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The Korean Journal of Pathology 2001;35(2): 115-122.
The Expression of Transforming Growth Factor-1 and Its Signaling Receptors in Human Colorectal Carcinoma.
Gyeong Seon Kim, Joo Heon Kim, Woo Sung Moon, Myoung Ja Chung, Dong Geun Lee, Myoung Jae Kang
1Department of Pathology, College of Medicine, Institute for Medical Science, Chonbuk National University, Chonju 561-712, Korea. mjkang@moak.chonbuk.ac.kr
2Department of Pathology, Eulji University School of Medicine, Daejeon 301-070, Korea.
BACKGROUND: Resistance to the potent growth inhibitory effects of TGF- (transforming growth factor-) is a characteristic of many malignancies. TGF- insensitivity has been attributed to alterations in the number and function of the TGF- receptors as well as disturbances of downstream signal transduction. The aim of this study was to examine the expression of TGF-1 and its receptors in human colorectal cancer tissue and determine its relationship with cancer growth and with prognostic factors. METHODS: Immunohistochemical staining of TGF-1, TGF-RI, and TGF-RII was performed on 20 human colorectal adenomas, 30 carcinomas and 10 normal mucosas as a control. RESULTS: The staining indices of TGF-1, TGF-RI, and TGF-RII increased in adenomas and carcinomas compared with normal mucosas and adenomas, respectively. In adenomas the staining index of TGF-1 significantly increased with the severity of atypism. The staining index of TGF-RII increased in the carcinomas in the right colon and rectum, compared with those in the left colon. CONCLUSION: The enhanced expression of TGF-1, TGF-RI and II in the colorectal carcinoma suggests an important role of colorectal carcinogenesis and tumor progression.
Key Words: Colorectal neoplasms; Transforming growth factor beta; Receptors; Immunohistochemistry