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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2018.03.29    [Epub ahead of print]
Collagenous Spherulosis Associated with Lobular Carcinoma In Situ of the Breast: Two Case Reports
Ga-Eon Kim1, Nah Ihm Kim1, Ji Shin Lee1, Min Ho Park2
1Department of Pathology, Chonnam National University Medical School, Gwangju, Korea
2Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
Corresponding Author: Ji Shin Lee ,Tel: +82-61-379-7072, Fax: +82-61-379-7079, Email: jshinlee@hanmail.net
Received: January 23, 2018;  Revised: March 19, 2018  Accepted: March 27, 2018.  Published online: March 29, 2018.
Collagenous spherulosis (CS) of the breast is a distinctive disease, and is characterized by myoepithelial and epithelial proliferation of nodules in the eosinophilic or basophilic basement membrane enclosed in spherical spaces. CS is rare, but frequently occurs in association with other benign proliferative lesions of the breast. CS is also associated with lobular carcinoma in situ (LCIS). Here, we report two cases of CS associated with LCIS of the breast. Two patients presented with nodules on ultrasound imaging. The lesions had LCIS, a classic type and pleomorphic type, respectively. The multiple spherules showing a cribriform architecture appear adjacent to the LCIS area. Overall, the spherules displayed microscopic characteristics typical of CS. E-cadherin-negative LCIS cells colonized several spherules of CS and replaced the luminal epithelial cells. This is the first reported case of CS associated with LCIS of the breast in Korea.
Key Words: Collagenous spherulosis; Lobular carcinoma in situ; Breast