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The Korean Journal of Pathology 1976;10(1): 113-122.
한국인 신경계 종양의 임상 및 병리조직학적 고찰
Clinico-Pathologic Study of Tumors of the Nervous System among Koreans
ABSTRACT
The tumors of the nervous system have been investigated by many workers in other countries about incidence, classification and pathogenesis. However only one report dealing just incidence of the tumors of central nervous system is available in this country. Therefore, a comprehensive study is needed to understand the status of tumors of nervous system among Koreans. Material and Methods; The materials used in this study consisted of 511 cases during period from 1959 to 1974. For histologic studies, the specimens fixed with 10% neutral formalin were followed by Paraffin embedding and were cut in 5μ thickness. Sections were stained with Hematoxylin-Eosin for routine examination and histologic classification was made. The intracranial tumors were classified by Escourolle and Poirier (1973), intraspinal tumors by Rubinstein (1972), and tumors of the peripheral nervous system by Abell (1970). Result and Summary; Histological and clinical studies were made on 511 tumors of nervous system submitted to the Department of Pathology, Yonsei University College of Medicine during the period from 1959 to 1974, and the results were as follows. 1. In the 511 tumors of the nervous system, the central nervous system tumors were 281 cases and the tumors of peripheral nervous system were 230 cases. 2. In the 281 central nervous system tumors, the tumors, arising from intracranial cavity were 72.2% and tumors of the intraspinal cavity were 27.8%. 3. In the 203 intracranial tumors, glial tumors were 44.6%, meningiomas 17.8%, Schwannomas 11.8%, pituitary adenomas 10.4%, metastatic tumors 4.9%, craniopharyngiomas 3.5%, pinealomas 1.5%, ectopic pinealoma 0.5%, and teratoma 0.5%. 4. In the 90 gliomas, glioblastoma multiforme were 43.3%, astrocytomas 33.3%, medulloblastomas 11.1%, ependymomas 6.7%, oligodendrogliomas 3.3%, and choroid plexus papilloma 2.3%. 5. In the 24 children gliomas, astrocytomas were 36,5%, medulloblastomas 34.0%, ependymomas 12.6%, and oligodendrogliomas 8.4% . 6. In the 36 intracranial meningiomas, the meningotheliomatous type were 61.2%, angioblastic type 13.9%, fibroblastic type 11.1%, psammomatous type 5.6%, transitional type 2.3%, and low grade malignancy 2.3%. 7. In the 11 intracranial metastatic tumors, the primary sites were most common in lungs. 8. In the 78 intraspinal tumors, the neurilemmomas were 64.1%, sarcomas 11.5%, metastatic tumors 10.3%, meningiomas 8.9%, gliomas 3.9% and vascular tumor 1.3%. 9. In the Peripheral nervous system, the tumors of peripheral nerve were 183 cases, tumors of sympathetic nervous system 15 cases, pheochromocytomas 2 cases, and retinoblastomas 31 cases. In summary, the overall features of the intracranial tumors are similar to reports in other countries, but the incidence of neurilemmoma among intraspinal tumors is higher than those of other countries.