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HOME > J Pathol Transl Med > Volume 32(9); 1998 > Article
Case Report Primary Malignant Melanoma of the Esophagus: A case report.
Lee So Maeng, Kyoung Mee Kim, Eun Jung Lee, Anhi Lee, Sang In Shim
Journal of Pathology and Translational Medicine 1998;32(9):694-696
DOI: https://doi.org/
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Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea.

This report presents an unusual case of primary malignant melanoma in the midesophagus. The patient was a 36-year-old woman presenting with dysphagia and odynophagia. The resected esophagus and proximal stomach showed a dark purple large polypoid mass, measuring 6.0 3.3 2.0 cm, with a diffuse tan pigmentation of surrounding mucosa in the mid-esophagus and two small daughter nodules, up to 1.2 0.3 cm, in the lower esophagus near the gastro-esophageal junction. A microscopic examination revealed a malignant melanoma of epithelioid cell type confined to mucosa and submucosa with a diffuse melanosis. Cytoplasmic immunoreactivity for HMB 45 and S-100 protein were noted. An electron microscopic examination revealed large, loosely cohesive variable shaped cells with a few cytoplasmic premelanosomes.

JPTM : Journal of Pathology and Translational Medicine