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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2018.11.12    [Epub ahead of print]
Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
Hyun Min Koh1, Hyo Jung An1, Gyung Hyuck Ko2,3,4, Jeong Hee Lee2,3,4, Jong Sil Lee2,3,4, Dong Chul Kim2,3,4, Jung Wook Yang4, Min Hye Kim4, Sung Hwan Kim2,3,5, Kyung Nyeo Jeon2,3,6, Gyeong-Won Lee2,3,7, Se Min Jang8, Dae Hyun Song1,2,3
1Department of pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea
2Gyeongsang National University School of Medicine, Jinju, Korea
3Gyeongsang Institute of Health Science, Jinju, Korea
4Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea
5Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University Changwon Hospital, Changwon, Korea
6Department of Radiology, Gyeongsang National University Changwon Hospital, Changwon, Korea
7Department of internal medicine, Gyeongsang National University Hospital, Jinju, Korea
8Department of Pathology, Konyang University Hospital, Daejeon, Korea
Corresponding Author: Dae Hyun Song ,Tel: +82-55-214-3150, Fax: +82-55-214-3174, Email: golgy@hanmail.net
Received: May 15, 2018;  Revised: November 7, 2018  Accepted: November 12, 2018.  Published online: November 26, 2018.
ABSTRACT

Background:
S100A8 and S100A9 have been gaining recognition for modulating tumor growth and metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 in non-small cell lung cancer (NSCLC).
Methods:
We analyzed the relationship between S100A8 and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumor cells and peritumoral inflammatory cells.
Results:
The positive staining in tumor cells for S100A8 was significantly increased in male (p < .001), smoker (p = .034), other surgical method (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022) compared to female, non-smoker, lobectomy, adenocarcinoma (ADC) and lower stage. The proportion of stained tumor cells for S100A8 was related with histologic type (p < .001) and patient sex (p < .027). The proportion of stained inflammatory cells for S100A8 showed correlation with patient age (p = .022), whereas the proportion of stained inflammatory cells for S100A9 showed relation with patient sex (p < .001) and smoking history (p = .031). Moreover, the positive staining in tumor cells, more than 50% stained in tumor cells and less than 30% stained in inflammatory cells for S100A8 and S100A9 suggested a tendency to increase survivability with significantly favorable prognosis in more than 50% stained in tumor cells for S100A9 (hazard ratio, 0.483; 95% confidence interval, 0.265-0.880; p = 0.017) in SQCC, and an opposite trend of survival in ADC.
Conclusions:
S100A8 and S100A9 expressions might be potential prognostic markers in patients suffering from NSCLC.