Comparison of Cytologic Evaluation between Conventional Method and CellprepPlus(R) Liquid-Based Cytology in Body Fluid.

Ji Hae Koo; Ho Chang Lee; Hyung Geun Song; Hye Suk Han; Ki Hyeong Lee; Kang Hyeon Choe; Ki Man Lee; Ok Jun Lee

doi:10.4132/KoreanJPathol.2009.43.5.448

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Original Article Comparison of Cytologic Evaluation between Conventional Method and CellprepPlus(R) Liquid-Based Cytology in Body Fluid.: Ji Hae Koo, Ho Chang Lee, Hyung Geun Song, Hye Suk Han, Ki Hyeong Lee, Kang Hyeon Choe, Ki Man Lee, Ok Jun Lee; Journal of Pathology and Translational Medicine 2009;43(5):448-452
DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.5.448

¹Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea. ojlee@chungbuk.ac.kr
²Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.

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Abstract

BACKGROUND
Assessment of body fluid cytology is a useful means of evaluating a metastatic tumor. Liquid-based cytology (LBC) has been developed as a replacement for the conventional Papanicolaou (CP) test. This study was performed to compare CellprepPlus(R) LBC with CP in cytologic diagnosis. METHODS: Body fluid samples (n=188, including 72 peritoneal fluid and 116 pleural fluid samples) were divided equally and analyzed by both CellprepPlus(R) and CP.
RESULTS
CellprepPlus(R) revealed distributed thin layers of non-overlapping cells. All CellprepPlus(R) preparations were adequate, while 18 (9.57%) CP preparations were inadequate. The respective diagnostic rates of CellprepPlus(R) and CP were 75.0% and 76.1% negative, 10.6% and 6.38% atypical, 5.85% and 2.66% suspicious, and 8.51% and 5.32% malignant. Of the 58 confirmed cases, the sensitivity of CellprepPlus(R) and CP was 94.4% and 73.3%, respectively, and the negative predictive value was 97.2% and 87.9%, respectively.
CONCLUSIONS
CellprepPlus(R) LBC has better sensitivity and negative predictive value, and produces higher quality slide preparations than than CP, making it suitable as in screening of body fluid as a cytologic diagnostic tool.

Keywords: Body fluids;Cytology;Neoplasm metastasis;

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