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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2018.10.18    [Epub ahead of print]
Primary Malignant Melanoma of the Breast: A Report of Two Cases
Jiwon Koh1, Jihyeon Lee2, So Youn Jung3, Han Sung Kang3, Tak Yun4, Youngmee Kwon2,3
1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
2Department of Pathology, National Cancer Center, Goyang, Korea
3Center for Breast Cancer, National Cancer Center, Goyang, Korea
4Center for Specific Organs Center, National Cancer Center, Goyang, Korea
Corresponding Author: Youngmee Kwon ,Tel: +82-31-920-1742, Fax: +82-31-920-1369, Email: ymk@ncc.re.kr
Received: September 26, 2018;  Revised: October 13, 2018  Accepted: October 18, 2018.  Published online: November 26, 2018.
Primary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one with tumor derived from breast parenchyma and the other from breast skin. The first case consisted of atypical epithelioid cells without overt melanocytic differentiation. The tumor cells showed diffuse positivity for S100 protein, tyrosinase, and BRAF (V600E). However, the tumor cells were negative for cytokeratin, epithelial membrane antigen, and HMB-45. The second case showed atypical melanocytic proliferation with heavy melanin pigmentation. The tumor cells were positive for S100 protein, HMB-45, tyrosinase, and BRAF (V600E). These two cases represent two distinct presentations of PMMB in terms of skin involvement, melanin pigmentation, and HMB-45 positivity. Although PMMB is very rare, these cases show that it should be considered in malignant epithelioid neoplasms in the breast parenchyma.