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The Korean Journal of Pathology 2009;43(5): 408-412.
doi: https://doi.org/10.4132/KoreanJPathol.2009.43.5.408
Significance of the Expression of Cathepsins B, H, & L in Colonic Epithelial Neoplasms.
Jae Young Sim, Mi Ja Lee, Keun Hong Kee
Department of Pathology, College of Medicine, Chosun University, Gwangju, Korea. khkee@chosun.ac.kr
BACKGROUND: Cathepsin is associated with tumorigenesis, tumor invasion and metastasis through its ability to induce degradation of extracellular matrix components. METHODS: To investigate the correlation between cathepsin expression and tumor progression, invasion depth or nodal metastasis, immunohistochemical staining for cathepsins B, H and L were done on 20 hyperplastic polyps, 48 adenomas, and 67 adenocarcinomas of the colon. Evaluation of the expression of cathepsins B, H and L was based on the percentage of neoplastic cells that stained positive for any given cathepsin. RESULTS: Cathepsin B expression was significantly higher in adenocarcinomas than adenomas (29.33 vs 5.48%), but was not associated with the degree of differentiation, depth of invasion and nodal status of the tumors. Expression of cathepsins H and L was absent or low in both adenomas and adenocarcinomas. CONCLUSIONS: We suggest that cathepsin B is involved in progression of a subset of colonic adenomas, while cathepsins H and L are not.
Key Words: Cathepsin; Colon; Adenoma; Adenocarcinoma