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The Korean Journal of Pathology 1991;25(6): 594-600.
Early Gastric Carcinoma with Hepatoid Differentiation: Report of a case with histotopographic analysis.
Gyeong Hoon Kang, Chong Jai Kim, Yong Il Kim
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
ABSTRACT
A 56-year-old man received subtotal gastrectomy for an early gastric carcinoma type IIa+IIc with submucosal invasion. The tumor was made up of mixed papillo-tubular adenocarcinoma and solid carcinomatous portion, the latter comprising approximately four-fifths of the total tumor mass. The solid portion was confined within the submucosa and revealed a mixture of trabecular, compact and pelioid patterns of large polyhedra cells, resembling hepatocellular carcinoma of the liver(Edmondson-Steiner grade 2). Sinusoid-like vascular stroma of classical trabecular hepatocellular carcinoma intervened the tumor cell nests but was not associated with endothelial-cell lining. Immunohistochemical stainings with alpha-fetoprotein and alpha1-antitrypsin gave a strong reactivity in those areas of hepatoid differentiation and in the adjacent minute portion of adenocarcinoma. The findings suggest that a portion of gastric carcinoma may transdifferentiate into cells with hepatoid features along the line of endodermal lineage.
Key Words: Hepatoid carcinoma; Early gastric carcinoma; Stomach; Transdifferentiation