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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2018.04.28    [Epub ahead of print]
Hyalinizing Trabecular Tumor of the Thyroid Gland, a Diagnostic Challenge in Fine-Needle Aspiration Cytology: Case Report
Ye-Young Rhee1, Hong Kyu Jung2, Se Hoon Kim3, Soo Hee Kim1
1Pathology Center, Seegene Medical Foundation, Seoul, Korea
2Department of Surgery and Health Care Center, Seran Hospital, Seoul, Korea
3Department of Pathology, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
Corresponding Author: Soo Hee Kim ,Tel: +82-2-2218-9346, Fax: +82-2-2218-9310, Email: kshpath@gmail.com
Received: March 16, 2018;  Revised: April 18, 2018  Accepted: April 27, 2018.  Published online: June 11, 2018.
Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor with low to minimal malignant potential. HTT is often misinterpreted as other thyroid tumors, including papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC), on fine-needle aspiration (FNA) cytology, because of its overlapping cytologic features, such as nuclear grooves and intranulcear pseudoinclusions. Although cytopathologists cannot definitely conclude HTT by FNA cytology, suspicion of HTT is necessary to avoid misdiagnosing HTT as PTC or MTC and to avoid unnecessary aggressive treatment. Here, we report a case of HTT with novel cytologic features in CellPrep liquid based cytology that was diagnosed as suspicious for papillary carcinoma by FNA and finally diagnosed as HTT in the surgical specimen.
Key Words: Hyalinizing trabecular tumor; Thyroid gland; Liquid-based cytology