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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2018.09.03    [Epub ahead of print]
Squamous Cell Carcinoma of the Extrahepatic Common Hepatic Duct: A Case Report and Review
Myunghee Kang1, Na Rae Kim1, Dong Hae Chung1, Hyun Yee Cho1, Yeon Ho Park2
1Department of Pathology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
2Department of Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
Corresponding Author: Na Rae Kim ,Tel: +82 32 460 3073, Fax: +82 32 460 2394, Email: clara_nrk@gilhospital.com
Received: July 9, 2018;  Revised: August 22, 2018  Accepted: September 3, 2018.  Published online: October 1, 2018.
ABSTRACT
We report a rare case of hilar squamous cell carcinoma. A 62-year-old Korean woman complaining of nausea was referred to our hospital. Her biliary CT revealed a 28-mm-sized protruding solid mass in the proximal common bile duct. The patient underwent left hemihepatectomy with S1 segmentectomy and segmental excision of the common bile duct. Microscopically, the tumor was a moderately differentiated squamous cell carcinoma of the extrahepatic bile duct, without any component of adenocarcinoma or metaplastic portion in the biliary epithelium. Immunohistochemically, the tumor was positive for CK5/6, CK19, p40, and p63. Squamous cell carcinoma of the extrahepatic bile duct is rare. To date, only 24 cases of biliary squamous cell carcinomas have been reported. Here, we provide a clinicopathologic review of previously reported extrahepatic bile duct squamous cell carcinomas.
Key Words: Squamous cell carcinoma; Klatskin tumor; Common hepatic duct; Hilum; Chemotherapy