Journal of Pathology and Translational Medicine

Original Articles

Diagnostic Difficulties in Fine Needle Aspiration of Benign Salivary Glandular Lesions: Hye Jung Jo, Hyo Jung Ahn, Soojin Jung, Hye-Kyoung Yoon; Korean J Pathol. 2012;46(6):569-575. Published online December 26, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.569

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Background

The diagnostic accuracy of fine needle aspiration cytology (FNAC) of salivary lesions is relatively high, but cytologic interpretation might be confusing if the sample is lacking typical cytologic features.

Methods

There were 77 cases of benign salivary lesions, consisting of pleomorphic adenoma (PA) in 61 cases, Warthin's tumor (WT) in 12 cases, and other benign lesions in 4 cases. The causes of the discrepancies between the FNAC and the histologic diagnoses were evaluated.

Results

Major discrepancies were noted in 4 of the 61 PA cases, and in 1 of 12 WT cases. The causes of the major discrepancies were a mislabeled site in 1 PA and 1 WT case, and an interpretation error in 3 PA cases. Minor discrepancies were more common in the WT cases (7 of 12 cases) than in the PA cases (11 of 61 cases). The causes of the minor discrepancies were a mislabeled site in 1 PA and 1 WT case, an inadequate sample in 7 PA and 2 WT cases, a lack of typical cytomorphology in 2 PA and 2 WT cases, and an interpretation error in 1 PA and 2 WT cases.

Conclusions

To increase the diagnostic accuracy in the benign salivary lesions, recognition of both characteristic and less typical cytomorphology is needed.

Citations

Citations to this article as recorded by

Clinical decision making when cytology indicates a Warthin tumor
Minna Sirviö, Katri Aro, Mira Naukkarinen, Antti Mäkitie, Jussi Tarkkanen, Jetta Kelppe, Timo Atula
Scientific Reports.2024;[Epub] CrossRef
Different MRI-based radiomics models for differentiating misdiagnosed or ambiguous pleomorphic adenoma and Warthin tumor of the parotid gland: a multicenter study
Jing Yang, Qiu Bi, Yiren Jin, Yong Yang, Ji Du, Hongjiang Zhang, Kunhua Wu
Frontiers in Oncology.2024;[Epub] CrossRef
Diagnostic Accuracy of Fine Needle Aspiration Cytology (FNAC) in Salivary Gland Lesions with Histopathological Examination (HPE) Correlation in a Tertiary Care Centre in Southern India
Banumathi Kasinathan, Babu Manohar, H. Ganapathy
Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(2): 871. CrossRef
Diagnostic performance of qualitative and radiomics approach to parotid gland tumors: which is the added benefit of texture analysis?
Federica Vernuccio, Federica Arnone, Roberto Cannella, Barbara Verro, Albert Comelli, Francesco Agnello, Alessandro Stefano, Rosalia Gargano, Vito Rodolico, Giuseppe Salvaggio, Roberto Lagalla, Massimo Midiri, Antonio Lo Casto
The British Journal of Radiology.2021;[Epub] CrossRef
Improving the diagnosis of common parotid tumors via the combination of CT image biomarkers and clinical parameters
Dan Zhang, Xiaojiao Li, Liang Lv, Jiayi Yu, Chao Yang, Hua Xiong, Ruikun Liao, Bi Zhou, Xianlong Huang, Xiaoshuang Liu, Zhuoyue Tang
BMC Medical Imaging.2020;[Epub] CrossRef
Evaluation of Salivary Gland Lesions by Fine Needle Aspiration Cytology at a Tertiary Care Hospital, Western Nepal

Anuj Poudel, Bigya Shrestha, Sudeep Regmi
Pathology and Laboratory Medicine International.2020; Volume 12: 9. CrossRef
Ultrasound-guided fine-needle capillary cytology of parotid gland masses coupled with a rapid-on-site evaluation improves results
R. Barats, S. Evrard, L. Collin, S. Vergez, S. Gellée, M. Courtade-Saïdi
Morphologie.2018; 102(336): 25. CrossRef
The Value of Ultrasound-Guided Fine-Needle Aspiration Cytology by Cytopathologists in the Diagnosis of Major Salivary Gland Tumors
Shahrzad Negahban, Sadegh Shirian, Bijan Khademi, Ahmad Oryan, Roshanak Sadoughifar, Mohammadian-Panah Mohammad, Azita Aledavood, Khosrow Daneshbod, Yayha Daneshbod
Journal of Diagnostic Medical Sonography.2016; 32(2): 92. CrossRef
Salivary Gland Tumors: A Diagnostic Dilemma!
Ranjit Kumar Peravali, H. Hari Kishore Bhat, Varsha H. Upadya, Anmol Agarwal, Sushma Naag
Journal of Maxillofacial and Oral Surgery.2015; 14(S1): 438. CrossRef
Diagnostic problems of salivary gland tumors
Ruchita Tyagi, Pranab Dey
Diagnostic Cytopathology.2015; 43(6): 495. CrossRef
Pleomorphic Adenoma of the Accessory Parotid Gland: Case Report and Reappraisal of Intraoral Extracapsular Dissection for Management
Tibebu M. Tsegga, Jennifer D. Britt, Aragon R. Ellwanger
Journal of Oral and Maxillofacial Surgery.2015; 73(3): 564. CrossRef

Neoplastic Stromal Cells of Intracranial Hemangioblastomas Disclose Pericyte-derived Mesenchymal Stromal Cells-like Phenotype.: Yong Han Jung, Jeong Kim, Bo Mi Kim, Eun Kyoung Kim, Mi Seon Kang, Soojin Jung, Young Il Yang, Shin Kwang Khang; Korean J Pathol. 2011;45(6):564-572.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.564

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18 Download
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Abstract PDF

BACKGROUND
Stromal cells (SCs) of hemangioblastomas (HBs) have been regarded as true neoplastic components, but their ontogeny remains unclear. Convincing evidence suggests that embryonic mesenchymal cells may be the cells of origin of HBs. The aim of the present study was to investigate the immunophenotypic characteristics of neoplastic SCs using a set of markers against endothelial cells (ECs), vascular smooth muscle cells (vSMCs), mesenchymal stromal cells (MSCs), and pericytes.
METHODS
Intracranial HBs (n=46), angiolipoma (n=9), and pyogenic granuloma (n=11) were retrieved and the immunophenotypic profile of SCs was determined by immune stainings.
RESULTS
The MIB-1 labeling index was significantly higher in SCs compared to that of ECs and vSMCs, regardless of the type of lesion. The neoplastic SCs of HBs consistently expressed both MSC and pericyte markers, but did not express markers of ECs and vSMCs. Double immunofluorescent staining demonstrated that the neoplastic SCs of HBs expressing MSC or pericyte markers directly abutted onto the ECs of capillaries/venules.
CONCLUSIONS
The results suggest that the neoplastic SCs of HBs share the immunophenotypic profile and distribution with those of pericyte-derived MSCs. Thus, HBs might originate from a distinctive population of pericyte-derived MSCs in the central nervous system.

Citations

Citations to this article as recorded by

Role of Endothelial-to-Mesenchymal Transition in the Pathogenesis of Central Nervous System Hemangioblastomas
Shigeki Takada, Masato Hojo, Noriyoshi Takebe, Kenji Tanigaki, Susumu Miyamoto
World Neurosurgery.2018; 117: e187. CrossRef
Endogenous Gastric-Resident Mesenchymal Stem Cells Contribute to Formation of Cancer Stroma and Progression of Gastric Cancer
Eun-Kyung Kim, Hye-Jung Kim, Young-Il Yang, Jong Tae Kim, Min-Young Choi, Chang Soo Choi, Kwang-Hee Kim, Jeong-Han Lee, Won-Hee Jang, Soon-Ho Cheong
Korean Journal of Pathology.2013; 47(6): 507. CrossRef

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