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The Korean Journal of Pathology 2001;35(2): 111-114.
Microsatellite Instability in Colorectal Carcinomas.
Hee Jeong Cha, Dong Kyun Woo, Sun Hee Kim, Yong ll Kim, Jae Gahb Park, Woo Ho Kim
Department of Pathology, Cancer Research Institute and Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea. woohokim@snu.ac.kr
ABSTRACT
BACKGROUND: Microsatellite instability (MSI), which is caused by a deficient mismatch repair system, is seen in most of the hereditary non-polyposis colon cancers and a portion of sporadic colorectal cancers. METHODS: Two hundreds forty-six consecutive sporadic colorectal cancer patients were analyzed for MSI using an ABI 377 automatic sequencer and fluorescent dye-labelled primers (BAT-25 and BAT-26). RESULTS: The overall incidence of MSI in studied cases was 9.8% (24/246). This incidence is lower than most of the reported incidences in western countries. The incidence of MSI tumors in the proximal colon was 29.6%, while that of the distal colon was only 4.2% (p<0.001). MSI in sporadic colorectal cancers was more prevalent in poorly differentiated adenocarcinoma. In contrast to western countries, mucinous carcinoma did not show higher incidence of MSI. CONCLUSION: The results suggest that MSI frequently occurs in cancers of the proximal colon and in tumors with poorly differentiated histology.
Key Words: Colorectal neoplasms; Microsatellite repeats; Sequence analysis