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The Korean Journal of Pathology 2005;39(6): 401-405.
Expression of Vascular Endothelial Growth Factor-C in Breast Carcinoma.
Myoung Ja Chung, Sun Ho Yang, Kyu Yun Jang, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee
1Department of Pathology, Chonbuk National University Medical School, Institute for Medical Sciences, Jeonju, Korea. kyjang@chonbuk.ac.kr
2Department of Rehabilitation, Chonbuk National University Medical School, Institute for Medical Sciences, Jeonju, Korea.
ABSTRACT
BACKGROUND: Vascular endothelial growth factor-C (VEGF-C) is a novel growth factor that regulates lymphangiogenesis and/or angiogenesis via binding to the vascular endothelial growth factor receptor-3 (VEGFR-3) or VEGFR-2. Recent studies have suggested that VEGF-C may play a role in lymph node metastasis. This study was conducted to examine whether the expression of VEGF-C is associated with the clinicopathologic parameters, and especially lymph node metastasis, of invasive ductal carcinoma. METHODS: Immunohistochemical staining was performed for VEGF-C and CD31 in the surgically resected specimens from 83 patients with invasive breast carcinoma. RESULTS: Of the 83 breast carcinomas, 61 (74%) cases showed cytoplasmic VEGF-C imunoreactivity. VEGF-C expression was associated with lymph node metastasis (p=0.03), but it did not correlate with tumor size, the histologic grade, and the presence of estrogen receptor or progesteron receptor. The mean microvessel density in the cases without VEGF-C expression was 51.9+/-30.1 and it was 72.9+/-33.0 in the cases with 2+ expression for VEGF-C (p=0.07). CONCLUSIONS: This study suggests that VEGF-C expression may have an association with lymph node metastasis in the patients with breast carcinoma.
Key Words: Breast Carcinoma; VEGF-C