E-submission
Search
- Page Path
- HOME > Search
- Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low-Grade Sarcoma: An Immunohistochemical Study
- Hyun-Jin Son, Tae-Hwa Baek, Seung Yun Lee, Joo-Heon Kim, Dong-Wook Kang, Hye-Kyung Lee, Mee-Ja Park
- Korean J Pathol. 2014;48(4):270-275. Published online August 26, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.270
- 6,682 View
- 26 Download
- 2 Crossref
-
Abstract
PDF Background Nodular fasciitis is the most common reactive mesenchymal lesion to be misidentified as a type of sarcoma. HuR is an mRNA-binding protein that can stabilize cyclooxygenase-2 (COX-2) mRNA leading to COX-2 overexpression. The aim of this study is a comparison of the expressions of COX-2 and HuR and the relationships between their expressions and the clinicopathological parameters in nodular fasciitis and low-grade sarcoma.
Methods We measured the expression of HuR and COX-2 in 21 cases of nodular fasciitis and 37 cases of low-grade sarcoma using immunohistochemistry.
Results The frequency of cytoplasmic immunoreactivity for HuR was 5 of 21 cases of nodular fasciitis (23.8%) and 23 of 37 cases of low-grade sarcoma (62.1%) (p=.013). COX-2 expression was moderate or strong in nodular fasciitis (12/21, 57.1%) and in low-grade sarcoma (29/37, 78.4%) (p=.034). In addition, a significant difference existed between these two entities in terms of the relationship between moderate or strong COX-2 expression and HuR cytoplasmic immunoreactivity (p=.009). Moderate or strong COX-2 immunoreactivity correlated with nuclear (p=.016) or cytoplasmic HuR (p=.024) expression in low-grade sarcoma but not in nodular fasciitis.
Conclusions This study suggests that HuR and COX-2 expression may be useful to differentiate nodular fasciitis from low-grade sarcoma.
-
Citations
Citations to this article as recorded by
- Nodular Fasciitis of the Cubital Fossa in a Young Female Mimicking a Neurogenic Tumor
Hyung-Joon Lee, Ji-Kang Park, Seok-Won Kim, Min-Boo Kim
Journal of the Korean Orthopaedic Association.2023; 58(2): 179. CrossRef - Nodular fasciitis of the anterior chest wall mimicking myxofibrosarcoma: A case report and literature review
Antonino Cattafi, Mariarosaria Galeano, Pietro Pitrone, Carmelo Sofia, Maria Adele Marino, Giorgio Ascenti, Maria Lentini, Antonio Ieni, Roberta Cardia, Alfio Luca Costa, Dario Familiari, Mario Barone, Francesco Monaco, Michele Rosario Colonna
Radiology Case Reports.2021; 16(6): 1557. CrossRef
- Nodular Fasciitis of the Cubital Fossa in a Young Female Mimicking a Neurogenic Tumor
- Cytopathology of Hurthle Cell Adenoma: A Cese Report by Fine Needle Aspiration.
- Bohng Hee Kim, Myoung Suk Kang, Jae Hoon Park, Youn Wha Kim, Yong Ku Park, Ju Hie Lee, Moon Ho Yang
- Korean J Cytopathol. 1995;6(2):193-198.
- 1,741 View
- 19 Download
-
Abstract
PDF
- The increased use of thyroid fine needle aspiration (FNA) has refocused on Hurthle cell lesions. The cytologic diagnosis of Hurthle cell tumor is a challenge due to the presence of Hurthle cells in non-neoplastic lesions and the inability to differentiate between benign and malignant Hurthle cell tumor. We report a case of Hurthle cell adenoma(HCA) in a 68-year old woman, with reivew of the cytopathologic findings. FNA revealed losely cohesive or sheets of sheets of large oval to polygonal Hurthle cells containing bundant granular cytoplasm. The histopathologic examination confirmed the diagnosis of HCA with follicular growth pattern, Ultrastructurally, the cytoplasm was packed with variable sized mitochondria.
- Correlation Between Cyclooxygenase-2 Expression and HuR Cytoplasmic Translocation of Breast Cancer.
- Sung Im Do, In Gu Do, Gou Young Kim, Sun Lee, Youn Wha Kim, Yong Koo Park, Juhie Lee, Sung Jig Lim
- Korean J Pathol. 2008;42(2):75-80.
- 1,573 View
- 15 Download
-
Abstract
PDF
- BACKGROUND
Embryonic lethal abnormal vision (ELAV)-like protein HuR is known to stabilize mRNA through binding AU-rich elements in the 3'-untranslated region. Recent studies show that HuR expression is associated with the expression of several genes including cyclooxygenase-2 (COX-2). HuR exists predominantly in the nucleus, but cytoplasmic translocation of HuR is thought to be more important for its activity. COX-2 is a well-known enzyme that promotes tumor growth.
METHODS
To evaluate the correlation of HuR and COX-2 expression, we analyzed expression of HuR and COX-2 in 91 cases of breast cancer using immunohistochemistry.
RESULTS
Nuclear and cytoplasmic expression of HuR was seen in 76 (83.5%) and 19 (20.9%) of 91 cases respectively. COX-2 immunoreactivity was seen in 54 (59.4%) cases. Cytoplasmic HuR expression showed significant correlation with COX-2 expression (p=0.001). Nuclear HuR showed no correlation with COX-2 expression or other clinicopathological parameters. COX-2 expression is significantly associated with tumor grade (p=0.028). COX-2 (p=0.092) and cytoplasmic (p=0.569) and nuclear HuR (p=0.247) expression showed no correlation with survival.
CONCLUSIONS
These results suggest that cytoplasmic HuR expression is associated with COX-2 expression in breast cancer and cytoplasmic location of HuR might contribute to the stabilization of COX-2 mRNA.
- Hurthle Cell Tumor of the Thyroid Gland in an Infant: A case report.
- Kyoung Ho Kim, Mi Kyung Lee, Dong Hwan Shin, Tae Seung Kim, Eui Ho Hwang
- Korean J Pathol. 1989;23(4):476-481.
- 1,962 View
- 12 Download
-
Abstract
PDF
- Hurthle cell tumors are an infrequent neoplasm of the thyroid gland in adults. Hurthle cell tumors represent 4. 5% to 10% of all primary thyroid epithelial neoplasms in the foreign literature. It has been known as Hurthle cell tumor since Ewing was the first to use this term in 1928. Tumor occurring in an infant was described by Symmers(1941) and Morrow(1945). The authors experienced a case of congenital Hurthle cell tumor of the thyroid gland in a 2 months old boy. He was admitted to the pediatric surgical department because of a growing mass in the neck since birth. Ultrasonogram showed a huge lobulated homogenous solid mass with medium level echogenicity in the region of the thyroid gland. Subtotal thyroidectomy of right lobe and total thyroidectomy of left lobe were done. The specimen measures 2x3x1.5 cm and 7x3x3 cm, respectively. It was an encapsulated, yellow gray firm and solid mass. The cut surface was smooth, glistening and homogenous. Microscopicully, the tumor was composed of tightly packed regular follicles lined by polyhedral, cuboidal, large cells with a granular acidophilic cytoplasms. The nuclei are vesicular, usually only a little bit larger than those of normal thyroid cells.
First
Prev
