1 |
58/M |
Proximal CBD (upper 1/4) |
Jaundice, knife-like abdominal pain |
No |
Liver, retroperitoneal lymph node |
Stage IVBa
|
No surgery |
Died (23 days) |
2 |
24/F |
Junction of proximal CBD and cystic duct |
Jaundice, RUQ pain, elevated CEA |
SCC, MD without lymphovascular, perineural invasion |
Liver |
T2aN0M1 Stage IVBa
|
Pancreaticoduodenectomy, CTx (cyclophosphamide, MTX, doxorubicin, procarbazine) |
Died (8 mo) |
3 |
68/M |
Mid CBD |
Secondary biliary cirrhosis, portal hypertension, hepatic failure |
SCC, WD |
No |
TxNOMO in autopsy Stage I |
Cholecystectomy with T tube and wedge biopsy of liver |
Died (6 mo) |
4 |
56/M |
Hilar |
Jaundice |
SCC, PD |
Liver |
Stage IVBa
|
Cholecystectomy with T tube, RT |
Died (3 mo) |
5 |
68/M |
Mid CBD |
Jaundice, elevated CA19-9, elastase I |
SCC, WD with direct invasion of pancreas head |
No |
TxNOMO Stage III |
Pancreaticoduodenectomy, CTx (cisplatin, 5-FU), immunotherapy (OK-432) |
Alive (3 mo) |
6 |
68/M |
Distal CBD |
Jaundice, elevated CA19-9 |
1.8 cm, direct invasion of pancreas |
No |
T3N0M0 Stage IIIAa
|
Pancreaticoduodenectomy |
Alive (27 mo) |
7 |
50/M |
Hilar |
Elevated CA19-9, AFR CEA, PIVKA II |
4 cm |
Liver (S2,1 cm) |
TxNxMl Stage IVBa
|
Extended left hepatic lobectomy, T tube |
Died (10 mo) |
8 |
75/M |
Distal CBD |
Jaundice, elevated CA19-9 |
1.5 cm |
No |
TxN1M0 Stage IIIa
|
Pancreaticoduodenectomy |
Alive (6 mo) |
CEA+CA19-9+ |
9 |
57/F |
Distal CBD and ampulla of Vater |
Jaundice |
Invasion to pancreas and duodenum, CEA- PAS- |
No |
T3bN0M0 Stage IIIAa
|
Pylorus-preserving pancreatoduodenectomy |
Not described |
10 |
63/M |
Distal CBD |
Jaundice, elevated CA19-9 |
1.5 cm invasion to pancreas and duodenum |
No |
T2N1M0 Stage II |
Pancreaticoduodenectomy |
Alive (6 mo) |
11 |
86/F |
Junction of CBD and cystic duct |
Jaundice, RUQ pain |
PanCK |
Not described |
Not described |
CTx, external beam radiation, and high-dose radiation endoluminal brachytherapy (1,800 cGy) |
Died (18 mo) |
12 |
61/F |
Mid CBD |
Jaundice, WNL of CA19-9, CA125, AFP |
3 cm,CK(MNF116)+ CK10/13+ |
Peritoneal carcinomatosis |
T3N0M1 Stage IIIAa
|
Simple resection and hepatojejunal anastomosis |
Died (16 mo) |
History of cholecystectomy |
13 |
60/M |
Distal CBD |
Recurrent episodes of cholangitis and obstructive jaundice |
SCC, WD, 2 cm with metaplasia, dysplasia |
No |
T2N0M0 Stage lla
|
Pancreaticoduodenectomy |
Not described |
14 |
28/F |
Hilar |
Jaundice, RUQ pain |
SCC, MD with high-grade squamous dysplasia |
Not described |
Not described |
Extended left hepatic lobectomy, RT |
Alive (18 mo) |
15 |
41/F |
Hilar |
Jaundice, elevated CA19-9, choledochal cyst |
Direct invasion to portal vein and duodenum |
Not described |
T4NxMx, Stage IVa
|
Endoscopic biliary stent, palliative CTx, RT |
Not described |
16 |
64/M |
Distal CBD |
Abdominal discomfort, jaundice |
3 cm, CK19+ |
No |
T3N2M0, Stage IIIBa
|
Pancreaticoduodenectomy, CTx (CPT-11, PPD) |
Hepatic metastasis (30 days) and died (5 mo) |
17 |
66/M |
Hilar |
Jaundice, elevated CA19-9, SPan-1, DUPAN-2 |
SCC, WD, 3 cm, invasion of portal vein and liver, CK+ CAM5.2- |
T4 (Stage IV) |
T4N1M0 Stage IVAa
|
Extended right hepatic lobectomy, CTx (cisplatin+5-FU, gemcitabine+S-1) |
Hepatic metastasis (6 mo) and died (12 mo) |
18 |
67/M |
CHD |
Icteric sclera, elevated CA19-9 |
Synchronous double SCC, WD, 1.5 cm and adenocarcinoma |
No |
T1N1M0 Stage IIIBa
|
Pylorus-preserving pancreatoduodenectomy |
Multiple hepatic metastasis (3 mo) and died (8 mo) |
Metastatic adenocarcinoma in one regional lymph node |
19 |
77/F |
Mid CBD |
Jaundice, WNLofCA19-9, CEA, DUPAN-2 |
SCC, PD, 1.7 cm, invasion to right hepatic artery |
No |
T4N0M0, Stage IVAa
|
Pylorus-preserving pancreaticoduodenectomy, CTx (gemcitabine) |
Local recurrence (20 mo) and died (32 mo) |
CK5/6+ p53+ PAS- |
20 |
78/M |
Distal CBD |
Jaundice, brown urine, WNL of CEA, CA19-9, DUPAN-2 |
SCC, MD, 3 cm |
No |
T1N1M0 Stage IIIBa
|
Subtotal stomach-preserving pancreaticoduodenectomy, CTx (S-1, cisplatin) |
Paraaortic lymph node metastasis (6 mo), alive (10 mo), |
21 |
62/M |
CHD |
Jaundice, RUQ pain, elevated CA19-9 |
1.5 cm, perineural invasion |
Not described |
T1N0M0 Stage la
|
Curative resection and choledochojejunostomy, CTx (oral fluoropyrimidine S-1) |
Died (5 mo) |
PanCK+ CAM5.2+ CK5/6+ p63+ p40+ PAS- |
22 |
77/M |
CHD |
Elevated CA19-9, choledochal cyst |
Not described |
Not described |
Not described |
Curative resection and choledochojejunostomy |
Died (32 mo) |
23 |
67/F |
CHD |
티 evated CA19-9 |
Not described |
Not described |
Not described |
Pancreatiocoduodenectomy |
Died (47 mo) |
24 |
73/M |
Mid CBD |
WNL of CA19-9 and CEA |
4 cm, CK5/6+ p63+ |
No |
Not described |
Left hepatic lobe and caudate lobe resection, subtotal preserving pancreatoduodenectomy |
Alive (45 mo) |
25 (present case) |
62/F |
Hilar |
Nausea, abdominal discomfort, elevated CA19-9 |
2.8 cm, CEA- p40+ p63+ CK5/6+ CK7- |
No |
T2N1M0, Stage IIIC |
Cholecystectomy, left hemihepatectomy, S1 segmentectomy, CTx (5-FU, cisplatin) |
Alive (9 mo) |