| Home | E-Submission | Sitemap | Contact Us |  
top_img
JPTM > Volume 19(2); 2008 > Article
The Korean Journal of Cytopathology 2008;19(2): 119-125.
doi: https://doi.org/10.3338/kjc.2008.19.2.119
Comparison of Clinical Efficacy between an HPV DNA Chip and a Hybrid-Capture II Assay in a Patient with Abnormal Colposcopic Findings.
Tae Jung Kim, Chan Kwon Jung, Ahwon Lee, Eun Sun Jung, Young Jin Choi, Kyo Young Lee, Jong Sup Park
1Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. klee@catholic.ac.kr
2Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
ABSTRACT
This study was performed to compare the efficacy between a DNA chip method and a Hybrid-Capture II assay (HC-II) for detecting human papillomavirus in patients with intraepithelial lesions of the uterine cervix. From May, 2005, to June, 2006, 192 patients with abnormal colposcopic findings received cervical cytology, HC-II and HPV DNA chip tests, and colposcopic biopsy or conization. We compared the results of HC-II and HPV DNA chip in conjunction with liquid based cervical cytology (LBCC) and confirmed the results of biopsy or conization. The sensitivity of the HPV DNA chip test was higher than HC-II or LBCC. The HPV DNA chip in conjunction with LBCC showed higher sensitivity than any single method and higher sensitivity than HC-II with LBCC. We confirmed that the HPV DNA chip test was more sensitive for detecting HPV in cervical lesions than HC-II, and that it would provide more useful clinical information about HPV type and its multiple infections.
Key Words: HPV; HC-II; HPV DNA chip