14-bp Insertion/Deletion Polymorphism of the HLA-G Gene in Osteosarcoma Patients.

Ahrim Moon; Su Kang Kim; Joo Ho Chung; Ki Yong Na; Liliana G Olvi; Eduardo Santini-Araujo; Youn Wha Kim; Yong Koo Park

doi:10.4132/KoreanJPathol.2011.45.5.485

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Original Article 14-bp Insertion/Deletion Polymorphism of the HLA-G Gene in Osteosarcoma Patients.: Ahrim Moon, Su Kang Kim, Joo Ho Chung, Ki Yong Na, Liliana G Olvi, Eduardo Santini-Araujo, Youn Wha Kim, Yong Koo Park; The Korean Journal of Pathology 2011;45(5):485-490
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.5.485

¹Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea. ykpark@khmc.or.kr
²Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Korea.
³Laboratory of Orthopaedic Pathology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
⁴Department of Pathology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.

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Abstract

BACKGROUND
The major histocompatibility complex class I, G (human leukocyte antigen-G [HLA-G]) gene plays a vital role in the suppression of immune responses. Recently, a number of studies have reported an association between HLA-G and diseases (pregnancy complications, organ transplantation, and tumors). Some of the studies have revealed that the 14-bp insertion/deletion polymorphism might be associated with various diseases. The aim of the present study was to explore a possible influence of the 14-bp insertion/deletion polymorphism on osteosarcoma.
METHODS
Genomic DNA was extracted from 75 formalin-fixed, paraffin-embedded tumor tissues derived from patients with conventional osteosarcoma (OSA) and 183 peripheral blood samples of healthy controls. Fifty-eight cases were South Korean patients with OSA and 17 cases were Argentine patients with OSA. The HLA-G 14-bp insertion/deletion polymorphism at exon 8 of the HLA-G locus was analyzed by polymerase chain reaction.
RESULTS
There was a significantly different distribution profile for the 14-bp genotypes between the Korean OSA and Korean control groups. Specifically, there were more heterozygote 210 bp/224 bp genotypes in the Korean OSA group when compared to the Korean control group (62.1% vs 40.4%, p=0.002).
CONCLUSIONS
The results suggest that HLA-G heterozygote patients may be more susceptible to OSA in the Korean population.

Keywords: HLA-G;14-bp insertion/deletion polymorphism;Osteosarcoma

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Bernardin Ahouty, Mathurin Koffi, David Courtin, Ilboudo Hamidou, Didier Sokouri, Innocent Abé, Laure Gineau, Thomas Konan, Lingué Kouakou, Tidou Abiba Sanogo, Enock Matovu, Bruno Bucheton, Vincent Jamonneau, Simon-Pierre N’Guetta
Open Journal of Genetics.2019; 09(02): 31. CrossRef
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