Uncoupling Protein 2 (UCP2) and p53 Expression in Invasive Ductal Carcinoma of Breast.

Kyu Yeoun Won; Gou Young Kim; Youn Wha Kim; Sung Jig Lim; Jeong Yoon Song

doi:10.4132/KoreanJPathol.2010.44.6.565

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Original Article Uncoupling Protein 2 (UCP2) and p53 Expression in Invasive Ductal Carcinoma of Breast.: Kyu Yeoun Won, Gou Young Kim, Youn Wha Kim, Sung Jig Lim, Jeong Yoon Song; Journal of Pathology and Translational Medicine 2010;44(6):565-570
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.6.565

¹Department of Pathology, East-West Neo Medical Center, Kyung Hee University College of Medicine, Seoul, Korea.
²Department of Pathology, Kyung Hee Medical Center, Kyung Hee University College of Medicine, Seoul, Korea.
³Department of Surgery, East-West Medical Center, Kyung Hee University College of Medicine, Seoul, Korea. jeonguni@khu.ac.kr

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Abstract

BACKGROUND
Uncoupling protein 2 (UCP2) is a recently identified mitochondrial inner membrane anion carrier and a negative regulator of reactive oxygen species production. In this study, we evaluated the characteristics and relationships of UCP2 and p53 expression in breast cancer tissues.
METHODS
Tissue microarray slides from 107 cases of invasive ductal carcinoma of the breast were constructed, UCP2 and p53 immunohistochemical staining was conducted, and clinicopathological correlations were investigated.
RESULTS
UCP2 expression in invasive ductal carcinoma was high in 53 cases (49.5%), while p53 expression in invasive ductal carcinoma was high in 37 cases (34.6%). UCP2 expression was correlated significantly with histological grade (p = 0.038) and mitotic count (p = 0.050). UCP2 expression was correlated significantly with p53 expression in invasive ductal carcinoma of the breast (p = 0.045). UCP2 expression (p = 0.8308) and p53 expression (p = 0.3292) showed no significant difference for the overall survival rate in patients with invasive ductal carcinoma.
CONCLUSIONS
UCP2 expression in invasive ductal carcinoma increased proportionally with histological grade and mitotic count. High UCP2 expression in invasive ductal carcinoma was observed in conjunction with high p53 expression.

Keywords: Carcinoma, ductal, breast;Mitochondrial uncoupling protein 2;Tumor suppressor protein p53;Reactive oxygen species

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Forkhead box protein A1 inhibits the expression of uncoupling protein 2 in hydrogen peroxide-induced A549 cell line
Lan Song, Zhaojun Xu, Ling Li, Mei Hu, Lijuan Cheng, Lingli Chen, Bo Zhang
Cell Stress and Chaperones.2014; 19(1): 53. CrossRef
New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis
Delira Robbins, Yunfeng Zhao
International Journal of Molecular Sciences.2011; 12(8): 5285. CrossRef

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