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JPTM > Volume 53(1); 2019 > Article
Journal of Pathology and Translational Medicine 2019;53(1): 13-22.
doi: https://doi.org/10.4132/jptm.2018.11.12
Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
Hyun Min Koh1 , Hyo Jung An1 , Gyung Hyuck Ko2,3,4 , Jeong Hee Lee2,3,4 , Jong Sil Lee2,3,4 , Dong Chul Kim2,3,4 , Jung Wook Yang4 , Min Hye Kim4 , Sung Hwan Kim2,3,5 , Kyung Nyeo Jeon2,3,6 , Gyeong-Won Lee2,3,7 , Se Min Jang8 , Dae Hyun Song1,2,3
1Department of pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea
2Gyeongsang National University School of Medicine, Jinju, Korea
3Gyeongsang Institute of Health Science, Jinju, Korea
4Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea
5Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University Changwon Hospital, Changwon, Korea
6Department of Radiology, Gyeongsang National University Changwon Hospital, Changwon, Korea
7Department of internal medicine, Gyeongsang National University Hospital, Jinju, Korea
8Department of Pathology, Konyang University Hospital, Daejeon, Korea
Corresponding Author: Dae Hyun Song ,Tel: +82-55-214-3150, Fax: +82-55-214-3174, Email: golgy@hanmail.net
Received: May 15, 2018;  Revised: November 7, 2018  Accepted: November 12, 2018.  Published online: November 26, 2018.
ABSTRACT

Background:
S100A8 and S100A9 have been gaining recognition for modulating tumor growthand metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 innon-small cell lung cancer (NSCLC).
Methods:
We analyzed the relationship between S100A8and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumorcells and peritumoral inflammatory cells.
Results:
The positive staining of S100A8 in tumorcells was significantly increased in male (p < .001), smoker (p = .034), surgical method other thanlobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022)compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. Theproportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patientsex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patientage (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlatedwith patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumorcells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cellsstained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCCbut towards decreased survivability in ADC.
Conclusions:
S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.
Key Words: S100A8; S100A9; Carcinoma, non-small cell lung; Prognosis