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The Korean Journal of Pathology 1998;32(9): 691-693.
Mineralizing Pulmonary Elastosis Associated with a Giant Cell Carcinoma.
Min Kyung Kim, Kwang Il Kim, Min Joo Kim, Young Woo Suh, Il Hun Seo, Hyun Ju Lee, Han Gyeom Kim
Department of Pathology, College of Medicine, Korea University, Seoul, Korea.
ABSTRACT
Mineralizing pulmonary elastosis is a result of chronic alveolar hemorrhage forming iron encrustation of a pulmonary elastic tissue. It has been reported as a complication of some diseases such as bronchiectasis, idiopathic pulmonary hemosiderosis, and cardiac failure. It is extremely rare to occur with a giant cell carcinoma as we experienced. A 59 year-old man visited our hospital for cough and blood tinged sputum. A chest CT scan revealed 10 9 6 cm sized round mass in the left upper lobe. He had lobectomy of left upper lobe, but died of respiratory failure at the postoperative eighteenth day. The lung showed a necrotic tumor and a yellow tan consolidation around the mass. Microscopically, the tumor was composed of nests or syncytia of large bizarre cells and tumor giant cells, and was diagnosed as a giant cell carcinoma. Interestingly, in the surrounding lung parenchyma there were a lot of foreign body type giant cells phagocytizing iron encrustated elastic fibers, which were easily identified by elastic van Gieson and prussian blue stains. Those degenerated elastic fibers appeared in pulmonary interstitial tissue as well as blood vessel walls. The authors concluded tumoral hemorrhage and necrosis resulted in mineralizing pulmonary elastosis.
Key Words: Lung; Mineralizing elastosis; Giant cell carcinoma