patil, Swapnil Ulhas Rane, Palgun Nisarga, Katha Rabade, Amit Janu, Deepa Nair, Shiva Thiagarajan, Sarbani Ghosh Laskar, Kumar Prabhash, Munita Bal
    American Journal of Surgical Pathology.2025; 49(4): 381.     CrossRef
  • International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors
    Edward C. Kuan, Eric W. Wang, Nithin D. Adappa, Daniel M. Beswick, Nyall R. London, Shirley Y. Su, Marilene B. Wang, Waleed M. Abuzeid, Borislav Alexiev, Jeremiah A. Alt, Paolo Antognoni, Michelle Alonso‐Basanta, Pete S. Batra, Mihir Bhayani, Diana Bell,
    International Forum of Allergy & Rhinology.2024; 14(2): 149.     CrossRef
  • Yolk sac tumor of postpubertal-type does not exhibit immunohistochemical loss of SMARCB1/INI1 and SMARCA4/BRG1…but choriocarcinoma?
    Costantino Ricci, Francesca Ambrosi, Tania Franceschini, Francesca Giunchi, Eugenia Franchini, Francesco Massari, Veronica Mollica, Federico Mineo Bianchi, Maurizio Colecchia, Andres Martin Acosta, Michelangelo Fiorentino
    Pathology - Research and Practice.2023; 241: 154269.     CrossRef
  • Pure yolk sac tumor primarily in the nasal cavity: A case report
    Zijun Liu, Baohong Wen, Yan Zhang
    Asian Journal of Surgery.2023; 46(10): 4712.     CrossRef
  • A case of Yolk sac tumor arising from paranasal sinus
    Kaori Shinomura, Munehito Moriyama, Keigo Fujita, Takashi Hirano, Masashi Suzuki
    JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY.2023; 33(1): 41.     CrossRef
  • A Novel Successful Case of Nasal and Sinus Yolk Sac Tumor With SMARCB1 (INI-1) Deficiency: A Case Report
    Tianyu He, Zhiyu Wang, Hongbo Su, Sihan Li, Zheng He
    Cureus.2022;[Epub]     CrossRef
Original Articles
Article image
Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma
Uiree Jo, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho
J Pathol Transl Med. 2020;54(6):489-496.   Published online August 31, 2020
DOI: https://doi.org/10.4132/jptm.2020.07.19
  • 10,128 View
  • 206 Download
  • 18 Web of Science
  • 18 Crossref
AbstractAbstract PDFSupplementary Material
Background
Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, and distinguishing primary SCC from metastatic SCC is difficult. This study investigated the histological and immunohistochemical differences between primary and metastatic salivary gland SCC to improve the accuracy of diagnosis and to explore the pathogenesis of this disease.
Methods
Data of 16 patients who underwent surgery for SCC of salivary glands between 2000 and 2018 at Asan Medical Center were retrieved. Eight patients had a history of SCC at other sites, and eight patients had only salivary gland SCC. Immunostaining for p16, p53, androgen receptor (AR), gross cystic disease fluid protein 15 (GCDFP-15), and c-erbB2, as well as mucicarmine staining, were compared between the two groups.
Results
Most tumors were located in the center of the salivary glands with extraparenchymal extension. The histology of primary SCC of the salivary gland was consistent with moderately differentiated SCC with extensive desmoplastic reaction and peritumoral inflammation. Involvement of the salivary gland ducts and transition into the ductal epithelium were observed in two cases. Metastatic SCC resembled the primary tumor histologically and was associated with central necrosis. Both groups exhibited negative mucin staining. Two, one, and one primary SCC case exhibited AR, GCDFP-15, and c-erbB2 positivity, respectively.
Conclusions
A subset of primary SCCs originated in salivary ducts or was related to salivary duct carcinoma. Distinguishing primary from metastatic SCC of the salivary gland is difficult using histologic features and immunoprofiles. A comprehensive review of the medical history is essential.

Citations

Citations to this article as recorded by  
  • Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study
    Shubin Dong, Mengru Li, Zhiwei Zhang, Bowei Feng, Wei Ding, Jiang Chang, Feng Liu
    PeerJ.2025; 13: e19626.     CrossRef
  • Characterization of undifferentiated carcinoma of the salivary gland: clinicopathological and immunohistochemical analyses in comparison with lymphoepithelial carcinoma
    Sangjoon Choi, Gyuheon Choi, Hee Jin Lee, Joon Seon Song, Yoon Se Lee, Seung-Ho Choi, Kyung-Ja Cho
    Journal of Pathology and Translational Medicine.2025; 59(6): 361.     CrossRef
  • Primary salivary gland squamous cell carcinoma with sialolithiasis in the submandibular gland: A case report and literature review
    Sawako Ono, Katsutoshi Hirose, Yuji Hirata, Marie Yamada, Satoko Nakamura, Hidetaka Yamamoto
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2024; 36(5): 768.     CrossRef
  • A case of primary squamous cell carcinoma of the parotid gland and review of the literature
    Jingli Zhao, Xinrong Nan, Chuhuan Zhou, Nan Jiang, Liangliang Tian
    Journal of Case Reports and Images in Oncology.2024; 10(1): 7.     CrossRef
  • Metastatic cutaneous squamous cell carcinoma accounts for nearly all squamous cell carcinomas of the parotid gland
    Patrick J. Bradley, Göran Stenman, Lester D. R. Thompson, Alena Skálová, Roderick H. W. Simpson, Pieter J. Slootweg, Alessandro Franchi, Nina Zidar, Alfons Nadal, Henrik Hellquist, Michelle D. Williams, Ilmo Leivo, Abbas Agaimy, Alfio Ferlito
    Virchows Archiv.2024; 485(1): 3.     CrossRef
  • Common skin cancers and their association with other non-cutaneous primary malignancies: a review of the literature
    Lindsay Holic
    Medical Oncology.2024;[Epub]     CrossRef
  • Salivary duct carcinoma with squamous differentiation: histomorphological and immunophenotypical analysis of six cases
    Melad N Dababneh, Christopher C Griffith, Kelly R Magliocca, Ivan J Stojanov
    Histopathology.2024; 85(4): 590.     CrossRef
  • Comprehensive Next Generation Sequencing Reveals that Purported Primary Squamous Cell Carcinomas of the Parotid Gland are Genetically Heterogeneous
    Justin A. Bishop, Masato Nakaguro, Ilan Weinreb, Doreen Palsgrove, Lisa M. Rooper, Travis W. Vandergriff, Brian Carlile, Jeffrey A. Sorelle, Jeffrey Gagan, Toshitaka Nagao
    Head and Neck Pathology.2024;[Epub]     CrossRef
  • Salivary gland fine needle aspiration: a focus on diagnostic challenges and tips for achieving an accurate diagnosis
    Carla Saoud, Hansen Lam, Sandra I. Sanchez, Zahra Maleki
    Diagnostic Histopathology.2023; 29(8): 357.     CrossRef
  • Salivary gland pathologies: evolution in classification and association with unique genetic alterations
    Michał Żurek, Łukasz Fus, Kazimierz Niemczyk, Anna Rzepakowska
    European Archives of Oto-Rhino-Laryngology.2023; 280(11): 4739.     CrossRef
  • A retrospective study of nonneoplastic and neoplastic disorders of the salivary glands
    Sorin Vamesu, Oana Andreea Ursica, Ana Maria Gurita, Raluca Ioana Voda, Mariana Deacu, Mariana Aschie, Madalina Bosoteanu, Georgeta Camelia Cozaru, Anca Florentina Mitroi, Cristian Ionut Orasanu
    Medicine.2023; 102(42): e35751.     CrossRef
  • Pembrolizumab as a first line therapy in a patient with extensive mucoepidermoid salivary gland carcinoma. A complete clinical, radiological and pathological response. A very specific case
    Raed Farhat, Noam Asna, Yaniv Avraham, Ashraf Khater, Majd Asakla, Alaa Safia, Sergio Szvalb, Nidal Elkhatib, Shlomo Merchavy
    Discover Oncology.2022;[Epub]     CrossRef
  • Morphologic CT and MRI features of primary parotid squamous cell carcinoma and its predictive factors for differential diagnosis with mucoepidermoid carcinoma
    Xiaohua Ban, Huijun Hu, Yue Li, Lingjie Yang, Yu Wang, Rong Zhang, Chuanmiao Xie, Cuiping Zhou, Xiaohui Duan
    Insights into Imaging.2022;[Epub]     CrossRef
  • A Rare Case of Primary Squamous Cell Carcinoma of the Submandibular Salivary Gland: Brief Overview of Diagnostic Ambiguity and Treatment Challenges
    Pawan Hingnikar, Anendd Jadhav, Nitin D Bhola
    Cureus.2022;[Epub]     CrossRef
  • Necrotizing Sialometaplasia of the Hard Palate: Diagnosis and Treatment
    Sangeun Lee, Yun Sung Lim, Kyuho Lee, Bo Hae Kim
    Journal of Clinical Otolaryngology Head and Neck Surgery.2022; 33(4): 236.     CrossRef
  • Parotid Salivary Duct Carcinoma With a Prominent Squamous Component: Immunohistochemical Profile, Diagnostic Pitfalls, and Therapeutic Implications
    Naomi Hardy, Joshua Thompson, Ranee Mehra, Cinthia B. Drachenberg, Kyle Hatten, John C. Papadimitriou
    International Journal of Surgical Pathology.2021; 29(7): 726.     CrossRef
  • Intrasalivary Thymic Carcinoma: A Case Report and Literature Review
    Michał Kunc, Alexandra Kamieniecki, Grzegorz Walczak, Tomasz Nowicki, Bartosz Wasąg, Bogusław Mikaszewski, Dominik Stodulski, Wojciech Biernat
    Head and Neck Pathology.2021; 16(3): 857.     CrossRef
  • Cancer Stem Cell Markers in Squamous Cell Carcinomas of the Salivary Glands
    Mattis Bertlich, Julia Kitz, Marie Kruizenga, Jennifer Lee Spiegel, Martin Canis, Friedrich Ihler, Frank Haubner, Bernhard G. Weiss, Mark Jakob
    Oncology.2021; 99(6): 402.     CrossRef
Article image
Sarcoma metastasis to the pancreas: experience at a single institution
Miseon Lee, Joon Seon Song, Seung-Mo Hong, Se Jin Jang, Jihun Kim, Ki Byung Song, Jae Hoon Lee, Kyung-Ja Cho
J Pathol Transl Med. 2020;54(3):220-227.   Published online April 22, 2020
DOI: https://doi.org/10.4132/jptm.2020.03.04
  • 8,672 View
  • 167 Download
  • 12 Web of Science
  • 13 Crossref
AbstractAbstract PDF
Background
Reports of metastatic sarcoma to the pancreas are limited. We reviewed the clinicopathologic characteristics of such cases.
Methods
We reviewed 124 cases of metastatic tumors to the pancreas diagnosed at Asan Medical Center between 2000 and 2017.
Results
Metastatic tumors to the pancreas consisted of 111 carcinomas (89.5%), 12 sarcomas (9.6%), and one melanoma (0.8%). Primary sarcoma sites were bone (n = 4); brain, lung, and soft tissue (n = 2 for each); and the uterus and pulmonary vein (n = 1 for each). Pathologically, the 12 sarcomas comprised 2 World Health Organization grade III solitary fibrous tumors/hemangiopericytomas, and one case each of synovial sarcoma, malignant solitary fibrous tumor, undifferentiated pleomorphic sarcoma, osteosarcoma, mesenchymal chondrosarcoma, intimal sarcoma, myxofibrosarcoma, myxoid liposarcoma, rhabdomyosarcoma, subtype uncertain, and high-grade spindle-cell sarcoma of uncertain type. The median interval between primary cancer diagnosis and pancreatic metastasis was 28.5 months. One case manifested as a solitary pancreatic osteosarcoma metastasis 15 months prior to detection of osteosarcoma in the femur and was initially misdiagnosed as sarcomatoid carcinoma of the pancreas.
Conclusions
The metastatic sarcoma should remain a differential diagnosis when spindle-cell malignancy is found in the pancreas, even for solitary lesions or in patients without prior history.

Citations

Citations to this article as recorded by  
  • Metastatic synovial sarcoma masquerading as primary neuroendocrine tumor of pancreas: a diagnostic conundrum
    Sherrin Jacob, Balamurugan Thirunavukkarasu, Rajni Yadav, Anany Gupta, Samagra Agarwal, Shamim A. Shamim, Sameer Rastogi, Adarsh Barwad, Deepali Jain
    Clinical Journal of Gastroenterology.2025; 18(3): 499.     CrossRef
  • Metastatic tumors to the pancreas: An institutional experience
    Matthew Romanish, Rana Naous
    Annals of Diagnostic Pathology.2025; 79: 152528.     CrossRef
  • Visceral Metastases of Osteosarcoma in the Hepatopancreatobiliary System
    Anna Hohensteiner, Lars Kowalscheck, Kevin Döring, Gerhard Martin Hobusch, Raphael Johannes Tanios, Oliver Strobel, Reinhard Windhager, Philipp Theodor Funovics
    Journal of Clinical Medicine.2025; 14(24): 8702.     CrossRef
  • Metastatic clear cell sarcoma of the pancreas: A sporadic cancer
    Vittorio Gebbia, Carlo Carnaghi
    World Journal of Clinical Cases.2024; 12(18): 3291.     CrossRef
  • Metastatic clear cell sarcoma of the pancreas: An overview
    Rachid Ait Addi
    World Journal of Clinical Cases.2024; 12(29): 6262.     CrossRef
  • Myxofibrosarcoma with pancreatic metastasis, a case report and literature reviews
    Kodai ABE, Yasutomo SEKIDO, Yasuo KABESHIMA
    Suizo.2024; 39(5): 334.     CrossRef
  • Metástasis pancreática de sarcoma, un hallazgo infrecuente
    Daniel Aparicio-López, Jorge Chóliz-Ezquerro, Carlos Hörndler-Algárate, Mario Serradilla-Martín
    Gastroenterología y Hepatología.2023; 46(5): 376.     CrossRef
  • Pancreatic metastasis from sarcoma, an infrequent finding
    Daniel Aparicio-López, Jorge Chóliz-Ezquerro, Carlos Hörndler-Algárate, Mario Serradilla-Martín
    Gastroenterología y Hepatología (English Edition).2023; 46(5): 376.     CrossRef
  • Acute pancreatitis secondary to osteosarcoma metastasis
    Pablo Salmón Olavarría, Ana Gordo Ortega, Maren Eizagirre Ubegun, Verónica Ubieto Capella, Elena Carracedo Vega, Juan Carrascosa Gil, David Ruiz-Clavijo García
    Revista Española de Enfermedades Digestivas.2023;[Epub]     CrossRef
  • First Recurrence of Synovial Sarcoma Presenting With Solitary Pancreatic Mass
    Raja R Narayan, Greg W Charville, Daniel Delitto, Kristen N Ganjoo
    Cureus.2022;[Epub]     CrossRef
  • Intravenous Leiomyosarcoma of the Lower Extremity: As Peripheral as It Gets
    Levent F Umur, Selami Cakmak, Mehmet Isyar, Hamdi Tokoz
    Cureus.2021;[Epub]     CrossRef
  • Could the burden of pancreatic cancer originate in childhood?
    Smaranda Diaconescu, Georgiana Emmanuela Gîlcă-Blanariu, Silvia Poamaneagra, Otilia Marginean, Gabriela Paduraru, Gabriela Stefanescu
    World Journal of Gastroenterology.2021; 27(32): 5322.     CrossRef
  • Staged Surgical Resection of Primary Pulmonary Synovial Sarcoma with Synchronous Multiple Pancreatic Metastases: Report of a Rare Case and Review of the Literature
    Panagiotis Dorovinis, Nikolaos Machairas, Stylianos Kykalos, Paraskevas Stamopoulos, George Agrogiannis, Nikolaos Nikiteas, Georgios C. Sotiropoulos
    Journal of Gastrointestinal Cancer.2021; 52(3): 1151.     CrossRef
Article image
Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients
Gyuheon Choi, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jong-Lyel Roh, Bu-Kyu Lee, Kyung-Ja Cho
J Pathol Transl Med. 2019;53(6):369-377.   Published online October 11, 2019
DOI: https://doi.org/10.4132/jptm.2019.09.16
  • 8,284 View
  • 192 Download
  • 8 Web of Science
  • 12 Crossref
AbstractAbstract PDFSupplementary Material
Background
The worldwide incidence of squamous cell carcinoma of the tongue (SCCOT) in young patients has been increasing. We investigated clinicopathologic features of this unique population and compared them with those of SCCOT in the elderly to delineate its pathogenesis.
Methods
We compared clinicopathological parameters between patients under and over 45 years old. Immunohistochemical assays of estrogen receptor, progesterone receptor, androgen receptor, p53, p16, mdm2, cyclin D1, and glutathione S-transferase P1 were also compared between them.
Results
Among 189 cases, 51 patients (27.0%) were under 45 years of age. A higher proportion of women was seen in the young group, but was not statistically significant. Smoking and drinking behaviors between age groups were similar. Histopathological and immunohistochemical analysis showed no significant difference by age and sex other than higher histologic grades observed in young patients.
Conclusions
SCCOT in young adults has similar clinicopathological features to that in the elderly, suggesting that both progress via similar pathogenetic pathways.

Citations

Citations to this article as recorded by  
  • Oral Tongue Squamous Cell Carcinoma in Young Adults in Brazil: Temporal Trends From 2013 to 2023
    Natália Santos Barcelos, Yohana Cordeiro de Miranda Magno, Juliana Maria Braga Sclauser, Renata de Castro Martins, Rodnei Alves Marques, Maria Cássia Ferreira de Aguiar, Patrícia Carlos Caldeira
    Oral Diseases.2026;[Epub]     CrossRef
  • Oral Cavity Squamous Cell Carcinoma in Young Patients: A Multi-Institutional Study of the Canadian Head & Neck Collaborative Research Initiative
    Xinyuan Hong, Alexandra E. Quimby, Dorsa Mavedatnia, A. Travis Pickett, Martin Corsten, Tinghua Zhang, Angelina Tohme, Stephanie Johnson-Obaseki, Carlos Khalil, Mark Khoury, Antoine Eskander, Hesameddin Noroozi, David Goldstein, John De Almeida, James Fow
    Journal of Otolaryngology - Head & Neck Surgery.2025;[Epub]     CrossRef
  • Epidemiological trends and characteristics of oral tongue cancer in females: systematic review and meta-analysis
    J. Hu, N. Kaunein, A. DeAngelis
    International Journal of Oral and Maxillofacial Surgery.2025;[Epub]     CrossRef
  • High Failure Rates in Young Nonsmoker Nondrinkers With Squamous Cell Carcinoma of the Oral Tongue
    Brianna M. Jones, Dillan F. Villavisanis, Eric J. Lehrer, Daniel R. Dickstein, Kunal K. Sindhu, Krzysztof J. Misiukiewicz, Marshall Posner, Jerry T. Liu, Vishal Gupta, Sonam Sharma, Scott A. Roof, Marita Teng, Eric M. Genden, Richard L. Bakst
    The Laryngoscope.2023; 133(5): 1110.     CrossRef
  • Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study
    Hiroyuki Harada, Masahiro Kikuchi, Ryo Asato, Kiyomi Hamaguchi, Hisanobu Tamaki, Masanobu Mizuta, Ryusuke Hori, Tsuyoshi Kojima, Keigo Honda, Takashi Tsujimura, Yohei Kumabe, Kazuyuki Ichimaru, Yoshiharu Kitani, Koji Ushiro, Morimasa Kitamura, Shogo Shino
    Head & Neck.2023; 45(7): 1812.     CrossRef
  • Genetic characteristics of advanced oral tongue squamous cell carcinoma in young patients
    Sehui Kim, Chung Lee, Hyangmi Kim, Sun Och Yoon
    Oral Oncology.2023; 144: 106466.     CrossRef
  • Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World
    Rafael Ferreira e Costa, Marina Luiza Baião Leão, Maria Sissa Pereira Sant’Ana, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Alan Roger Santos-Silva, Syed Ali Khurram, Artysha Tailor, Ciska-Mari Schouwstra, Liam Robinson, Willie F. P. van Heerden, Rami
    Head and Neck Pathology.2022; 16(3): 755.     CrossRef
  • Early-onset oral cancer as a clinical entity: aetiology and pathogenesis
    E.S. Kolegova, M.R. Patysheva, I.V. Larionova, I.K. Fedorova, D.E. Kulbakin, E.L. Choinzonov, E.V. Denisov
    International Journal of Oral and Maxillofacial Surgery.2022; 51(12): 1497.     CrossRef
  • The effect of age on the clinicopathological features of oral squamous cell carcinoma
    Alaa S Saeed, Bashar H Abdullah
    Journal of Baghdad College of Dentistry.2022; 34(1): 25.     CrossRef
  • Survival Outcomes in Oral Tongue Cancer: A Mono-Institutional Experience Focusing on Age
    Mohssen Ansarin, Rita De Berardinis, Federica Corso, Gioacchino Giugliano, Roberto Bruschini, Luigi De Benedetto, Stefano Zorzi, Fausto Maffini, Fabio Sovardi, Carolina Pigni, Donatella Scaglione, Daniela Alterio, Maria Cossu Rocca, Susanna Chiocca, Sara
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • A Meta-analysis of Oral Squamous Cell Carcinoma in Young Adults with a Comparison to the Older Group Patients (2014–2019)
    Khadijah Mohideen, C. Krithika, Nadeem Jeddy, Thayumanavan Balakrishnan, R. Bharathi, S. Leena Sankari
    Contemporary Clinical Dentistry.2021; 12(3): 213.     CrossRef
  • Modern perspectives of oral squamous cell carcinoma
    A.A. Ivina
    Arkhiv patologii.2020; 82(3): 55.     CrossRef
Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas
Junyoung Shin, Hee Jeong Kim, Dae-Yeon Kim, Gyungyub Gong, Kyung-Ja Cho
J Pathol Transl Med. 2019;53(5):308-316.   Published online August 2, 2019
DOI: https://doi.org/10.4132/jptm.2019.07.22
  • 7,426 View
  • 139 Download
  • 5 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Background
Primary breast sarcoma (PBS) is rare, comprising approximately 1% of breast malignancies. Rhabdomyosarcoma (RMS) accounts for an extremely small proportion of PBSs, often leading to delayed histologic confirmation.
Methods
Upon reviewing Asan Medical Center’s pathology database between 2000 and 2018, 41 PBS cases were retrieved, including three cases of primary RMS of the breast. Their clinicopathological features were analyzed, and the literature related to PBS and primary RMS of the breast was reviewed.
Results
We identified three primary breast RMS cases from our institution database, comprising 7.3% of PBS: one case each of spindle cell/sclerosing RMS (ssRMS), alveolar RMS (aRMS), and embryonal RMS (eRMS). All cases involved adolescents or young adults (14, 16, and 25 years, respectively) who underwent mastectomy or radiotherapy and were confirmed using immunohistochemical testing for myogenin, desmin, and myogenic differentiation. The ssRMS patient experienced recurrence at the operation site 4 months post-surgery despite undergoing concurrent chemoradiotherapy. The aRMS patient had multiple metastases at diagnosis and showed FAX3-FOXO1 fusion transcripts; she died 22 months after the diagnosis. The eRMS patient had enlarged axillary lymph nodes; post-radiotherapy, the lesion recurred as multiple metastases to the bone and lung. She died 18 months post-diagnosis.
Conclusions
Our experience on RMS cases suggests that spindle cell or small round cell malignancy in breasts of young female should raise suspicion for the possibility of primary or secondary RMS. To our knowledge, this is the second report of primary breast ssRMS and it may help clinicians who encounter this rare disease in the future.

Citations

Citations to this article as recorded by  
  • Management of Pediatric Breast Masses for the Pediatric Surgeon: Expert Consensus Recommendations From the APSA Cancer Committee
    Dana Schwartz, Elisabeth T. Tracy, Bindi Naik-Mathuria, Richard D. Glick, Stephanie F. Polites, Peter Mattei, David Rodeberg, Andres F. Espinoza, Sara A. Mansfield, Dave R. Lal, Meera Kotagal, Timothy Lautz, Jennifer Aldrink, Barrie S. Rich
    Journal of Pediatric Surgery.2025; 60(2): 161916.     CrossRef
  • Differential diagnosis of primary mesenchymal neoplasms of the breast
    Mine Ozsen, Seyit Ali Volkan Polatkan, Ulviye Yalcınkaya, Sahsine Tolunay, Mustafa Sehsuvar Gokgoz
    Clinical and Translational Oncology.2024; 27(1): 223.     CrossRef
  • Primary breast rhabdomyosarcoma in a 17-year-old girl
    Laxmi Singotia, V.S. Haritha
    Journal of Cancer Research and Therapeutics.2023; 19(7): 2070.     CrossRef
  • High-Grade Spindle Cell Lesions of the Breast
    Esther Yoon, Qingqing Ding, Kelly Hunt, Aysegul Sahin
    Surgical Pathology Clinics.2022; 15(1): 77.     CrossRef
  • Primary Small Cell Malignancies of the Breast: Are They Rare Malignancies?
    Kemal Behzatoğlu, Fernando Schmitt
    Acta Cytologica.2022; 66(4): 347.     CrossRef
  • Recurrent malignant phyllodes tumor of the breast: An extremely rare case of recurrence with only rhabdomyosarcoma components
    Jia Han, Shuice Liu, Akihoro Shioya, Motona Kumagai, Emi Morioka, Miki Noguchi, Masafumi Inokuchi, Sohsuke Yamada
    SAGE Open Medical Case Reports.2022;[Epub]     CrossRef
  • Primary rhabdomyosarcoma: An extremely rare and aggressive variant of male breast cancer
    Cătălin Bogdan Satală, Ioan Jung, Tivadar Jr Bara, Patricia Simu, Iunius Simu, Madalina Vlad, Rita Szodorai, Simona Gurzu
    World Journal of Clinical Cases.2020; 8(19): 4466.     CrossRef
Case Study
WITHDRAWN:Primary Rhabdomyosarcoma of the Breast: A Report of Two Cases and Literature Review
Junyoung Shin, Hee Jeong Kim, Dae-Yeon Kim, Gyungyub Gong, Kyung-Ja Cho
Received August 6, 2018  Accepted September 13, 2018  Published online October 4, 2018  
DOI: https://doi.org/10.4132/jptm.2018.09.14
  • 4,109 View
  • 62 Download
  • 1 Crossref

Citations

Citations to this article as recorded by  
  • Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case
    Helen J. Trihia, Natasa Novkovic, Ioannis Provatas, Anastasios Mavrogiorgis, Evangelos Lianos
    Case Reports in Pathology.2019; 2019: 1.     CrossRef
Original Article
Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus
Kyung-Ja Cho, Se Un Jeong, Sung Bae Kim, Sang-wook Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
J Pathol Transl Med. 2017;51(4):374-380.   Published online June 8, 2017
DOI: https://doi.org/10.4132/jptm.2017.03.03
  • 21,338 View
  • 483 Download
  • 11 Web of Science
  • 12 Crossref
AbstractAbstract PDF
Background
Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has been suggested to originate from a totipotent primitive cell in the basal cell layer of the surface epithelium or in the proximal duct of secretory glands.
Methods
Twenty-six cases of head and neck BSCC from Asan Medical Center, Seoul, Korea, reported during a 14-year-period were subclassified into basal, ductal, and mixed subtypes according to the expression of basal (cytokeratin [CK] 5/6, p63) or ductal markers (CK7, CK8/18). The cases were also subject to immunohistochemical study for CK19, p53, cyclin D1, epidermal growth factor receptor (EGFR), and p16 and to in situ hybridization for human papillomavirus (HPV), and the results were clinico-pathologically compared.
Results
Mixed subtype (12 cases) was the most common, and these cases showed hypopharyngeal predilection, older age, and higher expression of CK19, p53, and EGFR than other subtypes. The basal subtype (nine cases) showed frequent comedo-necrosis and high expression of cyclin D1. The ductal subtype (five cases) showed the lowest expression of p53, cyclin D1, and EGFR. A small number of p16- and/or HPV-positive cases were not restricted to one subtype. BSCC was the cause of death in 19 patients, and the average follow-up period for all patients was 79.5 months. Overall survival among the three subtypes was not significantly different.
Conclusions
The results of this study suggest a heterogeneous pathogenesis of head and neck BSCC. Each subtype showed variable histology and immunoprofiles, although the clinical implication of heterogeneity was not determined in this study.

Citations

Citations to this article as recorded by  
  • Histopathological variants of head and neck squamous cell carcinomas: A multicenter study in Latin America
    Heitor Albergoni Silveira, Karina Helen Martins, Ana Lia Anbinder, Thais Aguiar Santos, Elton Fernandes Barros, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka, Ana Terezinha Marques Mesquita, Matheus Henrique Lopes Dominguete, Rafael Rodrigues Dia
    Annals of Diagnostic Pathology.2026; 80: 152565.     CrossRef
  • HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management
    Matt Lechner, Jacklyn Liu, Liam Masterson, Tim R. Fenton
    Nature Reviews Clinical Oncology.2022; 19(5): 306.     CrossRef
  • Neoadjuvant treatment combined with planned endoscopic surgery in locally advanced sphenoid sinus basaloid squamous cell carcinoma
    Yinghong Zhang, Suqing Tian, Yali Du, Qiang Zuo, Li Zhu, Furong Ma
    Medicine: Case Reports and Study Protocols.2022; 3(6): e0044.     CrossRef
  • Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus
    Satoshi Koyama, Kazunori Fujiwara, Tsuyoshi Morisaki, Taihei Fujii, Yosuke Nakamura, Takahiro Fukuhara, Hiromi Takeuchi
    Auris Nasus Larynx.2021; 48(6): 1189.     CrossRef
  • Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling
    Marina Grachtchouk, Jianhong Liu, Mark E Hutchin, Paul W Harms, Dafydd Thomas, Lebing Wei, Aiqin Wang, Donelle Cummings, Lori Lowe, Jonathan Garlick, James Sciubba, Arul M Chinnaiyan, Monique E Verhaegen, Andrzej A Dlugosz
    Carcinogenesis.2021; 42(8): 1100.     CrossRef
  • Conjunctival ‘mucoepidermoid carcinoma’ revisited: a revision of terminology, based on morphologic, immunohistochemical and molecular findings of 14 cases, and the 2018 WHO Classification of Tumours of the Eye
    Hardeep S. Mudhar, Tatyana Milman, Paul J.L. Zhang, Carol L. Shields, Ralph C. Eagle, Sara E. Lally, Jerry A. Shields, Sachin M. Salvi, Paul A. Rundle, Jennifer Tan, Ian G. Rennie
    Modern Pathology.2020; 33(7): 1242.     CrossRef
  • Basaloid squamous cell carcinoma with adenoid cystic‐like features of the head and neck region: A report of two cases
    Kimihide Kusafuka, Haruna Yagi, Satoshi Baba, Hiroshi Inagaki, Chinatsu Tsuchiya, Kazuki Hirata, Aya Muramatsu, Makoto Suzuki, Kazumori Arai, Tadashi Terada
    Pathology International.2020; 70(10): 767.     CrossRef
  • Association study of cell cycle proteins and human papillomavirus in laryngeal cancer in Chinese population
    Lifang Cui, Congling Qu, Honggang Liu
    Clinical Otolaryngology.2019; 44(3): 323.     CrossRef
  • Liver metastatic basaloid squamous cell carcinoma with negative expression of pancytokeratin: a case report and literature review
    Linxiu Liu, Xuemin Xue, Liyan Xue
    Diagnostic Pathology.2019;[Epub]     CrossRef
  • Basaloid Squamous Cell Carcinoma at the Floor of the Mouth and Mandible: A Case Report
    Jun-Sang Lee, Uk-Kyu Kim, Dae-Seok Hwang, Jun-Ho Lee, Hong-Seok Choi, Na-Rae Choi, Mi Heon Ryu, Gyoo Cheon Kim
    The Korean Journal of Oral and Maxillofacial Pathology.2019; 43(5): 197.     CrossRef
  • p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma
    Allisson Filipe Lopes Martins, Carlos Henrique Pereira, Marília Oliveira Morais, Paulo Otávio Carmo Souza, Lucas Borges Fleury Fernandes, Aline Carvalho Batista, Elismauro Francisco Mendonça
    Oral Cancer.2018; 2(1-2): 7.     CrossRef
  • Expression and role of EGFR, cyclin�D1 and KRAS in laryngocarcinoma tissues
    Xinsheng Lin, Guofeng Wen, Shuangle Wang, Hangui Lu, Chuangwei Li, Xin Wang
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
Case Studies
Malignant Solitary Fibrous Tumor with Heterologous Rhabdomyosarcomatous Differentiation: A Case Report
Jeong-Hwa Kwon, Joon Seon Song, Hye Won Jung, Jong-Seok Lee, Kyung-Ja Cho
J Pathol Transl Med. 2017;51(2):171-175.   Published online February 3, 2017
DOI: https://doi.org/10.4132/jptm.2016.08.29
  • 9,601 View
  • 117 Download
  • 4 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Malignant solitary fibrous tumor (MSFT) is a well-described entity, from which heterologous differentiation is extremely rare. We encountered a case of MSFT with rhabdomyosarcomatous differentiation in a 56-year-old man. This patient presented with a large mass in his posterior thigh. He had been treated with chemoradiation for sarcoma involving the cervical spine, right femoral head, and both lungs 6 months earlier. A wide excision was performed. The mass measured 10.6 cm and showed a fish-flesh cut surface with necrotic foci. Microscopically, the tumor showed heterogeneous cellularity with a hemangiopericytic vascular pattern. A hypercellular area showed spindle cells or epithelioid cells with high mitotic activity (63/10 high-power fields) and immunoreactivity for CD34 and CD99. A hypocellular area and a cystic area showed pleomorphic rhabdoid cells with immunoreactivity for desmin and myogenin. This is a report of a rare case of MSFT with rhabdomyosarcomatous differentiation and presents new histologic features of MSFT.

Citations

Citations to this article as recorded by  
  • A Rare Case of Malignant Solitary Fibrous Tumor on the Scalp
    Kwang-Ryeol Kim, Ki Hong Kim
    Keimyung Medical Journal.2023; 42(2): 107.     CrossRef
  • Malignant solitary fibrous tumor of maxilla presenting as proptosis: A case report
    Pravin Kumar, Arpita Jindal, Bhushan Bhalgat, Phanindra Kumar Swain, Raj Govind Sharma
    Journal of Cancer Research and Therapeutics.2023; 19(Suppl 2): S991.     CrossRef
  • Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review
    Ahmed Rabie, Abdulkarim Hasan, Yasein Mohammed, Ayman Abdelmaksoud, Ali A. Rabaan
    Journal of Pathology and Translational Medicine.2022; 56(2): 103.     CrossRef
  • Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
    Myunghee Kang, Na Rae Kim, Dong Hae Chung, Gie-Taek Yie
    Journal of Pathology and Translational Medicine.2019; 53(3): 192.     CrossRef
Mammary-Type Myofibroblastoma: A Report of Two Cases
Soyeon An, Joon Seon Song, Soonchan Park, Jung Won Lee, Kyung-Ja Cho
J Pathol Transl Med. 2016;50(5):385-389.   Published online June 6, 2016
DOI: https://doi.org/10.4132/jptm.2016.03.26
  • 12,725 View
  • 151 Download
  • 6 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Mammary-type myofibroblastoma (MFB) is a rare, benign spindle cell neoplasm occurring along the milkline, with extension from the mid-axilla to the medial groin. It is histologically and immunohistochemically identical to MFB of the breast and is part of a spectrum of lesions that includes spindle cell lipoma and cellular angiofibroma. Recently, we experienced two cases of mammary-type MFB involving male patients aged 30 and 58 years, respectively. The tumors were located in the right scrotal sac and in the right axilla. Wide excisions were performed. Microscopically, the masses were composed of haphazardly arranged, variably sized fascicles of bland spindle cells and were admixed with mature fat tissue. The spindle cells in both cases showed immunopositivity for desmin and CD34 and negativity for smooth muscle actin. Loss of retinoblastoma (RB)/13q14 loci is a characteristic genetic alteration of mammary-type MFB, and we identified loss of RB protein expression by immunohistochemical staining. We emphasize the importance of awareness of this rare neoplasm when a spindle cell neoplasm is accompanied by desmin immunopositivity. The second patient was alive without recurrence for 20 months, and the first patient had not been followed.

Citations

Citations to this article as recorded by  
  • “Low-fat” intradermal spindle cell lipoma of the upper eyelid: a case report
    Mary Kate Wilson, Elizabeth Goldberg, Aldo Fantin, Gulsun Erdag
    Digital Journal of Ophthalmology.2024;[Epub]     CrossRef
  • Myofibroblastoma in the Liver: A Case Report and Review of Literature
    Mohan Narasimhamurthy, Deepika Savant, Lauren Shreve, Mark A. Rosen, Major Kenneth Lee, Kumarasen Cooper, Emma E. Furth, Paul J. Zhang, Zhaohai Yang
    International Journal of Surgical Pathology.2023; 31(8): 1559.     CrossRef
  • Mammary-type myofibroblastoma of the thigh mimicking liposarcoma
    Natasha Akhlaq, Bibianna Purgina, Joel Werier, Zaid Jibri
    Skeletal Radiology.2022; 51(2): 441.     CrossRef
  • Mammary‐type myofibroblastoma of the perineum: Typical or rare location?
    Akihiro Naito, Yuta Takeshima, Sayuri Takahashi
    IJU Case Reports.2022; 5(3): 161.     CrossRef
  • Identifying the uncommon solitary fibrous tumour in a rare location – A case report
    Shanthi Periasamy, Anita Mani, Graham J. Stewart, Jacob P. Hampton
    International Journal of Surgery Case Reports.2022; 94: 107058.     CrossRef
  • Mammary-Type Myofibroblastoma of Perineal Region: A Case Report and Literature Review
    晓虹 江
    Advances in Clinical Medicine.2021; 11(04): 1722.     CrossRef
  • A case of mammary-type myofibroblastoma of the inguinal region
    Atsushi Ishihara, Takeo Yasuda, Yukari Sakae, Masayuki Sakae, Tooru Hamada, Hideki Tsukazaki, Takashi Tsukazaki, Masaru Furumoto
    International Journal of Surgery Case Reports.2018; 53: 464.     CrossRef
  • Radiologic presentation of a myofibroblastoma of the adult male breast
    Evan Rochlis, Pauline Germaine
    Radiology Case Reports.2017; 12(3): 439.     CrossRef
  • Imaging features of mammary-type myofibroblastoma of soft tissue: a case series with literature review
    Gokhan Kuyumcu, Brian P. Rubin, Carl Winalski
    Skeletal Radiology.2017; 46(9): 1283.     CrossRef
  • Mammary-type myofibroblastoma of the psoas
    Kamran Khan, Arun A Mavanur
    BMJ Case Reports.2016; 2016: bcr2016217862.     CrossRef
Original Article
Accuracy of Core Needle Biopsy Versus Fine Needle Aspiration Cytology for Diagnosing Salivary Gland Tumors
In Hye Song, Joon Seon Song, Chang Ohk Sung, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jeong Hyun Lee, Jung Hwan Baek, Kyung-Ja Cho
J Pathol Transl Med. 2015;49(2):136-143.   Published online March 12, 2015
DOI: https://doi.org/10.4132/jptm.2015.01.03
  • 17,400 View
  • 238 Download
  • 79 Web of Science
  • 82 Crossref
AbstractAbstract PDF
Background
Core needle biopsy is a relatively new technique used to diagnose salivary gland lesions, and its role in comparison with fine needle aspiration cytology needs to be refined. Methods: We compared the results of 228 ultrasound-guided core needle biopsy and 371 fine needle aspiration procedures performed on major salivary gland tumors with their postoperative histological diagnoses. Results: Core needle biopsy resulted in significantly higher sensitivity and more accurate tumor subtyping, especially for malignant tumors, than fine needle aspiration. No patient developed major complications after core needle biopsy. Conclusions: We recommend ultrasoundguided core needle biopsy as the primary diagnostic tool for the preoperative evaluation of patients with salivary gland lesions, especially when malignancy is suspected.

Citations

Citations to this article as recorded by  
  • Fine-needle aspiration or core needle biopsy? A meta-analysis of diagnostic accuracy and procedural outcomes in salivary gland tumors
    Kenan Kassem, Alaa Safia, Uday Abd Elhadi, Shlomo Merchavy
    European Journal of Radiology.2026; 194: 112532.     CrossRef
  • Controversial issues in core needle biopsy for diagnosing parotid neoplasms
    N. V. Vishneva, P. A. Demenchuk, O. Yu. Petropavlovskaya, E. I. Selifanova, A. N. Lanina, N. V. Kalakutsky, A. I. Yaremenko
    Parodontologiya.2026;[Epub]     CrossRef
  • Frozen Section Analysis in Submandibular Gland Tumors: Optimizing Intraoperative Decision-Making
    Amir Bolooki, Felix Johnson, Anna Stenzl, Zhaojun Zhu, Benedikt Gabriel Hofauer
    Cancers.2025; 17(5): 895.     CrossRef
  • The Myriad Spectrum of Salivary Gland Lesions: Cytohistological Correlation on Fine Needle Aspiration Cytology, Core Needle Biopsy, and Resections in a 5‐Year Single Institutional Experience of North India
    Zachariah Chowdhury, Pallavi Majumdar, Sumeet Narain, Komal Lamba
    Diagnostic Cytopathology.2025; 53(8): 391.     CrossRef
  • Salivary Duct Carcinoma: A 12-Year Single Center Experience
    Hyowon Ahn, Dongbin Ahn, Ji Hye Kwak
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2025; 68(6): 232.     CrossRef
  • Cytological Spectrum of Salivary Gland Lesions Using the Milan System and their Histopathological Correlation: Retrospective Study in a Peripheral Medical College of Eastern India
    Ujjwal Bandyopadhyay, Sarmila Guha Banerjee, Sirshak Dutta
    Indian Journal of Otolaryngology and Head & Neck Surgery.2025; 77(11): 4887.     CrossRef
  • Parotid Secretory Carcinoma: A Distinct Entity from Acinic Cell Carcinoma
    Muhammad Adzha Musa, Muhamad Arif Ahmad Radzi, Moharzudi Mohamed, Ikram Hakim
    Indian Journal of Otolaryngology and Head & Neck Surgery.2025;[Epub]     CrossRef
  • Diagnostic performance of ultrasound guided salivary gland core needle biopsy and fine needle aspiration in children
    Vicente Oliveira, Anthea Lafrenière, Nikolaus Wolter, Joao Amaral, Alessandro Gasparetto, Dimitri Parra Rojas
    Pediatric Radiology.2025;[Epub]     CrossRef
  • Giant Pleomorphic Adenoma of Submandibular Gland
    Harendra Kumar, Qazi Saquib Rizwan, Mayank Gupta, Tarun Kumar
    Indian Journal of Otolaryngology and Head & Neck Surgery.2024; 76(1): 1361.     CrossRef
  • CT-guided core needle biopsies of head and neck tumors: a comprehensive monocenter analysis of safety and outcomes
    Thomas Joseph Vogl, Heinrich Johannes Ketelsen, Scherwin Mahmoudi, Jan-Erik Scholtz, Vitali Koch, Leon David Grünewald, Peter Wild, Timo Stoever, Simon Bernatz
    European Radiology.2024; 34(8): 5370.     CrossRef
  • Indications for Submandibulectomy Within a 20-Year Period
    Amir Bolooki, Anna Stenzl, Christopher Weusthof, Benedikt Hofauer
    Ear, Nose & Throat Journal.2024;[Epub]     CrossRef
  • Treatment of Warthin’s Tumors of the Parotid Gland With Radiofrequency Ablation: A Systematic Review of the Current Literature
    Kenny Do, Eric Kawana, Sisi Tian, Jo-Lawrence Bigcas
    Ear, Nose & Throat Journal.2024;[Epub]     CrossRef
  • Evaluation of the anterior processes of the parotid gland: an ultrasonographic study
    Tarık Ali Uğur, Hümeyra Tercanlı
    Surgical and Radiologic Anatomy.2024; 46(6): 915.     CrossRef
  • Salivary Gland Fine-Needle Aspiration
    Federica Policardo, Antonino Mule’, Esther Diana Rossi
    Surgical Pathology Clinics.2024; 17(3): 347.     CrossRef
  • Implementation of the Milan System for Reporting Salivary Gland Cytology: A Two-Year Outcome Cytopathology Data of a Tertiary Care Center
    Soudamini Mahapatra, Chinmaya Sundar Ray, Aparajita Mishra, Dileswari Pradhan
    Cureus.2024;[Epub]     CrossRef
  • Preoperative cytopathological investigatory aids in the diagnosis of salivary gland lesions
    S Vidyalakshmi, K Shanmugasamy
    Journal of Oral and Maxillofacial Pathology.2024; 28(2): 172.     CrossRef
  • Machine Learning on Ultrasound Texture Analysis Data for Characterizing of Salivary Glandular Tumors: A Feasibility Study
    Li-Jen Liao, Ping-Chia Cheng, Feng-Tsan Chan
    Diagnostics.2024; 14(16): 1761.     CrossRef
  • Association of Membranous Basal Cell Adenoma and Basal Cell Adenocarcinoma With Brooke-Spiegler Syndrome
    Lexi Goehring, Debby Rampisela, Jordan L Pleitz
    Cureus.2024;[Epub]     CrossRef
  • A Retrospective 8‐Year Single Institutional Study in Germany Regarding Diagnosis, Treatment, and Outcome of Malignant Parotid Tumors
    S. Andrianopoulou, L. S. Fiedler, B. M. Lippert, O. C. Bulut, Mohamed Rahouma
    International Journal of Surgical Oncology.2024;[Epub]     CrossRef
  • High Field MRI in Parotid Gland Tumors: A Diagnostic Algorithm
    Chiara Gaudino, Andrea Cassoni, Martina Lucia Pisciotti, Resi Pucci, Chiara Veneroso, Cira Rosaria Tiziana Di Gioia, Francesca De Felice, Patrizia Pantano, Valentino Valentini
    Cancers.2024; 17(1): 71.     CrossRef
  • Nationwide Incidence Trends of Pediatric Parotid Malignancy in Korea and a Retrospective Analysis of Single-Institution Surgical Experience of Parotidectomy
    Hyun Seong Kim, Seo Young Kim, Eun-Jae Chung, Seong Keun Kwon, Soon-Hyun Ahn, Yuh-Seog Jung, Jungirl Seok
    Korean Society of Head and Neck Oncology.2024; 40(2): 7.     CrossRef
  • The Usefulness of Ultrasound-Guided Core Needle Biopsy Compared to Fine Needle Aspiration in Pre-Operative Diagnosis of Cystic-Predominant Parotid Tumors
    Youn Jin Cho, Young Rok Jo, Hyun Jun Hong, Hye Ran Lee
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(8): 532.     CrossRef
  • The Value of Ultrasound-guided Core Needle Biopsy in Differentiating Benign from Malignant Salivary Gland Lesions
    Mohammad Ali Kazemi, Farzaneh Amini, Bita Kargar, Maryam Lotfi, Keyvan Aghazadeh, Hashem Sharifian, Behnaz Moradi, Javid Azadbakht
    Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(2): 266.     CrossRef
  • Schnellschnittdiagnostik bei Tumoren des Trigonum submandibulare
    S. Riemann, A. Knopf
    HNO.2023; 71(3): 164.     CrossRef
  • Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Submandibular Gland: A Case Report
    Georgia Syrnioti, Antonia Syrnioti, Alharith Abdullah, Xuehui Lui, Ernesto Mendoza
    Cureus.2023;[Epub]     CrossRef
  • Intraductal Carcinoma: The Carcinoma In Situ of the Salivary Gland
    Rhema Thomas, Tijjani Umar, Farzad Borumandi
    Journal of Craniofacial Surgery.2023; 34(5): e432.     CrossRef
  • Fine-Needle Aspiration Cytology for Parotid Tumors
    Masataka Taniuchi, Tetsuya Terada, Ryo Kawata
    Life.2022; 12(11): 1897.     CrossRef
  • Utility of the Milan System for Reporting Salivary Gland Cytology, with focus on the incidence and histologic correlates of atypia of undetermined significance (AUS) and salivary gland neoplasm of uncertain malignant potential (SUMP): A 3‐year institution
    Christopher M. Cormier, Shweta Agarwal
    Cancer Cytopathology.2022; 130(4): 303.     CrossRef
  • Percutaneous CT-Guided Core Needle Biopsies of Head and Neck Masses: Review of 184 Cases at a Single Academic Institution, Common and Special Techniques, Diagnostic Yield, and Safety
    R.W. Jordan, D.P. Shlapak, J.C. Benson, F.E. Diehn, D.K. Kim, V.T. Lehman, G.B. Liebo, A.A. Madhavan, J.M. Morris, P.P. Morris, J.T. Verdoorn, C.M. Carr
    American Journal of Neuroradiology.2022; 43(1): 117.     CrossRef
  • Nodular fasciitis of the submandibular gland
    Ting Suen Wong, Richard Wei Chern Gan, Laszlo Karsai, Bun Yin Winson Wong
    BMJ Case Reports.2022; 15(4): e245584.     CrossRef
  • Validation of the Milan system for reporting salivary gland cytopathology: a single institution’s 10-year experience
    Christopher Felicelli, Joseph Reznicek, Yevgen Chornenkyy, Lucy Jager, Daniel Johnson
    Journal of the American Society of Cytopathology.2022; 11(5): 264.     CrossRef
  • Application of the Milan system for reporting salivary gland cytopathology using cell blocks
    Grégoire B. Morand, Raihanah Alsayegh, Alex M. Mlynarek, Marianne Plourde, Tiffany Mach, Marco A. Mascarella, Michael P. Hier, Livia Florianova, Marc P. Pusztaszeri
    Virchows Archiv.2022; 481(4): 575.     CrossRef
  • Comparisons among the Ultrasonography Prediction Model, Real-Time and Shear Wave Elastography in the Evaluation of Major Salivary Gland Tumors
    Ping-Chia Cheng, Wu-Chia Lo, Chih-Ming Chang, Ming-Hsun Wen, Po-Wen Cheng, Li-Jen Liao
    Diagnostics.2022; 12(10): 2488.     CrossRef
  • A Novel Sonographic Scoring Model in the Prediction of Major Salivary Gland Tumors
    Wu‐Chia Lo, Chih‐Ming Chang, Chi‐Te Wang, Po‐Wen Cheng, Li‐Jen Liao
    The Laryngoscope.2021;[Epub]     CrossRef
  • Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi‐institutional study
    Derek B. Allison, Alexander P. Smith, Daniel An, James Adam Miller, Khurram Shafique, Sharon Song, Kartik Viswanathan, Elizabeth Eykman, Rema A. Rao, Austin Wiles, Güliz A. Barkan, Ritu Nayar, Guido Fadda, Celeste N. Powers, Esther Diana Rossi, Momin T. S
    Cancer Cytopathology.2021; 129(1): 43.     CrossRef
  • Magnetic resonance imaging of salivary gland tumours: Key findings for imaging characterisation
    Davide Maraghelli, Michele Pietragalla, Cesare Cordopatri, Cosimo Nardi, Anna Julie Peired, Giandomenico Maggiore, Stefano Colagrande
    European Journal of Radiology.2021; 139: 109716.     CrossRef
  • The Milan System, from Its Introduction to Its Current Adoption in the Diagnosis of Salivary Gland Cytology
    Esther Diana Rossi
    Journal of Molecular Pathology.2021; 2(2): 114.     CrossRef
  • Utility of the Milan system for reporting salivary gland cytopathology during rapid on‐site evaluation (ROSE) of salivary gland aspirates
    Aanchal Kakkar, Mukin Kumar, Priyadarsani Subramanian, Arshad Zubair, Rajeev Kumar, Alok Thakar, Deepali Jain, Sandeep R. Mathur, Venkateswaran K. Iyer
    Cytopathology.2021; 32(6): 779.     CrossRef
  • Contribution of small tissue biopsy and flow cytometry to preoperative cytological categorization of salivary gland fine needle aspirates according to the Milan System: Single center experience on 287 cases
    Tolga Bağlan, Serpil Dizbay Sak, Cevriye Cansız Ersöz, Koray Ceyhan
    Diagnostic Cytopathology.2021; 49(4): 509.     CrossRef
  • Is Milan for kids?: The Milan System for Reporting Salivary Gland Cytology in pediatric patients at an academic children's hospital with cytologic‐histologic correlation
    Swati P. Satturwar, Maren Y. Fuller, Sara E. Monaco
    Cancer Cytopathology.2021; 129(11): 884.     CrossRef
  • Radiographic Interpretation in Oral Medicine and Hospital Dental Practice
    Katherine France, Anwar A.A.Y. AlMuzaini, Mel Mupparapu
    Dental Clinics of North America.2021; 65(3): 509.     CrossRef
  • Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings
    Can Wang, Qiang Yu, Siyi Li, Jingjing Sun, Ling Zhu, Pingzhong Wang
    Dentomaxillofacial Radiology.2021; 50(7): 20200485.     CrossRef
  • Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations
    Aurore Surun, Dominik T. Schneider, Andrea Ferrari, Teresa Stachowicz‐Stencel, Jelena Rascon, Anna Synakiewicz, Abbas Agaimy, Kata Martinova, Denis Kachanov, Jelena Roganovic, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Frédéric Kolb, Juliette Thariat, Anto
    Pediatric Blood & Cancer.2021;[Epub]     CrossRef
  • A Call for Universal Acceptance of the Milan System for Reporting Salivary Gland Cytopathology
    Eric Barbarite, Sidharth V. Puram, Adeeb Derakhshan, Esther D. Rossi, William C. Faquin, Mark A. Varvares
    The Laryngoscope.2020; 130(1): 80.     CrossRef
  • Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins
    Liliya Benchetrit, Sina J. Torabi, Elliot Morse, Saral Mehra, Rahmatullah Rahmati, Heather A. Osborn, Benjamin L. Judson
    The Laryngoscope.2020; 130(6): 1450.     CrossRef
  • α‐Synuclein Real‐Time Quaking‐Induced Conversion in the Submandibular Glands of Parkinson's Disease Patients
    Sireesha Manne, Naveen Kondru, Huajun Jin, Vellareddy Anantharam, Xuemei Huang, Arthi Kanthasamy, Anumantha G. Kanthasamy
    Movement Disorders.2020; 35(2): 268.     CrossRef
  • The Accessory Parotid Gland and its Clinical Significance
    Mateusz A. Rosa, Dominik P. Łazarz, Jakub R. Pękala, Bendik Skinningsrud, Sigurd S. Lauritzen, Bernard Solewski, Przemysław A. Pękala, Jerzy A. Walocha, Krzysztof A. Tomaszewski
    Journal of Craniofacial Surgery.2020; 31(3): 856.     CrossRef
  • Comparison of core needle biopsy and fine‐needle aspiration in diagnosis of ma lignant salivary gland neoplasm: Systematic review and meta‐analysis
    Jungheum Cho, Junghoon Kim, Ji Sung Lee, Choong Guen Chee, Youngjune Kim, Sang Il Choi
    Head & Neck.2020; 42(10): 3041.     CrossRef
  • The Milan system for reporting salivary gland cytopathology: The clinical impact so far. Considerations from theory to practice
    Esther Diana Rossi, William C. Faquin
    Cytopathology.2020; 31(3): 181.     CrossRef
  • The role of core needle biopsy in parotid glands lesions with inconclusive fine needle aspiration
    Farrokh Heidari, Firouzeh Heidari, Benyamin Rahmaty, Neda Jafari, Kayvan Aghazadeh, Saeed Sohrabpour, Ebrahim Karimi
    American Journal of Otolaryngology.2020; 41(6): 102718.     CrossRef
  • Role of Fine Needle Aspiration Cytology in the Diagnosis of Parotid Gland Tumors: Analysis of 193 Cases
    Rahim Dhanani, Haissan Iftikhar, Muhammad Sohail Awan, Nida Zahid, Sehrish Nizar Ali Momin
    International Archives of Otorhinolaryngology.2020; 24(04): e508.     CrossRef
  • Cytohistological correlation of salivary gland tumours with emphasis on Milan system for reporting: A novel step towards internal quality assurance
    Anandraj Vaithy.K, ATM Venkat Raghava, E S Keerthika Sri, K R Umadevi
    IP Archives of Cytology and Histopathology Research.2020; 5(4): 283.     CrossRef
  • Diagnosing Recently Defined and Uncommon Salivary Gland Lesions in Limited Cellularity Specimens: Cytomorphology and Ancillary Studies
    Esther Diana Rossi, Zubair Baloch, William Faquin, Liron Pantanowitz
    AJSP: Reviews and Reports.2020; 25(5): 210.     CrossRef
  • Peripheral T Cell Lymphoma of Parotid Gland: A Diagnostic Challenge
    J. G. Aishwarya, Satish Nair, C. N. Patil, Swarna Shivakumar, N. Shrivalli, Ashish Shah
    Indian Journal of Otolaryngology and Head & Neck Surgery.2019; 71(S1): 533.     CrossRef
  • Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis
    Kenichi Takano, Tsuyoshi Okuni, Keisuke Yamamoto, Ryuta Kamekura, Ryoto Yajima, Motohisa Yamamoto, Hiroki Takahashi, Tetsuo Himi
    Modern Rheumatology.2019; 29(2): 393.     CrossRef
  • Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature
    Sahar J Farahani, Zubair Baloch
    Diagnostic Cytopathology.2019; 47(2): 67.     CrossRef
  • Values of fine‐needle aspiration cytology of parotid gland tumors: A review of 996 cases at a single institution
    Manabu Suzuki, Ryo Kawata, Masaaki Higashino, Shuji Nishikawa, Tetsuya Terada, Shin‐Ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose
    Head & Neck.2019; 41(2): 358.     CrossRef
  • Positive Surgical Margins in Submandibular Malignancies: Facility and Practice Variation
    Liliya Benchetrit, Elliot Morse, Benjamin L. Judson, Saral Mehra
    Otolaryngology–Head and Neck Surgery.2019; 161(4): 620.     CrossRef
  • The growth rate and the positive prediction of needle biopsy of clinically diagnosed Warthin’s tumor
    Jungirl Seok, Woo-Jin Jeong, Soon-Hyun Ahn, Young Ho Jung
    European Archives of Oto-Rhino-Laryngology.2019; 276(7): 2091.     CrossRef
  • The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma
    Jungirl Seok, Se Jin Hyun, Woo-Jin Jeong, Soon-Hyun Ahn, Hyojin Kim, Young Ho Jung
    Ear, Nose & Throat Journal.2019; 98(8): 504.     CrossRef
  • Fine‐needle aspiration cytology and radiological imaging in parotid gland tumours: Our experience in 103 patients
    Clare Perkins, Edward Toll, Philip Reece
    Clinical Otolaryngology.2019; 44(6): 1124.     CrossRef
  • Application of the Milan system of reporting salivary cytopathology – A retrospective cytohistological correlation study
    Ramya Katta, Devi Padmavathi Chaganti
    Journal of Dr. NTR University of Health Sciences.2019; 8(1): 11.     CrossRef
  • Ultrasound‐guided core needle biopsy in salivary glands: A meta‐analysis
    Hee Joon Kim, Jong Seung Kim
    The Laryngoscope.2018; 128(1): 118.     CrossRef
  • Accuracy and effectiveness of ultrasound-guided core-needle biopsy in the diagnosis of focal lesions in the salivary glands
    Jose Luis del Cura, Gloria Coronado, Rosa Zabala, Igone Korta, Ignacio López
    European Radiology.2018; 28(7): 2934.     CrossRef
  • The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): an ASC-IAC–sponsored system for reporting salivary gland fine-needle aspiration
    Esther Diana Rossi, Zubair Baloch, Marc Pusztaszeri, William C. Faquin
    Journal of the American Society of Cytopathology.2018; 7(3): 111.     CrossRef
  • Routine and Advanced Ultrasound of Major Salivary Glands
    Kunwar Suryaveer Singh Bhatia, Yuk-Ling Dai
    Neuroimaging Clinics of North America.2018; 28(2): 273.     CrossRef
  • The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): An ASC-IAC-Sponsored System for Reporting Salivary Gland Fine-Needle Aspiration
    Esther Diana Rossi, Zubair W. Baloch, Marc Pusztaszeri, William C. Faquin
    Acta Cytologica.2018; 62(3): 157.     CrossRef
  • Evaluation and diagnosis of salivary gland neoplasms
    Erica Jackson Mayland, Anna M. Pou
    Operative Techniques in Otolaryngology-Head and Neck Surgery.2018; 29(3): 129.     CrossRef
  • Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
    Lana M. Chahine, Thomas G. Beach, Nicholas Seedorff, Chelsea Caspell-Garcia, Christopher S. Coffey, Michael Brumm, Charles H. Adler, Geidy E. Serrano, Carly Linder, Sherri Mosovsky, Tatiana Foroud, Holly Riss, Dixie Ecklund, John Seibyl, Danna Jennings, V
    Journal of Parkinson’s Disease.2018; 8(4): 517.     CrossRef
  • Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy?
    Peter Zbären, Asterios Triantafyllou, Kenneth O. Devaney, Vincent Vander Poorten, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito
    European Archives of Oto-Rhino-Laryngology.2018; 275(11): 2609.     CrossRef
  • A comparison study of the reporting systems for salivary gland fine needle aspirations: Are they really different?
    Diana Montezuma, Sule Canberk, Ozlem Aydın, Mehmet Polat Dermirhas, André F. Vieira, Süha Goksel, Ümit İnce, Fernando Schmitt
    Diagnostic Cytopathology.2018; 46(10): 859.     CrossRef
  • Pediatric salivary gland carcinomas: Diagnostic and therapeutic management
    Céleste Rebours, Vincent Couloigner, Louise Galmiche, Odile Casiraghi, Cécile Badoual, Sabah Boudjemaa, Anthony Chauvin, Monique Elmaleh, Brice Fresneau, Sylvie Fasola, Erea‐Noël Garabédian, Thierry Van Den Abeele, Daniel Orbach
    The Laryngoscope.2017; 127(1): 140.     CrossRef
  • Agreement between rapid on‐site evaluation and the final cytological diagnosis of salivary gland specimens
    S. Wangsiricharoen, S. Lekawanvijit, S. Rangdaeng
    Cytopathology.2017; 28(4): 321.     CrossRef
  • Mesenchymal neoplasms of the head and neck: a cytopathologic analysis on fine needle aspiration
    James Lee, Samia Kazmi, Christopher J. VandenBussche, Syed Z. Ali
    Journal of the American Society of Cytopathology.2017; 6(3): 105.     CrossRef
  • Clinical Results of Surgical Treatment in Parotid Tumors
    Ahmet Kara
    Journal of Otolaryngology-ENT Research.2017;[Epub]     CrossRef
  • Parotid gland metastases of distant primary tumours: A diagnostic challenge
    Achim M. Franzen, Thomas Günzel, Anja Lieder
    Auris Nasus Larynx.2016; 43(2): 187.     CrossRef
  • Modern Radiology in the Management of Head and Neck Cancer
    G.J.C. Burkill, R.M. Evans, V.V. Raman, S.E.J. Connor
    Clinical Oncology.2016; 28(7): 440.     CrossRef
  • Fine‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
    Paul A. VanderLaan
    Cancer Cytopathology.2016; 124(12): 862.     CrossRef
  • Staging and follow-up of high-grade malignant salivary gland tumours: The role of traditional versus functional imaging approaches – A review
    Nicole Freling, Flavio Crippa, Roberto Maroldi
    Oral Oncology.2016; 60: 157.     CrossRef
  • Biopsy of parotid masses: Review of current techniques
    Sananda Haldar, Joseph D Sinnott, Kemal M Tekeli, Samuel S Turner, David C Howlett
    World Journal of Radiology.2016; 8(5): 501.     CrossRef
  • Review on the applications of ultrasonography in dentomaxillofacial region
    Şehrazat Evirgen
    World Journal of Radiology.2016; 8(1): 50.     CrossRef
  • Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma
    Seokhwi Kim, Jinah Chu, Hojoong Kim, Joungho Han
    Journal of Pathology and Translational Medicine.2015; 49(6): 511.     CrossRef
Brief Case Report
Combined Squamous Cell Carcinoma and Follicular Carcinoma of the Thyroid
Da Hye Son, Jong-Lyel Roh, Kyung-Ja Cho
Korean J Pathol. 2014;48(6):418-422.   Published online December 31, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.6.418
  • 9,893 View
  • 58 Download
  • 4 Crossref
PDF

Citations

Citations to this article as recorded by  
  • Efficacy of combined immunotherapy and targeted therapy in overcoming barriers to postoperative recurrence in squamous subtype anaplastic thyroid carcinoma with abscess: a case report and literature review
    Shuyun Jiang, Xiaowu Wang, Zhijun Ma
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • State of Knowledge About Thyroid Cancers in the Era of COVID-19—A Narrative Review
    Agnieszka Bronowicka-Szydełko, Maciej Rabczyński, Ilias Dumas, Żanna Fiodorenko-Dumas, Beata Wojtczak, Łukasz Kotyra, Irena Kustrzeba-Wójcicka, Łukasz Lewandowski, Beata Ponikowska, Aleksandra Kuzan, Joanna Kluz, Andrzej Gamian, Katarzyna Madziarska
    Biomedicines.2024; 12(12): 2829.     CrossRef
  • Primary and metastatic squamous cell carcinoma of the thyroid gland: Two case reports
    Xing Zhao, Pengyu Hao, Jiangbei Tian, Jirun Sun, Dawei Chen, Zhehui Cui, Libo Xin, Yanmin Song, Gang Zhang
    Open Life Sciences.2022; 17(1): 1148.     CrossRef
  • Aggressive Thyroid Gland Carcinoma: A Case Series
    JP Dworkin-Valenti
    Archives of Otolaryngology and Rhinology.2017; : 129.     CrossRef
Original Articles
Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas
Min Jeong Song, Joon Seon Song, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Sung Bae Kim, Sang-wook Lee, Kyung-Ja Cho
Korean J Pathol. 2014;48(5):346-350.   Published online October 27, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.346
  • 12,901 View
  • 55 Download
  • 4 Crossref
AbstractAbstract PDF
Background: The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas. Methods: We studied the immunohistochemical expression of Mdm2 and p53 of 8 RISs. The intervals between radiation therapy and diagnosis of secondary sarcomas ranged from 3 to 17 years. Results: Mdm2 expression was more common in de novo sarcomas than RISs (75% vs 37.5%), and p53 expression was more common in RISs than in de novo cases (75% vs 37.5%). While half of the RISs were Mdm2(–)/p53(+), none of de novo cases showed such combination; while half of de novo sarcomas were Mdm2(+)/p53(–), which are a candidate group of Mdm2 inhibitors, only 1 RIS showed such a combination. Variable immunoprofiles observed in both groups did not correlate with tumor types, except that all of 2 myxofibrosarcomas were Mdm2(+)/p53(+). Conclusions: In conclusion, we speculated that both radiation- induced and de novo sarcomagenesis are not due to a unique genetic mechanism. Mdm2- expression without p53 overexpression in 1 case of RIS decreases the future possibility of applying Mdm2 inhibitors on a subset of these difficult tumors.

Citations

Citations to this article as recorded by  
  • Radiation-induced osteosarcoma in the head and neck region: Case report and literature review
    Iara Vieira Ferreira, Marcelo Elias Schempf Cattan, Carlos Takahiro Chone, Arthur Antolini, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
    Oral Oncology.2025; 162: 107216.     CrossRef
  • Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review
    Andrés Coca-Pelaz, Antti A. Mäkitie, Primož Strojan, June Corry, Avraham Eisbruch, Jonathan J. Beitler, Sandra Nuyts, Robert Smee, Johannes A. Langendijk, William M. Mendenhall, Cesare Piazza, Alessandra Rinaldo, Alfio Ferlito
    Advances in Therapy.2021; 38(1): 90.     CrossRef
  • Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma
    Christopher S. Hong, Edwin Partovi, James Clune, Anita Huttner, Henry S. Park, Sacit Bulent Omay, Balraj Mittal
    Case Reports in Genetics.2021; 2021: 1.     CrossRef
  • Radiation-Induced Sarcoma of the Head and Neck: A Review of the Literature
    Lorenzo Giannini, Fabiola Incandela, Marco Fiore, Alessandro Gronchi, Silvia Stacchiotti, Claudia Sangalli, Cesare Piazza
    Frontiers in Oncology.2018;[Epub]     CrossRef
Cytological Evaluation and REBA HPV-ID HPV Testing of Newly Developed Liquid-Based Cytology, EASYPREP: Comparison with SurePath
Youn Soo Lee, Gyungyub Gong, Jin Hee Sohn, Ki Sung Ryu, Jung Hun Lee, Shin Kwang Khang, Kyung-Ja Cho, Yong-Man Kim, Chang Suk Kang
Korean J Pathol. 2013;47(3):265-274.   Published online June 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.265
  • 11,968 View
  • 98 Download
  • 4 Crossref
AbstractAbstract PDF
Background

The objective of this study was to evaluate a newly-developed EASYPREP liquid-based cytology method in cervicovaginal specimens and compare it with SurePath.

Methods

Cervicovaginal specimens were prospectively collected from 1,000 patients with EASYPREP and SurePath. The specimens were first collected by brushing for SurePath and second for EASYPREP. The specimens of both methods were diagnosed according to the Bethesda System. Additionally, we performed to REBA HPV-ID genotyping and sequencing analysis for human papillomavirus (HPV) on 249 specimens.

Results

EASYPREP and SurePath showed even distribution of cells and were equal in cellularity and staining quality. The diagnostic agreement between the two methods was 96.5%. Based on the standard of SurePath, the sensitivity, specificity, positive predictive value, and negative predictive value of EASYPREP were 90.7%, 99.2%, 94.8%, and 98.5%, respectively. The positivity of REBA HPV-ID was 49.4% and 95.1% in normal and abnormal cytological samples, respectively. The result of REBA HPV-ID had high concordance with sequencing analysis.

Conclusions

EASYPREP provided comparable results to SurePath in the diagnosis and staining quality of cytology examinations and in HPV testing with REBA HPV-ID. EASYPREP could be another LBC method choice for the cervicovaginal specimens. Additionally, REBA HPV-ID may be a useful method for HPV genotyping.

Citations

Citations to this article as recorded by  
  • Virome capture sequencing for comprehensive HPV genotyping in cervical samples
    Thanayod Sasivimolrattana, Sasiprapa Liewchalermwong, Wasun Chantratita, Insee Sensorn, Arkom Chaiwongkot, Parvapan Bhattarakosol
    Science Progress.2025;[Epub]     CrossRef
  • High-Risk Human Papillomavirus Detection via Cobas® 4800 and REBA HPV-ID® Assays
    Sasiprapa Liewchalermwong, Shina Oranratanaphan, Wichai Termrungruanglert, Surang Triratanachat, Patou Tantbirojn, Nakarin Kitkumthorn, Parvapan Bhattarakosol, Arkom Chaiwongkot
    Viruses.2022; 14(12): 2713.     CrossRef
  • Evaluation of nuclear chromatin using grayscale intensity and thresholded percentage area in liquid‐based cervical cytology
    Hyekyung Lee, Myungein Han, Taejo Yoo, Chanho Jung, Hyun‐Jin Son, Migyung Cho
    Diagnostic Cytopathology.2018; 46(5): 384.     CrossRef
  • Comparison of EASYPREP® and SurePath® in thyroid fine‐needle aspiration
    Yosep Chong, Ki Hyun Baek, Jee Young Kim, Tae‐Jung Kim, Eun Jung Lee, Chang Suk Kang
    Diagnostic Cytopathology.2016; 44(4): 283.     CrossRef
Case Study
A Solitary Fibrous Tumor with Giant Cells in the Lacrimal Gland: A Case Study
Da Hye Son, Su Hyun Yoo, Ho-Seok Sa, Kyung-Ja Cho
Korean J Pathol. 2013;47(2):158-162.   Published online April 24, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.158
  • 9,033 View
  • 60 Download
  • 9 Crossref
AbstractAbstract PDF

Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and fibrous histiocytoma of the orbit. The lacrimal gland is a very rare location for both SFT and GCAF. A 39-year-old man presented with a painless left upper eyelid mass. An orbital computed tomography scan identified a 1.1 cm-sized well-defined nodule located in the left lacrimal gland. He underwent a mass excision. Histopathologic examination showed a proliferation of relatively uniform spindle cells with a patternless or focally storiform pattern. Dilated vessels were prominent, but angiectoid spaces lined with giant cells were absent. Floret-type giant cells were mostly scattered in the periphery. The tumor was immunoreactive for CD34 and CD99, but negative for smooth muscle actin and S-100 protein. This is the first Korean case of SFT of the lacrimal gland with overlapping features of GCAF, suggesting a close relationship between the two entities.

Citations

Citations to this article as recorded by  
  • Radiological features of lacrimal gland masses
    Sonia Huang, Jessica Y. Tong, Valerie Juniat, Abdullah Almater, Ilse Mombaerts, Dinesh Selva
    Survey of Ophthalmology.2026; 71(2): 700.     CrossRef
  • Imaging features of lacrimal gland disease
    Carmelo Caltabiano, Khizar Rana, Alexander Buckby, Sandy Patel, Dinesh Selva
    Frontiers in Ophthalmology.2026;[Epub]     CrossRef
  • A review of solitary fibrous tumours of the orbit and ocular adnexa
    Cornelius René, Paolo Scollo, Dominic O’Donovan
    Eye.2023; 37(5): 858.     CrossRef
  • A giant orbital solitary fibrous tumor treated by surgical excision: a case report and literature review
    Qi Zhou, Yuting Liu, Fang Wang, Yang Cao, Hongbin Lv, Xibo Zhang
    Diagnostic Pathology.2023;[Epub]     CrossRef
  • Giant cell-rich solitary fibrous tumour of the lacrimal gland with prominent angiomatoid cystic changes and an underlying NAB2ex3-STAT6ex18 fusion
    Khaled A Alsaadi, Manar Alwohaib, Karen Pinto, Rola H Ali
    BMJ Case Reports.2022; 15(2): e247141.     CrossRef
  • Cystic appearance - a new feature of solid fibrous tumours in the lacrimal gland: a case report with literature review
    Ancuta-Augustina Gheorghisan-Galateanu, Dana Cristina Terzea, Iulia Burcea, Roxana Dusceac, Cristina Capatina, Catalina Poiana
    Diagnostic Pathology.2019;[Epub]     CrossRef
  • Solitary Fibrous Tumor in the Lacrimal Gland Fossa: A Case Report
    Jacqueline Mupas-Uy, Yoshiyuki Kitaguchi, Yasuhiro Takahashi, Emiko Takahashi, Hirohiko Kakizaki
    Case Reports in Ophthalmology.2016; 7(2): 398.     CrossRef
  • Ocular adnexal (orbital) solitary fibrous tumor: nuclear STAT6 expression and literature review
    Aleksandra Petrovic, Aurélie Obéric, Alexandre Moulin, Mehrad Hamedani
    Graefe's Archive for Clinical and Experimental Ophthalmology.2015; 253(9): 1609.     CrossRef
  • Angiofibroma de células gigantes en mucosa yugal: una entidad rara en una localización infrecuente
    Alejandro Rubio Fernández, María López Macías, Weimar Toro Zambrano, Mario Díaz Delgado, Alicia Hernández Amate
    Revista Española de Patología.2014; 47(4): 223.     CrossRef
Original Articles
Human Papillomavirus Prevalence and Cell Cycle Related Protein Expression in Tonsillar Squamous Cell Carcinomas of Korean Patients with Clinicopathologic Analysis
Miji Lee, Sung Bae Kim, Sang-wook Lee, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho
Korean J Pathol. 2013;47(2):148-157.   Published online April 24, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.148
  • 9,096 View
  • 52 Download
  • 5 Crossref
AbstractAbstract PDF
Background

Human papillomavirus (HPV)-related tonsillar squamous cell carcinoma (TSCC) has recently been characterized as a distinct subset with a favorable prognosis. The prevalence and clinicopathologic significance of HPV-related TSCC in Koreans are not well known.

Methods

HPV in situ hybridization (ISH) accompanied by p53, p16, pRb, and cyclin D1 immunohistochemical staining were performed on 89 resection cases of TSCC from 2000 through 2010.

Results

HPV was detected by ISH in 59 of 89 cases (66.3%). HPV-positive TSCCs were more common in younger ages (p=0.005), and tumor sizes were smaller in the HPV-positive compared to the HPV-negative group (p=0.040). Positive HPV staining was significantly correlated with p16 expression (p<0.001), pRb inactivation (p=0.003), and cyclin D1 down-regulation (p<0.001) but not with p53 expression (p=0.334). Seventeen cases that showed p16-immunopositivity with HPV-negativity by ISH were retested by HPV typing; HPV DNA was not detected in all cases. There was no significant difference between HPV-positive and HPV-negative patients either in the disease-specific survival (DSS, p=0.857) or overall survival (p=0.910). Furthermore, pRb-inactivated cases showed better DSS (p=0.023), and p53-positive cases showed worse DSS (p=0.001).

Conclusions

Although high HPV prevalence was noted, it was not correlated with histopathologic findings or survival benefit. In addition to p53 expression, pRb inactivation along with p16 overexpression and down-regulation of cyclin D1 are thought to be important pathogenetic steps for developing TSCCs.

Citations

Citations to this article as recorded by  
  • Assessment of the Mutation Profile of Tonsillar Squamous Cell Carcinomas Using Targeted Next-Generation Sequencing
    Ha Young Park, Joong Seob Lee, Jee Hye Wee, Jeong Wook Kang, Eun Soo Kim, Taeryool Koo, Hee Sung Hwang, Hyo Jung Kim, Ho Suk Kang, Hyun Lim, Nan Young Kim, Eun Sook Nam, Seong Jin Cho, Mi Jung Kwon
    Biomedicines.2023; 11(3): 851.     CrossRef
  • Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea
    Miseon Lee, Uiree Jo, Joon Seon Song, Youn Soo Lee, Chang Gok Woo, Dong-Hoon Kim, Jung Yeon Kim, Sun Och Yoon, Kyung-Ja Cho
    Journal of Pathology and Translational Medicine.2023; 57(3): 166.     CrossRef
  • Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
    Hyunchul Kim, Mi Jung Kwon, Bumjung Park, Hyo Geun Choi, Eun Sook Nam, Seong Jin Cho, Kyueng-Whan Min, Eun Soo Kim, Hee Sung Hwang, Mineui Hong, Taeryool Koo, Hyo Jung Kim
    Indian Journal of Surgical Oncology.2021; 12(S1): 134.     CrossRef
  • Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas
    Yuil Kim, Young-Hoon Joo, Min-Sik Kim, Youn Soo Lee
    Journal of Pathology and Translational Medicine.2020; 54(5): 411.     CrossRef
  • Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus–negative tonsillar squamous cell carcinoma and their prognostic significances
    Mi Jung Kwon, Dong Hoon Kim, Hye-Rim Park, Hyung Sik Shin, Ji Hyun Kwon, Dong Jin Lee, Jin Hwan Kim, Seong Jin Cho, Eun Sook Nam
    Human Pathology.2014; 45(7): 1327.     CrossRef
Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland
Min Jung Jung, Joon Seon Song, Sang Yoon Kim, Soon Yuhl Nam, Jong-Lyel Roh, Seung-Ho Choi, Sung-Bae Kim, Kyung-Ja Cho
Korean J Pathol. 2013;47(1):36-43.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.36
  • 14,780 View
  • 117 Download
  • 73 Crossref
AbstractAbstract PDF
Background

A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. MASC was originally diagnosed as adenocarcinoma, not otherwise specified (ANOS), or acinic cell carcinoma (AciCC) by the current World Health Organization classification. We aimed to identify MASC cases by molecular tests, and to characterize their clinical, histological, and immunohistochemical features.

Methods

Thirty cases of MASC candidates were selected after review of 196 salivary gland tumors, and subjected to break-apart ETV6 fluorescence in situ hybridization (FISH), and immunohistochemical study for S100 protein, gross cystic disease fluid protein 15, DOG1, estrogen receptor, and progesterone receptor.

Results

Valid FISH results were obtained in 23 cases, and 13 positive cases were retrieved. MASCs were histologically varied, and the most frequent features observed in 10 cases were low-grade papillary/cystic/glandular patterns, intraluminal secretory materials, ovoid/wrinkled nuclei, and relatively abundant granular eosinophilic cytoplasms, corresponding to papillary-cystic or follicular types of AciCC. All cases showed diffuse immunopositivity for S100 protein. Three cases developed recurrences, but all patients remained alive.

Conclusions

MASC could be a molecularly well-defined salivary gland neoplasm, encompassing some portions of AciCC and ANOS, but its histological spectrum and clinical implication require further investigation.

Citations

Citations to this article as recorded by  
  • Rare Tumors of Oral Cavity: A Case Report and Literature Review on Secretory Carcinoma of Minor Salivary Glands
    Emilio Salerno, Silvio Abati, Gianluigi Arrigoni, Daniela Finocchiaro, Giorgio Gastaldi, Alessandra Lissoni, Andrea Galli, Matteo Trimarchi
    Clinical and Experimental Dental Research.2025;[Epub]     CrossRef
  • Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis
    Eyal Yosefof, Tomer Boldes, Daniel Dan, Eyal Robenshtok, Yulia Strenov, Gideon Bachar, Thomas Shpitzer, Aviram Mizrachi
    The Laryngoscope.2024; 134(4): 1716.     CrossRef
  • Salivary gland secretory carcinoma presenting as a cervical soft tissue mass: a case report
    Parisa Mokhles, Alireza Sadeghipour, Pegah Babaheidarian, Saleh Mohebbi, Zahra Keshtpour Amlashi, Mohammad Hadi Gharib, Mohammad Saeid Ahmadi, Zeinab Khastkhodaei
    Journal of Medical Case Reports.2024;[Epub]     CrossRef
  • Mammary analogue secretory carcinoma of the head and neck — Clinicopathological, imaging features and prognosis analysis
    Runjia Liu, Chuanzheng Sun, Likang Zhao, Shiyu Zhou, Tao Xie, Ji Zhang, Dengpeng Tang, Lei Li, Yan Xi
    Journal of Radiation Research and Applied Sciences.2024; 17(2): 100914.     CrossRef
  • Mammary analogue secretory carcinoma involving submandibular gland: Diagnostic pitfall with review of literature
    Nimisha Dhankar, Nidhi Verma, Abhinav Agarwal, Ravi Mehar, Sunil Pasricha
    Journal of Cancer Research and Therapeutics.2024; 20(5): 1658.     CrossRef
  • Metastatic salivary gland mammary analogue secretory carcinoma (MASC) of parotid gland – A rare case report in the literature review
    Aynur Aliyeva, Ziya Karimov, Togay Muderris
    Acta Oto-Laryngologica Case Reports.2023; 8(1): 38.     CrossRef
  • Secretory carcinoma of minor salivary glands of buccal mucosa: A case report and review of the literature
    Noshad Ali Langah, Abdul Ahad, Shayan Khalid Ghaloo, Muhammad Faisal, Raza Tasawar Hussain, Fareed Akbar Shah
    International Journal of Surgery Case Reports.2023; 107: 108357.     CrossRef
  • An Underappreciated Cytomorphological Feature of Secretory Carcinoma of Salivary Gland on Fine Needle Aspiration Biopsy: Case Report with Literature Review
    Yinan Hua, Bing Leng, Kenneth E. Youens, Lina Liu
    Head and Neck Pathology.2022; 16(2): 567.     CrossRef
  • Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report
    Kensuke Suzuki, Hiroshi Harada, Masayuki Takeda, Chisato Ohe, Yoshiko Uemura, Akihiko Kawahara, Shunsuke Sawada, Akira Kanda, Bhaswati Sengupta, Hiroshi Iwai
    BMC Medical Genomics.2022;[Epub]     CrossRef
  • DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis
    Vincenzo Fiorentino, Patrizia Straccia, Pietro Tralongo, Teresa Musarra, Francesco Pierconti, Maurizio Martini, Guido Fadda, Esther Diana Rossi, Luigi Maria Larocca
    International Journal of Molecular Sciences.2022; 23(17): 9711.     CrossRef
  • Secretory carcinoma of the sinonasal cavity and pharynx: A retrospective analysis of four cases and literature review
    Changli Yue, Xiaoli Zhao, Donglin Ma, Yingshi Piao
    Annals of Diagnostic Pathology.2022; 61: 152052.     CrossRef
  • Secretory carcinoma of the salivary gland: a multi‐institutional clinicopathologic study of 90 cases with emphasis on grading and prognostic factors
    Bin Xu, Kartik Viswanathan, Kavita Umrau, Thair A. D. Al‐Ameri, Snjezana Dogan, Kelly Magliocca, Ronald A. Ghossein, Nicole A. Cipriani, Nora Katabi
    Histopathology.2022; 81(5): 670.     CrossRef
  • A systematic review of secretory carcinoma of the salivary gland: where are we?
    Lísia Daltro Borges Alves, Andreia Cristina de Melo, Thayana Alves Farinha, Luiz Henrique de Lima Araujo, Leandro de Souza Thiago, Fernando Luiz Dias, Héliton Spíndola Antunes, Ana Lucia Amaral Eisenberg, Luiz Claudio Santos Thuler, Daniel Cohen Goldember
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2021; 132(4): e143.     CrossRef
  • A case report of surgical resection of secretory carcinoma in the maxillary and ethmoid sinus
    Kurt Willis, Martin Bullock, Matthew H. Rigby
    International Journal of Surgery Case Reports.2021; 81(C): 105750.     CrossRef
  • High‐grade salivary gland carcinoma with the ETV6‐NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high‐grade transformation
    Satsuki Asai, Shinji Sumiyoshi, Yosuke Yamada, Ichiro Tateya, Toshitaka Nagao, Sachiko Minamiguchi, Hironori Haga
    Pathology International.2021; 71(6): 427.     CrossRef
  • High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance
    Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H.W. Simpson, Göran Stenman, Vincent Vander Poorten, Justin A. Bishop, Alessandro Franchi, Juan C. Hernandez-Prera, David Slouka, Stefan M. Willems, Kerry D. Olsen, Alfio Ferlito
    Advances in Anatomic Pathology.2021; 28(3): 107.     CrossRef
  • Radiological features of head and neck mammary analogue secretory carcinoma: 11 new cases with a systematic review of 29 cases reported in 28 publications
    Ryo Kurokawa, Mariko Kurokawa, Akira Baba, Yoshiaki Ota, Toshio Moritani, Ashok Srinivasan
    Neuroradiology.2021; 63(11): 1901.     CrossRef
  • A case of secretory carcinoma of the salivary glands in the lower lip
    Reiko OHARA, Haruki SATO, Kensuke NAGANAWA, Taihei HAYAKAWA, Tatsuya KATAOKA, Ichiro OH-IWA
    Japanese Journal of Oral and Maxillofacial Surgery.2021; 67(2): 83.     CrossRef
  • Undifferentiated and dedifferentiated head and neck carcinomas
    Alessandro Franchi, Alena Skalova
    Seminars in Diagnostic Pathology.2021; 38(6): 127.     CrossRef
  • Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
    Yuria Egusa, Midori Filiz Nishimura, Satoko Baba, Kengo Takeuchi, Takuma Makino, Tomoyasu Tachibana, Asami Nishikori, Azusa Fujita, Hiroyuki Yanai, Yasuharu Sato
    Diagnostics.2021; 11(12): 2284.     CrossRef
  • Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland
    Masaru Ogawa, Satoshi Yokoo, Takahiro Yamaguchi, Keisuke Suzuki, Mai Seki-Soda, Takahiro Shimizu, Jun Kurihara, Takaya Makiguchi
    Medicine.2021; 100(51): e28390.     CrossRef
  • A biphasic sessile mass of the buccal mucosa
    Tiffany M. Peters, James A. Phero, Brent A. Golden, Alice E. Curran
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2020; 130(6): 612.     CrossRef
  • Don't stop the champions of research now: a brief history of head and neck pathology developments
    Lester D.R. Thompson, James S. Lewis, Alena Skálová, Justin A. Bishop
    Human Pathology.2020; 95: 1.     CrossRef
  • High Grade Transformation in Mucoepidermoid Carcinoma of the Minor Salivary Gland with Polyploidy of the Rearranged MAML2 Gene
    Hyun Lee, Jong-Lyel Roh, Young-Jun Choi, Jene Choi, Kyung-Ja Cho
    Head and Neck Pathology.2020; 14(3): 822.     CrossRef
  • Pan‐Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6–NTRK3 fusion
    Bin Xu, Mohamed R Haroon Al Rasheed, Cristina R Antonescu, Deepu Alex, Denise Frosina, Ronald Ghossein, Achim A Jungbluth, Nora Katabi
    Histopathology.2020; 76(3): 375.     CrossRef
  • Characterization of novel genetic alterations in salivary gland secretory carcinoma
    Kiyong Na, Juan C. Hernandez-Prera, Jae-Yol Lim, Ha Young Woo, Sun Och Yoon
    Modern Pathology.2020; 33(4): 541.     CrossRef
  • Mammary analogue secretory carcinoma: An Indian experience of a novel entity
    Zeba Nisar, JaydeepN Pol, RakhiV Jagdale, MadhuraD Phadke, GirishA Kadkol
    Indian Journal of Pathology and Microbiology.2020; 63(5): 134.     CrossRef
  • Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report
    Kiyofumi Takabatake, Keisuke Nakano, Hotaka Kawai, Saori Yoshida, Haruka Omori, May Wathone Oo, Shan Qiusheng, Kenichiro Uchida, Katsuaki Mishima, Hitoshi Nagatsuka
    Reports.2020; 3(2): 6.     CrossRef
  • Secretory carcinoma of the salivary gland (mammary analogue secretory carcinoma) in children
    I. V. Sidorov, I. S. Kletskaya, D. M. Konovalov
    Arkhiv patologii.2020; 82(2): 43.     CrossRef
  • Secretory carcinoma of the major salivary gland: Provincial population‐based analysis of clinical behavior and outcomes
    Gareth Ayre, Martin Hyrcza, Jonn Wu, Eric Berthelet, Alena Skálová, Tom Thomson
    Head & Neck.2019; 41(5): 1227.     CrossRef
  • Higher Ki67 Index, Nodal Involvement, and Invasive Growth Were High Risk Factors for Worse Prognosis in Conventional Mammary Analogue Secretory Carcinoma
    Jingjing Sun, Lizhen Wang, Zhen Tian, Yuhua Hu, Ronghui Xia, Jiang Li
    Journal of Oral and Maxillofacial Surgery.2019; 77(6): 1187.     CrossRef
  • Mammary analogue secretory carcinoma of salivary gland diagnosed on submandibular gland cytology: A case report and review of the literature
    Ethar Al‐Husseinawi, Soheila Hamidpour, Evanthia Omoscharka
    Cytopathology.2019; 30(3): 318.     CrossRef
  • Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature
    Durga Paudel, Michiko Nishimura, Bhoj Raj Adhikari, Daichi Hiraki, Aya Onishi, Tetsuro Morikawa, Puja Neopane, Sarita Giri, Koki Yoshida, Jun Sato, Masayuki Ono, Yoshitaka Kamino, Hiroki Nagayasu, Yoshihiro Abiko
    Case Reports in Pathology.2019; 2019: 1.     CrossRef
  • Estrogen Receptor, Progesterone Receptor, and HER-2 Expression in Recurrent Pleomorphic Adenoma
    Ana Amélia de Souza, Albina Altemani, Ney Soares de Araujo, Lucas Novaes Texeira, Vera Cavalcanti de Araújo, Andresa Borges Soares
    Clinical Pathology.2019;[Epub]     CrossRef
  • Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications
    Bin Xu, Ruth Aryeequaye, Lu Wang, Nora Katabi
    Head and Neck Pathology.2018; 12(2): 274.     CrossRef
  • Primary mammary analogue secretory carcinoma of the lung: a case report
    Tao Huang, Jonathan B. McHugh, Gerald J. Berry, Jeffrey L. Myers
    Human Pathology.2018; 74: 109.     CrossRef
  • Salivary Secretory Carcinoma With a Novel ETV6-MET Fusion
    Lisa M. Rooper, Theodoros Karantanos, Yi Ning, Justin A. Bishop, Sarah W. Gordon, Hyunseok Kang
    American Journal of Surgical Pathology.2018; 42(8): 1121.     CrossRef
  • Secretory carcinoma: The eastern Canadian experience and literature review
    David Forner, Martin Bullock, Daniel Manders, Timothy Wallace, Christopher J. Chin, Liane B. Johnson, Matthew H. Rigby, Jonathan R. Trites, Mark S. Taylor, Robert D. Hart
    Journal of Otolaryngology - Head & Neck Surgery.2018;[Epub]     CrossRef
  • Newly described salivary gland tumors
    Alena Skalova, Michal Michal, Roderick HW Simpson
    Modern Pathology.2017; 30: S27.     CrossRef
  • Diagnóstico, tratamiento y seguimiento de un tumor de reciente descripción: el carcinoma análogo secretor de mama (MASC) de glándula salival. A propósito de 2 nuevos casos
    Marina Alexandra Gavín-Clavero, M. Victoria Simón-Sanz, Ana M. López-López, Alberto Valero-Torres, Esther Saura-Fillat
    Revista Española de Cirugía Oral y Maxilofacial.2017; 39(4): 221.     CrossRef
  • Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description
    Bacem A. Khalele
    Head & Neck.2017; 39(6): 1243.     CrossRef
  • Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib
    Nicole A. Cipriani, Elizabeth A. Blair, Joshua Finkle, Jennifer L. Kraninger, Christopher M. Straus, Victoria M. Villaflor, Daniel Thomas Ginat
    International Journal of Surgical Pathology.2017; 25(7): 613.     CrossRef
  • A systematic review including an additional pediatric case report: Pediatric cases of mammary analogue secretory carcinoma
    Amanda L. Ngouajio, Sarah M. Drejet, D. Ryan Phillips, Don-John Summerlin, John P. Dahl
    International Journal of Pediatric Otorhinolaryngology.2017; 100: 187.     CrossRef
  • Newly Described Entities in Salivary Gland Pathology
    Alena Skálová, Douglas R. Gnepp, James S. Lewis, Jennifer L. Hunt, Justin A. Bishop, Henrik Hellquist, Alessandra Rinaldo, Vincent Vander Poorten, Alfio Ferlito
    American Journal of Surgical Pathology.2017; 41(8): e33.     CrossRef
  • Mammary Analogue Secretory Carcinoma of Salivary Glands: Diagnostic Pitfall with Distinct Immunohistochemical Profile and Molecular Features
    Oliver Bissinger, Carolin Götz, Andreas Kolk, Henning A. Bier, Abbas Agaimy, Henning Frenzel, Sven Perner, Julika Ribbat-Idel, Klaus Dietrich Wolff, Wilko Weichert, Caroline Mogler
    Rare Tumors.2017; 9(3): 89.     CrossRef
  • Mammary Analogue Secretory Carcinoma of Salivary Gland. A Case Report Emphasizing its Diagnostic Histological, Immunohistochemistry and Molecular Findings
    Monalisa Hui, Shantveer G Uppin, Vamshi Krishna Thamtam, Abhiram Kalle
    International Journal of Head and Neck Surgery.2017; 8(4): 160.     CrossRef
  • A case of mammary analog secretory carcinoma of the lower lip
    Takako Aizawa, Taro Okui, Ken Kitagawa, Yoshikazu Kobayashi, Koji Satoh, Hideki Mizutani
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2016; 28(3): 277.     CrossRef
  • Mammary analogue secretory carcinoma of parotid: Is preoperative cytological diagnosis possible?
    Nikita Oza, Kintan Sanghvi, Tanuja Shet, Asawari Patil, Santosh Menon, Mukta Ramadwar, Shubhada Kane
    Diagnostic Cytopathology.2016; 44(6): 519.     CrossRef
  • Lysozyme Expression Can be Useful to Distinguish Mammary Analog Secretory Carcinoma from Acinic Cell Carcinoma of Salivary Glands
    Fernanda Viviane Mariano, Camila Andrea Concha Gómez, Juliana de Souza do Nascimento, Harim Tavares dos Santos, Erika Said Egal, Victor Angelo Martins Montalli, Pablo Agustin Vargas, Oslei Paes de Almeida, Albina Altemani
    Head and Neck Pathology.2016; 10(4): 429.     CrossRef
  • Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands
    Syed A. Khurram, Jemel Sultan-Khan, Neil Atkey, Paul M. Speight
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2016; 122(6): 731.     CrossRef
  • The role of DOG1 immunohistochemistry in dermatopathology
    Keisuke Goto
    Journal of Cutaneous Pathology.2016; 43(11): 974.     CrossRef
  • Extended immunologic and genetic lineage of mammary analogue secretory carcinoma of salivary glands
    Hao Ni, Xue-ping Zhang, Xiao-tong Wang, Qiu-yuan Xia, Jing-huan Lv, Xuan Wang, Shan-shan Shi, Rui Li, Xiao-jun Zhou, Qiu Rao
    Human Pathology.2016; 58: 97.     CrossRef
  • A New Hitherto Unreported Histopathologic Manifestation of Mammary Analogue Secretory Carcinoma: “Masked MASC” Associated With Low-grade Mucinous Adenocarcinoma and Low-grade In Situ Carcinoma Components
    Fredrik Petersson, Michael Michal, Dmitry V. Kazakov, Petr Grossmann, Michal Michal
    Applied Immunohistochemistry & Molecular Morphology.2016; 24(9): e80.     CrossRef
  • Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland
    Min-Shu Hsieh, Yueh-Hung Chou, Shin-Joe Yeh, Yih-Leong Chang
    Virchows Archiv.2015; 467(2): 145.     CrossRef
  • Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study
    Todd M Stevens, Andra O Kovalovsky, Claudia Velosa, Qiuying Shi, Qian Dai, Randall P Owen, Walter C Bell, Shi Wei, Pamela A Althof, Jennifer N Sanmann, Larissa Sweeny, William R Carroll, Gene P Siegal, Martin J Bullock, Margaret Brandwein-Gensler
    Modern Pathology.2015; 28(8): 1084.     CrossRef
  • Aspiration cytology of mammary analogue secretory carcinoma of the salivary gland
    Min Jung Jung, Sang Yoon Kim, Soon Yuhl Nam, Jong‐Lyel Roh, Seung‐Ho Choi, Jeong Hyun Lee, Jung Hwan Baek, Kyung‐Ja Cho
    Diagnostic Cytopathology.2015; 43(4): 287.     CrossRef
  • A Unique Case of a Cutaneous Lesion Resembling Mammary Analog Secretory Carcinoma
    Jennifer Albus, Jacqueline Batanian, Bruce M. Wenig, Claudia I. Vidal
    The American Journal of Dermatopathology.2015; 37(4): e41.     CrossRef
  • Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement
    Hanna Majewska, Alena Skálová, Dominik Stodulski, Adéla Klimková, Petr Steiner, Czesław Stankiewicz, Wojciech Biernat
    Virchows Archiv.2015; 466(3): 245.     CrossRef
  • A comparative immunohistochemistry study of diagnostic tools in salivary gland tumors: usefulness of mammaglobin, gross cystic disease fluid protein 15, and p63 cytoplasmic staining for the diagnosis of mammary analog secretory carcinoma?
    Fabrice Projetti, Magali Lacroix‐Triki, Elie Serrano, Sebastien Vergez, Béatrice Herbault Barres, Julie Meilleroux, Marie‐Bernadette Delisle, Emmanuelle Uro‐Coste
    Journal of Oral Pathology & Medicine.2015; 44(4): 244.     CrossRef
  • Mammary Analogue Secretory Carcinoma of Salivary Glands
    Yohei Ito, Kenichiro Ishibashi, Ayako Masaki, Kana Fujii, Yukio Fujiyoshi, Hideo Hattori, Daisuke Kawakita, Manabu Matsumoto, Satoru Miyabe, Kazuo Shimozato, Toshitaka Nagao, Hiroshi Inagaki
    American Journal of Surgical Pathology.2015; 39(5): 602.     CrossRef
  • Cytopathological features of mammary analogue secretory carcinoma—Review of literature
    Maiko Takeda, Takahiko Kasai, Kohei Morita, Mao Takeuchi, Takeshi Nishikawa, Akinori Yamashita, Shinji Mikami, Hiroshi Hosoi, Chiho Ohbayashi
    Diagnostic Cytopathology.2015; 43(2): 131.     CrossRef
  • Mammary Analog Secretory Carcinoma of Salivary Glands
    Justin A. Bishop
    Pathology Case Reviews.2015; 20(1): 7.     CrossRef
  • Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers
    Akihiko Kawahara, Tomoki Taira, Hideyuki Abe, Yorihiko Takase, Takashi Kurita, Eiji Sadashima, Satoshi Hattori, Ichio Imamura, Shinji Matsumoto, Hitomi Fujisaki, Kazunobu Sueyoshi, Jun Akiba, Masayoshi Kage
    Cancer Cytopathology.2015; 123(10): 603.     CrossRef
  • A Case of Mammary Analogue Secretory Carcinoma Arising from Parotid Gland
    Hee Tae Kim, Cha Hee Lee, Han Su Kim, Hae Sang Park
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2015; 58(8): 563.     CrossRef
  • WITHDRAWN: A biphasic sessile mass of the buccal mucosa
    Tiffany M. Peters, Jose P. Zevallos, Brent A. Golden, Alice E. Curran
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2015;[Epub]     CrossRef
  • Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics
    Peter P. Luk, Christina I. Selinger, Timothy J. Eviston, Trina Lum, Bing Yu, Sandra A. O’Toole, Jonathan R. Clark, Ruta Gupta
    Pathology.2015; 47(7): 659.     CrossRef
  • A case of mammary analogue secretory carcinoma arising in the submandibular region
    Kotaro ISHII, Koji NAKAMATSU, Koji SATO, Chikashi MINEMURA, Wataru KUMAMARU, Hiroyo YOSHIKAWA
    Japanese Journal of Oral and Maxillofacial Surgery.2015; 61(11): 564.     CrossRef
  • DOG1, p63, and S100 protein: a novel immunohistochemical panel in the differential diagnosis of oncocytic salivary gland neoplasms in fine-needle aspiration cell blocks
    Alessandra C. Schmitt, Ryan McCormick, Cynthia Cohen, Momin T. Siddiqui
    Journal of the American Society of Cytopathology.2014; 3(6): 303.     CrossRef
  • Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma
    Douglas R. Gnepp
    Head and Neck Pathology.2014; 8(1): 42.     CrossRef
  • Hepatoid differentiation in renal cell carcinoma: a rare histologic pattern with clinical significance
    Jungweon Shim, Heounjeong Go, Young-Suk Lim, Kyung Chul Moon, Jae Y. Ro, Yong Mee Cho
    Annals of Diagnostic Pathology.2014; 18(6): 363.     CrossRef
  • Mammary analogue secretory carcinoma: Update on a new diagnosis of salivary gland malignancy
    Roshan Sethi, Elliott Kozin, Aaron Remenschneider, Josh Meier, Paul VanderLaan, William Faquin, Daniel Deschler, Robert Frankenthaler
    The Laryngoscope.2014; 124(1): 188.     CrossRef
  • Mammary analog secretory carcinoma of salivary gland in a 5 year old: Case report
    Matthew Keisling, Michael Bianchi, Judy Mae Pascasio
    International Journal of Pediatric Otorhinolaryngology Extra.2014; 9(4): 163.     CrossRef
  • Fine-Needle Aspiration Cytology of Mammary Analog Secretory Carcinoma Masquerading as Low-Grade Mucoepidermoid Carcinoma: Case Report with a Review of the Literature
    Jaya Bajaj, Cecilia Gimenez, Farah Slim, Mohamed Aziz, Kasturi Das
    Acta Cytologica.2014; 58(5): 501.     CrossRef
Metastatic Carcinomas to the Oral Cavity and Oropharynx
Su-Jin Shin, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Sung Bae Kim, Sang-wook Lee, Kyung-Ja Cho
Korean J Pathol. 2012;46(3):266-271.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.266
  • 12,128 View
  • 109 Download
  • 19 Crossref
AbstractAbstract PDF
Background

Metastases to the oral/oropharynx are very rare and their diagnosis is challenging.

Methods

We reviewed pathologic data for malignant tumors of the oral/oropharynx that were diagnosed at the Asan Medical Center, Seoul, Korea from 1995 until 2010.

Results

Twenty-nine cases of oral/oropharyngeal metastases were retrieved, comprising 2.0% of 1,445 malignancies. The most common primary sites were the liver and lung, followed by the stomach, colon, breast, prostate, and kidney. The gingiva was the most common metastatic site, followed by the tonsil/pillar, mandible, tongue, tongue base, palate mucosa, mouth floor, and buccal mucosa. Intervals between detection of primary tumors and metastases were variable, from -1 month to 104 months. Ten patients with lung (7 cases), liver, stomach, and kidney carcinomas manifested with oral/oropharyngeal metastases as the first sign of systemic metastases. The majority of patients had died within one year of the onset of an oral/oropharyngeal metastasis, but exceptionally long-lived cases were also present. The survival periods of patients with lung cancers were longer than those of patients with non-pulmonary tumors.

Conclusions

An awareness of the incidence, common primary sites, metastatic subsites, and metastatic courses or patterns of oral/oropharyngeal metastases is helpful in the diagnosis of metastatic carcinomas.

Citations

Citations to this article as recorded by  
  • Metastasis of leiomyosarcoma to the sublingual region
    Seiji Baba, Kyoko Ishimaru, Eiji Ito, Saki Goto, Keizo Kato, Yoichi Yamada
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2024; 36(1): 95.     CrossRef
  • A Case of Oropharyngeal Carcinoma Accompanying a Presacral Malignant Epidermoid Cyst
    Daiki Kitano, Yuki Komatsu, Makoto Omori
    Cureus.2024;[Epub]     CrossRef
  • Mandibular metastasis of follicular thyroid carcinoma: A case report along with the concise review of literature
    MK Jawanda, R Narula, S Gupta, P Gupta
    Journal of Oral and Maxillofacial Pathology.2022; 26(1): 133.     CrossRef
  • Gingival metastasis from primary hepatocellular carcinoma: a case report
    Yuan Huang, Yanqiu Bao, Dongyuan Xu, Lan Liu
    Journal of International Medical Research.2022;[Epub]     CrossRef
  • Mandibular metastasis of follicular thyroid carcinoma
    Manveen Kaur Jawanda, Sonia Gupta, Priya Gupta, Ravi Narula
    Journal of Oral and Maxillofacial Pathology.2022; 26(2): 283.     CrossRef
  • Lung carcinoma presenting as bilateral metastases in the mandibular gingivae: a case report and literature review
    Nusaybah Elsherif, Predrag Jeremic, Tim Blackburn
    Dental Update.2021; 48(10): 846.     CrossRef
  • Recurrent clear cell carcinoma of the tongue base with high grade transformation in a pregnant patient
    Emad M. Al Haj Ali, Ahmed M. Ibrahim, Tamer A. Ghanem, Christian E. Keller
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2020; 32(2): 104.     CrossRef
  • Primary Lingual Colonic-Type Adenocarcinoma: A Rare and Emerging Distinct Entity!
    Stephen M. Smith, Matthew Old, O. Hans Iwenofu
    Head and Neck Pathology.2017; 11(2): 234.     CrossRef
  • Rare Gingival Metastasis by Hepatocellular Carcinoma
    Li-Jun Xue, Xiao-Bei Mao, Jian Geng, Ya-Nan Chen, Qian Wang, Xiao-Yuan Chu
    Case Reports in Medicine.2017; 2017: 1.     CrossRef
  • Hepatoid adenocarcinoma of the lung metastasizing to the tonsil
    Luca Valle, Joel Thomas, Chul Kim, Eva Szabo, G. Thomas Brown, Deborah Citrin, Arun Rajan
    Molecular and Clinical Oncology.2017; 6(5): 705.     CrossRef
  • Epulis-Like Presentation of Gingival Renal Cancer Metastasis
    Gianfilippo Nifosì, Hubert Bressand, Antonio Fabrizio Nifosì, Lorenzo Nifosì, Pierre Damseaux
    Case Reports in Oncology.2017; 10(2): 758.     CrossRef
  • A Case of Oral Metastasis From Hepatocellular Carcinoma Displayed on 18F-FDG PET/CT Imaging
    Lei Jiang, Taoying Gu, Fang Liu, Lijuan Luan, Hongcheng Shi
    Clinical Nuclear Medicine.2016; 41(1): 72.     CrossRef
  • A case of renal cell carcinoma diagnosed in association with a palatal mucosa mass
    Masaharu NOI, Yoshizou TSUDA, Shota SAITO, Takeshi ADACHI, Tomoki HIGO, Gaku YAMAMOTO
    Japanese Journal of Oral and Maxillofacial Surgery.2016; 62(2): 62.     CrossRef
  • Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature
    Sibel Elif Gultekin, Burcu Senguven, Ipek Isik Gonul, Begum Okur, Reinhard Buettner
    Journal of Oral and Maxillofacial Surgery.2016; 74(10): 2007.e1.     CrossRef
  • A Case of Hepatocellular Carcinoma Presenting as a Gingival Mass
    Min Jung Kwon, Soo Hyung Ryu, Soo Yeon Jo, Chul Hoon Kwak, Won Jae Yoon, Jeong Seop Moon, Hye Kyung Lee
    The Korean Journal of Gastroenterology.2016; 68(6): 321.     CrossRef
  • Mandibular metastasis of cholangiocarcinoma: A case report
    Tae Min You, Kee-Deog Kim, Ho-Gul Jeong, Wonse Park
    Imaging Science in Dentistry.2015; 45(4): 247.     CrossRef
  • Oral Floor and Gingival Metastasis of Cholangiocarcinoma: A Case Report and Review of the Literature
    Yukihiro Nakanishi, Bo Xu, Charles LeVea
    Case Reports in Pathology.2014; 2014: 1.     CrossRef
  • Primary Squamous Cell Carcinoma of Lung Leading to Metastatic Jaw Tumor
    Chintamaneni Raja Lakshmi, M. Sudhakara Rao, Sujana Mulk Bhavana, Sivan Sathish
    Case Reports in Pulmonology.2014; 2014: 1.     CrossRef
  • A Case of Gingival Metastasis from Rectal Cancer in Which Immunohistochemistry and PET-CT Were Useful for the Diagnostic Procedure
    Masami Yamauchi, Katsunori Shinozaki, Mihoko Doi, Tomoko Nitta, Takashi Nishisaka
    Case Reports in Oncology.2014; 7(1): 246.     CrossRef
J Pathol Transl Med : Journal of Pathology and Translational Medicine
© The Korean Society of Pathologists and the Korean Society for Cytopathology.
TOP