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The Korean Journal of Pathology 1995;29(4): 530-532.
Angiomyofibroblastoma of Vulva: A case report.
Hye Kyung Lee, Myung Jin Joo, Kwang Min Lee, Dong Kyu Chung
Department of Anatomical Pathology, Presbyterian Medical Center.
Angiomyofibroblastoma of the vulva is a rare mesenchymal tumor. It has been diagnostically confused with aggressive angiomyxoma which has a somewhat different clinical course and therapy. Herein we report a case of angiomyofibroblastoma of the vulva in a 46-year-old female. Microscopically, there were alternating hypercellular and hypocelluar edematous zones in which abundant capillary blood vessels were irregularly distributed. Spindle, plump spindle, and oval stromal cells were concentrated around the blood vessels, or loosely dispersed in the hypocellular area. Immunohistochemically, the stromal cells were positive for desmin, vimentin, muscle-specific actin and weakly positive for S-100 protein. Ultrastructural studies showed well developed rough endoplasmic reticulum, abundant intermediate filaments, and pinocytic vesicles in the stromal cells.
Key Words: Angiomyofibroblastoma; Vulva; Aggressive angiomyxoma
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