Journal of Pathology and Translational Medicine

Original Articles

Frequent apocrine changes in pleomorphic adenoma with malignant transformation: a possible pre-malignant step in ductal carcinoma ex pleomorphic adenoma: Joon Seon Song, Yeseul Kim, Yoon-Se Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho; J Pathol Transl Med. 2023;57(3):158-165. Published online May 10, 2023; DOI: https://doi.org/10.4132/jptm.2023.03.13

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Background
The most common type of carcinoma ex pleomorphic adenoma (CPA) is histologically equivalent to salivary duct carcinoma, which has an apocrine phenotype. Invasive CPA is often accompanied by non-invasive or in situ carcinoma, an observation that suggests the presence of precursor lesions. The aim of this study was to identify candidate precursor lesions of CPA within pleomorphic adenoma (PA).
Methods
Eleven resected cases of CPA with residual PA and 17 cases of PA with atypical changes were subjected to immunohistochemistry (IHC) for p53, human epidermal growth factor receptor 2 (HER2), androgen receptor (AR), pleomorphic adenoma gene 1, gross cystic disease fluid protein-15 (GCDFP-15), and anti-mitochondrial antibody.
Results
Invasive or in situ carcinoma cells in all CPAs were positive for AR, GCDFP-15, and HER2. Atypical foci in PAs corresponded to either apocrine or oncocytic changes on the basis of their reactivity to AR, GCDFP-15, and anti-mitochondrial antibody. Atypical cells in PAs surrounding CPAs had an apocrine phenotype without HER2 expression.
Conclusions
Our study identified frequent apocrine changes in residual PAs in CPA cases, suggesting a possible precursor role of apocrine changes. We recommend the use of HER2 IHC in atypical PAs, and that clinicians take HER2 positivity into serious consideration.

Citations

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Characterization of a Molecularly Distinct Subset of Oncocytic Pleomorphic Adenomas/Myoepitheliomas Harboring Recurrent ZBTB47-AS1::PLAG1 Gene Fusion
Ziyad Alsugair, Jimmy Perrot, Françoise Descotes, Jonathan Lopez, Anne Champagnac, Daniel Pissaloux, Claire Castain, Mihaela Onea, Philippe Céruse, Pierre Philouze, Charles Lépine, Marie-Delphine Lanic, Marick Laé, Valérie Costes-Martineau, Nazim Benzerdj
American Journal of Surgical Pathology.2024; 48(5): 551. CrossRef

Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas: Su Jung Kum, Hye Won Lee, Soon Gu Kim, Hyungsik Park, Ilseon Hwang, Sang Pyo Kim; J Pathol Transl Med. 2022;56(1):22-31. Published online October 15, 2021; DOI: https://doi.org/10.4132/jptm.2021.08.31

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Abstract PDF

Background
Pituitary tumor transforming gene 1 (PTTG1), paired-like homeodomain 2 (PITX2), and galectin-3 have been widely studied as predictive biomarkers for various tumors and are involved in tumorigenesis and tumor progression. We evaluated the usefulness of PTTG1, PITX2, and galectin-3 as predictive biomarkers for invasive non-functioning pituitary adenomas (NFPAs) by determining the relationship between the expressions of these three proteins and the invasiveness of the NFPAs. We also investigated whether PTTG1, E-cadherin, and Ki-67, which are known to be related to each other, show a correlation with NFPA features.
Methods
A retrospective study was conducted on 87 patients with NPFAs who underwent surgical removal. The NFPAs were classified into three groups based on magnetic resonance imaging findings of suprasellar extension and cavernous sinus invasion. Immunohistochemical staining for PTTG1, PITX2, galectin-3, E-cadherin, and Ki-67 was performed on tissue microarrays.
Results
PTTG1 expression showed a statistically significant correlation with the invasiveness of NFPAs, whereas PITX2 and galectin-3 did not have a relationship with the invasiveness of NFPAs. Moreover, there was no association among PTTG1, E-cadherin, and Ki-67 expression.
Conclusions
PTTG1 has the potential to serve as a predictive biomarker for invasive NFPA. Furthermore, this study may serve as a reference for the development of PTTG1-targeted therapeutic agents.

Citations

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Neoplasms and tumor-like lesions of the sellar region: imaging findings with correlation to pathology and 2021 WHO classification
Lorenzo Ugga, Raduan Ahmed Franca, Alessandra Scaravilli, Domenico Solari, Sirio Cocozza, Fabio Tortora, Luigi Maria Cavallo, Marialaura Del Basso De Caro, Andrea Elefante
Neuroradiology.2023; 65(4): 675. CrossRef
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Clinical Epigenetics.2023;[Epub] CrossRef
Expression and clinical significance of Cathepsin K and MMPs in invasive non-functioning pituitary adenomas
Hongyan Liu, Saichun Zhang, Ting Wu, Zhaohui Lv, Jianming Ba, Weijun Gu, Yiming Mu
Frontiers in Oncology.2022;[Epub] CrossRef

Reviews

Hepatocellular adenomas: recent updates: Haeryoung Kim, Young Nyun Park; J Pathol Transl Med. 2021;55(3):171-180. Published online April 7, 2021; DOI: https://doi.org/10.4132/jptm.2021.02.27

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Abstract PDF

Hepatocellular adenoma (HCA) is a heterogeneous entity, from both the histomorphological and molecular aspects, and the resultant subclassification has brought a strong translational impact for both pathologists and clinicians. In this review, we provide an overview of the recent updates on HCA from the pathologists’ perspective and discuss several practical issues and pitfalls that may be useful for diagnostic practice.

Citations

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Fatal rupture of hepatic adenomatosis: Autopsy case and review of the literature
Sarra Ben Abderrahim, Khouloud Chérif, Zeineb Nfikha, Sarra Gharsallaoui, Imen El Aini, Maher Jedidi, Moncef Mokni, Mohamed Ben Dhiab
Journal of Forensic Sciences.2023; 68(4): 1393. CrossRef
Large Hepatocellular Adenoma Presenting with Iron Deficiency Anemia: A Case Report
Young Kwon Koh, Su Hyun Yoon, Sung Han Kang, Hyery Kim, Ho Joon Im, Suhyeon Ha, Jung-Man Namgoong, Kyung-Nam Koh
Clinical Pediatric Hematology-Oncology.2023; 30(1): 25. CrossRef
A Case Report on a Giant Hepatic Inflammatory Adenoma in a Young Female That Presented as Spontaneous Intrahepatic Hematoma
Andreas Kyvetos, Panagiota Voukelatou, Ioannis Vrettos, Spyridon Pantzios , Ioannis Elefsiniotis
Cureus.2023;[Epub] CrossRef
Advances in Histological and Molecular Classification of Hepatocellular Carcinoma
Joon Hyuk Choi, Swan N. Thung
Biomedicines.2023; 11(9): 2582. CrossRef
Estrobolome and Hepatocellular Adenomas—Connecting the Dots of the Gut Microbial β-Glucuronidase Pathway as a Metabolic Link
Sandica Bucurica, Mihaela Lupanciuc, Florentina Ionita-Radu, Ion Stefan, Alice Elena Munteanu, Daniela Anghel, Mariana Jinga, Elena Laura Gaman
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Hepatocellular adenoma: what we know, what we do not know, and why it matters
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Evolving pathologic concepts of serrated lesions of the colorectum: Jung Ho Kim, Gyeong Hoon Kang; J Pathol Transl Med. 2020;54(4):276-289. Published online June 26, 2020; DOI: https://doi.org/10.4132/jptm.2020.04.15

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Abstract PDF Supplementary Material

Here, we provide an up-to-date review of the histopathology and molecular pathology of serrated colorectal lesions. First, we introduce the updated contents of the 2019 World Health Organization classification for serrated lesions. The sessile serrated lesion (SSL) is a new diagnostic terminology that replaces sessile serrated adenoma and sessile serrated polyp. The diagnostic criteria for SSL were revised to require only one unequivocal distorted serrated crypt, which is sufficient for diagnosis. Unclassified serrated adenomas have been included as a new category of serrated lesions. Second, we review ongoing issues concerning the morphology of serrated lesions. Minor morphologic variants with distinct molecular features were recently defined, including serrated tubulovillous adenoma, mucin-rich variant of traditional serrated adenoma (TSA), and superficially serrated adenoma. In addition to intestinal dysplasia and serrated dysplasia, minimal deviation dysplasia and not otherwise specified dysplasia were newly suggested as dysplasia subtypes of SSLs. Third, we summarize the molecular features of serrated lesions. The critical determinant of CpG island methylation development in SSLs is patient age. Interestingly, there may be ethnic differences in BRAF/KRAS mutation frequencies in SSLs. The molecular pathogenesis of TSAs is divided into KRAS and BRAF mutation pathways. SSLs with MLH1 methylation can progress into favorable prognostic microsatellite instability-positive (MSI+)/CpG island methylator phenotype-positive (CIMP+) carcinomas, whereas MLH1-unmethylated SSLs and BRAF-mutated TSAs can be precursors of poor-prognostic MSI−/CIMP+ carcinomas. Finally, based on our recent data, we propose an algorithm for stratifying risk subgroups of non-dysplastic SSLs.

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Original Articles

Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue: Yo Han Jeon, Ji Hyun Ahn, Hee Kyung Chang; J Pathol Transl Med. 2020;54(2):135-145. Published online January 29, 2020; DOI: https://doi.org/10.4132/jptm.2019.11.06

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Abstract PDF: Background
Colorectal epithelial neoplasm extending into the submucosal gut-associated lymphoid tissue (GALT) can cause difficulties in the differential diagnosis. Regarding GALT-associated epithelial neoplasms, a few studies favor the term “GALT carcinoma” while other studies have mentioned the term “GALT-associated pseudoinvasion/epithelial misplacement (PEM)”.
Methods
The clinicopathologic characteristics of 11 cases of colorectal epithelial neoplasm associated with submucosal GALT diagnosed via endoscopic submucosal dissection were studied.
Results
Eight cases (72.7%) were in males. The median age was 59 years, and age ranged from 53 to 73. All cases had a submucosal tumor component more compatible with GALT-associated PEM. Eight cases (72.7%) were located in the right colon. Ten cases (90.9%) had a non-protruding endoscopic appearance. Nine cases (81.8%) showed continuity between the submucosal and surface adenomatous components. Nine cases showed (81.8%) focal defects or discontinuation of the muscularis mucosae adjacent to the submucosal GALT. No case showed hemosiderin deposits in the submucosa or desmoplastic reaction. No case showed single tumor cells or small clusters of tumor cells in the submucosal GALT. Seven cases (63.6%) showed goblet cells in the submucosa. No cases showed oncocytic columnar cells lining submucosal glands.
Conclusions
Our experience suggests that pathologists should be aware of the differential diagnosis of GALT-associated submucosal extension by colorectal adenomatous neoplasm. Further studies are needed to validate classification of GALT-associated epithelial neoplasms.

PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms: Ji Hyun Lee, Hye Ju Kang, Chong Woo Yoo, Weon Seo Park, Jun Sun Ryu, Yuh-Seog Jung, Sung Weon Choi, Joo Yong Park, Nayoung Han; J Pathol Transl Med. 2019;53(1):23-30. Published online November 14, 2018; DOI: https://doi.org/10.4132/jptm.2018.10.12

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Abstract PDF

Background
Recent findings in molecular pathology suggest that genetic translocation and/oroverexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. Weinvestigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues.
Methods
A total of 113 cases of surgically resected salivary gland neoplasms at the NationalCancer Center from January 2007 to March 2017 were identified. Immunohistochemical stainingof PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays.
Results
Among the 113 cases, 82 (72.6%) were benign and 31 (27.4%) were malignant. PLAG1 showednuclear staining and normal parotid gland was not stained. Among 48 cases of pleomorphicadenoma, 29 (60.4%) were positive for PLAG1. All other benign and malignant salivary glandneoplasms were PLAG1-negative. SOX10 showed nuclear staining. In normal salivary gland tissuesSOX10 was expressed in cells of acinus and intercalated ducts. In benign tumors, SOX10 expressionwas observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not inother benign tumors. SOX10 positivity was observed in nine of 31 (29.0%) malignant tumors.Myb showed nuclear staining but was not detected in normal parotid glands. Four of 31 (12.9%)malignant tumors showed Myb positivity: three adenoid cystic carcinomas (AdCC) and onemyoepithelial carcinoma with focal AdCC-like histology.
Conclusions
PLAG1 expression is specificto pleomorphic adenoma. SOX10 expression is helpful to rule out excretory duct origin tumor,but its diagnostic value is relatively low. Myb is useful for diagnosing AdCC when histology isunclear in the surgical specimen.

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Case Studies

Squamous Metaplasia in Pleomorphic Adenoma: A Diagnostic and Prognostic Enigma: Swati Sharma, Monica Mehendiratta, Nivedita Chaudhary, Vineet Gupta, Maulshree Kohli, Anjana Arora; J Pathol Transl Med. 2018;52(6):411-415. Published online October 1, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.15

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Abstract PDF

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Histologically, squamous metaplasia has been reported in PA, but has rarely been documented as being extensive enough to cause significant misdiagnosis. Here, we present an unusual case of PA in a 50-year-old female patient presenting with swelling on the postero-lateral aspect of the palate for a week. Histopathologically, the tumor exhibited the features of conventional PA with extensive squamous metaplasia and giant keratotic lamellae in cyst-like areas. Such exuberant squamous metaplasia and keratin can be a diagnostic and prognostic pitfall and lead to overtreatment of the patient.

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Pleomorphic adenoma of the upper lip: A rare site for a common tumor- Case report
Prasath Sathiah, Sujaya Mazumder, Santosh Tummidi, Vijay Kannaujiya
SN Comprehensive Clinical Medicine.2023;[Epub] CrossRef
Variable metaplastic entities in pleomorphic adenoma a review of a rare case report with a note on its significance
N. Mahapatra, L. Bhuyan, Dash Chandra, P. Mishra
Archive of Oncology.2023; 29(2): 18. CrossRef
Pleomorphic Adenoma with Extensive Squamous and Adipocytic Metaplasia Mimicking as Low Grade Mucoepidermoid Carcinoma on FNAC
Anu Singh, Ravi Hari Phulware, Arvind Ahuja, Ankur Gupta, Manju Kaushal
Indian Journal of Otolaryngology and Head & Neck Surgery.2022; 74(S2): 2132. CrossRef
Aspiration cytology of pleomorphic adenoma with squamous metaplasia: A case series and literature review illustrating diagnostic challenges
Joshua J. X. Li, Joanna K. M. Ng, Eric H. L. Lau, Amy B. W. Chan
Diagnostic Cytopathology.2022; 50(2): 64. CrossRef
Pleomorphic adenoma with extensive squamous metaplasia: The first well-documented case involving the submandibular gland
David A. Gaskin, Alain Reid, Pamela S. Gaskin
Human Pathology Reports.2022; 27: 300600. CrossRef
Salivary Gland Pleomorphic Adenomas Presenting With Extremely Varied Clinical Courses. A Single Institution Case-Control Study†
Krzysztof Piwowarczyk, Ewelina Bartkowiak, Paweł Kosikowski, Jadzia Tin-Tsen Chou, Małgorzata Wierzbicka
Frontiers in Oncology.2021;[Epub] CrossRef
A case report of pleomorphic adenoma squamous metaplasia resembling metastatic oral squamous cell carcinoma
E. Donohoe, R. Courtney, S. Phelan, P.J. McCann
Advances in Oral and Maxillofacial Surgery.2021; 2: 100074. CrossRef
Extensive squamous metaplasia in minor salivary gland neoplasm mimicking squamous cell carcinoma: Diagnostic dilemma in aspiration cytology
Renu Sukumaran, Nileena Nayak, RariP Mony
Clinical Cancer Investigation Journal.2021; 10(5): 257. CrossRef
Navigating small biopsies of salivary gland tumors: a pattern-based approach
J. Stephen Nix, Lisa M. Rooper
Journal of the American Society of Cytopathology.2020; 9(5): 369. CrossRef
Giant Parotid Pleomorphic Adenoma with Atypical Histological Presentation and Long-Term Recurrence-Free Follow-Up after Surgery: A Case Report and Review of the Literature
Mohammed AlKindi, Sundar Ramalingam, Lujain Abdulmajeed Hakeem, Manal A. AlSheddi
Case Reports in Dentistry.2020; 2020: 1. CrossRef
Pleomorphic adenoma of soft palate with extensive squamous metaplasia – A diagnostic enigma
Rashmi Patnayak, Sandip Mohanty, AnjanKumar Sahoo, AdyaKinkara Panda, Amitabh Jena
Journal of Dr. NTR University of Health Sciences.2019; 8(4): 268. CrossRef

Hepatocellular Carcinoma Arising in a Huge Hepatocellular Adenoma with Bone Marrow Metaplasia: Hyo Jeong Kang, Hui Jeong Jeong, So-Woon Kim, Eunsil Yu, Young-Joo Lee, So Yeon Kim, Jihun Kim; J Pathol Transl Med. 2018;52(4):226-231. Published online December 27, 2017; DOI: https://doi.org/10.4132/jptm.2017.11.12

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Abstract PDF

Hepatocellular adenoma (HCA) is the most common type of benign liver tumor, and its major complication is malignant transformation to hepatocellular carcinoma (HCC). Here, we report a case of HCC arising in HCA with bone marrow metaplasia in a 24-year-old Korean woman who presented with abdominal discomfort. A huge liver mass was found on abdominal ultrasonography. She underwent surgical hepatic resection, and the resected specimen was entirely involved by a 20-cm-sized tumor. Histological review revealed a well differentiated HCC arising from inflammatory HCA with β-catenin nuclear positivity and bone marrow metaplasia that contained hematopoietic cells. This case was unique because malignant transformation, inflammatory type HCA, β-catenin nuclear staining, and bone marrow metaplasia were simultaneously observed. Additionally, it should be noted that a large HCA with β-catenin activation can undergo malignant transformation and should be surgically resected in a timely manner.

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Adult Hepatocellular Carcinoma Coexisting with Extramedullary Hematopoiesis
Hirotsugu Noguchi, Michiyo Higashi, Ryo Desaki, Takashi Tasaki, Mari Kirishima, Ikumi Kitazono, Kazuhiro Tabata, Akihide Tanimoto
International Journal of Surgical Pathology.2022; 30(3): 339. CrossRef
Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice
Wenhua Shao, Orgil Jargalsaikhan, Mayuko Ichimura-Shimizu, Qinyi Cai, Hirohisa Ogawa, Yuko Miyakami, Kengo Atsumi, Mitsuru Tomita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Yasusei Kudo, Takeshi Oya, Koichi Tsuneyama
International Journal of Molecular Sciences.2022; 23(19): 11923. CrossRef
Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma
Pattamon Sutthatarn, Cara E. Morin, Jessica Gartrell, Wayne L. Furman, Max R. Langham, Teresa Santiago, Andrew J. Murphy
Children.2021; 8(3): 226. CrossRef
Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon
Juan Putra, Linda D. Ferrell, Annette S.H. Gouw, Valerie Paradis, Arvind Rishi, Christine Sempoux, Charles Balabaud, Swan N. Thung, Paulette Bioulac-Sage
Modern Pathology.2020; 33(4): 665. CrossRef
Hepatocellular carcinoma arising from hepatic adenoma in a young woman
Haythem Yacoub, Hela Kchir, Dhouha Cherif, Hajer Hassine, Slim Haouet, Asma Ayari, Habiba Mizouni, Saber Mannai, Mohamed Tahar Khalfallah, Nadia Maamouri
Clinical Case Reports.2020; 8(9): 1659. CrossRef
Metanephric adenoma with osseous metaplasia and bone marrow elements
Alessandro Pietro Aldera, Jeff John, Dharshnee Chetty, Dhirendra Govender
Human Pathology: Case Reports.2019; 17: 200316. CrossRef

Mucinous Cystadenoma of the Testis: A Case Report with Immunohistochemical Findings: Gilhyang Kim, Dohee Kwon, Hee Young Na, Sehui Kim, Kyung Chul Moon; J Pathol Transl Med. 2017;51(2):180-184. Published online February 13, 2017; DOI: https://doi.org/10.4132/jptm.2016.08.30

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Abstract PDF

Mucinous cystadenoma of the testis is a very rare tumor. Herein, we report a case of mucinous cystadenoma arising in the testis of a 61-year-old man, along with a literature review. Computed tomography showed a 2.5-cm-sized poorly enhancing cystic mass. Grossly, the tumor was a unilocular cystic mass filled with mucinous material and confined to the testicular parenchyma. Histologically, the cyst had a fibrotic wall lined by mucinous columnar epithelium without atypia. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, as well as focally positive for cytokeratin 7. The pathologic diagnosis was mucinous cystadenoma.

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Cistoadenoma Mucinoso Paratesticular: Caso Interesante en el Instituto Guatemalteco de Seguridad Social
Edgar Estuardo González López, Carlos Gonzalo Estrada Pazos
Revista Guatemalteca de Urología.2023; 10(2): 16. CrossRef
Primary borderline mucinous tumor of the testis with postoperative metastasis: A rare case report
Yingyu Shi, Ling Song, Yan Luo
Radiology Case Reports.2023; 18(9): 3203. CrossRef
Case report: Misdiagnosis of primary mucinous cystadenoma of the testicle by ultrasound
Linlin Zhang, Jianyuan Xuan, Manxi Li, Mei Zhang, Yu Song, Ziang Pan, Bo Fan, Lin Lu, Hongyan Zhou, Yang Li
Frontiers in Oncology.2023;[Epub] CrossRef
Primary Borderline Mucinous Testicular Tumor: A Case Report and Literature Review
Changjuan Hao, Chunsong Kang, Xiaoyan Kang, Zhuanzhuan Yu, Tingting Li, Jiping Xue
Frontiers in Oncology.2021;[Epub] CrossRef
Ovarian-type Tumors (Mullerian Tumors) of the Testis: Clinicopathologic Findings with Recent Advances
Michelle S Lin, Alberto G Ayala, Jae Y Ro
annals of urologic oncology.2019; : 1. CrossRef
Borderline Mucinous Testicular Tumour: Diagnostic and Management difficulties
Krishan Pratap, Marlon Perera, Frances Malczewski, Rachel Esler
BMJ Case Reports.2018; : bcr-2017-223787. CrossRef
Mucinous tumor arising in a giant sacrococcygeal teratoma
Fengtian Zhang, Xiaolong Yu, Jin Zeng, Min Dai
Medicine.2017; 96(47): e8759. CrossRef

Oncocytic Lipoadenoma: A Rare Case of Parotid Gland Tumor and Review of the Literature: Chen-lin Chi, Tseng-tong Kuo, Li-yu Lee; J Pathol Transl Med. 2015;49(2):144-147. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2014.02.10

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Abstract PDF

Oncocytic lipoadenoma is a rare tumor, with only 18 cases having been reported since the first in 1998. We encountered a case of oncocytic lipoadenoma presenting as a slowly growing parotid mass in a 71-year-old man. This tumor is characteristically comprised of a mixture of oncocytes and adipocytes. The present case is one of five reported cases of oncocytic lipoadenoma showing sebaceous differentiation. The results of immunohistochemical study with DOG1 antibody supported the origination of this tumor in the striated duct.

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Oncocytic sialolipoma of parotid gland: Case report and literature review
VenuPatel Sureja, KoyyeRavindranath Tagore
Indian Journal of Pathology and Microbiology.2023; 66(3): 591. CrossRef
Complex Component of Oncocytic and Non-Oncocytic Lipoadenomas in the Parotid Gland: A Case Report
Fuyuki Sato, Takashi Nakajima, Takashi Sugino
Diagnostics.2021; 11(8): 1478. CrossRef
Oncocyitic lipoadenoma of the parotid gland
Renato PIANTANIDA, Alberto CARANTI, Adele CHIESA, Jessica BARIZZI, Ulrike PERRIARD, Filippo BARUCCA, Antonio PELLANDA
Otorinolaringologia.2021;[Epub] CrossRef
A case of oncocytic lipoadenoma of the submandibular gland and its diagnostic cytology challenges
Khaled A. Murshed, Ammar Khalafalla, Belal Alani, Hanan Farghaly, Moustafa Alkhalil
Diagnostic Cytopathology.2020; 48(4): 364. CrossRef
An extremely rare case of giant oncocytic adenolipoma of the parotid gland
Dipesh Shakya, Ajit Nepal
Clinical Case Reports.2020; 8(12): 2390. CrossRef
A rare cause of primary hyperparathyroidism: Parathyroid lipoadenoma
Sabri Özden, Servet Güreşci, Barış Saylam, Gül Dağlar
Auris Nasus Larynx.2018; 45(6): 1245. CrossRef
Oncocytic osteolipoadenoma of the submandibular gland
Domenico Corradi, Rodolfo Monaco, Giulia D'Angelo, Paola Bini, Teore Ferri, Enrico M Silini
Histopathology.2016; 69(1): 148. CrossRef

Brief Case Report

Cytokeratin-Positive Gastrointestinal Stromal Tumor of Biphasic Morphology: A Case Report: Sung Sun Kim, Yoo Duk Choi, Jae Hyuk Lee, Chan Choi; Korean J Pathol. 2014;48(5):375-378. Published online October 27, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.375

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CYTOKERATINS: NOT AN EPITHELIAL ENTITY ANYMORE?
Geetpriya Kaur, Devicharan Shetty, Seema Sikka, Aparna Pathak
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 15. CrossRef
Gastrointestinal stromal tumors of the stomach in a 10-year-old child
Saeed Nasher, Fayed Al-Yousofy, Faisal Ahmed
Journal of Pediatric Surgery Case Reports.2021; 74: 102044. CrossRef

Case Study

Development of Six Tumors in a Sebaceus Nevus of Jadassohn: Report of a Case: Serap Gozel, Melahat Donmez, Noyan Can Akdur, Hulya Yikilkan; Korean J Pathol. 2013;47(6):569-574. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.569

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Abstract PDF

Nevus sebaceus of Jadassohn is a congenital cutaneous hamartoma comprised of multiple skin structures. It has the potential to develop into variety of neoplasms of various epidermal adnexal origins. While multiple tumors may occasionally arise, it is unusual for more than four tumors to arise simultaneously within a single sebaceus nevus. Here in, we report a case of a 70-year-old woman with six neoplastic proliferations including a syringocystadenoma papilliferum, pigmented trichoblastoma, tubular apocrine adenoma, sebaceoma, tumors of follicular infundibulum and superficial epithelioma with sebaceus differentiation arising in a long standing nevus sebaceus on the scalp. Our case is extraordinary because a single nevus sebaceus contained six neoplastic proliferations with differentiation toward the folliculosebaceous-apocrine unit.

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Tumor of follicular infundibulum – reappraisal in a series of 28 patients with critical review of the literature
Michael Wilk, Bettina G. Zelger, Bernhard Zelger
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Tumor des follikulären Infundibulums – Neubewertung in einer Serie von 28 Patienten mit kritischer Analyse der Literatur
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Adnexal neoplasms of the eye
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Multiple secondary neoplasms in nevus sebaceus excision
Travis S. Dowdle, David A. Mehegran, Dylan Maldonado, Cort D. McCaughey
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Congenital tumors arising from nevus sebaceous in 2 neonates
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Multiple rare neoplasms arising from the nevus sebaceous of the scalp: A case report
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Syringocystadenoma Papilliferum and Basal Cell Carcinoma Arising in Nevus Sebaceous
Jingjing Jiang, Yujuan Chen, Qi He, Jiao Yang, Zhengzhong Zhang, Hao Yang, Huan Zhang, Chuan Yang
Clinical, Cosmetic and Investigational Dermatology.2022; Volume 15: 2021. CrossRef
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Trichilemmoma coexisting with sebaceous nevus
AngooriG Rao, VangaliS Reddy, M Tejal, M Divya
Indian Dermatology Online Journal.2020; 11(2): 253. CrossRef
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Oumama El Ezzi, Anthony S. de Buys Roessingh, Michèle Bigorre, Guillaume Captier
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Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous
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Vishwas Parekh, Cesar E. Guerrero, Charles F. Knapp, Craig A. Elmets, Kristopher M. McKay
The American Journal of Dermatopathology.2016; 38(1): 56. CrossRef
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet‐ring cells, all arising in nevus sebaceus
Emilie Dore, Megan H. Noe, Brian L. Swick
Journal of Cutaneous Pathology.2015; 42(9): 645. CrossRef
Ceruminous adenoma (ceruminoma) arising in a nevus sebaceus of Jadassohn within the external auditory canal of a 3 year-old boy – A case report
Elżbieta Niemczyk, Kazimierz Niemczyk, Jadwiga Małdyk, Lidia Zawadzka-Głos
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Original Article

Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases: Hyunchul Kim, Ja-June Jang, Dong-Sik Kim, Beom Woo Yeom, Nam Hee Won; Korean J Pathol. 2013;47(5):411-417. Published online October 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.411

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Abstract PDF

Background

Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group.

Methods

We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports.

Results

Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for β-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA.

Conclusions

Although the new classification is now generally accepted, validation through follow-up studies is necessary.

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Relevance of morphological features for hepatocellular adenoma classification in pathology practice
Carla Henriques Agostini, Osmar Damasceno Ribeiro, Arlete Fernandes, Adriana Caroli-Bottino, Vera Lucia Pannain
Surgical and Experimental Pathology.2020;[Epub] CrossRef
The molecular functions of hepatocyte nuclear factors – In and beyond the liver
Hwee Hui Lau, Natasha Hui Jin Ng, Larry Sai Weng Loo, Joanita Binte Jasmen, Adrian Kee Keong Teo
Journal of Hepatology.2018; 68(5): 1033. CrossRef
Hepatocellular adenoma: Classification, variants and clinical relevance
Paulette Bioulac-Sage, Christine Sempoux, Charles Balabaud
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A Limited Immunohistochemical Panel Can Subtype Hepatocellular Adenomas for Routine Practice
Brent K. Larson, Maha Guindi
American Journal of Clinical Pathology.2017; 147(6): 557. CrossRef
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Sounak Gupta, Bita V. Naini, Richard Munoz, Rondell P. Graham, Benjamin R. Kipp, Michael S. Torbenson, Taofic Mounajjed
American Journal of Surgical Pathology.2016; 40(4): 454. CrossRef
Pigmented hepatocellular adenomas have a high risk of atypia and malignancy
Taofic Mounajjed, Saba Yasir, Patrice A Aleff, Michael S Torbenson
Modern Pathology.2015; 28(9): 1265. CrossRef

Case Study

Sebaceous Carcinoma Arising in Mature Cystic Teratoma of Ovary: Hyo Jeong An, Yong Han Jung, Hye Kyoung Yoon, Soo Jin Jung; Korean J Pathol. 2013;47(4):383-387. Published online August 26, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.383

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Abstract PDF

Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.

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Sara Pakbaz, Tanya Chawla, Marcus Q Bernardini, Liat Hogen, Marjan Rouzbahman
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Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma
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Malignant transformation of an ovary mature cystic teratoma: case report and review of the literature
Elkin Fabián Dorado-Roncancio, Oscar Joel Carrillo-Garibaldi
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A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma
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Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
Alyssa Wield, Melissa Hodeib, Mohammad Khan, Lindsay Gubernick, Andrew J. Li, Shivani Kandukuri
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Review

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor: Suk Keun Lee, Yeon Sook Kim; Korean J Pathol. 2013;47(3):191-202. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.191

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Abstract PDF

Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke's pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively. AOTs are classified into follicular, extrafollicular, and peripheral types. Ameloblastomas are common, have an aggressive behavior and recurrent course, and are rarely metastatic, while AOTs are hamartomatous benign lesions derived from the complex system of the dental lamina or its remnants. With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. Therefore, it is suggested that comprehensive pathological observation including molecular genetic information can provide a more reliable differential diagnosis for the propagation and prognosis of ameloblastomas and AOTs. This study aimed to review the current concepts of ameloblastomas and AOTs and to discuss their clinico-pathological features relevant to tumorigenesis and prognosis.

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Wen Li, Yang Li, Xiaoling Liu, Li Wang, Wenqian Chen, Xueshen Qian, Xianglong Zheng, Jiang Chen, Yiming Liu, Lisong Lin
Frontiers in Immunology.2023;[Epub] CrossRef
Clinicopathological relevance of BRAF and SMO mutations in Chinese patients with ameloblastoma
Chen Ruixue, Li Hexiang, Hou Yali, Li Xiangjun, Sun Xu, Wang Jie, Zhang Xudong
All Life.2023;[Epub] CrossRef
Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors
TP Chaturvedi, Kanupriya Gupta, Rahul Agrawal, PG Naveen Kumar, Jatin Gupta
Journal of Cancer Research and Therapeutics.2022; 18(9): 205. CrossRef
Hypoxia enhances basal autophagy of epithelial‐derived ameloblastoma cells
Anwar A. A. Y. AlMuzaini, Kathleen Boesze‐Battaglia, Faizan Alawi, Sunday O. Akintoye
Oral Diseases.2022; 28(8): 2175. CrossRef
Giant ameloblastoma
Muthuvel Ramesh, A. N. Gurumoorthy, Jeevan G. Sanjive
Formosan Journal of Surgery.2022; 55(1): 27. CrossRef
Hemangiomatous Ameloblastoma with Spindle Cell Proliferation: A Rare Case Report and Review of Literature
PavanD Puri, Abhinandh Krishna, Suchitra Gosavi, Vivek Nayyar
Journal of Oral and Maxillofacial Pathology.2022; 26(1): 132. CrossRef
Clinical, Radiographic and Histopathological Analysis of Craniopharyngiomas and Ameloblastomas: A Systematic Review
Luana Amorim Morais da Silva, Solimar Ribeiro Carlete Filho, Marcelo Jales Diniz Saraiva, Caio Rodrigues Maia, Camila Dannyelle Fernandes Dutra Pe Santos, Pedro Paulo de Andrade Santos
Head and Neck Pathology.2022; 16(4): 1195. CrossRef
CDC7 Expression in Selected Odontogenic Tumors
Zohreh Jaafari-Ashkavandi, Nahid Alizadeh, Luca Testarelli
International Journal of Dentistry.2022; 2022: 1. CrossRef
Fibroblastic Growth Factor as a Diagnostic and Prognostic Marker in Odontogenic Cysts and Tumors: A Systematic Review
Gururaj Narayana Rao, Adlin Saroja Rosaian, Gowthami Jawahar, P. Hari Nivas Raj, J. Beryl Rachel, P. Blessing Emmanuel
Journal of Pharmacy and Bioallied Sciences.2021; 13(Suppl 1): S6. CrossRef
A View of Adenomatoid Odontogenic Tumor in Ameloblastoma: A Hybrid Variant
Priya Thomas, Sapna Chandran Lathakumari
Journal of Health Sciences & Research.2021; 12(1): 21. CrossRef
Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma
Yao-Cheng Yang, Jun-Jie Wang, Yun Huang, Wei-Xin Cai, Qian Tao
Cancer Management and Research.2021; Volume 13: 4403. CrossRef
Peripheral Adenomatoid Odontogenic Tumor — A Rare Cause of Gingival Enlargement: A Case Report with CBCT Findings

Arun Sadasivan, Roshni Ramesh, Nikhil M Kurien
Clinical, Cosmetic and Investigational Dentistry.2020; Volume 12: 297. CrossRef
Adenomatoid odontogenic tumour: A rare threat to orthodontic treatment planning
Laura Han, Alison Downing, David Farr, Kaushik Dasgupta, Duncan Stewart
Journal of Orthodontics.2019; 46(3): 259. CrossRef
Recurrence of plexiform ameloblastoma as acanthomatous ameloblastoma: A rare case report
SanatKumar Bhuyan, Ruchi Bhuyan, TapanKumar Sahoo, Pinali Das
Contemporary Clinical Dentistry.2019; 10(1): 178. CrossRef
Immunoexperssion of cancer stem cell marker (CD44) in ameloblastoma
ManjushriMadhukar Vanje, Shahela Tanveer, SyedAfroz Ahmed, Shravan Kumar, Tejashree Vanje
Journal of Oral and Maxillofacial Pathology.2019; 23(3): 400. CrossRef
Unklare Schwellung im Bereich eines Oberkiefereckzahns
S. H. Baum, C. Loef, D. Baumhoer, C. Mohr
Der MKG-Chirurg.2018; 11(2): 111. CrossRef
Ameloblastoma Secondary to Third Molar Extraction and Sagittal Split Ramus Osteotomy : A Case Report
Sung-Tak Lee, Santhiya Iswarya Vinothini Udayakumar, Tae-Geon Kwon, Hong-In Shin, So-Young Choi
The Korean Journal of Oral and Maxillofacial Pathology.2018; 42(2): 39. CrossRef
Glypican‐3 distinguishes aggressive from non‐aggressive odontogenic tumors: a preliminary study
Ramon Barreto Mendes, Rosane Borges Dias, Andreia Leal Figueiredo, Clarissa Araújo Gurgel, Manoel Santana Filho, Leonardo Araújo Melo, Marília Trierveiler, Patrícia Ramos Cury, Rosalia Leonardi, Jean Nunes Dos Santos
Journal of Oral Pathology & Medicine.2017; 46(4): 297. CrossRef
Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors
Marcelo Anderson Barbosa Nascimento, Cassiano Francisco Weege Nonaka, Carlos Augusto Galvão Barboza, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza
Archives of Oral Biology.2017; 73: 223. CrossRef
Rare case of ameloblastoma with pulmonary metastases
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Intractable & Rare Diseases Research.2017; 6(3): 211. CrossRef
High strength oil palm shell concrete beams reinforced with steel fibres
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Materiales de Construcción.2017; 67(328): 142. CrossRef
A novel marker of ameloblastoma and systematic review of immunohistochemical findings
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Annals of Diagnostic Pathology.2016; 22: 18. CrossRef
Adenoid variant of peripheral ameloblastoma with cellular atypia in the retromolar pad area: A case report
Bacem A.E.O. Khalele
Future Dental Journal.2016; 2(2): 91. CrossRef
Ameloblastoma during pregnancy: a case report
Helbert Eustáquio Cardoso da Silva, Erika do Socorro Ramos Costa, Antônio Carlos Quintão Medeiros, Paulo Sérgio dos Santos Pereira
Journal of Medical Case Reports.2016;[Epub] CrossRef
A case report and short review on changing trends in the site of occurrence of adenomatoid odontogenic tumor: Unravelling the past 15 years
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Dental Research Journal.2016; 13(5): 462. CrossRef
De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis
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Interdisciplinary Neurosurgery.2015; 2(3): 149. CrossRef
Understanding ameloblastomas through tooth development
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Journal of Dentistry and Oral Care.2015;[Epub] CrossRef
New Features in Mucous-Ameloblastoma. A Case Report of rare Entity
IS Gataa
International Journal of Oral and Craniofacial Science.2015; : 001. CrossRef
Adenomatoid odontogenic tumor associated with a dentigerous cyst: A case report
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Indian Journal of Dentistry.2014; 5: 82. CrossRef

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