Recently the utility of the Dextrostix blood sugar estimation method has been greatly increased by the use of the reflectance meter which was devided for quantitative reading of color change in Dextrostix. A comparison study of 300 blood sugar determinations were done using blood serum from in patient and patients attanding diabetic clinic. The Dextrostix-Reflectance meter method was used and the results were compared to an Auto Analyzer Ⅱ method. The correlation of these blood sugar results with those obtained with an Auto Analyzer Ⅱ method was very high (r=0.996) and the replication of the Dextrostix-Refectance meter method by the different experimenters was also satisfactory. These results indicate that Dextrostix-Reflectance meter is a simple and reliable for estimating the blood sugar level if procedure are accurately performed.