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The Korean Journal of Cytopathology 2007;18(1): 69-73.
Invasine Ductal Carcinoma with Osteoclast-Like Giant Cell in a Young Woman.
Hyun Jeong Kang, Jee Yeon Kim, Kyung Un Choi, Hee Suk Kwak, Mee Young Sol
1Department of Pathology, College of Medicine, Pusan National University, Pusan, Korea. artinus2000@naver.com, jeykim@pusan.ac.kr
2Department of Surgery, College of Medicine, Pusan National University, Pusan, Korea.
ABSTRACT
Mammary carcinoma with osteoclast-like giant cells is an unusual neoplasm characterized by giant cells, mononuclear stromal cells, and hemorrhage accompanying a low grade carcinoma. We present the cytological findings in a case of invasive ductal carcinoma with osteoclast-like giant cells that was initially confused with a fibroadenoma, due to its well-demarcated and soft mass and the young age of the patient. A 28-year-old female presented with a 4.5 cm, well demarcated, soft and nontender mass in the right breast. Fine needle aspiration cytology (FNAC) showed a combination of low grade malignant epithelial cell clusters and osteoclast-like giant cells. The atypical epithelial cells were present in cohesive sheets and clusters. Osteoclast-like giant cells and bland-looking mononuclear cells were scattered. An histological examination revealed the presence of an invasive ductal carcinoma with osteoclast-like giant cells. We report here the cytological findings of this rare carcinoma in a very young woman. The minimal atypia of the epithelial cells and its soft consistency may lead to a false negative diagnosis in a young woman. The recognition that osteoclastlike giant cells are rarely present in a low grade carcinoma, but not in benign lesion, can assist the physician in making a correct diagnosis.
Key Words: Osteoclast-like giant cell; Cytology; Aspiration; Breast; Young woman