Journal of Pathology and Translational Medicine

Original Article

Diagnostic yield of fine needle aspiration with simultaneous core needle biopsy for thyroid nodules: Mohammad Ali Hasannia, Ramin Pourghorban, Hoda Asefi, Amir Aria, Elham Nazar, Hojat Ebrahiminik, Alireza Mohamadian; Received December 6, 2024 Accepted March 4, 2025 Published online April 16, 2025; DOI: https://doi.org/10.4132/jptm.2025.03.04 [Epub ahead of print]

218 View
24 Download

Abstract PDF: Background
Fine needle aspiration (FNA) is a widely utilized technique for assessing thyroid nodules; however, its inherent non-diagnostic rate poses diagnostic challenges. The present study aimed to evaluate and compare the diagnostic efficacy of FNA, core needle biopsy (CNB), and their combined application in the assessment of thyroid nodules.
Methods
A total of 56 nodules from 50 patients was analyzed using both FNA and simultaneous CNB. The ultrasound characteristics were categorized according to the American College of Radiology Thyroid Imaging Reporting and Data Systems classification system. The study compared the sensitivity, specificity, and accuracy of FNA, CNB, and the combination of the two techniques.
Results
The concordance between FNA and CNB was notably high, with a kappa coefficient of 0.837. The sensitivity for detecting thyroid malignancy was found to be 25.0% for FNA, 66.7% for CNB, and 83.3% for the combined FNA/CNB approach, with corresponding specificities of 84.6%, 97.4%, and 97.4%. The accuracy of the FNA/CNB combination was the highest at 94.1%.
Conclusions
The findings of this study indicate that both CNB and the FNA/CNB combination offer greater diagnostic accuracy for thyroid malignancy compared to FNA alone, with no significant complications reported. Integrating CNB with FNA findings may enhance management strategies and treatment outcomes for patients with thyroid nodules.

Reviews

Reevaluating diagnostic categories and associated malignancy risks in thyroid core needle biopsy: Chan Kwon Jung; J Pathol Transl Med. 2023;57(4):208-216. Published online July 11, 2023; DOI: https://doi.org/10.4132/jptm.2023.06.20

3,810 View
236 Download
6 Web of Science
6 Crossref

As the application of core needle biopsy (CNB) in evaluating thyroid nodules rises in clinical practice, the 2023 Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules have officially recognized its value for the first time. CNB procures tissue samples preserving both histologic structure and cytologic detail, thereby supplying substantial material for an accurate diagnosis and reducing the necessity for repeated biopsies or subsequent surgical interventions. The current review introduces the risk of malignancy within distinct diagnostic categories, emphasizing the implications of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on these malignancy risks. Prior research has indicated diagnostic challenges associated with follicular-patterned lesions, resulting in notable variation within indeterminate diagnostic categories. The utilization of mutation-specific immunostaining in CNB enhances the accuracy of lesion classification. This review underlines the essential role of a multidisciplinary approach in diagnosing follicular-patterned lesions and the potential of mutation-specific immunostaining to strengthen diagnostic consensus and inform patient management decisions.

Citations

Citations to this article as recorded by

Diagnostic implication of thyroid spherules for cytological diagnosis of thyroid nodules
Heeseung Sohn, Kennichi Kakudo, Chan Kwon Jung
Cytopathology.2024; 35(3): 383. CrossRef
A Narrative Review of the 2023 Korean Thyroid Association Management Guideline for Patients with Thyroid Nodules
Eun Kyung Lee, Young Joo Park, Chan Kwon Jung, Dong Gyu Na
Endocrinology and Metabolism.2024; 39(1): 61. CrossRef
The Diagnostic Role of Repeated Biopsy of Thyroid Nodules with Atypia of Undetermined Significance with Architectural Atypia on Core-Needle Biopsy
Hye Hyeon Moon, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek
Endocrinology and Metabolism.2024; 39(2): 300. CrossRef
Core needle biopsy for thyroid nodules assessment-a new horizon?
David D Dolidze, Serghei Covantsev, Grigorii M Chechenin, Natalia V Pichugina, Anastasia V Bedina, Anna Bumbu
World Journal of Clinical Oncology.2024; 15(5): 580. CrossRef
Educational exchange in thyroid core needle biopsy diagnosis: enhancing pathological interpretation through guideline integration and peer learning
Agnes Stephanie Harahap, Chan Kwon Jung
Journal of Pathology and Translational Medicine.2024; 58(5): 205. CrossRef
A simplified four-tier classification for thyroid core needle biopsy
M. Paja, J. L. Del Cura, R. Zabala, I. Korta, Mª T. Gutiérrez, A. Expósito, A. Ugalde
Journal of Endocrinological Investigation.2024; 48(4): 895. CrossRef

2019 Practice guidelines for thyroid core needle biopsy: a report of the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association: Chan Kwon Jung, Jung Hwan Baek, Dong Gyu Na, Young Lyun Oh, Ka Hee Yi, Ho-Cheol Kang; J Pathol Transl Med. 2020;54(1):64-86. Published online January 15, 2020; DOI: https://doi.org/10.4132/jptm.2019.12.04

21,669 View
958 Download
37 Web of Science
43 Crossref

Abstract PDF

Ultrasound-guided core needle biopsy (CNB) has been increasingly used for the pre-operative diagnosis of thyroid nodules. Since the Korean Society of the Thyroid Radiology published the ‘Consensus Statement and Recommendations for Thyroid CNB’ in 2017 and the Korean Endocrine Pathology Thyroid CNB Study Group published ‘Pathology Reporting of Thyroid Core Needle Biopsy’ in 2015, advances have occurred rapidly not only in the management guidelines for thyroid nodules but also in the diagnostic terminology and classification schemes. The Clinical Practice Guidelines Development Committee of the Korean Thyroid Association (KTA) reviewed publications on thyroid CNB from 1995 to September 2019 and updated the recommendations and statements for the diagnosis and management of thyroid nodules using CNB. Recommendations for the resolution of clinical controversies regarding the use of CNB were based on expert opinion. These practical guidelines include recommendations and statements regarding indications for CNB, patient preparation, CNB technique, biopsy-related complications, biopsy specimen preparation and processing, and pathology interpretation and reporting of thyroid CNB.

Citations

Citations to this article as recorded by

Comparison of core-needle biopsy and repeat fine-needle aspiration biopsy for thyroid nodules with initially inconclusive findings: a systematic review, diagnostic accuracy meta-analysis, and meta-regression
Hendra Zufry, Timotius Ivan Hariyanto
Journal of the American Society of Cytopathology.2025; 14(3): 159. CrossRef
Ultrasound-guided core-needle biopsy for diagnosis of thyroid cancer
D.D. Dolidze, S.D. Kovantsev, Z.A. Bagatelia, A.V. Bumbu, Yu.V. Barinov, G.M. Chechenin, N.V. Pichugina, D.G. Gogolashvili
Pirogov Russian Journal of Surgery.2025; (3): 87. CrossRef
A comparative analysis of core needle biopsy and repeat fine needle aspiration in patients with inconclusive initial cytology of thyroid nodules
Xuejiao Su, Can Yue, Wanting Yang, Buyun Ma
Frontiers in Endocrinology.2024;[Epub] CrossRef
A Narrative Review of the 2023 Korean Thyroid Association Management Guideline for Patients with Thyroid Nodules
Eun Kyung Lee, Young Joo Park, Chan Kwon Jung, Dong Gyu Na
Endocrinology and Metabolism.2024; 39(1): 61. CrossRef
Doing more with less: integrating small biopsies in cytology practice
Anjali Saqi, Michiya Nishino, Mauro Saieg, Amy Ly, Abberly Lott Limbach
Journal of the American Society of Cytopathology.2024; 13(4): 233. CrossRef
2023 Update of the Korean Thyroid Association Guidelines for the Management of Thyroid Nodules
Eun Kyung Lee, Young Joo Park
Clinical Thyroidology®.2024; 36(4): 153. CrossRef
Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 2. Surgical Management of Thyroid Cancer 2024
Yoon Young Cho, Cho Rok Lee, Ho-Cheol Kang, Bon Seok Koo, Hyungju Kwon, Sun Wook Kim, Won Woong Kim, Jung-Han Kim, Dong Gyu Na, Young Joo Park, Kyorim Back, Young Shin Song, Seung Hoon Woo, Ho-Ryun Won, Chang Hwan Ryu, Jee Hee Yoon, Min Kyoung Lee, Eun Ky
International Journal of Thyroidology.2024; 17(1): 30. CrossRef
Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules 2024
Young Joo Park, Eun Kyung Lee, Young Shin Song, Su Hwan Kang, Bon Seok Koo, Sun Wook Kim, Dong Gyu Na, Seung-Kuk Baek, So Won Oh, Min Kyoung Lee, Sang-Woo Lee, Young Ah Lee, Yong Sang Lee, Ji Ye Lee, Dong-Jun Lim, Leehi Joo, Yuh-Seog Jung, Chan Kwon Jung,
International Journal of Thyroidology.2024; 17(1): 208. CrossRef
Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Overview and Summary 2024
Young Joo Park, Eun Kyung Lee, Young Shin Song, Bon Seok Koo, Hyungju Kwon, Keunyoung Kim, Mijin Kim, Bo Hyun Kim, Won Gu Kim, Won Bae Kim, Won Woong Kim, Jung-Han Kim, Hee Kyung Kim, Hee Young Na, Shin Je Moon, Jung-Eun Moon, Sohyun Park, Jun-Ook Park, J
International Journal of Thyroidology.2024; 17(1): 1. CrossRef
Educational exchange in thyroid core needle biopsy diagnosis: enhancing pathological interpretation through guideline integration and peer learning
Agnes Stephanie Harahap, Chan Kwon Jung
Journal of Pathology and Translational Medicine.2024; 58(5): 205. CrossRef
Current role of interventional radiology in thyroid nodules
Onur Taydas, Erbil Arik, Omer Faruk Sevinc, Ahmet Burak Kara, Mustafa Ozdemir, Hasret Cengiz, Zulfu Bayhan, Mehmet Halil Ozturk
Frontiers in Endocrinology.2024;[Epub] CrossRef
Neck Schwannoma Masking as Thyroid Tumour: Into the Deep of Diagnostics and Anatomy
Serghei Covantsev, Anna Bumbu, Anna Sukhotko, Evghenii Zakurdaev, Ivan Kuts, Andrey Evsikov
Diagnostics.2024; 14(20): 2332. CrossRef
Thermal ablation for Bethesda III and IV thyroid nodules: current diagnosis and management
Wen-Hui Chan, Pi-Ling Chiang, An-Ni Lin, Yen-Hsiang Chang, Wei-Che Lin
Ultrasonography.2024; 43(6): 395. CrossRef
A new LNC89/LNC60-Col11a2 axis revealed by whole-transcriptome analysis may be associated with goiters related to excess iodine nutrition
Guanying Nie, Shuang Li, Wei Zhang, Fangang Meng, Zixuan Ru, Jiahui Li, Dianjun Sun, Ming Li
Frontiers in Endocrinology.2024;[Epub] CrossRef
A simplified four-tier classification for thyroid core needle biopsy
M. Paja, J. L. Del Cura, R. Zabala, I. Korta, Mª T. Gutiérrez, A. Expósito, A. Ugalde
Journal of Endocrinological Investigation.2024; 48(4): 895. CrossRef
Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT
Hyobin Seo, Kwang Nam Jin, Ji Sang Park, Koung Mi Kang, Eun Kyung Lee, Ji Ye Lee, Roh-Eul Yoo, Young Joo Park, Ji-hoon Kim
Ultrasonography.2023; 42(2): 275. CrossRef
Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subtyping and RAS Variant-specific Immunohistochemistry
Meejeong Kim, Sora Jeon, Chan Kwon Jung
Endocrine Pathology.2023; 34(2): 247. CrossRef
Differential regional importance mapping for thyroid nodule malignancy prediction with potential to improve needle aspiration biopsy sampling reliability
Liping Wang, Yuan Wang, Wenliang Lu, Dong Xu, Jincao Yao, Lijing Wang, Lei Xu
Frontiers in Oncology.2023;[Epub] CrossRef
Preoperative evaluation of thyroid nodules – Diagnosis and management strategies
Tapoi Dana Antonia, Lambrescu Ioana Maria, Gheorghisan-Galateanu Ancuta-Augustina
Pathology - Research and Practice.2023; 246: 154516. CrossRef
2023 Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules
Young Joo Park, Eun Kyung Lee, Young Shin Song, Soo Hwan Kang, Bon Seok Koo, Sun Wook Kim, Dong Gyu Na, Seung-Kuk Baek, So Won Oh, Min Kyoung Lee, Sang-Woo Lee, Young Ah Lee, Yong Sang Lee, Ji Ye Lee, Dong-Jun Lim, Leehi Joo, Yuh-Seog Jung, Chan Kwon Jung
International Journal of Thyroidology.2023; 16(1): 1. CrossRef
Fast Track Management of Primary Thyroid Lymphoma in the Very Elderly Patient
Pierre Yves Marcy, Frederic Bauduer, Juliette Thariat, Olivier Gisserot, Edouard Ghanassia, Bruno Chetaille, Laurys Boudin, Jean Baptiste Morvan
Current Oncology.2023; 30(6): 5816. CrossRef
Reevaluating diagnostic categories and associated malignancy risks in thyroid core needle biopsy
Chan Kwon Jung
Journal of Pathology and Translational Medicine.2023; 57(4): 208. CrossRef
Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysis
Yuxuan Qiu, Zhichao Xing, Qianru Yang, Yan Luo, Buyun Ma
Heliyon.2023; 9(10): e20654. CrossRef
Comparison of the diagnostic value of fine needle aspiration and ultrasound in thyroid pathology
P. S. Glushkov, R. Kh. Azimov, N. L. Aleshenko, E. A. Maruchak, Y. P. Sych, G. N. Minkova, K. A. Shemyatovsky, V. A. Gorsky
Endocrine Surgery.2023; 17(3): 43. CrossRef
Comparison of Core Needle Biopsy and Repeat Fine-Needle Aspiration in Avoiding Diagnostic Surgery for Thyroid Nodules Initially Diagnosed as Atypia/Follicular Lesion of Undetermined Significance
Leehi Joo, Dong Gyu Na, Ji-hoon Kim, Hyobin Seo
Korean Journal of Radiology.2022; 23(2): 280. CrossRef
Diagnostic efficacy, performance and safety of side-cut core needle biopsy for thyroid nodules: comparison of automated and semi-automated biopsy needles
Ji Yeon Park, Seong Yoon Yi, Soo Heui Baek, Yu Hyun Lee, Heon-Ju Kwon, Hee Jin Park
Endocrine.2022; 76(2): 341. CrossRef
Thyroid Cancer Diagnostics Related to Occupational and Environmental Risk Factors: An Integrated Risk Assessment Approach
Gabriela Maria Berinde, Andreea Iulia Socaciu, Mihai Adrian Socaciu, Andreea Cozma, Armand Gabriel Rajnoveanu, Gabriel Emil Petre, Doina Piciu
Diagnostics.2022; 12(2): 318. CrossRef
Approach to Bethesda system category III thyroid nodules according to US-risk stratification
Jieun Kim, Jung Hee Shin, Young Lyun Oh, Soo Yeon Hahn, Ko Woon Park
Endocrine Journal.2022; 69(1): 67. CrossRef
Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management
Marie Nguyen, George He, Alfred King-Yin Lam
International Journal of Molecular Sciences.2022; 23(6): 3242. CrossRef
Diagnostic Performance of Thyroid Core Needle Biopsy Using the Revised Reporting System: Comparison with Fine Needle Aspiration Cytology
Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, So Lyung Jung, Chan Kwon Jung
Endocrinology and Metabolism.2022; 37(1): 159. CrossRef
Core Needle Biopsy Can Early and Precisely Identify Large Thyroid Masses
Antonio Matrone, Luigi De Napoli, Liborio Torregrossa, Aleksandr Aghababyan, Piermarco Papini, Carlo Enrico Ambrosini, Rosa Cervelli, Clara Ugolini, Fulvio Basolo, Eleonora Molinaro, Rossella Elisei, Gabriele Materazzi
Frontiers in Oncology.2022;[Epub] CrossRef
Primary thyroid leiomyosarcoma with transvenous extension to the right atrium: a case report
Juraj Dubrava, Peter Martanovic, Marina Pavlovicova, Pavel Babal, Akhil Narang, Maria Mattioli, Nidhish Tiwari, Zhiyu Liu, Mariame Chakir
European Heart Journal - Case Reports.2022;[Epub] CrossRef
Radiofrequency ablation for management of thyroid nodules in quarantine zone of COVID-19 pandemic setting in Indonesia
Kristanto Yuli Yarso, Sumadi Lukman Anwar
Annals of Medicine and Surgery.2022; 81: 104132. CrossRef
A Matched-Pair Analysis of Nuclear Morphologic Features Between Core Needle Biopsy and Surgical Specimen in Thyroid Tumors Using a Deep Learning Model
Faridul Haq, Andrey Bychkov, Chan Kwon Jung
Endocrine Pathology.2022; 33(4): 472. CrossRef
Diagnostic performance of core needle biopsy as a first‐line diagnostic tool for thyroid nodules according to ultrasound patterns: Comparison with fine needle aspiration using propensity score matching analysis
Hye Shin Ahn, Inyoung Youn, Dong Gyu Na, Soo Jin Kim, Mi Yeon Lee
Clinical Endocrinology.2021; 94(3): 494. CrossRef
Hydrodissection: A Novel Approach for Safe Core Needle Biopsy of Small High-Risk Subcapsular Thyroid Nodules
Hojat Ebrahiminik, Hossein Chegeni, Javad Jalili, Rambod Salouti, Hadi Rokni, Afshin Mohammadi, Ali Mosaddegh Khah, Seyed Mohammad Tavangar, Zahra Ebrahiminik
CardioVascular and Interventional Radiology.2021; 44(10): 1651. CrossRef
Application of biomarkers in the diagnosis of uncertain samples of core needle biopsy of thyroid nodules
Yan Xiong, Xin Li, Li Liang, Dong Li, Limin Yan, Xueying Li, Jiting Di, Ting Li
Virchows Archiv.2021; 479(5): 961. CrossRef
VE1 immunohistochemistry is an adjunct tool for detection of BRAFV600E mutation: Validation in thyroid cancer patients
Faiza A. Rashid, Sobia Tabassum, Mosin S. Khan, Hifzur R. Ansari, Muhammad Asif, Ahmareen K. Sheikh, Syed Sameer Aga
Journal of Clinical Laboratory Analysis.2021;[Epub] CrossRef
The Diagnostic Value of the American College of Radiology Thyroid Imaging Reporting and Data System Classification and Shear-Wave Elastography for the Differentiation of Thyroid Nodules
Gül Bora Makal, Aydın Aslan
Ultrasound in Medicine & Biology.2021; 47(5): 1227. CrossRef
Comparison of the diagnostic performance of the modified Korean Thyroid Imaging Reporting and Data System for thyroid malignancy with three international guidelines
Eun Ju Ha, Jung Hee Shin, Dong Gyu Na, So Lyung Jung, Young Hen Lee, Wooyul Paik, Min Ji Hong, Yeo Koon Kim, Chang Yoon Lee
Ultrasonography.2021; 40(4): 594. CrossRef
VE1 Immunohistochemistry Improves the Limit of Genotyping for Detecting BRAFV600E Mutation in Papillary Thyroid Cancer
Sonam Choden, Somboon Keelawat, Chan Kwon Jung, Andrey Bychkov
Cancers.2020; 12(3): 596. CrossRef
The 2019 core-needle biopsy practice guidelines
So Yeong Jeong, Jung Hwan Baek
Ultrasonography.2020; 39(3): 311. CrossRef
Re: The 2019 core-needle biopsy practice guidelines
Ji-hoon Kim
Ultrasonography.2020; 39(3): 313. CrossRef

Original Article

Core Needle Biopsy Is a More Conclusive Follow-up Method Than Repeat Fine Needle Aspiration for Thyroid Nodules with Initially Inconclusive Results: A Systematic Review and Meta-Analysis: Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang; J Pathol Transl Med. 2016;50(3):217-224. Published online April 14, 2016; DOI: https://doi.org/10.4132/jptm.2016.02.15

10,719 View
116 Download
17 Web of Science
17 Crossref

Abstract PDF

Background
This study investigated the appropriate management of thyroid nodules with prior non-diagnostic or atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) through a systematic review and meta-analysis.
Methods
This study included 4,235 thyroid nodules from 26 eligible studies. We investigated the conclusive rate of follow-up core needle biopsy (CNB) or repeat fine needle aspiration (rFNA) after initial fine needle aspiration (FNA) with non-diagnostic or AUS/FLUS results. A diagnostic test accuracy (DTA) review was performed to determine the diagnostic role of the follow-up CNB and to calculate the area under the curve (AUC) on the summary receiver operating characteristic (SROC) curve.
Results
The conclusive rates of follow-up CNB and rFNA after initial FNA were 0.879 (95% confidence interval [CI], 0.801 to 0.929) and 0.684 (95% CI, 0.627 to 0.736), respectively. In comparison of the odds ratios of CNB and rFNA, CNB had more frequent conclusive results than rFNA (odds ratio, 5.707; 95% CI, 2.530 to 12.875). Upon subgroup analysis, follow-up CNB showed a higher conclusive rate than rFNA in both initial non-diagnostic and AUS/FLUS subgroups. In DTA review of followup CNB, the pooled sensitivity and specificity were 0.94 (95% CI, 0.88 to 0.97) and 0.88 (95% CI, 0.84 to 0.91), respectively. The AUC for the SROC curve was 0.981, nearing 1.
Conclusions
Our results show that CNB has a higher conclusive rate than rFNA when the initial FNA produced inconclusive results. Further prospective studies with more detailed criteria are necessary before follow-up CNB can be applied in daily practice.

Citations

Citations to this article as recorded by

Fine Needle Aspiration Cytology vs. Core Needle Biopsy for Thyroid Nodules: A Prospective, Experimental Study Using Surgical Specimen
Hyuk Kwon, Jandee Lee, Soon Won Hong, Hyeong Ju Kwon, Jin Young Kwak, Jung Hyun Yoon
Journal of the Korean Society of Radiology.2022; 83(3): 645. CrossRef
Comparison of Core Needle Biopsy and Repeat Fine-Needle Aspiration in Avoiding Diagnostic Surgery for Thyroid Nodules Initially Diagnosed as Atypia/Follicular Lesion of Undetermined Significance
Leehi Joo, Dong Gyu Na, Ji-hoon Kim, Hyobin Seo
Korean Journal of Radiology.2022; 23(2): 280. CrossRef
Diagnostic performance of core needle biopsy as a first‐line diagnostic tool for thyroid nodules according to ultrasound patterns: Comparison with fine needle aspiration using propensity score matching analysis
Hye Shin Ahn, Inyoung Youn, Dong Gyu Na, Soo Jin Kim, Mi Yeon Lee
Clinical Endocrinology.2021; 94(3): 494. CrossRef
Usage and Diagnostic Yield of Fine-Needle Aspiration Cytology and Core Needle Biopsy in Thyroid Nodules: A Systematic Review and Meta-Analysis of Literature Published by Korean Authors
Soon-Hyun Ahn
Clinical and Experimental Otorhinolaryngology.2021; 14(1): 116. CrossRef
2021 Korean Thyroid Imaging Reporting and Data System and Imaging-Based Management of Thyroid Nodules: Korean Society of Thyroid Radiology Consensus Statement and Recommendations
Eun Ju Ha, Sae Rom Chung, Dong Gyu Na, Hye Shin Ahn, Jin Chung, Ji Ye Lee, Jeong Seon Park, Roh-Eul Yoo, Jung Hwan Baek, Sun Mi Baek, Seong Whi Cho, Yoon Jung Choi, Soo Yeon Hahn, So Lyung Jung, Ji-hoon Kim, Seul Kee Kim, Soo Jin Kim, Chang Yoon Lee, Ho K
Korean Journal of Radiology.2021; 22(12): 2094. CrossRef
Malignancy rate of Bethesda category III thyroid nodules according to ultrasound risk stratification system and cytological subtype
Won Sang Yoo, Hwa Young Ahn, Hye Shin Ahn, Yun Jae Chung, Hee Sung Kim, Bo Youn Cho, Mirinae Seo, Jae Hoon Moon, Young Joo Park
Medicine.2020; 99(2): e18780. CrossRef
2019 Practice guidelines for thyroid core needle biopsy: a report of the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association
Chan Kwon Jung, Jung Hwan Baek, Dong Gyu Na, Young Lyun Oh, Ka Hee Yi, Ho-Cheol Kang
Journal of Pathology and Translational Medicine.2020; 54(1): 64. CrossRef
Laser Ablation Versus Radiofrequency Ablation for Benign Non-Functioning Thyroid Nodules: Six-Month Results of a Randomized, Parallel, Open-Label, Trial (LARA Trial)
Roberto Cesareo, Claudio Maurizio Pacella, Valerio Pasqualini, Giuseppe Campagna, Mario Iozzino, Andrea Gallo, Angelo Lauria Pantano, Roberto Cianni, Claudio Pedone, Paolo Pozzilli, Chiara Taffon, Anna Crescenzi, Silvia Manfrini, Andrea Palermo
Thyroid.2020; 30(6): 847. CrossRef
Diagnostic Efficacy and Safety of Core Needle Biopsy as a First-Line Diagnostic Method for Thyroid Nodules: A Prospective Cohort Study
Min Ji Hong, Dong Gyu Na, Hunkyung Lee
Thyroid.2020; 30(8): 1141. CrossRef
Is thyroid core needle biopsy a valid compliment to fine-needle aspiration?
Liron Pantanowitz, Lester D.R. Thompson, Xin Jing, Esther Diana Rossi
Journal of the American Society of Cytopathology.2020; 9(5): 383. CrossRef
A Monocentric Retrospective Study about the Correlation between Histology and Cytology of Thyroid Indeterminate Nodules Classified as TIR 3A and TIR 3B, according to 2014 Italian Consensus for Classification and Reporting of Thyroid Cytology
Francesco Quaglino, Giulia Arnulfo, Sergio Sandrucci, Claudio Rossi, Valentina Marchese, Roberto Saracco, Stefano Guzzetti, Stefano Taraglio, Enrico Mazza
Advances in Medicine.2019; 2019: 1. CrossRef
Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho, Younghye Kim, Seung Yeon Ha
Annals of Diagnostic Pathology.2018; 32: 35. CrossRef
Statement and Recommendations on Interventional Ultrasound as a Thyroid Diagnostic and Treatment Procedure
Christoph F. Dietrich, Thomas Müller, Jörg Bojunga, Yi Dong, Giovanni Mauri, Maija Radzina, Manjiri Dighe, Xin-Wu Cui, Frank Grünwald, Andreas Schuler, Andre Ignee, Huedayi Korkusuz
Ultrasound in Medicine & Biology.2018; 44(1): 14. CrossRef
Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study
Min Ji Hong, Dong Gyu Na, Soo Jin Kim, Dae Sik Kim
Ultrasonography.2018; 37(3): 244. CrossRef
Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
Dong Gyu Na, Jung Hwan Baek, So Lyung Jung, Ji-hoon Kim, Jin Yong Sung, Kyu Sun Kim, Jeong Hyun Lee, Jung Hee Shin, Yoon Jung Choi, Eun Ju Ha, Hyun Kyung Lim, Soo Jin Kim, Soo Yeon Hahn, Kwang Hwi Lee, Young Jun Choi, Inyoung Youn, Young Joong Kim, Hye Sh
Korean Journal of Radiology.2017; 18(1): 217. CrossRef
Ultrasound-guided fine needle aspiration versus core needle biopsy: comparison of post-biopsy hematoma rates and risk factors
In Hye Chae, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y. Park, Jin Young Kwak
Endocrine.2017; 57(1): 108. CrossRef
The Role of Core Needle Biopsy for Thyroid Nodules with Initially Indeterminate Results on Previous Fine-Needle Aspiration: A Systematic Review and Meta-Analysis
C.H. Suh, J.H. Baek, C. Park, Y.J. Choi, J.H. Lee
American Journal of Neuroradiology.2017; 38(7): 1421. CrossRef

Review

Pathology Reporting of Thyroid Core Needle Biopsy: A Proposal of the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group: Chan Kwon Jung, Hye Sook Min, Hyo Jin Park, Dong Eun Song, Jang Hee Kim, So Yeon Park, Hyunju Yoo, Mi Kyung Shin, Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group; J Pathol Transl Med. 2015;49(4):288-299. Published online June 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.06.04

18,306 View
456 Download
104 Web of Science
99 Crossref

Abstract PDF

In recent years throughout Korea, the use of ultrasound-guided core needle biopsy (CNB) has become common for the preoperative diagnosis of thyroid nodules. However, there is no consensus on the pathology reporting system for thyroid CNB. The Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group held a conference on thyroid CNB pathology and developed guidelines through contributions from the participants. This article discusses the outcome of the discussions that led to a consensus on the pathology reporting of thyroid CNB.

Citations

Citations to this article as recorded by

The Diagnostic Role of Repeated Biopsy of Thyroid Nodules with Atypia of Undetermined Significance with Architectural Atypia on Core-Needle Biopsy
Hye Hyeon Moon, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek
Endocrinology and Metabolism.2024; 39(2): 300. CrossRef
Core needle biopsy for thyroid nodules assessment-a new horizon?
David D Dolidze, Serghei Covantsev, Grigorii M Chechenin, Natalia V Pichugina, Anastasia V Bedina, Anna Bumbu
World Journal of Clinical Oncology.2024; 15(5): 580. CrossRef
Ultrasonographic features and diagnostic accuracy of FNA and CNB in secondary thyroid malignancies: A retrospective study
Zhen Xia, Xiaochen Huang, Ting Zhang, Zhigang Gao, Xiuliang Tang, Wei Zhang, Qing Miao
Heliyon.2024; 10(16): e36305. CrossRef
Current role of interventional radiology in thyroid nodules
Onur Taydas, Erbil Arik, Omer Faruk Sevinc, Ahmet Burak Kara, Mustafa Ozdemir, Hasret Cengiz, Zulfu Bayhan, Mehmet Halil Ozturk
Frontiers in Endocrinology.2024;[Epub] CrossRef
A simplified four-tier classification for thyroid core needle biopsy
M. Paja, J. L. Del Cura, R. Zabala, I. Korta, Mª T. Gutiérrez, A. Expósito, A. Ugalde
Journal of Endocrinological Investigation.2024; 48(4): 895. CrossRef
Follow-up of benign thyroid nodules confirmed by ultrasound-guided core needle biopsy after inconclusive cytology on fine-needle aspiration biopsy
Yoon Ji Hwang, Hye Ryoung Koo, Jeong Seon Park
Ultrasonography.2023; 42(1): 121. CrossRef
Subcategorization of intermediate suspicion thyroid nodules based on suspicious ultrasonographic findings
Haejung Kim, Jung Hee Shin, Ka Eun Kim, Myoung Kyoung Kim, Jiyun Oh, Soo Yeon Hahn
Ultrasonography.2023; 42(2): 307. CrossRef
Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subtyping and RAS Variant-specific Immunohistochemistry
Meejeong Kim, Sora Jeon, Chan Kwon Jung
Endocrine Pathology.2023; 34(2): 247. CrossRef
Cytological and Ultrasound Features of Thyroid Nodules Correlate With Histotypes and Variants of Thyroid Carcinoma
Daniele Sgrò, Alessandro Brancatella, Giuseppe Greco, Liborio Torregrossa, Paolo Piaggi, Nicola Viola, Teresa Rago, Fulvio Basolo, Riccardo Giannini, Gabriele Materazzi, Rossella Elisei, Ferruccio Santini, Francesco Latrofa
The Journal of Clinical Endocrinology & Metabolism.2023; 108(11): e1186. CrossRef
Reevaluating diagnostic categories and associated malignancy risks in thyroid core needle biopsy
Chan Kwon Jung
Journal of Pathology and Translational Medicine.2023; 57(4): 208. CrossRef
Contrast Enhancement Ultrasound Improves Diagnostic Accuracy for Thyroid Nodules: A Prospective Multicenter Study
Jianming Li, Jianping Dou, Huarong Li, Fan Xiao, Jie Yu, Mingxing Xie, Ping Zhou, Lei Liang, Guiming Zhou, Ying Che, Cun Liu, Zhibin Cong, Fangyi Liu, Zhiyu Han, Ping Liang
Journal of the Endocrine Society.2023;[Epub] CrossRef
Core needle biopsy and ultrasonography are superior to fine needle aspiration in the management of follicular variant papillary thyroid carcinomas
Ji-Ye Kim, Sunhee Chang, Ah-Young Kwon, Eun Young Park, Tae Hyuk Kim, Sangjoon Choi, Minju Lee, Young Lyun Oh
Endocrine.2022; 75(2): 437. CrossRef
Fine Needle Aspiration Cytology vs. Core Needle Biopsy for Thyroid Nodules: A Prospective, Experimental Study Using Surgical Specimen
Hyuk Kwon, Jandee Lee, Soon Won Hong, Hyeong Ju Kwon, Jin Young Kwak, Jung Hyun Yoon
Journal of the Korean Society of Radiology.2022; 83(3): 645. CrossRef
Diagnostic efficacy, performance and safety of side-cut core needle biopsy for thyroid nodules: comparison of automated and semi-automated biopsy needles
Ji Yeon Park, Seong Yoon Yi, Soo Heui Baek, Yu Hyun Lee, Heon-Ju Kwon, Hee Jin Park
Endocrine.2022; 76(2): 341. CrossRef
Approach to Bethesda system category III thyroid nodules according to US-risk stratification
Jieun Kim, Jung Hee Shin, Young Lyun Oh, Soo Yeon Hahn, Ko Woon Park
Endocrine Journal.2022; 69(1): 67. CrossRef
Quantitative analysis of vascularity for thyroid nodules on ultrasound using superb microvascular imaging
Min Ji Hong, Hye Shin Ahn, Su Min Ha, Hyun Jeong Park, Jiyun Oh
Medicine.2022; 101(5): e28725. CrossRef
Diagnostic Performance of Thyroid Core Needle Biopsy Using the Revised Reporting System: Comparison with Fine Needle Aspiration Cytology
Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim, So Lyung Jung, Chan Kwon Jung
Endocrinology and Metabolism.2022; 37(1): 159. CrossRef
A Matched-Pair Analysis of Nuclear Morphologic Features Between Core Needle Biopsy and Surgical Specimen in Thyroid Tumors Using a Deep Learning Model
Faridul Haq, Andrey Bychkov, Chan Kwon Jung
Endocrine Pathology.2022; 33(4): 472. CrossRef
Role of echogenic foci in ultrasonographic risk stratification of thyroid nodules: Echogenic focus scoring in the American College of Radiology Thyroid Imaging Reporting and Data System
Renxu Li, Zhenwei Liang, Xiangyu Wang, Luzeng Chen
Frontiers in Oncology.2022;[Epub] CrossRef
Ultrasonographic characteristics of medullary thyroid carcinoma according to nodule size: application of the Korean Thyroid Imaging Reporting and Data System and American Thyroid Association guidelines
Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park
Acta Radiologica.2021; 62(4): 474. CrossRef
Malignancy risk of thyroid nodules with nonshadowing echogenic foci
Yu-Mee Sohn, Dong Gyu Na, Wooyul Paik, Hye Yun Gwon, Byeong-Joo Noh
Ultrasonography.2021; 40(1): 115. CrossRef
Assessing the diagnostic performance of thyroid biopsy with recommendations for appropriate interpretation
Su Min Ha, Jung Hwan Baek, Dong Gyu Na, Chan-Kwon Jung, Chong Hyun Suh, Young Kee Shong, Tae Yon Sung, Dong Eun Song, Jeong Hyun Lee
Ultrasonography.2021; 40(2): 228. CrossRef
Usage and Diagnostic Yield of Fine-Needle Aspiration Cytology and Core Needle Biopsy in Thyroid Nodules: A Systematic Review and Meta-Analysis of Literature Published by Korean Authors
Soon-Hyun Ahn
Clinical and Experimental Otorhinolaryngology.2021; 14(1): 116. CrossRef
Comparison of the Efficacy and Safety of the American Thyroid Association Guidelines and American College of Radiology TI-RADS
Jinghua Liu, Yajun Guo, Jiangxi Xiao, Luzeng Chen, Zhenwei Liang
Endocrine Practice.2021; 27(7): 661. CrossRef
Malignancy Rate of Bethesda Class III Thyroid Nodules Based on the Presence of Chronic Lymphocytic Thyroiditis in Surgical Patients
Yoon Young Cho, Yun Jae Chung, Hee Sung Kim
Frontiers in Endocrinology.2021;[Epub] CrossRef
Efficacy of Differential Diagnosis of Thyroid Nodules by Shear Wave Elastography—the Stiffness Map
Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Suyeon Park, Sumi Yun, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh
Journal of the Endocrine Society.2021;[Epub] CrossRef
The relationship of thyroid nodule size on malignancy risk according to histological type of thyroid cancer
Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Acta Radiologica.2020; 61(5): 620. CrossRef
Concordance of Three International Guidelines for Thyroid Nodules Classified by Ultrasonography and Diagnostic Performance of Biopsy Criteria
Younghee Yim, Dong Gyu Na, Eun Ju Ha, Jung Hwan Baek, Jin Yong Sung, Ji-hoon Kim, Won-Jin Moon
Korean Journal of Radiology.2020; 21(1): 108. CrossRef
2019 Practice guidelines for thyroid core needle biopsy: a report of the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association
Chan Kwon Jung, Jung Hwan Baek, Dong Gyu Na, Young Lyun Oh, Ka Hee Yi, Ho-Cheol Kang
Journal of Pathology and Translational Medicine.2020; 54(1): 64. CrossRef
Core-Needle Biopsy Does Not Show Superior Diagnostic Performance to Fine-Needle Aspiration for Diagnosing Thyroid Nodules
Ilah Shin, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Si Eun Lee, Hye Sun Lee, Jin Young Kwak
Yonsei Medical Journal.2020; 61(2): 161. CrossRef
Ultrasound‐guided fine‐needle aspiration or core needle biopsy for diagnosing follicular thyroid carcinoma?
Ko Woon Park, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung
Clinical Endocrinology.2020; 92(5): 468. CrossRef
Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules
Hye Min Son, Ji-hoon Kim, Soo Chin Kim, Roh-Eul Yoo, Jeong Mo Bae, Hyobin Seo, Dong Gyu Na
Ultrasonography.2020; 39(2): 159. CrossRef
CT features of thyroid nodules with isolated macrocalcifications detected by ultrasonography
Wooyul Paik, Dong Gyu Na, Hye Yun Gwon, Jinna Kim
Ultrasonography.2020; 39(2): 130. CrossRef
Contribution of cytologic examination to diagnosis of poorly differentiated thyroid carcinoma
Na Rae Kim, Jae Yeon Seok, Yoo Seung Chung, Joon Hyop Lee, Dong Hae Chung
Journal of Pathology and Translational Medicine.2020; 54(2): 171. CrossRef
Comparison Between Fine Needle Aspiration and Core Needle Biopsy for the Diagnosis of Thyroid Nodules: Effective Indications According to US Findings
Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park, Yaeji Lim
Scientific Reports.2020;[Epub] CrossRef
Thyroid Nodules with Isolated Macrocalcifications: Malignancy Risk of Isolated Macrocalcifications and Postoperative Risk Stratification of Malignant Tumors Manifesting as Isolated Macrocalcifications
Hye Yun Gwon, Dong Gyu Na, Byeong-Joo Noh, Wooyul Paik, So Jin Yoon, Soo-Jung Choi, Dong Rock Shin
Korean Journal of Radiology.2020; 21(5): 605. CrossRef
Diagnostic Efficacy and Safety of Core Needle Biopsy as a First-Line Diagnostic Method for Thyroid Nodules: A Prospective Cohort Study
Min Ji Hong, Dong Gyu Na, Hunkyung Lee
Thyroid.2020; 30(8): 1141. CrossRef
Re: The 2019 core-needle biopsy practice guidelines
Ji-hoon Kim
Ultrasonography.2020; 39(3): 313. CrossRef
Cytopathologic criteria and size should be considered in comparison of fine-needle aspiration vs. core-needle biopsy for thyroid nodules: results based on large surgical series
Jung Hyun Yoon, Hye Sun Lee, Eun-Kyung Kim, Hee Jung Moon, Vivian Youngjean Park, Jin Young Kwak
Endocrine.2020; 70(3): 558. CrossRef
Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses
Hee Young Na, Jae Hoon Moon, June Young Choi, Hyeong Won Yu, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park, Paula Soares
PLOS ONE.2020; 15(11): e0241597. CrossRef
The Role of Core Needle Biopsy for the Evaluation of Thyroid Nodules with Suspicious Ultrasound Features
Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Korean Journal of Radiology.2019; 20(1): 158. CrossRef
Pathological diagnosis of thyroid nodules based on core needle biopsies: comparative study between core needle biopsies and resected specimens in 578 cases
Yan Xiong, Limin Yan, Lin Nong, Yalin Zheng, Ting Li
Diagnostic Pathology.2019;[Epub] CrossRef
The Current Histologic Classification of Thyroid Cancer
Sylvia L. Asa
Endocrinology and Metabolism Clinics of North America.2019; 48(1): 1. CrossRef
Core-needle biopsy in thyroid nodules: performance, accuracy, and complications
Miguel Paja, Jose Luis del Cura, Rosa Zabala, Igone Korta, Aitziber Ugalde, José I. López
European Radiology.2019; 29(9): 4889. CrossRef
Ultrasound‐guided needle biopsy of large thyroid nodules: Core needle biopsy yields more reliable results than fine needle aspiration
Hyeon Jin Lee, Young Joong Kim, Hye Yeon Han, Jae Young Seo, Cheol Mog Hwang, KeumWon Kim
Journal of Clinical Ultrasound.2019; 47(5): 255. CrossRef
Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma
Hye-Seon Oh, Hyemi Kwon, Eyun Song, Min Ji Jeon, Tae Yong Kim, Jeong Hyun Lee, Won Bae Kim, Young Kee Shong, Ki-Wook Chung, Jung Hwan Baek, Won Gu Kim
Thyroid.2019; 29(5): 642. CrossRef
Role of Immunohistochemistry in Fine Needle Aspiration and Core Needle Biopsy of Thyroid Nodules
Seulki Song, Hyojin Kim, Soon-Hyun Ahn
Clinical and Experimental Otorhinolaryngology.2019; 12(2): 224. CrossRef
Echogenic foci in thyroid nodules: diagnostic performance with combination of TIRADS and echogenic foci
Su Min Ha, Yun Jae Chung, Hye Shin Ahn, Jung Hwan Baek, Sung Bin Park
BMC Medical Imaging.2019;[Epub] CrossRef
Risk of Malignancy According to the Sub-classification of Atypia of Undetermined Significance and Suspicious Follicular Neoplasm Categories in Thyroid Core Needle Biopsies
Sae Rom Chung, Jung Hwan Baek, Jeong Hyun Lee, Yu-Mi Lee, Tae-Yon Sung, Ki-Wook Chung, Suck Joon Hong, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Won Gu Kim, Dong Eun Song
Endocrine Pathology.2019; 30(2): 146. CrossRef
Thyroid core needle biopsy: patients’ pain and satisfaction compared to fine needle aspiration
Hyo Jin Kim, Yeo Koon Kim, Jae Hoon Moon, June Young Choi, Sang Il Choi
Endocrine.2019; 65(2): 365. CrossRef
Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study
Su Min Ha, Jun Young Shin, Jung Hwan Baek, Dong Eun Song, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
Endocrinology and Metabolism.2019; 34(2): 169. CrossRef
Differential Diagnosis of Thyroid Follicular Neoplasm from Nodular Hyperplasia by Shear Wave Elastography
Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Ji-Oh Mok, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh
Soonchunhyang Medical Science.2019; 25(1): 10. CrossRef
Ultrasound-Guided Core Needle Biopsy Techniques for Intermediate or Low Suspicion Thyroid Nodules: Which Method is Effective for Diagnosis?
Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park
Korean Journal of Radiology.2019; 20(10): 1454. CrossRef
Preoperative Diagnostic Categories of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Thyroid Core Needle Biopsy and Its Impact on Risk of Malignancy
Hee Young Na, Ji Won Woo, Jae Hoon Moon, June Young Choi, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park
Endocrine Pathology.2019; 30(4): 329. CrossRef
Utility of a formatted pathologic reporting system in thyroid core needle biopsy: A validation study of 1998 consecutive cases
Ji‐Young Choe, Yoonjin Kwak, Mimi Kim, Yul Ri Chung, Hyun Jeong Kim, Yeo Koon Kim, So Yeon Park
Clinical Endocrinology.2018; 88(1): 96. CrossRef
Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho, Younghye Kim, Seung Yeon Ha
Annals of Diagnostic Pathology.2018; 32: 35. CrossRef
Prevention of total thyroidectomy in noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) based on combined interpretation of ultrasonographic and cytopathologic results
Sung‐Hye You, Kyu Eun Lee, Roh‐Eul Yoo, Hye Jeong Choi, Kyeong Cheon Jung, Jae‐Kyung Won, Koung Mi Kang, Tae Jin Yoon, Seung Hong Choi, Chul‐Ho Sohn, Ji‐hoon Kim
Clinical Endocrinology.2018; 88(1): 114. CrossRef
Statement and Recommendations on Interventional Ultrasound as a Thyroid Diagnostic and Treatment Procedure
Christoph F. Dietrich, Thomas Müller, Jörg Bojunga, Yi Dong, Giovanni Mauri, Maija Radzina, Manjiri Dighe, Xin-Wu Cui, Frank Grünwald, Andreas Schuler, Andre Ignee, Huedayi Korkusuz
Ultrasound in Medicine & Biology.2018; 44(1): 14. CrossRef
Core needle biopsy of thyroid nodules: outcomes and safety from a large single-center single-operator study
Jooae Choe, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
Acta Radiologica.2018; 59(8): 924. CrossRef
Improvement of diagnostic performance of pathologists by reducing the number of pathologists responsible for thyroid fine needle aspiration cytology: An institutional experience
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho
Diagnostic Cytopathology.2018; 46(7): 561. CrossRef
Comparison of Immunohistochemistry and Direct Sanger Sequencing for Detection of theBRAFV600EMutation in Thyroid Neoplasm
Hye-Seon Oh, Hyemi Kwon, Suyeon Park, Mijin Kim, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Jene Choi, Won Gu Kim, Dong Eun Song
Endocrinology and Metabolism.2018; 33(1): 62. CrossRef
Comparison of the Diagnostic Efficacy of Ultrasound‐Guided Core Needle Biopsy With 18‐ Versus 20‐Gauge Needles for Thyroid Nodules
Hye Shin Ahn, Mirinae Seo, Su Min Ha, Hee Sung Kim
Journal of Ultrasound in Medicine.2018; 37(11): 2565. CrossRef
Impact of Nodule Size on Malignancy Risk Differs according to the Ultrasonography Pattern of Thyroid Nodules
Min Ji Hong, Dong Gyu Na, Jung Hwan Baek, Jin Yong Sung, Ji-Hoon Kim
Korean Journal of Radiology.2018; 19(3): 534. CrossRef
Web‐based thyroid imaging reporting and data system: Malignancy risk of atypia of undetermined significance or follicular lesion of undetermined significance thyroid nodules calculated by a combination of ultrasonography features and biopsy results
Young Jun Choi, Jung Hwan Baek, Jung Hee Shin, Woo Hyun Shim, Seon‐Ok Kim, Won‐Hong Lee, Dong Eun Song, Tae Yong Kim, Ki‐Wook Chung, Jeong Hyun Lee
Head & Neck.2018; 40(9): 1917. CrossRef
Thyroid Incidentalomas Detected on18F-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography: Malignant Risk Stratification and Management Plan
Sae Rom Chung, Young Jun Choi, Chong Hyun Suh, Hwa Jung Kim, Jong Jin Lee, Won Gu Kim, Tae Yon Sung, Yu-mi Lee, Dong Eun Song, Jeong Hyun Lee, Jung Hwan Baek
Thyroid.2018; 28(6): 762. CrossRef
The role of core needle biopsy in the diagnosis of initially detected thyroid nodules: a systematic review and meta-analysis
Sae Rom Chung, Chong Hyun Suh, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
European Radiology.2018; 28(11): 4909. CrossRef
The History of Korean Thyroid Pathology
Soon Won Hong, Chan Kwon Jung
International Journal of Thyroidology.2018; 11(1): 15. CrossRef
Ultrasonographic Echogenicity and Histopathologic Correlation of Thyroid Nodules in Core Needle Biopsy Specimens
Ji-hoon Kim, Dong Gyu Na, Hunkyung Lee
Korean Journal of Radiology.2018; 19(4): 673. CrossRef
Evaluation of Modified Core-Needle Biopsy in the Diagnosis of Thyroid Nodules
Soomin Ahn, Sejin Jung, Ji-Ye Kim, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh
Korean Journal of Radiology.2018; 19(4): 656. CrossRef
Role of core needle biopsy as a first-line diagnostic tool for thyroid nodules: a retrospective cohort study
Min Ji Hong, Dong Gyu Na, Soo Jin Kim, Dae Sik Kim
Ultrasonography.2018; 37(3): 244. CrossRef
Active Surveillance of Low-Risk Papillary Thyroid Microcarcinoma: A Multi-Center Cohort Study in Korea
Hye-Seon Oh, Jeonghoon Ha, Hye In Kim, Tae Hyuk Kim, Won Gu Kim, Dong-Jun Lim, Tae Yong Kim, Sun Wook Kim, Won Bae Kim, Young Kee Shong, Jae Hoon Chung, Jung Hwan Baek
Thyroid.2018; 28(12): 1587. CrossRef
Risk of malignancy according to sub‐classification of the atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda system for reporting thyroid cytopathology
S. J. Kim, J. Roh, J. H. Baek, S. J. Hong, Y. K. Shong, W. B. Kim, D. E. Song
Cytopathology.2017; 28(1): 65. CrossRef
Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm: a matched cohort study
Soo-Yeon Kim, Hye Sun Lee, Jieun Moon, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Jin Young Kwak
European Radiology.2017; 27(2): 801. CrossRef
Follicular variant of papillary thyroid carcinoma: comparison of ultrasound-guided core needle biopsy and ultrasound-guided fine needle aspiration in a multicentre study
Soo Yeon Hahn, Jung Hee Shin, Hyun Kyung Lim, So Lyung Jung
Clinical Endocrinology.2017; 86(1): 113. CrossRef
Core‐needle biopsy versus repeat fine‐needle aspiration for thyroid nodules initially read as atypia/follicular lesion of undetermined significance
Young Jun Choi, Jung Hwan Baek, Chong Hyun Suh, Woo Hyun Shim, Boseul Jeong, Jae Kyun Kim, Dong Eun Song, Tae Yong Kim, Ki‐Wook Chung, Jeong Hyun Lee
Head & Neck.2017; 39(2): 361. CrossRef
Preoperative differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and non-NIFTP
Soo Yeon Hahn, Jung Hee Shin, Hyun Kyung Lim, So Lyung Jung, Young Lyun Oh, In Ho Choi, Chan Kwon Jung
Clinical Endocrinology.2017; 86(3): 444. CrossRef
Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
Dong Gyu Na, Jung Hwan Baek, So Lyung Jung, Ji-hoon Kim, Jin Yong Sung, Kyu Sun Kim, Jeong Hyun Lee, Jung Hee Shin, Yoon Jung Choi, Eun Ju Ha, Hyun Kyung Lim, Soo Jin Kim, Soo Yeon Hahn, Kwang Hwi Lee, Young Jun Choi, Inyoung Youn, Young Joong Kim, Hye Sh
Korean Journal of Radiology.2017; 18(1): 217. CrossRef
First-Line Use of Core Needle Biopsy for High-Yield Preliminary Diagnosis of Thyroid Nodules
H.C. Kim, Y.J. Kim, H.Y. Han, J.M. Yi, J.H. Baek, S.Y. Park, J.Y. Seo, K.W. Kim
American Journal of Neuroradiology.2017; 38(2): 357. CrossRef
Ultrasound-Pathology Discordant Nodules on Core-Needle Biopsy: Malignancy Risk and Management Strategy
Sae Rom Chung, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Thyroid.2017; 27(5): 707. CrossRef
Current status of core needle biopsy of the thyroid
Jung Hwan Baek
Ultrasonography.2017; 36(2): 83. CrossRef
Cytology-Ultrasonography Risk-Stratification Scoring System Based on Fine-Needle Aspiration Cytology and the Korean-Thyroid Imaging Reporting and Data System
Min Ji Hong, Dong Gyu Na, Jung Hwan Baek, Jin Yong Sung, Ji-Hoon Kim
Thyroid.2017; 27(7): 953. CrossRef
Preoperative clinicopathological characteristics of patients with solitary encapsulated follicular variants of papillary thyroid carcinomas
Hyemi Kwon, Min Ji Jeon, Jong Ho Yoon, Suck Joon Hong, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Won Gu Kim, Dong Eun Song
Journal of Surgical Oncology.2017; 116(6): 746. CrossRef
Active Surveillance for Patients With Papillary Thyroid Microcarcinoma: A Single Center’s Experience in Korea
Hyemi Kwon, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Dong Eun Song, Jung Hwan Baek, Ki-Wook Chung, Tae Yong Kim
The Journal of Clinical Endocrinology & Metabolism.2017; 102(6): 1917. CrossRef
Comparison of Consecutive Results from Fine Needle Aspiration and Core Needle Biopsy in Thyroid Nodules
Soon-Hyun Ahn, So-Yeon Park, Sang Il Choi
Endocrine Pathology.2017; 28(4): 332. CrossRef
Efficacy and safety of core-needle biopsy in initially detected thyroid nodules via propensity score analysis
Chong Hyun Suh, Jung Hwan Baek, Young Jun Choi, Tae Yong Kim, Tae Yon Sung, Dong Eun Song, Jeong Hyun Lee
Scientific Reports.2017;[Epub] CrossRef
Comparison of Core-Needle Biopsy and Fine-Needle Aspiration for Evaluating Thyroid Incidentalomas Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: A Propensity Score Analysis
Chong Hyun Suh, Young Jun Choi, Jong Jin Lee, Woo Hyun Shim, Jung Hwan Baek, Han Cheol Chung, Young Kee Shong, Dong Eun Song, Tae Yon Sung, Jeong Hyun Lee
Thyroid.2017; 27(10): 1258. CrossRef
Thyroid Fine-Needle Aspiration Cytology Practice in Korea
Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
Journal of Pathology and Translational Medicine.2017; 51(6): 521. CrossRef
Recent Advances in Core Needle Biopsy for Thyroid Nodules
Chan Kwon Jung, Jung Hwan Baek
Endocrinology and Metabolism.2017; 32(4): 407. CrossRef
Core-needle biopsy for the preoperative diagnosis of follicular neoplasm in thyroid nodule screening: A validation study
Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung
Pathology - Research and Practice.2016; 212(1): 44. CrossRef
The Role of Core-Needle Biopsy as a First-Line Diagnostic Tool for Initially Detected Thyroid Nodules
Chong Hyun Suh, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Jae Kyun Kim, Tae-Yon Sung, Jong Ho Yoon, Young Kee Shong
Thyroid.2016; 26(3): 395. CrossRef
Thyroid nodules with minimal cystic changes have a low risk of malignancy
Dong Gyu Na, Ji-hoon Kim, Dea Sik Kim, Soo Jin Kim
Ultrasonography.2016; 35(2): 153. CrossRef
Thyroid nodules with isolated macrocalcification: malignancy risk and diagnostic efficacy of fine-needle aspiration and core needle biopsy
Dong Gyu Na, Dae Sik Kim, Soo Jin Kim, Jae Wook Ryoo, So Lyung Jung
Ultrasonography.2016; 35(3): 212. CrossRef
Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity
Dong Gyu Na, Jung Hwan Baek, Jin Yong Sung, Ji-Hoon Kim, Jae Kyun Kim, Young Jun Choi, Hyobin Seo
Thyroid.2016; 26(4): 562. CrossRef
Fine‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
Paul A. VanderLaan
Cancer Cytopathology.2016; 124(12): 862. CrossRef
The role of core-needle biopsy in the diagnosis of thyroid malignancy in 4580 patients with 4746 thyroid nodules: a systematic review and meta-analysis
Chong Hyun Suh, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Kyung Won Kim, Jayoun Lee, Ki-Wook Chung, Young Kee Shong
Endocrine.2016; 54(2): 315. CrossRef
The Role of Core-Needle Biopsy for Thyroid Nodules with Initially Nondiagnostic Fine-Needle Aspiration Results: A Systematic Review and Meta-Analysis
Chong Hyun Suh, Jung Hwan Baek, Kyung Won Kim, Tae Yon Sung, Tae Yong Kim, Dong Eun Song, Young Jun Choi, Jeong Hyun Lee
Endocrine Practice.2016; 22(6): 679. CrossRef
Should Core Needle Biopsy be Used in the Evaluation of Thyroid Nodules?
Beril Guler, Tugce Kiran, Dilek Sema Arici, Erhan Aysan, Fatma Cavide Sonmez
Endocrine Pathology.2016; 27(4): 352. CrossRef
A Multicenter Prospective Validation Study for the Korean Thyroid Imaging Reporting and Data System in Patients with Thyroid Nodules
Eun Ju Ha, Won-Jin Moon, Dong Gyu Na, Young Hen Lee, Nami Choi, Soo Jin Kim, Jae Kyun Kim
Korean Journal of Radiology.2016; 17(5): 811. CrossRef
Impact of Reclassification on Thyroid Nodules with Architectural Atypia: From Non-Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinomas to Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features
Min Ji Jeon, Dong Eun Song, Chan Kwon Jung, Won Gu Kim, Hyemi Kwon, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong, Jung Hwan Baek, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Rafael Rosell
PLOS ONE.2016; 11(12): e0167756. CrossRef

Original Articles

Fine Needle Aspiration Cytology of Thyroid Nodules: Assessment of diagnostic accuracy and evaluation of each cytologic diagnosis .: In Ae Park, Eui Keun Ham; Korean J Cytopathol. 1999;10(1):43-53.

1,629 View
11 Download

Abstract PDF: We retrospectively reviewed the results of 1,850 fine needle aspiration cytology (FNAC) of thyroid nodules performed from 1990 to 1991 in the Department of Pathology, Seoul National University Hospital. Among 1,528 cases and 322 cases aspirated by clinicians and a pathologist, 465 cases(30.4%) and 13 cases(4.0%) of the aspirates were inadequate, respectively. In 227 cases, correlation of the FNAC diagnosis and histologic diagnosis was done. Excluding the inadequate cases, the sensitivity for the detection of neoplasm(malignancy together with follicular adenoma) was 86.4% and the specificity was 70.7%. The overall diagnostic accuracy was 79.0%. There were 16 false-positive cases(7.0%), and 19 false-negative cases(8.4%). The predictive value of each cytologic diagnosis was 92% in papillary carcinoma, and 100% in Hashimoto's thyroiditis. The expectancy of malignancy was 52.8% in "suspicious malignancy" and 26.7% in "atypical lesion".

Fine Needle Aspiration Cytologic Diagnosis of Thymoma Presenting as a Thyroid Nodule: A Report of Two Cases.: Dong Ja Kim, Ji Young Park, Yoon Seup Kum, Tae In Park, Yoon Kyung Sohn; Korean J Cytopathol. 2000;11(1):41-46.

1,665 View
12 Download

Abstract PDF: Thymoma is the most common anterior mediastinal tumor in adults. Rarely, it is presented as the anterior neck mass, commonly located in the anterolateral aspect of the neck or adjacent to the thyroid. We experienced two cases of fine needle aspiration cytology of thymoma, mimicking thyroid mass. The first case was an ectopoic cervical thymoma in a 31-year-old female. The fine needle aspiration cytology was misinterpreted as reactive hyperplasia of lymph node. But the histologic diagnosis was thymoma, predominantly lymphocytic type. The second case was an invasive thymoma in a 66-year-old female, who complained a large anterior neck mass. The fine needle aspiration cytology revealed biphasic population of some clusters of epithelial cells and scattered lymphocytes. The cytologic diagnosis was thymoma and was confirmed as invasive thymoma after the biopsy. Therefore, when the cytologic feature of anterior neck mass shows the both lymphocyte and epithelial component, the differential diagnosis should include the possibility of thymoma.

Case Report

Intra-thyroid Thyroglossal Duct Cyst: A Case Report.: Hyun Joo Choi, Ji Han Jung, Jinyoung Yoo, Seok Jin Kang, Kyo Young Lee, Chung Soo Chun, Bong Joo Kang, Eun Suk Cha; Korean J Pathol. 2007;41(2):132-134.

2,276 View
62 Download

Abstract PDF: Thyroglossal duct cysts develop in the persistent remnants of the thyroglossal tract between the origin of the thyroid at the foramen cecum and the final position of the thyroid gland. Thyroglossal duct cyst can present anywhere from the base of the tongue to the manubrium, but its occurrence within the thyroid gland is very rare. We report here on a 41-year-old woman who presented with a cystic thyroid nodule that was due to an intrathyroid thyroglossal duct cyst. The sonogram, showed a hypoechoic nodule that measured 0.7 x 0.6 cm in the left thyroid lobe. Left lobectomy of the thyroid gland was performed and microscopic examination revealed a cyst lined by non-keratinized squamous epithelium, which was consistent with a thyroglossal duct cyst in the thyroid gland. Intrathyroid thyroglossal duct cyst should be considered in the differential diagnosis of a cystic thyroid nodule. This is the first reported case of a intrathyroid thyroglossal duct cyst in a Korean adult.

First
Prev
Page of 1
Next
Last

Search