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The Korean Journal of Pathology 2004;38(2): 121-125.
Minimal Deviation Adenocarcinoma, Mucinous Type, of the Uterine Cervix: Report of a Case with Extensive Metastasis to the Uterine Corpus and Bilateral Adnexae.
Eundeok Chang, Eunjung Lee, Kyoungmee Kim, Okran Shin, Youngmi Ku, Heejung An, Changsuk Kang
1Department of Clinical Pathology, The Catholic University of Korea, College of Medicine, Uijongbu, Korea. ejlpath@catholic.ac.kr
2Department of Radiology, The Catholic University of Korea, College of Medicine, Uijongbu, Korea.
3Department of Pathology, Pundang CHA Hospital, Pochon CHA University, Seoul, Korea.
ABSTRACT
Minimal deviation adenocarcinoma is an extremely well differentiated variant of cervical adenocarcinoma, and is frequently misdiagnosed due to its benign-looking histopathological features. A 38-year-old woman was diagnosed as having had a minimal deviation adenocarcinoma in the cervix, metastasizing to the uterine body and bilateral adnexae. She had a history of right salpingo-oophorectomy 3 years ago, and was diagnosed as having a mucinous cystadenoma. Histologically, the tumor cells were so well-differentiated that they appeared to be almost the same as those of the non-neoplastic cervical glands. Similar glands were found in both ovaries and in the left fallopian tube. PAS staining showed a negative or apical positive pattern in the endocervical-like glands. Immunohistochemical studies for CEA, ER/PR, cytokeratin 20, and p53 were negative, but positive for cytokeratin 7. The HPV DNA microarray test was negative. Clinically, this proved to be an advanced, biologically aggressive disease.
Key Words: Adenocarcinoma, Mucinous; Cervix
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