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The Korean Journal of Pathology 2004;38(2): 116-120.
Odontogenic Gingival Epithelial Hamartoma; with Reference to the Expression of Ameloblastin Gene by in situ Hybridization and Immunohistochemistry.
Na Rae Kim, Yeon Lim Suh, Je G Chi, Young Joon Lee, Suk Keun Lee, Jae Il Lee, Chang Yun Lim, Ji Young Park
1Department of Pathology, Gachon Medical School Gil Medical Center, Incheon, Korea.
2Department of Pharmacology, Gachon Medical School Gil Medical Center, Incheon, Korea.
3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ylsuh@smc.samsung.co.kr
4Department of Pathology, Ilsanpaik Hospital, College of Medicine Inje University, Koyang, Korea.
5Department of Oral Pathology, College of Dentistry, Kangnung National University, Kangnung, Korea.
6Department of Oral Pathology, College of Dentistry, Seoul National University, Seoul, Korea.
Odontogenic gingival epithelial hamartoma (OGEH) is an extremely rare lesion characterized by an abnormal proliferation of odontogenic epithelium. This lesion is thought to arise from the rest of the dental lamina lying dormant in the gingival tissue after odontogenesis. Distinguishing OGEH from the granular cell variant of ameloblastoma and central odontogenic fibroma is important. To date, only eleven cases have been reported, and its pathogenesis remains unclear. We report here on a case of OGEH, where the epithelial strands in the lesion were conspicuously positive for the antisera of cytokeratin 19 and ameloblastin. Tumor cells intensely expressed ameloblastin mRNA by in situ hybridization. To the best of our knowledge, this is the first case of OGEH to which ameloblastin immunohistochemical stain and in situ hybridization were applied. Although our study is limited to a single case, the coexpression of cytokeratin 19 and ameloblastin might indicate the origin and specific cytodifferentiation of OGEH is quite different and unique, when contrasted to other odontogenic tumors.
Key Words: Odontogenic Gingival Epithelial Hamartoma; Ameloblastin; Cytokeratin 19
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