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The Korean Journal of Pathology 2007;41(1): 51-54.
Intraneural Perineurioma in the Tongue: A Case Report.
Jun Kang, Shin Kwang Khang, Jene Choi, Jeong Won Kim, Eul Ju Seo, Bu kyu Lee, Eunsil Yu
1Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. esyu@amc.seoul.kr
2Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
3Department of Dentistry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
ABSTRACT
We report a case of an intraneural perineurioma that developed in an unusual location, the tongue. A 16-year-old male presented with a 1 cm sized protruding submucosal mass in his tongue without any sensory or motor signs or symptoms. The mass was excised. The mucosa was intact, with an ill-defined firm mass measuring 1.0 x 0.8 x 0.6 cm in the submucosa and muscle. The cut surface of the mass was pinkish gray and fibrotic. Microscopically, the mass contained tortuous and thickened peripheral nerve bundles in the submucosa, showing onion bulb like structures. The onion bulb like structures consisted of centrally located S-100 protein positive Schwann cells surrounded by Glut-1 positive perineurial cells. The FISH study did not reveal any genetic aberrations in chromosome 22.
Key Words: Nerve sheath neoplasms; Tongue neoplasms; Immunohistochemistry; In situ hybridization, Fluorescence; Genes, Neurofibromatosis 2