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Volume 52(4); July 2018
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Original Articles
Pulmonary Nodular Lymphoid Hyperplasia with Mass-Formation: Clinicopathologic Characteristics of Nine Cases and Review of the Literature
Jongmin Sim, Hyun Hee Koh, Sangjoon Choi, Jinah Chu, Tae Sung Kim, Hojoong Kim, Joungho Han
J Pathol Transl Med. 2018;52(4):211-218.   Published online June 15, 2018
DOI: https://doi.org/10.4132/jptm.2018.04.27
  • 8,533 View
  • 289 Download
  • 7 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Background
Pulmonary nodular lymphoid hyperplasia (PNLH) is a non-neoplastic pulmonary lymphoid disorder that can be mistaken for malignancy on radiography. Herein, we present nine cases of PNLH, emphasizing clinicoradiological findings and histological features.
Methods
We analyzed radiological and clinicopathological features from the electronic medical records of nine patients (eight females and one male) diagnosed with PNLH. IgG and IgG4 immunohistochemical staining was performed in three patients.
Results
Two of the nine patients had experienced tuberculosis 40 and 30 years prior, respectively. Interestingly, none were current smokers, although two were ex-smokers. Three patients complaining of persistent cough underwent computed tomography of the chest. PNLH was incidentally discovered in five patients during examination for other reasons. The remaining patient was diagnosed with the disease following treatment for pneumonia. Imaging studies revealed consolidation or a mass-like lesion in eight patients. First impressions included invasive adenocarcinoma and mucosal-associated lymphoid tissue‒type lymphoma. Aspergillosis was suspected in the remaining patient based on radiological images. Resection was performed in all patients. Microscopically, the lesions consisted of nodular proliferation of reactive germinal centers accompanied by infiltration of neutrophils and macrophages in various degrees and surrounding fibrosis. Ultimately, all nine patients were diagnosed with PNLH and showed no evidence of recurrence on follow-up.
Conclusions
PNLH is an uncommon but distinct entity with a benign nature, and understanding the radiological and clinicopathological characteristics of PNLH is important.

Citations

Citations to this article as recorded by  
  • Pulmonary Nodular Lymphoid Hyperplasia Evaluated with Bronchoalveolar Lavage Fluid Findings: A Case Report and Review of the Literature on Japanese Patients
    Sakiko Moriyama, Takashi Kido, Noriho Sakamoto, Mai Fuchigami, Takatomo Tokito, Daisuke Okuno, Takuto Miyamura, Shota Nakashima, Atsuko Hara, Hiroshi Ishimoto, Yoshitaka Imaizumi, Kazuto Tsuruda, Katsunori Yanagihara, Junya Fukuoka, Hiroshi Mukae
    Internal Medicine.2023; 62(1): 95.     CrossRef
  • A Case of Pulmonary Nodular Lymphoid Hyperplasia Responding to Corticosteroid Treatment
    Jonathan Teow Koon Goh, Issam Al Jajeh, Jessica Han Ying Tan
    Cureus.2023;[Epub]     CrossRef
  • Pulmonary nodular lymphoid hyperplasia presenting as cavitating lung mass
    Aqeel Alameer, Chary Duraikannu, Avinash Kumar Kanodia, David Dorward
    BMJ Case Reports.2023; 16(8): e254121.     CrossRef
  • Clinicopathological Characteristics and Curative Effect of Lymphoma Based on Sampling Theory
    Shuxiang Ding, Leipo Liu
    Mathematical Problems in Engineering.2022; 2022: 1.     CrossRef
  • Pulmonary nodular lymphoid hyperplasia presenting as multifocal subsolid nodules: A case report and literature review
    Yoon Jin Cha, Duk Hwan Moon, Ji Hyun Park, Sungsoo Lee, Ji Ae Choi, Tae Hoon Kim, Chul Hwan Park
    Respiratory Medicine Case Reports.2022; 36: 101581.     CrossRef
  • Pulmonary nodular lymphoid hyperplasia in a 53-year-old man with malignant sign: a case report
    Zhen Yang, Lianshuang Wei, Xu Li, Xin Liu
    Journal of Cardiothoracic Surgery.2021;[Epub]     CrossRef
  • The diagnostic challenge of adenocarcinoma in pulmonary nodular lymphoid hyperplasia
    Anita Savić Vuković, Melita Kukuljan, Morana Dinter, Ksenija Jurinović, Nives Jonjić
    SAGE Open Medical Case Reports.2021; 9: 2050313X2110393.     CrossRef
Endobronchial Smooth Muscle Tumors: A Series of Five Cases Highlighting Pitfalls in Diagnosis
Tripti Nakra, Aanchal Kakkar, Shipra Agarwal, Karan Madan, Suresh C Sharma, Deepali Jain
J Pathol Transl Med. 2018;52(4):219-225.   Published online July 11, 2018
DOI: https://doi.org/10.4132/jptm.2018.05.16
  • 5,212 View
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  • 5 Web of Science
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AbstractAbstract PDF
Background
Primary endobronchial smooth muscle tumors (SMTs), which are extremely rare, include endobronchial leiomyomas and leiomyosarcomas. Clinically, SMTs present with signs and symptoms of bronchial obstruction, and lack specific radiological findings. Thus, histopathological examination is required for accurate diagnosis as well as for tumor grading. We examined the histomorphological and immunohistochemical features of endobronchial SMTs and highlighted pitfalls in diagnosis, particularly when using small biopsies.
Methods
Cases of primary endobronchial SMTs diagnosed at our Institute over the last 6 years (2012–2017) were retrieved from the departmental archives. Histopathological features and immunohistochemistry performed for establishing the diagnosis were reviewed.
Results
Five cases of SMTs occurring in endobronchial locations were identified. These included three cases of leiomyoma, and two cases of leiomyosarcoma. The age distribution of patients ranged from 13 to 65 years. Leiomyomas showed more consistent staining with smooth muscle markers (smooth muscle actin, desmin, and smooth muscle myosin heavy chain), while tumors of higher grade showed variable, focal staining, leading to erroneous diagnosis, especially on small biopsies.
Conclusions
The diagnosis of endobronchial SMTs relies on histopathological examination, for both confirmation of smooth muscle lineage and determination of the malignant potential of the lesion. Appropriate immunohistochemical panels including more than one marker of smooth muscle differentiation are extremely valuable for differential diagnosis from morphological mimics, which is necessary for instituting appropriate management.

Citations

Citations to this article as recorded by  
  • Smooth Muscle Conditions of the Chest
    Matthew R. McCann, Lucas R. Massoth, Carlos A. Rojas, Yin P. Hung, John P. Lichtenberger, Gerald F. Abbott, Justin T. Stowell
    Journal of Thoracic Imaging.2021; 36(5): 263.     CrossRef
  • A Well-Defined Endobronchial Tumor in a 26-Year-Old Man
    Christina Triantafyllidou, Petros Effraimidis, Mirjam Schimanke, Simone Ignatova, Anders Ringman, Susann Skoog, Farkas Vánky, Miklós Boros, Karin Cederquist
    Chest.2021; 159(5): e313.     CrossRef
  • Primary Pulmonary Leiomyoma
    Mohammad Abu-Hishmeh, Gowthami Kobbari, Fouzia Shakil, Oleg Epelbaum
    Journal of Bronchology & Interventional Pulmonology.2020; 27(4): e54.     CrossRef
Case Studies
Hepatocellular Carcinoma Arising in a Huge Hepatocellular Adenoma with Bone Marrow Metaplasia
Hyo Jeong Kang, Hui Jeong Jeong, So-Woon Kim, Eunsil Yu, Young-Joo Lee, So Yeon Kim, Jihun Kim
J Pathol Transl Med. 2018;52(4):226-231.   Published online December 27, 2017
DOI: https://doi.org/10.4132/jptm.2017.11.12
  • 5,894 View
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  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Hepatocellular adenoma (HCA) is the most common type of benign liver tumor, and its major complication is malignant transformation to hepatocellular carcinoma (HCC). Here, we report a case of HCC arising in HCA with bone marrow metaplasia in a 24-year-old Korean woman who presented with abdominal discomfort. A huge liver mass was found on abdominal ultrasonography. She underwent surgical hepatic resection, and the resected specimen was entirely involved by a 20-cm-sized tumor. Histological review revealed a well differentiated HCC arising from inflammatory HCA with β-catenin nuclear positivity and bone marrow metaplasia that contained hematopoietic cells. This case was unique because malignant transformation, inflammatory type HCA, β-catenin nuclear staining, and bone marrow metaplasia were simultaneously observed. Additionally, it should be noted that a large HCA with β-catenin activation can undergo malignant transformation and should be surgically resected in a timely manner.

Citations

Citations to this article as recorded by  
  • Adult Hepatocellular Carcinoma Coexisting with Extramedullary Hematopoiesis
    Hirotsugu Noguchi, Michiyo Higashi, Ryo Desaki, Takashi Tasaki, Mari Kirishima, Ikumi Kitazono, Kazuhiro Tabata, Akihide Tanimoto
    International Journal of Surgical Pathology.2022; 30(3): 339.     CrossRef
  • Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice
    Wenhua Shao, Orgil Jargalsaikhan, Mayuko Ichimura-Shimizu, Qinyi Cai, Hirohisa Ogawa, Yuko Miyakami, Kengo Atsumi, Mitsuru Tomita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Yasusei Kudo, Takeshi Oya, Koichi Tsuneyama
    International Journal of Molecular Sciences.2022; 23(19): 11923.     CrossRef
  • Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma
    Pattamon Sutthatarn, Cara E. Morin, Jessica Gartrell, Wayne L. Furman, Max R. Langham, Teresa Santiago, Andrew J. Murphy
    Children.2021; 8(3): 226.     CrossRef
  • Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon
    Juan Putra, Linda D. Ferrell, Annette S.H. Gouw, Valerie Paradis, Arvind Rishi, Christine Sempoux, Charles Balabaud, Swan N. Thung, Paulette Bioulac-Sage
    Modern Pathology.2020; 33(4): 665.     CrossRef
  • Hepatocellular carcinoma arising from hepatic adenoma in a young woman
    Haythem Yacoub, Hela Kchir, Dhouha Cherif, Hajer Hassine, Slim Haouet, Asma Ayari, Habiba Mizouni, Saber Mannai, Mohamed Tahar Khalfallah, Nadia Maamouri
    Clinical Case Reports.2020; 8(9): 1659.     CrossRef
  • Metanephric adenoma with osseous metaplasia and bone marrow elements
    Alessandro Pietro Aldera, Jeff John, Dharshnee Chetty, Dhirendra Govender
    Human Pathology: Case Reports.2019; 17: 200316.     CrossRef
Combined Hepatocellular Carcinoma and Neuroendocrine Carcinoma with Ectopic Secretion of Parathyroid Hormone: A Case Report and Review of the Literature
Hyun Jung Kwon, Ji-Won Kim, Haeryoung Kim, YoungRok Choi, Soomin Ahn
J Pathol Transl Med. 2018;52(4):232-237.   Published online May 25, 2018
DOI: https://doi.org/10.4132/jptm.2018.05.17
  • 6,265 View
  • 150 Download
  • 14 Web of Science
  • 14 Crossref
AbstractAbstract PDF
Primary combined hepatocellular carcinoma (HCC) and neuroendocrine carcinoma is a rare entity, and so is hypercalcemia due to ectopic parathyroid hormone (PTH) secretion by tumor. A 44-year old man with hepatitis B virus associated chronic liver disease presented with a hepatic mass. Hemihepatectomy discovered the mass as combined HCC and poorly differentiated cholangiocarcinoma. During adjuvant chemoradiation therapy, he presented with nausea, and multiple systemic metastases were found. Laboratory tests revealed hypercalcemia with markedly elevated PTH and neuron specific enolase. Parathyroid scan showed normal uptake in parathyroid glands, suggestive of ectopic PTH secretion. Subsequently, immunohistochemistry of neuroendocrine marker was performed on the primary lesion, and confirmed the neuroendocrine differentiation in non-HCC component. The patient died 71 days after surgery. This report may suggest the possibility of ectopic PTH secretion by neuroendocrine carcinoma of hepatic origin causing hypercalcemia. Caution for neuroendocrine differentiation should be exercised when diagnosing poorly differentiated HCC.

Citations

Citations to this article as recorded by  
  • Case report: mixed large-cell neuroendocrine and hepatocellular carcinoma of the liver
    Xin Gao, Heng Wang, Zheyu Niu, Meng Liu, Xiaohan Kong, Hongrui Sun, Chaoqun Ma, Huaqiang Zhu, Jun Lu, Xu Zhou
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Mixed Primary Hepatocellular Carcinoma and Hepatic Neuroendocrine Carcinoma: Case Report and Literature Review
    Woo Young Shin, Keon Young Lee, Kyeong Deok Kim
    Medicina.2023; 59(2): 418.     CrossRef
  • Comparison of Metastatic Patterns Among Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Nonneuroendocrine Carcinomas of Various Primary Organs
    Hyung Kyu Park, Ghee Young Kwon
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Immunohistochemical characterization of a steroid-secreting oncocytic adrenal carcinoma responsible for paraneoplastic hyperparathyroidism
    Magalie Haissaguerre, Estelle Louiset, Christofer C Juhlin, Adam Stenman, Christophe Laurent, Hélène Trouette, Hervé Lefebvre, Antoine Tabarin
    European Journal of Endocrinology.2023; 188(4): K11.     CrossRef
  • Neuroendocrine neoplasms of the biliary tree, liver and pancreas: a pathological approach
    Claudio Luchini, Giuseppe Pelosi, Aldo Scarpa, Paola Mattiolo, Deborah Marchiori, Roberta Maragliano, Fausto Sessa, Silvia Uccella
    Pathologica.2021; 113(1): 28.     CrossRef
  • Contrast-Enhanced Ultrasound Findings of Hepatocellular Carcinoma With Neuroendocrine Carcinoma: A Case Report
    Hong Wang, Dan Yang, Zhenru Wu, Yan Luo, Wenwu Ling
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma: case report and literature review
    Akira Nakano, Kenichi Hirabayashi, Hiroshi Yamamuro, Taro Mashiko, Yoshihito Masuoka, Seiichiro Yamamoto, Soji Ozawa, Toshio Nakagohri
    World Journal of Surgical Oncology.2021;[Epub]     CrossRef
  • Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges
    Hsuan Yeh, Chung-Cheng Chiang, Tzung-Hai Yen
    World Journal of Gastroenterology.2021; 27(26): 4104.     CrossRef
  • Severe hypercalcaemia from ectopic intact parathyroid hormone secretion treated with continuous renal replacement therapy in a patient with two malignancies
    Nathaniel Hocker, Maria Story, Alysa Lerud, Sarat Kuppachi
    BMJ Case Reports.2021; 14(6): e242172.     CrossRef
  • Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone
    Filomena Cetani, Elena Pardi, Claudio Marcocci
    Endocrinology and Metabolism Clinics of North America.2021; 50(4): 683.     CrossRef
  • Primary hepatic neuroendocrine cancer coexisted with hepatocellular carcinoma: a case report
    Chikara Ebisutani, Seitetsu Yoon, Toshiki Hyodo, Takafumi Watanabe, Hirofumi Okada, Yutaka Shirakawa, Yoshio Sakamoto, Shigeya Hirohata
    Kanzo.2020; 61(3): 122.     CrossRef
  • Two-in-one: A pooled analysis of primary hepatic neuroendocrine carcinoma combined/collided with hepatocellular carcinoma
    Jia-Xi Mao, Fei Teng, Ke-Yan Sun, Cong Liu, Guo-Shan Ding, Wen-Yuan Guo
    Hepatobiliary & Pancreatic Diseases International.2020; 19(4): 399.     CrossRef
  • Primary hepatic neuroendocrine carcinoma coexisting with distal cholangiocarcinoma
    Qi Xin, Rong Lv, Cheng Lou, Zhe Ma, Gui-Qiu Liu, Qin Zhang, Hai-Bo Yu, Chuan-Shan Zhang
    Medicine.2020; 99(26): e20854.     CrossRef
  • Mixed hepatocellular carcinoma-neuroendocrine carcinoma—A diagnostic and therapeutic challenge
    Nusrat Jahan, Irfan Warraich, Edwin Onkendi, Sanjay Awasthi
    Current Problems in Cancer: Case Reports.2020; 1: 100020.     CrossRef
Primary Cutaneous Mucinous Carcinoma with Extramammary Paget’s Disease: Eccrine or Apocrine?
Sun-Ju Oh, Young-Ok Kim
J Pathol Transl Med. 2018;52(4):238-242.   Published online January 25, 2018
DOI: https://doi.org/10.4132/jptm.2017.11.21
  • 6,323 View
  • 128 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. The histogenesis of PCMC, whether eccrine or apocrine, remains controversial. We report a rare case of PCMC with secondary extramammary Paget’s disease in the groin of a 75-year-old man, which favored an apocrine origin. Furthermore, based on a review of the literature, we provide several histologic clues that can be used to differentiate PCMC from metastatic mucinous carcinoma.

Citations

Citations to this article as recorded by  
  • Primary cutaneous mucinous carcinoma of the scalp masquerading as a benign dermatological mass – A case report
    Fadi Alnehlaoui, Nafad Mohamed Lotfy Elhadidi, Shafik Fwakhrji, Shekhar V. Shikare, Majid Hassan Alhammadi, Salman Yousuf Guraya
    International Journal of Surgery Case Reports.2024; 114: 109175.     CrossRef
  • Primary Cutaneous Mucinous Carcinoma: A Review of the Literature
    Timothy Freeman, Aaron J. Russell, M. Laurin Council
    Dermatologic Surgery.2023; 49(12): 1091.     CrossRef
  • A Case of Eccrine Mucinous Carcinoma Involving Scalp
    Ramsha Saleem, Sachin Vaidya
    Cureus.2021;[Epub]     CrossRef
Recurrent Indeterminate Dendritic Cell Tumor of the Skin
Jin Woo Joo, Taek Chung, Yoon Ah Cho, Sang Kyum Kim
J Pathol Transl Med. 2018;52(4):243-247.   Published online April 5, 2018
DOI: https://doi.org/10.4132/jptm.2018.03.27
  • 5,760 View
  • 96 Download
  • 2 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Indeterminate dendritic cell tumor (IDCT) is a dendritic cell tumor that displays histologic features similar to those of Langerhans cells. The origin of the indeterminate cells may represent precursors of Langerhans cells or skin dendritic cells. IDCT is extremely rare, and tumor progression and predictive factors are not well known. Here, we report a case of a 61-year-old man who presented with a papule on his back and was finally diagnosed with IDCT based on histology and immunohistochemistry. The tumor recurred three months after surgical excision.

Citations

Citations to this article as recorded by  
  • Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features
    Simone Zanella, Emilio Berti, Arturo Bonometti
    Journal of the European Academy of Dermatology and Venereology.2023; 37(8): 1559.     CrossRef
Brief Case Report
Sudden Child Death due to Thrombotic Giant Coronary Artery Aneurysms Complicated by Atypical Kawasaki Disease: An Autopsy Case
DongJa Kim, Man-Hoon Han, SangHan Lee
J Pathol Transl Med. 2018;52(4):248-251.   Published online May 11, 2018
DOI: https://doi.org/10.4132/jptm.2017.10.23
  • 5,111 View
  • 123 Download
  • 1 Web of Science
  • 2 Crossref
PDF

Citations

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  • Autoptic Findings in Cases of Sudden Death Due to Kawasaki Disease
    Giacomo Visi, Federica Spina, Fabio Del Duca, Alice Chiara Manetti, Aniello Maiese, Raffaele La Russa, Paola Frati, Vittorio Fineschi
    Diagnostics.2023; 13(11): 1831.     CrossRef
  • Sudden Cardiac Death from Coronary Arteriosclerosis and Coronary Artery Aneurysm in Childhood: An Autopsy Case
    Ho Lee, Sang Jae Noh
    Korean Journal of Legal Medicine.2022; 46(1): 19.     CrossRef
Case Studies
Hyalinizing Trabecular Tumor of the Thyroid Gland, a Diagnostic Challenge in Fine-Needle Aspiration Cytology: Case Report
Ye-Young Rhee, Hong Kyu Jung, Se Hoon Kim, Soo Hee Kim
J Pathol Transl Med. 2018;52(4):252-256.   Published online June 11, 2018
DOI: https://doi.org/10.4132/jptm.2018.04.28
  • 8,272 View
  • 169 Download
  • 5 Web of Science
  • 8 Crossref
AbstractAbstract PDF
Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor with low to minimal malignant potential. HTT is often misinterpreted as other thyroid tumors, including papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC), on fine-needle aspiration (FNA) cytology, because of its overlapping cytologic features, such as nuclear grooves and intranulcear pseudoinclusions. Although cytopathologists cannot definitely conclude HTT by FNA cytology, suspicion of HTT is necessary to avoid misdiagnosing HTT as PTC or MTC and to avoid unnecessary aggressive treatment. Here, we report a case of HTT with novel cytologic features in CellPrep liquid based cytology that was diagnosed as suspicious for papillary carcinoma by FNA and finally diagnosed as HTT in the surgical specimen.

Citations

Citations to this article as recorded by  
  • Cytomorphological traits of fine-needle aspirates of hyalinizing trabecular tumor of the thyroid gland: A brief report
    Fei Wang, Yufei Liu
    Indian Journal of Pathology and Microbiology.2024; 67(1): 128.     CrossRef
  • Total thyroidectomy can still remain the method of choice in some Bethesda III cases
    Jindrich Lukas, Barbora Hintnausova, Vlasta Sykorova, Martin Syrucek, Marek Maly, Jaroslava Duskova
    Biomedical Papers.2023; 167(1): 61.     CrossRef
  • Diagnostic clues for hyalinizing trabecular tumor on fine needle aspiration cytology
    Lone Nielsen, Ana María Colino Gallardo, Pablo Pérez Alonso, Luis Ortega Medina, Esthefanía Latorre García, Cristina Díaz del Arco, Reyes Bergillos Jiménez, Lorenzo Alarcón García, Marta Cruz Blanco, Jesús Vega González, Montserrat De la Torre Serrano, Ma
    Cytojournal.2023; 20: 19.     CrossRef
  • Clinical Characteristics of the Hyalinizing Trabecular Tumor
    Byung-Chang Kim, Shin Jeong Pak, Jae Won Cho, Won Woong Kim, Yu-mi Lee, Tae-Yon Sung, Jung Hwan Baek, Ki-Wook Chung
    Journal of Endocrine Surgery.2022; 22(4): 116.     CrossRef
  • A Case of Multifocal Hyalinizing Trabecular Tumors of the Thyroid Gland
    Suhwan Jeong, Hanaro Park
    Journal of Clinical Otolaryngology Head and Neck Surgery.2021; 32(3): 308.     CrossRef
  • The Diagnosis of Hyalinizing Trabecular Tumor: A Difficult and Controversial Thyroid Entity
    Esther Diana Rossi, Mauro Papotti, William Faquin, Luigi Maria Larocca, Liron Pantanowitz
    Head and Neck Pathology.2020; 14(3): 778.     CrossRef
  • A large series of hyalinizing trabecular tumors: Cytomorphology and ancillary techniques on fine needle aspiration
    Marco Dell’Aquila, Carmen Gravina, Alessandra Cocomazzi, Sara Capodimonti, Teresa Musarra, Stefania Sfregola, Vincenzo Fiorentino, Luca Revelli, Maurizio Martini, Guido Fadda, Liron Pantanowitz, Luigi Maria Larocca, Esther Diana Rossi
    Cancer Cytopathology.2019; 127(6): 390.     CrossRef
  • GLIS rearrangements in thyroid nodules: A key to preoperative diagnosis of hyalinizing trabecular tumor
    Marina N. Nikiforova, Yuri E. Nikiforov, N. Paul Ohori
    Cancer Cytopathology.2019; 127(9): 560.     CrossRef
Malignant Pleural Effusion from Metastatic Prostate Cancer: A Case Report with Unusual Cytologic Findings
Jinyoung Jeon, Tae-Jung Kim, Hong Sik Park, Kyo-Young Lee
J Pathol Transl Med. 2018;52(4):257-261.   Published online June 7, 2018
DOI: https://doi.org/10.4132/jptm.2018.05.08
  • 8,165 View
  • 113 Download
  • 2 Crossref
AbstractAbstract PDF
We present a case of 55-year-old man who complained of dyspnea and sputum for a month. He was an ex-smoker with a history of prostate cancer and pulmonary tuberculosis. Chest radiographs revealed bilateral pleural effusions of a small to moderate amount. Pigtail catheters were inserted for drainage. The pleural fluid consisted of large clusters and tightly cohesive groups of malignant cells, which however could not be ascribed to prostate cancer with certainty. We performed immunocytochemical panel studies to determine the origin of cancer metastasis. The immunostaining results were positive for prostate-specific antigen, alpha-methylacyl-coenzyme A racemase, and Nkx 3.1, consistent with prostate cancer. Pleural effusion associated with prostate cancer is rare. To our knowledge, this is the first case report in Korea to describe cytologic features of malignant pleural effusion associated with prostate cancer.

Citations

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  • Rare metastatic prostate cancer mimicking lymphoma with malignant pleural effusion
    Tung Liu, En Meng, Yu-Chun Lin, Tai-Kuang Chao, Yi-Ming Chang
    Journal of Medical Sciences.2022; 42(1): 46.     CrossRef
  • Bilateral pleural effusion: etiology, diagnostics
    N. A. Stogova
    PULMONOLOGIYA.2022; 32(6): 885.     CrossRef
Cytologic Diagnosis of Metastatic Alveolar Rhabdomyosarcoma in Cerebrospinal Fluid: A Case Report
Bobae Shim, Jiwon Koh, Ji Hye Moon, In Ae Park, Han Suk Ryu
J Pathol Transl Med. 2018;52(4):262-266.   Published online June 14, 2018
DOI: https://doi.org/10.4132/jptm.2018.05.15
  • 5,565 View
  • 112 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Rhabdomyosarcoma is a malignant soft tissue tumor which shows skeletal muscle differentiation. Leptomeningeal metastasis can occur as a late complication, but currently there are no reports that have documented the cytologic features in cerebrospinal fluid (CSF). We report a case of metastatic alveolar rhabdomyosarcoma diagnosed in the CSF of a 28-year-old male who was originally diagnosed with rhabdomyosarcoma on the neck, and that went through systemic therapy. The tumor was positive for anaplastic lymphoma kinase, but progressed despite additional therapy with crizotinib. The CSF specimen revealed small round cells, large atypical cells with abundant cytoplasm and eccentric nuclei, and cells with horseshoe-shaped nuclei. These cytologic findings were in agreement with previous literature and well-correlated with histopathology. This is the first report to document the cytologic feature of rhabdomyosarcoma in CSF. In many cases it is difficult to perform ancillary tests in a CSF specimen and cytopathologists should be aware of the cytomorphologic characteristics to avoid misdiagnosis.

Citations

Citations to this article as recorded by  
  • A Review of Effusion Cytomorphology of Small Round Cell Tumors
    Lucy M. Han, Christopher J. VandenBussche, Mads Abildtrup, Ashish Chandra, Poonam Vohra
    Acta Cytologica.2022; 66(4): 336.     CrossRef
  • Cytologic diagnosis of metastatic embryonal rhabdomyosarcoma in cerebrospinal fluid: A case report
    Muxia Yan, Ying Wu, Jianqing Xia, Xiaohong Zhang, Yiqian Wang
    Diagnostic Cytopathology.2021;[Epub]     CrossRef
  • Effusion cytology of epithelioid rhabdomyosarcoma
    Andrew A. Renshaw, Edwin W. Gould
    Diagnostic Cytopathology.2019; 47(10): 1042.     CrossRef

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