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The Korean Journal of Pathology 2002;36(3): 191-194.
Primary Leiomyosarcoma of Adrenal Gland: A Case Report.
Heejeong Lee, Jinyoung Yoo, Seok Jin Kang, Byung Kee Kim
Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. Jinyyoo@vincent.cuk.ac.kr
Primary mesenchymal neoplasm of the adrenal gland is very rare. Recently we experienced a case of leiomyosarcoma of the adrenal gland in a 47-year-old female patient. The resected adrenal gland showed a large lobulated mass, which replaced the entire gland. The cut surface was firm and whitish gray with foci that showed hemorrhage and necrosis. Histologically, the tumor was composed of intersecting fascicles of pleomorphic spindle cells with numerous giant cells and mitotic figures. Some of the tumor cells showed elongated nuclei. Immunohistochemical studies were strongly positive for vimentin and smooth muscle actin. Cytokeratin, desmin, alpha-1-antitrypsin and lysozyme were all negative. To the best of our knowledge, this is the first case reported in Korea.
Key Words: Leiomyosarcoma; Adrenal Gland Neoplasms