Peripheral ameloblastoma (PA) in gingiva is rare and often confused with oral basal cell carcinoma (OBCC). The tissues of one case of PA and one case of OBCC with the same mandibular molar area affected were compared via an immunohistochemical examination using 50 antisera. The PA and OBCC showed similar proliferation of basaloid epithelial strands, but toluidine blue staining revealed that the PA had pinkish juxta-epithelial myxoid tissue, whereas the OBCC was infiltrated by many mast cells. Immunohistochemical comparisons showed that the PA was strongly positive for ameloblastin, KL1, p63, carcinoembryonic antigen, focal adhesion kinase, and cathepsin K, and slightly positive for amelogenin, Krox-25, E-cadherin, and PTCH1, whereas the OBCC was not. On the other hand, the OBCC was strongly positive for EpCam, matrix metalloprotease (MMP)-1, α1-antitrypsin, cytokeratin-7, p53, survivin, pAKT1, transforming growth factor-β1, NRAS, TGase-1, and tumor nescrosis factor-α, and consistently positive for β-catenin, MMP-2, cathepsin G, TGase-2, SOS-1, sonic hedgehog, and the β-defensins-1, -2, -3, while the PA was not. These data suggest that the tumorigeneses of PA and OBCC differ, and that PAs undergo odontogenic differentiation and generate oncogenic signals for infiltrative growth and bone resorption, whereas OBCCs undergo basaloid epidermal differentiation as a result of growth factor/cytokine-related oncogenic signals.

Citations

Citations to this article as recorded by  

• Role of HIF-1α in Ameloblastoma: A Systematic Review
  Ayushi Jain, Pooja Sharma, N Sivakumar, Priya Devi, Shalini Gupta, Shaleen Chandra
  Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 3136.     CrossRef
• Expression of ameloblastin in the human tooth germ and ameloblastoma
  Suganya Panneer Selvam, Irulandy Ponniah
  Oral Diseases.2018; 24(8): 1538.     CrossRef
• The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma
  Anthony Paulo Sunjaya, Angela Felicia Sunjaya, Sukmawati Tansil Tan
  Journal of Skin Cancer.2017; 2017: 1.     CrossRef
• Peripheral ameloblastoma of the mandible: A case report
  Takahiro Kaneko, Satoshi Nakamura, Ryutarou Kawano, Norio Horie, Tetsuo Shimoyama
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2016; 28(6): 565.     CrossRef

Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke's pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively. AOTs are classified into follicular, extrafollicular, and peripheral types. Ameloblastomas are common, have an aggressive behavior and recurrent course, and are rarely metastatic, while AOTs are hamartomatous benign lesions derived from the complex system of the dental lamina or its remnants. With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. Therefore, it is suggested that comprehensive pathological observation including molecular genetic information can provide a more reliable differential diagnosis for the propagation and prognosis of ameloblastomas and AOTs. This study aimed to review the current concepts of ameloblastomas and AOTs and to discuss their clinico-pathological features relevant to tumorigenesis and prognosis.

Citations

Citations to this article as recorded by  

• Differential Profile of Primary and Recurrent Ameloblastomas Among Afro-descendants and Non-Afro-descendants—a Systematic Review
  Parth Patel, Olajumoke A. Effiom, Abdul-Warith O. Akinshipo, Sunday O. Akintoye
  Journal of Racial and Ethnic Health Disparities.2024; 11(1): 92.     CrossRef
• Role of HIF-1α in Ameloblastoma: A Systematic Review
  Ayushi Jain, Pooja Sharma, N Sivakumar, Priya Devi, Shalini Gupta, Shaleen Chandra
  Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 3136.     CrossRef
• Machine learning-based radiomics for predicting BRAF-V600E mutations in ameloblastoma
  Wen Li, Yang Li, Xiaoling Liu, Li Wang, Wenqian Chen, Xueshen Qian, Xianglong Zheng, Jiang Chen, Yiming Liu, Lisong Lin
  Frontiers in Immunology.2023;[Epub]     CrossRef
• Clinicopathological relevance of BRAF and SMO mutations in Chinese patients with ameloblastoma
  Chen Ruixue, Li Hexiang, Hou Yali, Li Xiangjun, Sun Xu, Wang Jie, Zhang Xudong
  All Life.2023;[Epub]     CrossRef
• Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors
  TP Chaturvedi, Kanupriya Gupta, Rahul Agrawal, PG Naveen Kumar, Jatin Gupta
  Journal of Cancer Research and Therapeutics.2022; 18(9): 205.     CrossRef
• Hypoxia enhances basal autophagy of epithelial‐derived ameloblastoma cells
  Anwar A. A. Y. AlMuzaini, Kathleen Boesze‐Battaglia, Faizan Alawi, Sunday O. Akintoye
  Oral Diseases.2022; 28(8): 2175.     CrossRef
• Giant ameloblastoma
  Muthuvel Ramesh, A. N. Gurumoorthy, Jeevan G. Sanjive
  Formosan Journal of Surgery.2022; 55(1): 27.     CrossRef
• Hemangiomatous Ameloblastoma with Spindle Cell Proliferation: A Rare Case Report and Review of Literature
  PavanD Puri, Abhinandh Krishna, Suchitra Gosavi, Vivek Nayyar
  Journal of Oral and Maxillofacial Pathology.2022; 26(1): 132.     CrossRef
• Clinical, Radiographic and Histopathological Analysis of Craniopharyngiomas and Ameloblastomas: A Systematic Review
  Luana Amorim Morais da Silva, Solimar Ribeiro Carlete Filho, Marcelo Jales Diniz Saraiva, Caio Rodrigues Maia, Camila Dannyelle Fernandes Dutra Pe Santos, Pedro Paulo de Andrade Santos
  Head and Neck Pathology.2022; 16(4): 1195.     CrossRef
• CDC7 Expression in Selected Odontogenic Tumors
  Zohreh Jaafari-Ashkavandi, Nahid Alizadeh, Luca Testarelli
  International Journal of Dentistry.2022; 2022: 1.     CrossRef
• Fibroblastic Growth Factor as a Diagnostic and Prognostic Marker in Odontogenic Cysts and Tumors: A Systematic Review
  Gururaj Narayana Rao, Adlin Saroja Rosaian, Gowthami Jawahar, P. Hari Nivas Raj, J. Beryl Rachel, P. Blessing Emmanuel
  Journal of Pharmacy and Bioallied Sciences.2021; 13(Suppl 1): S6.     CrossRef
• A View of Adenomatoid Odontogenic Tumor in Ameloblastoma: A Hybrid Variant
  Priya Thomas, Sapna Chandran Lathakumari
  Journal of Health Sciences & Research.2021; 12(1): 21.     CrossRef
• Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma
  Yao-Cheng Yang, Jun-Jie Wang, Yun Huang, Wei-Xin Cai, Qian Tao
  Cancer Management and Research.2021; Volume 13: 4403.     CrossRef

• Peripheral Adenomatoid Odontogenic Tumor — A Rare Cause of Gingival Enlargement: A Case Report with CBCT Findings

  
  Arun Sadasivan, Roshni Ramesh, Nikhil M Kurien
  Clinical, Cosmetic and Investigational Dentistry.2020; Volume 12: 297.     CrossRef
• Adenomatoid odontogenic tumour: A rare threat to orthodontic treatment planning
  Laura Han, Alison Downing, David Farr, Kaushik Dasgupta, Duncan Stewart
  Journal of Orthodontics.2019; 46(3): 259.     CrossRef
• Recurrence of plexiform ameloblastoma as acanthomatous ameloblastoma: A rare case report
  SanatKumar Bhuyan, Ruchi Bhuyan, TapanKumar Sahoo, Pinali Das
  Contemporary Clinical Dentistry.2019; 10(1): 178.     CrossRef
• Immunoexperssion of cancer stem cell marker (CD44) in ameloblastoma
  ManjushriMadhukar Vanje, Shahela Tanveer, SyedAfroz Ahmed, Shravan Kumar, Tejashree Vanje
  Journal of Oral and Maxillofacial Pathology.2019; 23(3): 400.     CrossRef
• Unklare Schwellung im Bereich eines Oberkiefereckzahns
  S. H. Baum, C. Loef, D. Baumhoer, C. Mohr
  Der MKG-Chirurg.2018; 11(2): 111.     CrossRef
• Ameloblastoma Secondary to Third Molar Extraction and Sagittal Split Ramus Osteotomy : A Case Report
  Sung-Tak Lee, Santhiya Iswarya Vinothini Udayakumar, Tae-Geon Kwon, Hong-In Shin, So-Young Choi
  The Korean Journal of Oral and Maxillofacial Pathology.2018; 42(2): 39.     CrossRef
• Glypican‐3 distinguishes aggressive from non‐aggressive odontogenic tumors: a preliminary study
  Ramon Barreto Mendes, Rosane Borges Dias, Andreia Leal Figueiredo, Clarissa Araújo Gurgel, Manoel Santana Filho, Leonardo Araújo Melo, Marília Trierveiler, Patrícia Ramos Cury, Rosalia Leonardi, Jean Nunes Dos Santos
  Journal of Oral Pathology & Medicine.2017; 46(4): 297.     CrossRef
• Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors
  Marcelo Anderson Barbosa Nascimento, Cassiano Francisco Weege Nonaka, Carlos Augusto Galvão Barboza, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza
  Archives of Oral Biology.2017; 73: 223.     CrossRef
• Rare case of ameloblastoma with pulmonary metastases
  Ivan Valkadinov, Nikolay Conev, Dian Dzhenkov, Ivan Donev
  Intractable & Rare Diseases Research.2017; 6(3): 211.     CrossRef
• High strength oil palm shell concrete beams reinforced with steel fibres
  S. Poh-Yap, U. Johnson-Alengaram, K. Hung-Mo, M. Zamin-Jumaat
  Materiales de Construcción.2017; 67(328): 142.     CrossRef
• A novel marker of ameloblastoma and systematic review of immunohistochemical findings
  Bacem A.E.O. Khalele, Rami A. Al-Shiaty
  Annals of Diagnostic Pathology.2016; 22: 18.     CrossRef
• Adenoid variant of peripheral ameloblastoma with cellular atypia in the retromolar pad area: A case report
  Bacem A.E.O. Khalele
  Future Dental Journal.2016; 2(2): 91.     CrossRef
• Ameloblastoma during pregnancy: a case report
  Helbert Eustáquio Cardoso da Silva, Erika do Socorro Ramos Costa, Antônio Carlos Quintão Medeiros, Paulo Sérgio dos Santos Pereira
  Journal of Medical Case Reports.2016;[Epub]     CrossRef
• A case report and short review on changing trends in the site of occurrence of adenomatoid odontogenic tumor: Unravelling the past 15 years
  Sneha Sethi, Manish Kumar, Pratul Aggarwal, HS Indra Kumar, ChetanD Sugandhi, Silvie Singh
  Dental Research Journal.2016; 13(5): 462.     CrossRef
• De novo adamantinomatous craniopharyngioma presenting anew in an elderly patient with previous normal CT and MRI studies: A case report and implications on pathogenesis
  Amy Walker, Radmehr Torabi, Michael Punsoni, Edward Stopa, Curtis Doberstein
  Interdisciplinary Neurosurgery.2015; 2(3): 149.     CrossRef
• Understanding ameloblastomas through tooth development
  Amer Sehic
  Journal of Dentistry and Oral Care.2015;[Epub]     CrossRef
• New Features in Mucous-Ameloblastoma. A Case Report of rare Entity
  IS Gataa
  International Journal of Oral and Craniofacial Science.2015; : 001.     CrossRef
• Adenomatoid odontogenic tumor associated with a dentigerous cyst: A case report
  Ludmila de Faro Valverde, Tássia Amaral Gomes, Maria Lúcia Neves, Rosane Borges Dias, Manuela Torres Andion Vidal, Caroline Brandi Schlaepfer Sales, Clarissa Araújo Gurgel Rocha, Jean Nunes dos Santos
  Indian Journal of Dentistry.2014; 5: 82.     CrossRef