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The Korean Journal of Pathology 2007;41(1): 55-58.
A Case of Gastric Inverted Hyperplastic Polyp Associated with Gastritis Cystica Profunda and Early Gastric Carcinoma.
Min Sung Choi, So Young Jin, Dong Won Kim, Dong Wha Lee, Sang Mo Park
Department of Pathology, Soonchunhyang University Hospital, Seoul 140-743, Korea. jin0924@hosp.sch.ac.kr
ABSTRACT
A gastric inverted hyperplastic polyp is characterized by downward growth of the hyperplastic mucosal components into the submucosa. Lesions are composed of hyperplastic foveolar-type glands, and sometimes coexist with gastritis cystica profunda (GCP). Adenocarcinoma frequen- tly can coexist, but the relationship is not clear. A 71-year-old male was admitted to hospital because of dyspepsia for one month. He underwent a wedge resection of the stomach, after endoscopic biopsies. The gross finding showed a slightly elevated papillary lesion with central depression. Microscopically, the elevated lesion was composed of hyperplastic fundic glands and foveolar cells, and the central depressed lesion showed a nodular inverted proliferation of normal appearing gastric epithelium and glands in the submucosa. An additional proximal gastrectomy specimen exhibited marked GCP and a minute adenocarcinoma at the proximal margin with p53 protein overexpression.
Key Words: Stomach; Inverted hyperplastic polyp; Gastritis cystica profunda; Early gastric carcinoma