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JPTM > Volume 45(5); 2011 > Article
The Korean Journal of Pathology 2011;45(5): 485-490.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.5.485
14-bp Insertion/Deletion Polymorphism of the HLA-G Gene in Osteosarcoma Patients.
Ahrim Moon, Su Kang Kim, Joo Ho Chung, Ki Yong Na, Liliana G Olvi, Eduardo Santini-Araujo, Youn Wha Kim, Yong Koo Park
1Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea. ykpark@khmc.or.kr
2Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Korea.
3Laboratory of Orthopaedic Pathology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
4Department of Pathology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
BACKGROUND: The major histocompatibility complex class I, G (human leukocyte antigen-G [HLA-G]) gene plays a vital role in the suppression of immune responses. Recently, a number of studies have reported an association between HLA-G and diseases (pregnancy complications, organ transplantation, and tumors). Some of the studies have revealed that the 14-bp insertion/deletion polymorphism might be associated with various diseases. The aim of the present study was to explore a possible influence of the 14-bp insertion/deletion polymorphism on osteosarcoma. METHODS: Genomic DNA was extracted from 75 formalin-fixed, paraffin-embedded tumor tissues derived from patients with conventional osteosarcoma (OSA) and 183 peripheral blood samples of healthy controls. Fifty-eight cases were South Korean patients with OSA and 17 cases were Argentine patients with OSA. The HLA-G 14-bp insertion/deletion polymorphism at exon 8 of the HLA-G locus was analyzed by polymerase chain reaction. RESULTS: There was a significantly different distribution profile for the 14-bp genotypes between the Korean OSA and Korean control groups. Specifically, there were more heterozygote 210 bp/224 bp genotypes in the Korean OSA group when compared to the Korean control group (62.1% vs 40.4%, p=0.002). CONCLUSIONS: The results suggest that HLA-G heterozygote patients may be more susceptible to OSA in the Korean population.
Key Words: HLA-G; 14-bp insertion/deletion polymorphism; Osteosarcoma
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