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The Korean Journal of Cytopathology 1998;9(2): 201-206.
Cytologic Features of Adenoma Malignum of the Uterine Cervix: A Case Report.
Hyun Joo Choi, Young Shin Kim, Kyo Young Lee, Chang Suk Kang, Sang In Shim
Department of Clinical Pathology, Catholic University College of Medicine.
Adenoma malignum is an extremely well-differentiated variant of cervical adeno carcinoma in which the cells composing the tumor lack the typical cytological features of malignancy. The prognosis of this rare tumor is poor in spite of high degree of differentiation. The cytologic characteristics are extremely bland, so frequently make a confusion of adenoma malignum with endocervical glandular hyperplasia. We report a case of adenoma malignum in a 36-year-old woman who complained of mucoid vaginal discharge and vaginal bleeding. The cervicovaginal smear showed endocervical cells exhibiting a spectrum of atypical changes. The cells were arranged in multilayered strips and monolayered sheets. Individual cells ranged from cuboidal to columnar; typically the columnar cells had abundant lacy or vacuolated cytoplasm. The smear showed the majority of only atypical cells and small numbers of frankly malignant cells.
Key Words: Adenoma malignum; Uterine cervix; Cytology