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Pathologic Diagnosis of Intestinal Tuberculosis in Endoscopic Biopsied Material.
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HOME > J Pathol Transl Med > Volume 31(8); 1997 > Article
Original Article Pathologic Diagnosis of Intestinal Tuberculosis in Endoscopic Biopsied Material.
Kyoung Mee Kim, An Hi Lee, Kyu Yong Choi, Se Jeong Oh, Sang In Shim
Journal of Pathology and Translational Medicine 1997;31(8):754-764
DOI: https://doi.org/
1Department of Clinical Pathology, Catholic University College of Medicine, Seoul 150-010, Korea.
2Department of Internal Medicine, Catholic University College of Medicine, Seoul 150-010, Korea.
3Department of General Surgery, Catholic University College of Medicine, Seoul 150-010, Korea.
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The clinicopathologic features and the comparative analysis of diagnostic methods in 42 patients having intestinal tuberculosis were studied. In all the cases, clinical and colonoscopic diagnosis was confirmed by histological examination. Abdominal pain was the most common symptom (54%). Twenty nine patients had active pulmonary tuberculosis which was confirmed by a chest X-ray, or an AFB smear and a culture of sputum. A transverse ulcer with surrounding hypertrophic mucosa and multiple erosion was the usual colonoscopic findings. The granulomas were usually located in the just upper and lower portion of muscularis mucosa. The direct smear and culture of the fresh biopsy material showed AFB in 11 (32.4%) and 12 cases (36.4%) respectively. Ziehl-Neelsen staining in serially sectioned slides from formalin-fixed, paraffin- embedded tissue revealed AFB in 15 cases (35.7%). An immunohistochemical stain for Mycobacterium bovis was done in all cases and 13 cases were positive (31%). A polymerase chain reaction (PCR) was done and showed positivity in 4 out of 20 cases of fresh biospy material and 12 out of 40 cases in paraffin embedded tissue. For the conclusive diagnosis of intestinal tuberculosis, a Ziehl-Neelsen stain is the most sensitive, fast, and cost-effective method. The diagnostic accuracy will be increased when other diagnostic methods such as tissue culture and PCR are coupled with this simple staining method.

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