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The Korean Journal of Pathology 1991;25(6): 589-593.
Necrobiotic Xanthogranuloma with Paraproteinemia: A case report.
Yee Jeong Kim, Kwang Gil Lee, Soo Il Chun, Hyung Soon Lee
1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
2Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
Necrobiotic xanthogranuloma(NXG) is a characteristic cutaneous manifestation associated with paraproteinemia. A case of NXG associated with an IgG (lambda) monoclonal gammopathy occurred in a 48-year-old man. Skin lesions were dome-shaped, hard palpable nodules, 2x3 cm to 4x4 cm sized, on both arms and forearms. They were arranged in a linear pattern. Also, hard palpable tumors, 1x2 cm to 2x3 cm in size, were present on the left leg and the dorsum of the left foot. They were violaceous, slightly protruded, and hard on palpation. Histologically, the lesion was characterized by inflammatory xanthogranuloma with broad hands of hyaline necrobiosis. Many foreign body type of bizarre giant cells, Touton type of giant cells and foamy histiocytes were infiltrated into the dermis and subcutaneous fat tissue. Three days after medication with ledercort and immuran, the cutaneous masses decreased in size and became soft.
Key Words: Necrobiotic xanthogranuloma; Paraproteinemia
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