Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast: A Case Report.

Ga Eon Kim; Young Kim; Eun Hui Jeong; Jo Heon Kim; Min Ho Park; Ji Shin Lee

doi:10.4132/KoreanJPathol.2010.44.4.431

Skip Navigation: Skip to contents

SEARCH: Search

Advanced Search

mobile menu button

Articles

Page Path: HOME > J Pathol Transl Med > Volume 44(4); 2010 > Article

Case Report Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast: A Case Report.: Ga Eon Kim, Young Kim, Eun Hui Jeong, Jo Heon Kim, Min Ho Park, Ji Shin Lee; The Korean Journal of Pathology 2010;44(4):431-434
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.431

¹Department of Pathology, Chonnam National University Medical School, Gwangju, Korea. jshinlee@hanmail.net
²Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.

prev next

5,607 Views
77 Download
3 Crossref
5 Scopus

Full Article

Download PDF

Abstract

Smooth muscle cell metaplasia is an extremely rare form of stromal differentiation in fibroadenomas. We describe a case of fibroadenoma with exuberant smooth muscle cells in a 72-year-old woman. The mass was located in the upper central portion of the left breast. It was well circumscribed and its greatest dimension was 3 cm. Histologically, the glandular elements resembled the appearance of fibroadenoma, but the stromal elements were composed of spindle cell bundles with abundant eosinophilic cytoplasm and elongated cigar-shaped nuclei. Neither mitotic activity nor cellular atypia was seen. The stromal cells were immunohistochemically positive for smooth muscle actin, calponin, desmin, and estrogen receptor-beta, but negative for CD34, S-100 protein, p63, CD10, estrogen receptor-alpha, progesterone receptor and cytokeratin. These results proved that the stromal cells showed features of smooth muscle cells.

Keywords: Breast;Fibroadenoma;Muscle cells;Metaplasia

Figure & Data

References

Citations

Citations to this article as recorded by

Whole slide phase imaging by space-time digital holography for stain-free characterization of breast cancer and fibroadenoma in histological tissues
Zhe Wang, Vittorio Bianco, Lisa Miccio, Valentina Brancato, Giovanni Smaldone, Massimiliano D’ Aiuto, Gennaro Mossetti, Pier Luca Maffettone, Marco Salvatore, Pietro Ferraro
Journal of Physics: Photonics.2026; 8(1): 015074. CrossRef
Fibroadenomatoid Hyperplasia of the Breast with Prominent Smooth Muscle Component: An Uncommon Histopathological Encounter
Seetu Palo, Divya Donepudi, Shrinivas Bheemrao Somalwar
Journal of Mid-life Health.2025; 16(2): 226. CrossRef
Unusual Myoid Differentiation in a Canine Benign Mixed Mammary Tumour
Barbara Brunetti, Luisa Vera Muscatello, Louis J. DeTolla, Giancarlo Avallone, Isabel Pires
Case Reports in Veterinary Medicine.2021; 2021: 1. CrossRef

Cited

Related articles