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The Korean Journal of Pathology 1990;24(3): 321-325.
Cytophagic Histiocytic Panniculitis: 2 cases report.
Gil Ro Han, Hye Seon Ahn, In Sook Kim, Jin Hee Sohn, Jung Il Suh
Department of Pathology, National Medical Center, Seoul, Korea.
Cytophagic histiocytic panniculitis is a rescently described histiocytic disorder. It is characterized by the presence of fever, pancytopenia, and subcutaneous nodules resulting from the infiltration of lympho-histiocytes in the dermis and subcutaneous adipose tissue. The characteristic findings is presence of bean-bag histiocytes containing phagocytized red blood cells, lymphocytes, and platelets. We experienced two cases of cytophagic histiocytic panniculitis with hard and erythematous subcutaneous nodules. These skin lesions exhibited infiltration of the subcutaneous tissue by large, benign histiocytes with cytophagic features. Hemophagocytic histiocytes were observed in the cervical lymph node in case 1, and bone marrow in case 2. One patient is alive, while the other one died with hemorrhagic complications.
Key Words: Cytophagic histiocytic panniculitis; Bean-bag cell
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