- Primary Carcinoid Tumor of the Uterine Corpus: A Case Report.
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Sung Ran Hong, Hy Sook Kim, Jae Uk Shim
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Korean J Pathol. 2004;38(2):109-112.
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- Carcinoid tumors of the female genital tract are an uncommon clinical finding. This study presents a case of typical carcinoid tumor of the uterine corpus in a 61-year-old woman. The tumor was a primary carcinoid tumor arising from the endometrium which showed the typical organoid patterns with a positive reaction for neuroendocrine markers. The patient was treated by a total hysterectomy and bilateral salpingo-oophorectomy. No evidence for the carcinoid syndrome was noted. The carcinoid tumor recurred as a vaginal mass approximately six and a half years later. The patient died from a mechanical intestinal obstruction by the carcinoid tumor with distant metastasis approximately eight and a half years after operation of the endometrial primary tumor.
- Carcinosarcoma (Malignant M llerian Mixed Tumor) of the Female Genital Tract: A clinical and pathologic study of ten carcinosarcomas.
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Sung Ran Hong, Yee Jeong Kim, Hy Sook Kim, Jae Uk Shim, Chong Taik Park
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Korean J Pathol. 1998;32(5):362-369.
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Abstract
- Carcinosarcomas of the female genital tract have generally been regarded as a type of sarcoma. Recent studies, however, suggest the tumor may be more closely related to carcinoma and may represent metaplastic carcinoma in histogenesis. We analyzed clinicopathologic and immunohistochemical features of 10 carcinosarcomas to evaluate the relative importance of the carcinomatous and sarcomatous components in metastasis and recurrence. The primary tumor originated in the uterine body in seven cases, the uterine cervix in two and the ovary in one. Patient,s ages ranged from 54 to 71 years (mean, 64). The most common symptom of the uterine mass was vaginal bleeding. The median survival time was 21 months following diagnosis in five cases. Surgico-pathologic FIGO stages of five patients who received an operation were stage III and IV, but clinical FIGO stage of three patients (60%) among them were I. Lymphovascular invasions were identified in seven areas; five vascular invasion lesions showed the carcinomatous component alone, one the sarcomatous component alone, and remained one admixture of both components.
Metastatic and recurrent lesions to the paraaortic lymph node, ovary, pelvic wall, or vaginal vault showed characteristically carcinomatous component only.
Immunohistochemically, positive reactions for cytokeratin and epithelial membrane antigen were noted in the sarcomatous component of five cases. Vimentin positivity was detected in carcinomatous component of three cases. We conclude that the dominant element in carcinosarcomas of the female genital tract is the carcinomatous component. The survival rate of carcinosarcoma is extremely poor. The surgico-pathologic stage is better indicator of survival than the clinical stage. Immunohistochemical findings suggest that carcinosarcoma may represent a metaplastic carcinoma in histogenesis.
- Primary Transitional Cell Carcinoma of the Ovary: A case report.
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Eun Kyung Kim, Sung Ran Hong, Jae Uk Shim, Hy Sook Kim
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Korean J Pathol. 1993;27(1):78-80.
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- Primary ovarian transitional cell carcinoma(TCC) is a recently described, distinct subtype of ovarian carcinoma resembling TCC of the urinary bladder. TCC differs from malignant Brenner tumor(MBT) by absence of benign or proliferative Brenner component and prominent stromal calcification. TCC also represents a high-stage tumor with more aggressive biologic behavior than MBT, but it has a relatively favorable response to chemotherapy. TCC may arise from the pluripotential surface epithelium of the ovary or from the cells with urothelial differentiation, rather than from a benign or proliferative Brenner tumor precursors. We report a case of pure form of primary TCC presenting as a left ovarian mass in 45-year-old woman.
- Evaluation of "atypical squamous cells of undetermined significance" by the bethesda system.
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Yee Jeong Kim, Sung Ran Hong, Hy Sook Kim, Jong Sook Park, Kye Hyun Kim, Kyung Ho Lim, Jae Uk Shim, Chong Taik Park, Chong Soo Chun
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Korean J Cytopathol. 1993;4(2):81-86.
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- No abstract available.
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