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The Korean Journal of Pathology 2007;41(5): 337-342.
Multiple Glomus Tumors of the Ankle with Prominent Intranuclear Pseudoinclusions.
Jae Yeon Seok, Se Hoon Kim, Tae jung Kwon, Jieun Kwon, Yoon Hee Lee, Kyoo Ho Shin, Woo Ick Yang
1Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea. wiyang9660@yumc.yonsei.ac.kr
2Brain Korea 21 Project for Medical Science, Korea.
3Department of Forensic Medicine, National Institute of Scientific Investigation, Seoul, Korea.
4Department of Orthopedic Surgery, College of Medicine, Yonsei University, Seoul, Korea.
ABSTRACT
Glomus tumors are neoplasms that are composed of modified smooth muscle cells of the glomus body. Here, we report a case of multiple glomus tumors of the ankle that showed various histologic types, including the solid type (glomus tumor proper) and angiomatous type (glomangioma). The tumor cells observed in this case also showed prominent intranuclear inclusions, which has not yet been reported in glomus tumors. Ultrastructural examination demonstrated that the nuclear inclusions were not true inclusion bodies but were intranuclear cytoplasmic pseudoinclusions formed by cytoplasmic invaginations that formed as a result of the deep and complex nuclear contours.
Key Words: Glomus tumor; Glomangioma; Ankle; Intranuclear inclusion
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