1 |
Current case |
2020 |
33 |
M |
Lower extremity (Rt. knee) |
Epidermal cyst |
2.0 |
Excision |
8 mo |
NROMD |
S100 (diffuse, luminal component; patchy, solid component), EMA (patchy, luminal component; diffuse, solid component), CK7, CK5/6 (patchy), CD117 (patchy), EpCAM (patchy), CEA (intra-luminal), p63 (rare) |
CK20, GCDFP-15, ER, calponin, SMA |
History of intracranial hemorrhage due to arteriovenous malformation No evidence of other malignancies |
2 |
Requena et al. [1] |
1998 |
NA |
NA |
Lower extremity |
NA |
NA |
Excision |
NA |
NA |
NA |
NA |
First description Reported as mainly women with a mean age of 44 years (range, 20 to 55) Two cases of recurrent tumor after incomplete excision |
3 |
|
|
NA |
NA |
Lower extremity |
NA |
NA |
Excision |
NA |
NA |
NA |
NA |
4 |
|
|
NA |
NA |
Lower extremity |
NA |
NA |
Excision |
NA |
NA |
NA |
NA |
5 |
|
|
NA |
NA |
Upper extremity |
NA |
NA |
Excision |
NA |
NA |
NA |
NA |
6 |
|
|
NA |
NA |
Pubis |
NA |
NA |
Excision |
NA |
NA |
NA |
NA |
|
7 |
Adamski et al. [5] |
2005 |
37 |
M |
Lower extremity (Lt. popliteal fossa) |
NA |
2.0 |
Excision |
2 yr |
NROMD |
CK7 |
CK20, GCDFP-15, S100 |
- |
8 |
Fernandez-Flores et al. [4] |
2007 |
62 |
F |
Lower extremity (Lt. popliteal fossa) |
NA |
0.8 |
Excision |
NA |
NROMD |
CK AE1/AE3, CAM 5.2, CK7, EMA, ER (2+, 1%–5% cells), c-erbB-2 (2+, 50%–75% cells), p53 (1+, 1%–5% cells), S100 (2+, 50%–75% cells) |
CK20, CEA, PR, GCDFP-15, CD15, SMA |
- |
9 |
Rutten et al. [2] |
2009 |
48 |
M |
Lower extremity (Rt. thigh) |
Dermatofibroma (histiocytoma) |
- |
Excision |
18 yr |
NROMD |
CK MNF116, CK AE1/AE3, CAM 5.2, CK7, CEA (more prominent in the ductal structures), EMA (more prominent in the ductal structures) |
CK20, GCDFP-15, S100, α-SMA, MSA, calponin, CD68, vimentin |
- |
10 |
|
|
51 |
F |
Upper extremity (Rt. forearm) |
Cyst |
- |
Excision |
NA |
NA |
|
- |
11 |
|
|
44 |
F |
Back |
Dermatofibroma (histiocytoma) |
- |
Excision |
13 yr |
NROMD |
|
|
- |
12 |
|
|
77 |
F |
Neck |
NA |
- |
Excision |
NA |
NA |
|
|
Recurrent tumor after incomplete excision |
13 |
|
|
32 |
F |
Lower extremity (Rt. thigh) |
Dermatofibroma (histiocytoma) |
- |
Excision |
9 yr |
NROMD |
|
|
- |
14 |
|
|
42 |
F |
Lower extremity (Rt. thigh) |
Dermatofibroma (histiocytoma) |
- |
Excision |
NA |
NA |
|
|
- |
15 |
|
|
34 |
F |
Upper extremity (Rt. arm) |
Dermatofibroma (histiocytoma) |
- |
Excision |
11 yr |
NROMD |
|
|
- |
16 |
|
|
40 |
M |
Upper extremity (Lt. forearm) |
Dermatofibroma (histiocytoma) |
- |
Excision |
NA |
NA |
|
|
- |
17 |
|
|
23 |
M |
Lower extremity (Lt. calf) |
NA |
- |
Excision |
NA |
NA |
|
|
- |
18 |
|
|
20 |
F |
Rt. buttock |
Cyst |
- |
Excision |
NA |
NA |
|
|
No evidence of other malignancies |
19 |
|
|
67 |
F |
Lt. preauricular area |
BCC vs. adnexal tumor |
- |
Excision |
8 yr |
NROMD |
|
|
- |
20 |
|
|
60 |
M |
Lower extremity (Rt. foot dorsum) |
Dermatofibroma (histiocytoma) |
- |
Excision |
4 yr |
NROMD |
|
|
- |
21 |
|
|
54 |
F |
Upper extremity (acral) |
NA |
- |
Excision |
NA |
NA |
|
|
- |
22 |
|
|
49 |
F |
Lower extremity (Lt. thigh) |
Dermatofibroma (histiocytoma) |
- |
Excision |
4 yr |
NROMD |
|
|
- |
23 |
|
|
59 |
F |
Lt. shoulder |
Dermatofibroma (histiocytoma) |
- |
Excision |
NA |
NA |
|
|
- |
24 |
|
|
28 |
M |
Lower extremity (Rt. lower leg) |
NA |
- |
Excision |
NA |
NA |
|
|
- |
25 |
|
|
54 |
M |
Upper extremity (Rt. hand) |
NA |
- |
Excision |
NA |
NA |
|
|
- |
26 |
|
|
50 |
F |
Upper extremity (Rt. hand) |
NA |
- |
Excision |
NA |
NA |
|
|
- |
27 |
|
|
70 |
M |
Rt. trunk |
Long-standing lesion |
- |
Excision |
6 yr |
NROMD |
|
|
- |
28 |
|
|
64 |
F |
NA |
Dermatofibroma (histiocytoma) |
- |
Excision |
5 yr |
NROMD |
|
|
- |
29 |
|
|
40 |
F |
Lower extremity (Lower arm) |
NA |
- |
Excision |
5 yr |
NROMD |
|
|
- |
30 |
|
|
64 |
M |
Upper back |
Dermatofibroma (histiocytoma) or cyst |
- |
Excision |
3 yr |
NROMD |
|
|
- |
31 |
|
|
54 |
M |
Lower extremity (Lower arm) |
NA |
- |
Excision |
3 yr |
NROMD |
|
|
- |
32 |
|
|
44 |
F |
Upper extremity (Lt. thumb) |
NA |
- |
Excision |
2 yr |
NROMD |
|
|
- |
33 |
|
|
36 |
F |
Lower extremity (Lt. anterior thigh) |
Dermatofibroma (histiocytoma) |
- |
Excision |
NA |
NA |
|
|
- |
34 |
|
|
26 |
F |
Lower extremity (Lt. posterior leg) |
Fibroma |
- |
Excision |
NA |
NA |
|
|
- |
35 |
Arps et al. [3] |
2015 |
41 |
F |
Lower extremity (leg) |
Epidermal inclusion cyst |
0.6 |
Excision |
NA |
NROMD |
S100 (diffuse in three cases, patchy in one case), CD117 (diffuse in two cases, patchy in one case), CK5/6, CK7, EpCAM, CEA (luminal), EMA (luminal), p63 (rare) |
CK20, GCDFP-15, ER, PR, calponin, SMA |
- |
36 |
|
|
32 |
F |
Upper extremity (elbow) |
NA |
0.5 |
Excision |
NA |
NA |
|
- |
37 |
|
|
35 |
M |
Lower extremity (leg) |
NA |
0.5 |
Excision |
NA |
NROMD |
|
|
- |
38 |
|
|
59 |
F |
Upper extremity (arm) |
NA |
0.4 |
Excision |
NA |
NA |
|
|
- |
39 |
|
|
61 |
M |
Upper extremity (arm) |
Mobile nodule |
0.7 |
Excision |
NA |
NA |
|
|
- |
40 |
|
|
31 |
M |
Lower extremity (leg) |
Dermatofibroma |
1.2 |
Excision |
NA |
NA |
|
|
- |
41 |
Yokota et al. [7] |
2017 |
39 |
F |
Upper extremity (Rt. forearm) |
NA |
0.5 (clinical) |
Excision |
15 mo |
NROMD |
CK5/6, CK7, CA15-3, CA125, CD117, S100 (partially), p53 (partially), p63 (partially) |
CK20, calponin, GCDFP-15, mammaglobulin, MUC1, ER, AR, D2–40 |
Stable in size for more than 10 years, no evidence of other malignancies |
42 |
Bogner et al. [6] |
2018 |
65 |
M |
Lt. lateral neck |
NA |
0.6 (clinical) |
Excision |
3 mo |
NROMD |
CK7 (strong), EMA (strong), CAM 5.2 (strong), EpCAM (lesser degree), CEA (in some of the lumina), p63, p40 |
CK20, D2–40, TTF-1, CDX-2, hepatocyte antigen, PSA, PSAP, calponin, S100 |
No evidence of other malignancies |