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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2018.09.14    [Epub ahead of print]
Primary Rhabdomyosarcoma of the Breast: A Report of Two Cases and Literature Review
Junyoung Shin1, Hee Jeong Kim2, Dae-Yeon Kim3, Gyungyub Gong1, Kyung-Ja Cho1
1Department of Pathology, Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Department of Pathology, Pediatric Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Corresponding Author: Kyung-Ja Cho ,Tel: +82-2-3010-4545, Fax: +82-2-472-7898, Email: kjc@amc.seoul.kr
Received: August 6, 2018;  Revised: September 10, 2018  Accepted: September 13, 2018.  Published online: October 4, 2018.
ABSTRACT
Primary rhabdomyosarcoma (RMS) of the breast is very rare, which often leads to delayed histologic confirmation. Here, we report two cases of primary RMS of the breast: spindle cell/sclerosing (ssRMS) and alveolar (aRMS). These two primary RMS patients were teenage girls who underwent mastectomy. The patient with ssRMS experienced recurrence at the operative site four months after surgery despite concurrent chemoradiation therapy. The aRMS patient had multiple metastatic lesions at the time of diagnosis and an association with FAX3-FOXO1 (FKHR) fusion transcripts; she died 22 months post-diagnosis. This is the second report of primary ssRMS of the breast. We also reviewed all published literature concerning primary RMS of the breast.
Key Words: Spindle cell rhabdomyosarcoma; sclerosing rhabdomyosarcoma; primary sarcoma of the breast